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PE20080207A1 - DERIVADOS DE 1-N-AMINO-2-IMIDAZOLIDINONAS COMO INHIBIDORES DEL CANAL DE POTASIO Kv1.5 - Google Patents

DERIVADOS DE 1-N-AMINO-2-IMIDAZOLIDINONAS COMO INHIBIDORES DEL CANAL DE POTASIO Kv1.5

Info

Publication number
PE20080207A1
PE20080207A1 PE2007000778A PE2007000778A PE20080207A1 PE 20080207 A1 PE20080207 A1 PE 20080207A1 PE 2007000778 A PE2007000778 A PE 2007000778A PE 2007000778 A PE2007000778 A PE 2007000778A PE 20080207 A1 PE20080207 A1 PE 20080207A1
Authority
PE
Peru
Prior art keywords
ethyl
alkyl
methyl
imidazolidinones
inhibitors
Prior art date
Application number
PE2007000778A
Other languages
English (en)
Inventor
John Michael Janusz
Shengde Wu
Neil T Fairweather
Wenlin Lee
Benjamin E Blass
Andrew J Fluxe
Stephen J Hodson
Ii James M Ridgeway
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PE20080207A1 publication Critical patent/PE20080207A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE 1-N-AMINO-2-IMIDAZOLIDINONAS DE FORMULA (I) DONDE R ES FENILO OPCIONALMENTE SUSTITUIDO CON HALOGENO, HALOALQUILO(C1-C6), CN, NO2, ENTRE OTROS; R1 ES FENILO OPCIONALMENTE SUSTITUIDO CON HALOGENO, ALQUILO(C1-C6), CN, NO2, ENTRE OTROS; R2 ES ALQUILO(C1-C6), CICLOALQUILO(C3-C6) O C(O)R23, DONDE R23 ES ALQUILO(C1-C6) O CICLOALQUILO(C3-C6); R3 ES H, ALQUILO(C1-C6), CICLOALQUILO(C3-C6), ENTRE OTROS; L, L1 Y L2 SON CADA UNO [C(R19)2]n, DONDE R19 ES H, METILO O ETILO; n ES DE 1 A 4; x, y Y z SON CADA UNO 0 O 1. SON COMPUESTOS PREFERIDOS: 2-(4-CICLOPROPILFENIL)-3-[2-(4-METOXIFENIL)ETIL]-1-METIL-1,3,8-TRIAZAESPIRO[4.5]DECAN-4-ONA, 2-(4-TERC-BUTILFENIL)-3-[2-(4-METOXIFENIL)ETIL]-1-METIL-1,3,8-TRIAZAESPIRO[4.5]DECAN-4-ONA, 2-(4-DIFLUOROMETOXIFENIL)-3-[2-(4-METOXIFENIL)ETIL]-1-METIL-1,3,8-TRIAZAESPIRO[4.5]DECAN-4-ONA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DEL CANAL DE POTASIO Kv1.5 SIENDO UTILES EN EL TRATAMIENTO DE ARRITMIA, INSUFICIENCIA CARDIACA
PE2007000778A 2006-06-20 2007-06-19 DERIVADOS DE 1-N-AMINO-2-IMIDAZOLIDINONAS COMO INHIBIDORES DEL CANAL DE POTASIO Kv1.5 PE20080207A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81506606P 2006-06-20 2006-06-20

Publications (1)

Publication Number Publication Date
PE20080207A1 true PE20080207A1 (es) 2008-05-08

Family

ID=38799301

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000778A PE20080207A1 (es) 2006-06-20 2007-06-19 DERIVADOS DE 1-N-AMINO-2-IMIDAZOLIDINONAS COMO INHIBIDORES DEL CANAL DE POTASIO Kv1.5

Country Status (12)

