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PE20091173A1 - Derivados de heteroarilo como antagonistas de receptor de orexina - Google Patents

Derivados de heteroarilo como antagonistas de receptor de orexina

Info

Publication number
PE20091173A1
PE20091173A1 PE2008002139A PE2008002139A PE20091173A1 PE 20091173 A1 PE20091173 A1 PE 20091173A1 PE 2008002139 A PE2008002139 A PE 2008002139A PE 2008002139 A PE2008002139 A PE 2008002139A PE 20091173 A1 PE20091173 A1 PE 20091173A1
Authority
PE
Peru
Prior art keywords
methanone
pyrrolidin
chloro
phenyl
orexin receptor
Prior art date
Application number
PE2008002139A
Other languages
English (en)
Inventor
Henner Knust
Matthias Nettekoven
Emmanuel Pinard
Olivier Roche
Mark Rogers-Evans
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20091173A1 publication Critical patent/PE20091173A1/es

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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
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  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE HETEROARILO DONDE Ar ES ARILO O HETEROARILO OPCIONALMENTE SUSTITUIDO CON R2, DONDE R2 ES OH, HALOGENO, ALQUILO INFERIOR, ALCOXI INFERIOR, ENTRE OTROS; R1 ES H O ALQUILO INFERIOR; Het ES HETEROARILO OPCIONALMENTE SUSTITUIDO CON R3, DONDE R3 ES OH, HALOGENO, =O, ALQUILO INFERIOR, ENTRE OTROS; n ES 1 O 2. SON COMPUESTOS PREFERIDOS: [3-(6-CLORO-BENZOOXAZOL-2-ILAMINO)-PIRROLIDIN-1-IL]-(2,6-DI-METOXI-FENIL)-METANONA, [(R)-3-(6-CLORO-BENZOOXAZOL-2-ILAMINO)-PIRROLIDIN-1-IL]-(2-PIRROL-1-IL-FENIL)-METANONA, [(R)-3-(6-CLORO-BENZOOXAZOL-2-ILAMINO)-PIRROLIDIN-1-IL]-(2,6-DICLORO-FENIL)-METANONA, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR DE OREXINA SIENDO UTILES EN EL TRATAMIENTO DE NARCOLEPSIA, ANSIEDAD, DEPRESION, BULIMIA, ENFERMEDAD DE HUNTINGTON
PE2008002139A 2007-12-21 2008-12-18 Derivados de heteroarilo como antagonistas de receptor de orexina PE20091173A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07150294 2007-12-21

Publications (1)

Publication Number Publication Date
PE20091173A1 true PE20091173A1 (es) 2009-08-03

Family

ID=40568638

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008002139A PE20091173A1 (es) 2007-12-21 2008-12-18 Derivados de heteroarilo como antagonistas de receptor de orexina

Country Status (14)

Country Link
US (1) US7897627B2 (es)
EP (1) EP2234999A1 (es)
JP (1) JP5395808B2 (es)
KR (1) KR101204213B1 (es)
CN (1) CN101903372B (es)
AR (1) AR069849A1 (es)
AU (1) AU2008340421B2 (es)
BR (1) BRPI0821141A2 (es)
CA (1) CA2705411A1 (es)
CL (1) CL2008003787A1 (es)
IL (1) IL205665A (es)
PE (1) PE20091173A1 (es)
TW (1) TW200930362A (es)
WO (1) WO2009080533A1 (es)

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AR069849A1 (es) 2010-02-24
JP2011506534A (ja) 2011-03-03
CN101903372A (zh) 2010-12-01
CA2705411A1 (en) 2009-07-02
KR20100082807A (ko) 2010-07-19
IL205665A0 (en) 2010-11-30
KR101204213B1 (ko) 2012-11-26
WO2009080533A1 (en) 2009-07-02
AU2008340421A1 (en) 2009-07-02
CL2008003787A1 (es) 2010-02-19
AU2008340421B2 (en) 2013-12-19
EP2234999A1 (en) 2010-10-06
IL205665A (en) 2014-01-30
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US20090163485A1 (en) 2009-06-25
US7897627B2 (en) 2011-03-01

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