PE20081851A1 - Derivados de espiropiperidina-glicinamida - Google Patents
Derivados de espiropiperidina-glicinamidaInfo
- Publication number
- PE20081851A1 PE20081851A1 PE2008000099A PE2008000099A PE20081851A1 PE 20081851 A1 PE20081851 A1 PE 20081851A1 PE 2008000099 A PE2008000099 A PE 2008000099A PE 2008000099 A PE2008000099 A PE 2008000099A PE 20081851 A1 PE20081851 A1 PE 20081851A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- phenyl
- methyl
- independently
- spiropiperidine
- Prior art date
Links
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 3
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 3
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000005171 Dysmenorrhea Diseases 0.000 abstract 1
- 206010013935 Dysmenorrhoea Diseases 0.000 abstract 1
- WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical group F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 abstract 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- GEAXLHPORCRESC-UHFFFAOYSA-N chlorocyclohexatriene Chemical class ClC1=CC=C=C[CH]1 GEAXLHPORCRESC-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Reproductive Health (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A DERIVADOS DE ESPIROPIPERIDINA-GLICINAMIDA DE FORMULA (I) EN DONDE X E Y ES UNA COMBINACION DE: X ES CH2 E Y ES O, X ES CO E Y ES O, X ES O E Y ES CH2, X ES NR7 E Y ES CO, X ES NR7 E Y ES CH2, X-Y ES C=C O CH2-CH2; X ES O E Y ES CO; R1, R2 R3 Y R4 SON INDEPENDIENTEMENTE H, HALOGENO, ALQUILO(C1-C6), ENTRE OTROS; R5, R5', R6 Y R6' SON INDEPENDIENTEMENTE H O METILO; R7 ES H, ALQUILO(C1-C6), CO-O-ALQUILO(C1-C6), ENTRE OTROS; R8, R8', R9, R9', Y R10 SON INDEPENDIENTEMENTE H, HALOGENO, ALQUILO(C1-C4), ALCOXI(C1-C4), ENTRE OTROS; R11 ES H, ALQUILO(C1-C6) OPCIONALMENTE SUSTITUIDO, -(CRiRii)m-Riii. SON SELECCIONADOS: (RS)-N-[(4-CLOROFENIL)(FENIL)METIL]-2-OXO-2-(1'H,3H-ESPIRO[2-BENZOFURANO-1,4'PIPERIDIN]-1'-IL) ETANAMIDA, (RS)-2-OXO-N-{FENIL[3-(TRIFLUOROMETIL)FENIL]METIL}-2-ESPIRO[BENZOFURANO-1,4'-PIPERDIN]-1'-IL)ETANAMIDA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. ESTOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR DE V1A POR LO QUE SON UTILES EN EL TRATAMIENTO DE LA ANSIEDAD, LA DEPRESION, TRASTORNO OBSESIVO-COMPULSIVO, DISMENORREA, ENTRE OTRAS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07100486 | 2007-01-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20081851A1 true PE20081851A1 (es) | 2009-01-09 |
Family
ID=39201768
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008000099A PE20081851A1 (es) | 2007-01-12 | 2008-01-09 | Derivados de espiropiperidina-glicinamida |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US7498339B2 (es) |
| EP (1) | EP2104677B1 (es) |
| JP (1) | JP2010515700A (es) |
| KR (1) | KR101129791B1 (es) |
| CN (1) | CN101583615B (es) |
| AR (1) | AR064831A1 (es) |
| AT (1) | ATE536356T1 (es) |
| AU (1) | AU2008204491B2 (es) |
| BR (1) | BRPI0806538A2 (es) |
| CA (1) | CA2674958A1 (es) |
| CL (1) | CL2008000059A1 (es) |
| ES (1) | ES2376378T3 (es) |
| IL (1) | IL199583A0 (es) |
| MX (1) | MX2009007411A (es) |
| PE (1) | PE20081851A1 (es) |
| TW (1) | TW200836728A (es) |
