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PE20071152A1 - Compuestos derivados de azabiciclo[3.1.0]hex como moduladores de receptores de dopamina d3 - Google Patents

Compuestos derivados de azabiciclo[3.1.0]hex como moduladores de receptores de dopamina d3

Info

Publication number
PE20071152A1
PE20071152A1 PE2007000392A PE2007000392A PE20071152A1 PE 20071152 A1 PE20071152 A1 PE 20071152A1 PE 2007000392 A PE2007000392 A PE 2007000392A PE 2007000392 A PE2007000392 A PE 2007000392A PE 20071152 A1 PE20071152 A1 PE 20071152A1
Authority
PE
Peru
Prior art keywords
hex
phenyl
alkyl
azabicycle
dopamine
Prior art date
Application number
PE2007000392A
Other languages
English (en)
Inventor
Barbara Bertani
Giorgio Bonanomi
Anna Maria Capelli
Anna Checchia
Fabio Romano Di
Gabriella Gentille
Fabrizio Micheli
Alessandra Pasquarello
Giovanna Tedesco
Silvia Terreni
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0607892A external-priority patent/GB0607892D0/en
Priority claimed from GB0700363A external-priority patent/GB0700363D0/en
Priority claimed from GB0703404A external-priority patent/GB0703404D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PE20071152A1 publication Critical patent/PE20071152A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Gynecology & Obstetrics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE AZABICICLO[3.1.0]HEX DE FORMULA (I)' DONDE G ES FENILO, HETEROARILO MONOCICLICO DE 5 A 6 MIEMBROS O HETEROARILO BICICLICO DE 8 A 11 MIEMBROS; A ES UN COMPUESTO DE FORMULA (P1) O (P2), DONDE R4 ES H, HALOGENO, ALQUILO(C1-C4), CICLOALQUILO(C3-C7), ENTRE OTROS; R5 ES H, HIDROXI, HALOALQUILO(C1-C4), ALCOXI(C1-C4), ENTRE OTROS; p ES DE 0 A 5; R1 ES HALOGENO, CN, ALQUILO(C1-C4), ALCOXI(C1-C4), ENTRE OTROS; R2 ES H O ALQUILO(C1-C4); n ES DE 3 A 6; R7 ES H O ALQUILO(C1-C2). SON COMPUESTOS PREFERIDOS: 1-(3-{(1S,5R)-1-[4-(TRIFLUOROMETIL)FENIL]-3-AZABICICLO[3.1.0]HEX-3-IL}PROPIL)-2,4(1H,3H)-PIRIMIDINADIONA, 5-METIL-1-(3-{(1S,5R)-1-[4-(TRIFLUOROMETIL)FENIL]-3-AZABICICLO[3.1.0]HEX-3-IL}PROPIL)-2,4(1H,3H)-PIRIMIDINADIONA, 5-METIL-1-(4-{(1S,5R)-1-[4-(TRIFLUOROMETIL)FENIL]-3-AZABICICLO[3.1.0]HEX-3-IL}BUTIL)-2,4(1H,3H)-PIRIMIDINADIONA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DE LOS RECEPTORES DE DOPAMINA D3 SIENDO UTILES EN EL TRATAMIENTO DE ESQUIZOFRENIA, TRASTORNO PSICOTICO, ALCOHOLISMO, DEPRESION, ENFERMEDAD DE ALZHEIMER
PE2007000392A 2006-04-03 2007-03-30 Compuestos derivados de azabiciclo[3.1.0]hex como moduladores de receptores de dopamina d3 PE20071152A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0607892A GB0607892D0 (en) 2006-04-03 2006-04-03 Novel compounds
GB0700363A GB0700363D0 (en) 2007-01-09 2007-01-09 Novel compounds
GB0703404A GB0703404D0 (en) 2007-02-21 2007-02-21 Novel compounds

Publications (1)

Publication Number Publication Date
PE20071152A1 true PE20071152A1 (es) 2007-12-16

Family

ID=38283980

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000392A PE20071152A1 (es) 2006-04-03 2007-03-30 Compuestos derivados de azabiciclo[3.1.0]hex como moduladores de receptores de dopamina d3

Country Status (17)

