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PE20081496A1 - Derivados de 2,5-dihidro-3-h-pirazolo[4,3-c]piridazin-3-ona sustituidos como antagonistas de los receptores cb1 - Google Patents

Derivados de 2,5-dihidro-3-h-pirazolo[4,3-c]piridazin-3-ona sustituidos como antagonistas de los receptores cb1

Info

Publication number
PE20081496A1
PE20081496A1 PE2007001610A PE2007001610A PE20081496A1 PE 20081496 A1 PE20081496 A1 PE 20081496A1 PE 2007001610 A PE2007001610 A PE 2007001610A PE 2007001610 A PE2007001610 A PE 2007001610A PE 20081496 A1 PE20081496 A1 PE 20081496A1
Authority
PE
Peru
Prior art keywords
phenyl
ona
pirazolo
dihidro
receptors
Prior art date
Application number
PE2007001610A
Other languages
English (en)
Inventor
Christian Congy
Santos Victor Dos
Murielle Rinaldi-Carmona
Arnaud Rouquette
Broeck Didier Van
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of PE20081496A1 publication Critical patent/PE20081496A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
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    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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Abstract

SE REFIERE A DERIVADOS DE 2,5-DIHIDRO-3-H-PIRAZOLO[4,3-C]PIRIDAZIN-3-ONA SUSTITUIDOS DE FORMULA (I), EN DONDE R1 ES UN ALQUILO(C1-C12), CARBOCICLO NO AROMATICO(C3-C12), FENILO, PIRROLILO, ENTRE OTROS; R2 Y R3 SON INDEPENDIENTEMENTE FENILO SUSTITUIDO O NO POR HALOGENO, HIDROXI, -O(CH2)mR5, ENTRE OTROS; R4 ES H, ALQUILO(C1-C4), ALCOXI(C1-C4) O HIDROXI; R5 ES -NR7R8 O -SAlk. SON SELECCIONADOS: 5-(4-CLOROFENIL)-6-(2,4-DICLOROFENIL)-2-(4-ISOPROPILBENCIL)-2,5-DIHIDRO-3H-PIRAZOLO[4,3-c]PIRIDAZIN-3-ONA, N-{2-[(3-CLORO-4-{5-[4-(METILTIO)FENIL]-3-OXO-2-[4-(TRIFLUORO-METIL)BENCIL]-3,5-DIHIDRO-2H-PIRAZOLO[4,3-c]PIRIDAZIN-6-IL}FENIL)TIO]ETIL}CICLO-PROPANOCARBOXAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO O PREVENCION DE ENFERMEDADES LIGADAS A LOS RECEPTORES DE CANNABINOIDES CB1, TALES COMO TRASTORNOS DE PSIQUIATRICOS Y/O NEURODEGENERATIVOS
PE2007001610A 2006-11-23 2007-11-20 Derivados de 2,5-dihidro-3-h-pirazolo[4,3-c]piridazin-3-ona sustituidos como antagonistas de los receptores cb1 PE20081496A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0610371A FR2909090B1 (fr) 2006-11-23 2006-11-23 Derives de 2,5-dihydro-3h-pyrazolo[4,3-c]pyridazin-3-one substitues,leur preparation et leur application en therapeutique.

Publications (1)

Publication Number Publication Date
PE20081496A1 true PE20081496A1 (es) 2009-01-04

Family

ID=38229329

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007001610A PE20081496A1 (es) 2006-11-23 2007-11-20 Derivados de 2,5-dihidro-3-h-pirazolo[4,3-c]piridazin-3-ona sustituidos como antagonistas de los receptores cb1

Country Status (20)

Country Link
US (1) US7915258B2 (es)
EP (1) EP2094706B1 (es)
JP (1) JP2010510297A (es)
KR (1) KR20090092774A (es)
CN (1) CN101541802A (es)
AR (1) AR063898A1 (es)
AT (1) ATE494290T1 (es)
AU (1) AU2007330652A1 (es)
BR (1) BRPI0719291A2 (es)
CA (1) CA2668196A1 (es)
CL (1) CL2007003346A1 (es)
DE (1) DE602007011815D1 (es)
FR (1) FR2909090B1 (es)
IL (1) IL198523A0 (es)
MX (1) MX2009005447A (es)
PE (1) PE20081496A1 (es)
RU (1) RU2009123841A (es)
TW (1) TW200836739A (es)
UY (1) UY30742A1 (es)
WO (1) WO2008068424A2 (es)

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JP5800813B2 (ja) * 2010-08-04 2015-10-28 武田薬品工業株式会社 複素環化合物
TW201400446A (zh) 2012-05-22 2014-01-01 Genentech Inc Ｎ－取代之苯甲醯胺及其使用方法
WO2015038655A1 (en) 2013-09-12 2015-03-19 Alios Biopharma, Inc. Aza-pyridone compounds and uses thereof
MX370085B (es) * 2013-09-12 2019-11-29 Janssen Biopharma Inc Compuestos de piridazinona y usos de los mismos.
JP6422164B2 (ja) 2013-12-26 2018-11-14 塩野義製薬株式会社 含窒素６員環誘導体およびそれらを含有する医薬組成物
CN107531717B (zh) 2015-03-11 2021-07-27 詹森生物制药有限公司 氮杂-吡啶酮化合物及其用途
TWI715569B (zh) 2015-04-24 2021-01-11 日商塩野義製藥股份有限公司 ６員雜環衍生物及含有彼等之醫藥組合物
US11066409B2 (en) 2016-10-17 2021-07-20 Shionogi & Co., Ltd. Bicyclic nitrogen-containing heterocyclic derivatives and pharmaceutical composition comprising the same
PH12022550597A1 (en) 2019-09-16 2024-03-04 Takeda Pharmaceuticals Co Azole-fused pyridazin-3(2h)-one derivatives
TW202321229A (zh) 2021-08-18 2023-06-01 美商富曼西公司 殺真菌的取代的雜環化合物
CN118546389B (zh) * 2024-07-29 2024-10-15 陕西理工大学 哒嗪氢键骨架荧光传感材料及其制备方法和应用

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WO2008068424A2 (fr) 2008-06-12
KR20090092774A (ko) 2009-09-01
CA2668196A1 (fr) 2008-06-12
FR2909090A1 (fr) 2008-05-30
JP2010510297A (ja) 2010-04-02
FR2909090B1 (fr) 2009-01-09
EP2094706A2 (fr) 2009-09-02
MX2009005447A (es) 2009-08-07
WO2008068424A3 (fr) 2008-07-24
CL2007003346A1 (es) 2008-07-04
AU2007330652A1 (en) 2008-06-12
US20090281107A1 (en) 2009-11-12
EP2094706B1 (fr) 2011-01-05
IL198523A0 (en) 2010-02-17
BRPI0719291A2 (pt) 2014-02-25
UY30742A1 (es) 2008-07-03
US7915258B2 (en) 2011-03-29
ATE494290T1 (de) 2011-01-15
AR063898A1 (es) 2009-02-25
WO2008068424A8 (fr) 2009-07-02
TW200836739A (en) 2008-09-16
CN101541802A (zh) 2009-09-23
DE602007011815D1 (de) 2011-02-17
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