| WO (1) | WO2008084005A1 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101547923A (zh) * | 2006-12-07 | 2009-09-30 | 弗·哈夫曼-拉罗切有限公司 | 作为via受体拮抗剂的螺环-哌啶衍生物 |
| EP2097376A2 (en) * | 2006-12-22 | 2009-09-09 | F. Hoffmann-Roche AG | Spiro-piperidine derivatives |
| MX2009007411A (es) * | 2007-01-12 | 2009-07-17 | Hoffmann La Roche | Derivados de espiropiperidina-glicinamida. |
| BRPI0921110A2 (pt) * | 2008-11-13 | 2016-02-16 | Hoffmann La Roche | espiro-5,6-di-hidro-4h-2,3,5,10b-tetraaza-benzo[e]azulenos |
| AU2009317386B2 (en) | 2008-11-18 | 2013-07-25 | F. Hoffmann-La Roche Ag | Alkylcyclohexylethers of dihydrotetraazabenzoazulenes |
| CN102227428B (zh) | 2008-11-28 | 2015-03-25 | 弗·哈夫曼-拉罗切有限公司 | 用作加压素via受体拮抗剂的二氢四氮杂苯并薁的芳基环己基醚 |
| US8420633B2 (en) | 2010-03-31 | 2013-04-16 | Hoffmann-La Roche Inc. | Aryl-cyclohexyl-tetraazabenzo[e]azulenes |
| US8461151B2 (en) | 2010-04-13 | 2013-06-11 | Hoffmann-La Roche Inc. | Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes |
| US8492376B2 (en) | 2010-04-21 | 2013-07-23 | Hoffmann-La Roche Inc. | Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes |
| US8481528B2 (en) | 2010-04-26 | 2013-07-09 | Hoffmann-La Roche Inc. | Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes |
| US8513238B2 (en) | 2010-05-10 | 2013-08-20 | Hoffmann-La Roche Inc. | Heteroaryl-cyclohexyl-tetraazabenzo[E]azulenes |
| PT3083633T (pt) * | 2013-12-19 | 2018-01-25 | Hoffmann La Roche | Espiro-oxazolonas |
| TW201600522A (zh) * | 2014-02-20 | 2016-01-01 | 赫孚孟拉羅股份公司 | 螺－唑酮 |
| KR20170084047A (ko) * | 2014-11-14 | 2017-07-19 | 에프. 호프만-라 로슈 아게 | 스피로-티아졸론 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3370091A (en) | 1964-06-15 | 1968-02-20 | Hoffmann La Roche | 2 aminobenzhydrylhalides |
| US3531467A (en) | 1966-12-23 | 1970-09-29 | Hoffmann La Roche | Process for the preparation of 2,3,4,5-tetrahydro - 5 - aryl - 1h - 1,4 - benzodiazepine derivatives |
| DK78692D0 (da) | 1992-06-12 | 1992-06-12 | Lundbeck & Co As H | Dimere piperidin- og piperazinderivater |
| IT1271026B (it) | 1994-10-21 | 1997-05-26 | Isagro Ricerca Srl | Derivati dell'acido b-amminopropionico ad attivita' fungicida |
| GB9601724D0 (en) * | 1996-01-29 | 1996-03-27 | Merck Sharp & Dohme | Therapeutic agents |
| US20040152741A1 (en) | 2002-09-09 | 2004-08-05 | Nps Allelix Corporation | Arylglycine derivatives and their use as glycine transport inhibitors |
| WO2004026855A1 (en) | 2002-09-20 | 2004-04-01 | H. Lundbeck A/S | Method for manufacture of dihydroisobenzofuran derivatives |
| WO2004069809A1 (en) | 2003-02-03 | 2004-08-19 | Janssen Pharmaceutica N.V. | Mercaptoimidazoles as ccr2 receptor antagonists |
| US7244852B2 (en) * | 2003-02-27 | 2007-07-17 | Abbott Laboratories | Process for preparing 2-methylpyrrolidine and specific enantiomers thereof |
| WO2005046682A1 (en) * | 2003-11-04 | 2005-05-26 | Elixir Pharmaceuticals, Inc. | Therapeutic compounds and uses thereof |
| CA2615726C (en) * | 2005-07-14 | 2014-05-27 | Caterina Bissantz | Indol-3-yl-carbonyl-spiro-piperidine derivatives as v1a receptor antagonists |
| US8193208B2 (en) * | 2005-09-09 | 2012-06-05 | Purdue Pharma L.P. | Fused and spirocycle compounds and the use thereof |
