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PE20110843A1 - Derivados de 5-(1h-imidazol-5-il)-2-fenilpirimidina, como inhibidores de prostaglandina d sintasa hematopoyetica - Google Patents

Derivados de 5-(1h-imidazol-5-il)-2-fenilpirimidina, como inhibidores de prostaglandina d sintasa hematopoyetica

Info

Publication number
PE20110843A1
PE20110843A1 PE2011000665A PE2011000665A PE20110843A1 PE 20110843 A1 PE20110843 A1 PE 20110843A1 PE 2011000665 A PE2011000665 A PE 2011000665A PE 2011000665 A PE2011000665 A PE 2011000665A PE 20110843 A1 PE20110843 A1 PE 20110843A1
Authority
PE
Peru
Prior art keywords
prostaglandin
hematopoyetic
phenylpyrimidine
imidazol
inhibitors
Prior art date
Application number
PE2011000665A
Other languages
English (en)
Inventor
Gregory W Endres
Pil Heui Lee
Kirk Lang Olson
James Bernard Kramer
Fred Lawrence Ciske
Stephen Douglas Barrett
Original Assignee
Cayman Chem Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cayman Chem Co filed Critical Cayman Chem Co
Publication of PE20110843A1 publication Critical patent/PE20110843A1/es

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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61P11/06—Antiasthmatics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

REFERIDA A UN COMPUESTO DE FORMULA I, DONDE R1 ES ALQUILO C1-C6, CICLOALQUILO C3-C6, FENILO, 2-PIRIDILO, 3-PIRIDILO, ENTRE OTROS; R2 ES FENILO, 3-FLUOROFENIL, 2-PIRIDIL, PIRIDIN, ENTRE OTROS; W ES ENLACE COVALENTE, O, S, SO, SO2, CO, NH, ENTRE OTROS; Y1, Y2 E Y3 FORMAN JUNTO AL N UN ANILLO DE PREFERENCIA PIRIMIDIN; U1, U2, U3, U4 FORMAN UN ANILLO DE PREFERENCIA 4-IL-OMIDAZOL, 3-PIRAZOL, OXAZOL. SON COMPUESTOS PREFERIDOS: ACIDO-2-(2-FENILPIRIMIDINA-5-IL)TIAZOL-4-CARBOXILICO; FENIL-(5-(2-(PIRIDIN-3-IL)-1H-IMIDAZOL-5-IL)PIRIMIDINA-2-IL)METANONA; ENTRE OTROS. DICHOS COMPUESTOS SON INHIBIDORES DE PROSTAGLANDINA D HEMATOPOYETICA (H-PGDS) UTILES EN EL TRATAMIENTO Y PREVENCION DE ENFERMEDADES Y AFECCIONES MEDIADAS POR PROSTAGLANDINA D2
PE2011000665A 2008-09-22 2009-09-22 Derivados de 5-(1h-imidazol-5-il)-2-fenilpirimidina, como inhibidores de prostaglandina d sintasa hematopoyetica PE20110843A1 (es)

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US9894208P 2008-09-22 2008-09-22

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PE20110843A1 true PE20110843A1 (es) 2011-12-08

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PE2011000665A PE20110843A1 (es) 2008-09-22 2009-09-22 Derivados de 5-(1h-imidazol-5-il)-2-fenilpirimidina, como inhibidores de prostaglandina d sintasa hematopoyetica

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US (3) US8536185B2 (es)
EP (1) EP2350059B1 (es)
JP (1) JP2014001228A (es)
KR (2) KR101406433B1 (es)
AP (1) AP3272A (es)
AU (1) AU2009292931B2 (es)
BR (1) BRPI0919004A2 (es)
CA (1) CA2736955C (es)
CL (2) CL2011000604A1 (es)
CO (1) CO6362005A2 (es)
CR (1) CR20110196A (es)
EC (1) ECSP11010995A (es)
IL (3) IL211629A0 (es)
MX (1) MX2011003011A (es)
MY (1) MY154000A (es)
NI (1) NI201100056A (es)
NZ (1) NZ592297A (es)
PE (1) PE20110843A1 (es)
PH (1) PH12013502370A1 (es)
SG (1) SG2014014013A (es)
WO (1) WO2010033977A2 (es)

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