Country Link
US (1) US20070299072A1 (es)
EP (1) EP2035420A2 (es)
JP (1) JP2009541342A (es)
CN (1) CN101472924A (es)
AR (1) AR061522A1 (es)
AU (1) AU2007260984A1 (es)
CA (1) CA2654262A1 (es)
CL (1) CL2007001795A1 (es)
MX (1) MX2008016273A (es)
PE (1) PE20080207A1 (es)
TW (1) TW200813053A (es)
WO (1) WO2007149873A2 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008338368A1 (en) * 2007-12-19 2009-06-25 Wyeth Llc 4-imidazolidinones as Kv1.5 potassium channel inhibitors
AU2008338374A1 (en) * 2007-12-19 2009-06-25 Wyeth Llc 4-imidazolidinones as Kv1.5 potassium channel inhibitors
EP2318388A2 (en) * 2008-07-23 2011-05-11 Schering Corporation Tricyclic spirocycle derivatives and methods of use thereof
HRP20141126T1 (hr) 2009-04-28 2015-01-30 Chugai Seiyaku Kabushiki Kaisha Derivat spiroimidazolona
CN104854106B (zh) 2012-12-10 2017-07-04 中外制药株式会社 乙内酰脲衍生物
RU2701168C2 (ru) 2014-06-09 2019-09-25 Чугаи Сейяку Кабусики Кайся Фармацевтическая композиция, содержащая производные гидантоина
US20230025932A1 (en) * 2019-11-13 2023-01-26 Temple University-Of The Commonwealth System Of Higher Education Novel functionalized lactones as modulators of the 5-hydroxytryptamine receptor 7 and their method of use
EP4196121A4 (en) * 2020-08-11 2025-05-07 Board Of Trustees Of Michigan State University Proteasome enhancers and uses thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3155669A (en) * 1962-06-22 1964-11-03 Res Lab Dr C Janssen N V 2, 4, 8-triaza-spiro (4, 5) dec-2-enes
US3155670A (en) * 1962-06-22 1964-11-03 Res Lab Dr C Janssen N V 1-oxo-2, 4, 8, triaza-spiro (4, 5) decanes
US3839341A (en) * 1966-06-13 1974-10-01 Fmc Corp Substituted 1,3,8-triazaspiro(4.5)decanes
US3901898A (en) * 1971-04-15 1975-08-26 Sumitomo Chemical Co 8-aroylalkyl-1,3,8-triazaspiro (4,5)+0 decanes
US4656280A (en) * 1984-03-07 1987-04-07 E. I. Du Pont De Nemours And Company Radioiodinated dopamine receptor ligand
US4707484A (en) * 1986-11-25 1987-11-17 Hoffmann-La Roche Inc. Substituted piperidinomethylindolone and cyclopent(b)indolone derivatives
US4876260A (en) * 1987-10-28 1989-10-24 State Of Israel, Israel Institute Of Biological Research Oxathiolanes
US5244902A (en) * 1989-08-21 1993-09-14 Beth Israel Hospital Association Topical application of spiperone or derivatives thereof for treatment of pathological conditions associated with immune responses
PT921125E (pt) * 1997-12-05 2002-06-28 Hoffmann La Roche Derivados de 1,38-triaza-espiro 4,5 decan-4-ona
US6277991B1 (en) * 1998-05-18 2001-08-21 Novo Nordisk A/S 1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes
US6262066B1 (en) * 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
MY125533A (en) * 1999-12-06 2006-08-30 Bristol Myers Squibb Co Heterocyclic dihydropyrimidine compounds
US6482829B2 (en) * 2000-06-08 2002-11-19 Hoffmann-La Roche Inc. Substituted heterocyclic siprodecane compound active as an antagonist of neurokinin 1 receptor
RU2006117368A (ru) * 2003-10-23 2007-12-10 Ф.Хоффманн-Ля Рош Аг (Ch) Производные триазаспиропипередина, предназначенные для применения в качестве ингибиторов glyt-1 при лечении неврологических и психоневрологических нарушений
AR046756A1 (es) * 2003-12-12 2005-12-21 Solvay Pharm Gmbh Derivados de hidronopol como agonistas de receptores orl-1 humanos.

Also Published As

Publication number Publication date
AU2007260984A1 (en) 2007-12-27
MX2008016273A (es) 2009-01-15
TW200813053A (en) 2008-03-16
CA2654262A1 (en) 2007-12-27
CL2007001795A1 (es) 2008-01-18
EP2035420A2 (en) 2009-03-18
AR061522A1 (es) 2008-09-03
CN101472924A (zh) 2009-07-01
WO2007149873A3 (en) 2008-03-06
US20070299072A1 (en) 2007-12-27
JP2009541342A (ja) 2009-11-26
WO2007149873A2 (en) 2007-12-27

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