Country Link
US (1) US7727988B2 (es)
EP (1) EP2007750B1 (es)
JP (1) JP5189074B2 (es)
KR (1) KR20080109063A (es)
AR (1) AR060237A1 (es)
AU (1) AU2007233715A1 (es)
BR (1) BRPI0709660A2 (es)
CA (1) CA2648087A1 (es)
CR (1) CR10346A (es)
EA (1) EA200870404A1 (es)
ES (1) ES2434337T3 (es)
IL (1) IL194385A0 (es)
MA (1) MA30355B1 (es)
MX (1) MX2008012875A (es)
PE (1) PE20071152A1 (es)
TW (1) TW200815404A (es)
WO (1) WO2007113232A1 (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2060570T3 (da) * 2004-02-23 2012-04-30 Glaxo Group Ltd Som modulatorer af dopamin-d3-receptorer anvendelige azabicyclo(3.1.0)hexanderivater
GB0507602D0 (en) * 2005-04-14 2005-05-18 Glaxo Group Ltd Compounds
GB0507601D0 (en) * 2005-04-14 2005-05-18 Glaxo Group Ltd Compounds
GB0512099D0 (en) * 2005-06-14 2005-07-20 Glaxo Group Ltd Compounds
JP5068747B2 (ja) * 2005-06-14 2012-11-07 グラクソ グループ リミテッド ドーパミンｄ３受容体のモジュレーターとしてのアザビシクロ［３．１．０］ヘキサン誘導体
GB0517187D0 (en) * 2005-08-22 2005-09-28 Glaxo Group Ltd Compounds
GB0517193D0 (en) * 2005-08-22 2005-09-28 Glaxo Group Ltd Novel use
US7799815B2 (en) * 2005-08-22 2010-09-21 Glaxo Group Limited Triazole derivatives as modulators of dopamine D3 receptors
GB0517175D0 (en) * 2005-08-22 2005-09-28 Glaxo Group Ltd Compounds
GB0517191D0 (en) 2005-08-22 2005-09-28 Glaxo Group Ltd Compounds
US8222266B2 (en) * 2006-04-03 2012-07-17 Glaxo Group Limited Azabicyclo [3.1.0] hexyl derivatives as modulators of dopamine D3 receptors
EP2010518B1 (en) * 2006-04-03 2011-02-16 Glaxo Group Limited Azabicyclo [3. 1. o] hexane derivatives as modulators of dopamine d3 receptors
GB0719235D0 (en) 2007-10-02 2007-11-14 Glaxo Group Ltd Novel compounds
MX2012000231A (es) * 2009-06-26 2012-03-07 Panacea Biotec Ltd Nuevos aza-biciclo-hexanos.
EP2569298B1 (en) 2010-05-12 2015-11-25 Boehringer Ingelheim International GmbH Novel ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments
KR20150096794A (ko) * 2012-12-21 2015-08-25 제니쓰 에피제네틱스 코포레이션 브로모도메인 저해제로서의 신규한 헤테로사이클릭 화합물
SG11201510409QA (en) 2013-06-21 2016-01-28 Zenith Epigenetics Corp Novel bicyclic bromodomain inhibitors
WO2015004534A2 (en) 2013-06-21 2015-01-15 Zenith Epigenetics Corp. Novel substituted bicyclic compounds as bromodomain inhibitors
AU2014298051B2 (en) 2013-07-31 2018-11-15 Zenith Epigenetics Ltd. Novel quinazolinones as bromodomain inhibitors
CA2966303A1 (en) 2014-12-01 2016-06-09 Zenith Epigenetics Ltd. Substituted pyridines as bromodomain inhibitors
WO2016087936A1 (en) 2014-12-01 2016-06-09 Zenith Epigenetics Corp. Substituted pyridinones as bromodomain inhibitors
US10292968B2 (en) 2014-12-11 2019-05-21 Zenith Epigenetics Ltd. Substituted heterocycles as bromodomain inhibitors
EP3233846A4 (en) 2014-12-17 2018-07-18 Zenith Epigenetics Ltd. Inhibitors of bromodomains
US11447484B2 (en) 2018-01-26 2022-09-20 Shionogi & Co., Ltd. Cyclic compound having dopamine D3 receptor antagonistic effect
TWI702954B (zh) 2018-03-01 2020-09-01 美商美國禮來大藥廠 Cd73抑制劑
EP3906927B1 (en) * 2020-05-04 2022-05-25 BIOPROJET Pharma Use of dopamine d3 partial agonists for treating central nervous system disorders
CN116134029B (zh) * 2020-12-10 2025-09-12 上海翰森生物医药科技有限公司 氧代氮环类衍生物调节剂、其制备方法和应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204284B1 (en) 1991-12-20 2001-03-20 American Cyanamid Company Use of 1-(substitutedphenyl)-3-azabicyclo[3.1.0]hexanes for the treatment of chemical dependencies
DE4338396A1 (de) 1993-11-10 1995-05-11 Basf Ag N-Substituierte Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
DE4425143A1 (de) * 1994-07-15 1996-01-18 Basf Ag Substituierte Pyrimidinverbindungen und deren Verwendung
DE10311065A1 (de) 2003-03-13 2004-09-23 Abbott Gmbh & Co. Kg Pyrimidin-2-on-Verbindungen und ihre therapeutische Verwendung
DK2060570T3 (da) 2004-02-23 2012-04-30 Glaxo Group Ltd Som modulatorer af dopamin-d3-receptorer anvendelige azabicyclo(3.1.0)hexanderivater
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DE102004061593A1 (de) * 2004-12-21 2006-06-22 Abbott Gmbh & Co. Kg Substituierte N-heterocyclische Verbindungen und ihre therapeutische Verwendung
GB0507602D0 (en) 2005-04-14 2005-05-18 Glaxo Group Ltd Compounds
GB0512099D0 (en) 2005-06-14 2005-07-20 Glaxo Group Ltd Compounds
GB0517191D0 (en) * 2005-08-22 2005-09-28 Glaxo Group Ltd Compounds
US8222266B2 (en) 2006-04-03 2012-07-17 Glaxo Group Limited Azabicyclo [3.1.0] hexyl derivatives as modulators of dopamine D3 receptors
EP2010518B1 (en) 2006-04-03 2011-02-16 Glaxo Group Limited Azabicyclo [3. 1. o] hexane derivatives as modulators of dopamine d3 receptors

Also Published As

Publication number Publication date
IL194385A0 (en) 2009-08-03
TW200815404A (en) 2008-04-01
US20070249642A1 (en) 2007-10-25
MX2008012875A (es) 2008-10-13
JP5189074B2 (ja) 2013-04-24
CR10346A (es) 2008-10-29
AU2007233715A1 (en) 2007-10-11
MA30355B1 (fr) 2009-04-01
AR060237A1 (es) 2008-06-04
ES2434337T3 (es) 2013-12-16
KR20080109063A (ko) 2008-12-16
BRPI0709660A2 (pt) 2011-07-19
EP2007750A1 (en) 2008-12-31
EP2007750B1 (en) 2013-08-21
CA2648087A1 (en) 2007-10-11
US7727988B2 (en) 2010-06-01
EA200870404A1 (ru) 2009-04-28
WO2007113232A1 (en) 2007-10-11
JP2009532424A (ja) 2009-09-10

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