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PE20060599A1 - DERIVADOS PIRAZOLO-[3,4-d]-PIRIMIDINA COMO INHIBIDORES DE LA ACTIVIDAD DEL RECEPTOR CANNABINOIDE 1 - Google Patents

DERIVADOS PIRAZOLO-[3,4-d]-PIRIMIDINA COMO INHIBIDORES DE LA ACTIVIDAD DEL RECEPTOR CANNABINOIDE 1

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Publication number
PE20060599A1
PE20060599A1 PE2005001251A PE2005001251A PE20060599A1 PE 20060599 A1 PE20060599 A1 PE 20060599A1 PE 2005001251 A PE2005001251 A PE 2005001251A PE 2005001251 A PE2005001251 A PE 2005001251A PE 20060599 A1 PE20060599 A1 PE 20060599A1
Authority
PE
Peru
Prior art keywords
phenyl
activity
cannabinoid receptor
pyrazole
inhibitors
Prior art date
Application number
PE2005001251A
Other languages
English (en)
Inventor
Hong Liu
Xiaohui He
Kunyong Yang
Zhicheng Wang
Boagen Wu
Truc Ngoc Nguyen
Yun He
David Archer Ellis
David H Woodmansee
Ha-Soon Choi
Original Assignee
Irm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Irm Llc filed Critical Irm Llc
Publication of PE20060599A1 publication Critical patent/PE20060599A1/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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Abstract

SE REFIERE A UN COMPUESTO SELECCIONADO ENTRE Ia, Ib, ENTRE OTROS; DONDE Y ES O, NR7, S, DONDE R7 ES H, HIDROXILO, ALQUILO(C1-C6); R1 ES HETEROARILO(C5-C10), CICLOALQUILO(C3-C12), FENILO,ENTRE OTROS; R2 ES HETEROCICLOALQUILO(C3-C8), HETEROARILO(C5-C10), FENILO, ENTRE OTROS; R3 ES H, HALOGENO, CIANO, ENTRE OTROS; R4 ES ALQUILO(C1-C6), HETEROARILO(C5-C10), CICLOALQUILO(C3-C12), ENTRE OTROS; R5 ES H, HALOGENO, ALQUILO(C1-C6), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 5-(4-CLORO-FENIL)-6-(2,4-DICLORO-FENIL)-1-FENIL-1,5-DIHIDRO-PIRAZOLO-[3,4-d]-PIRIMIDIN-4-ONA, 5-(4-BROMO-FENIL)-1-FENIL-6-p-TOLIL-1,5-DIHIDRO-PIRAZOLO-[3,4-d]-PIRIMIDIN-4-ONA, 5-(4-CLORO-FENIL)-6-(2,4-DICLORO-FENIL)-1-FENIL-1H-PIRAZOLO-[3,4-d]-PIRIDIN-4-ILAMINA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS INHIBEN LA ACTIVIDAD DEL RECEPTOR CANNABINOIDE 1 (CB1) SIENDO UTILES EN EL TRATAMIENTO DE ENFERMEDADES TALES COMO PSICOSIS, NEUROPATIA, MIGRANA, ENTRE OTROS
PE2005001251A 2004-10-26 2005-10-25 DERIVADOS PIRAZOLO-[3,4-d]-PIRIMIDINA COMO INHIBIDORES DE LA ACTIVIDAD DEL RECEPTOR CANNABINOIDE 1 PE20060599A1 (es)

Applications Claiming Priority (2)

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US62250804P 2004-10-26 2004-10-26
US67267005P 2005-04-18 2005-04-18

Publications (1)

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PE20060599A1 true PE20060599A1 (es) 2006-08-22

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MX2007004936A (es) 2007-06-25
BRPI0517015A (pt) 2008-09-30
CN101048408B (zh) 2011-07-06
TNSN07161A1 (en) 2008-11-21
CA2730374A1 (en) 2006-05-04
CA2581225A1 (en) 2006-05-04
US8158634B2 (en) 2012-04-17
IL182527A0 (en) 2007-09-20
EP1807429A2 (en) 2007-07-18
KR100919524B1 (ko) 2009-10-01
MA28937B1 (fr) 2007-10-01
RU2007119449A (ru) 2008-12-10
CN102241680A (zh) 2011-11-16
CA2581225C (en) 2011-10-25
NO20072352L (no) 2007-05-31
EP1807429A4 (en) 2010-03-24
JP2008518016A (ja) 2008-05-29
JP2011190281A (ja) 2011-09-29
US20120225869A1 (en) 2012-09-06
WO2006047516A2 (en) 2006-05-04
AU2005299421A1 (en) 2006-05-04
RU2431635C2 (ru) 2011-10-20
ECSP077421A (es) 2007-05-30
WO2006047516A3 (en) 2006-10-12
TW200630096A (en) 2006-09-01
CN101048408A (zh) 2007-10-03
KR20070057980A (ko) 2007-06-07
AU2005299421B2 (en) 2010-01-28
US20090247517A1 (en) 2009-10-01
AU2009251216A1 (en) 2010-01-28
AR051596A1 (es) 2007-01-24

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