| MX2009007411A (es) * | 2007-01-12 | 2009-07-17 | Hoffmann La Roche | Derivados de espiropiperidina-glicinamida. |
-
2008
- 2008-01-03 MX MX2009007411A patent/MX2009007411A/es not_active Application Discontinuation
- 2008-01-03 CA CA002674958A patent/CA2674958A1/en not_active Abandoned
- 2008-01-03 BR BRPI0806538-1A2A patent/BRPI0806538A2/pt not_active IP Right Cessation
- 2008-01-03 EP EP08701212A patent/EP2104677B1/en not_active Not-in-force
- 2008-01-03 ES ES08701212T patent/ES2376378T3/es active Active
- 2008-01-03 WO PCT/EP2008/050028 patent/WO2008084005A1/en not_active Ceased
- 2008-01-03 JP JP2009545158A patent/JP2010515700A/ja active Pending
- 2008-01-03 CN CN200880002180XA patent/CN101583615B/zh not_active Expired - Fee Related
- 2008-01-03 AT AT08701212T patent/ATE536356T1/de active
- 2008-01-03 AU AU2008204491A patent/AU2008204491B2/en not_active Expired - Fee Related
- 2008-01-03 KR KR1020097016714A patent/KR101129791B1/ko not_active Expired - Fee Related
- 2008-01-07 US US11/969,975 patent/US7498339B2/en not_active Expired - Fee Related
- 2008-01-07 US US11/969,983 patent/US20080194610A1/en not_active Abandoned
- 2008-01-07 US US11/969,993 patent/US20080171760A1/en not_active Abandoned
- 2008-01-09 PE PE2008000099A patent/PE20081851A1/es not_active Application Discontinuation
- 2008-01-09 TW TW097100900A patent/TW200836728A/zh unknown
- 2008-01-10 CL CL200800059A patent/CL2008000059A1/es unknown
- 2008-01-10 AR ARP080100089A patent/AR064831A1/es unknown
-
2009
- 2009-06-25 IL IL199583A patent/IL199583A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2674958A1 (en) | 2008-07-17 |
| KR20090097217A (ko) | 2009-09-15 |
| US20080194610A1 (en) | 2008-08-14 |
| EP2104677A1 (en) | 2009-09-30 |
| CN101583615B (zh) | 2012-07-04 |
| WO2008084005A1 (en) | 2008-07-17 |
| AU2008204491B2 (en) | 2012-05-03 |
| KR101129791B1 (ko) | 2012-03-23 |
| JP2010515700A (ja) | 2010-05-13 |
| TW200836728A (en) | 2008-09-16 |
| EP2104677B1 (en) | 2011-12-07 |
| ATE536356T1 (de) | 2011-12-15 |
| BRPI0806538A2 (pt) | 2014-04-22 |
| US7498339B2 (en) | 2009-03-03 |
| CL2008000059A1 (es) | 2008-07-18 |
| US20080171760A1 (en) | 2008-07-17 |
| ES2376378T3 (es) | 2012-03-13 |
| IL199583A0 (en) | 2010-03-28 |
| US20080171759A1 (en) | 2008-07-17 |
| AU2008204491A1 (en) | 2008-07-17 |
| MX2009007411A (es) | 2009-07-17 |
| AR064831A1 (es) | 2009-04-29 |
| CN101583615A (zh) | 2009-11-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20081851A1 (es) | Derivados de espiropiperidina-glicinamida | |
| PE20091173A1 (es) | Derivados de heteroarilo como antagonistas de receptor de orexina | |
| PE20081504A1 (es) | Compuestos de biciclocarboxiamida sustituidos | |
| PE20091090A1 (es) | Derivados de piperidina como agonistas de receptores muscarinicos | |
| AR060535A1 (es) | Pirido-piridazinonas y ftalazinonas como antagonistas duales de los receptores h1 y h3 de histamina | |
| AR064355A1 (es) | Herbicidas derivados de isoxazol | |
| PE20140102A1 (es) | Compuestos de piperidina puenteada tipo quinoxalina sustituida con actividad sobre el receptor orl-1 | |
| PE20090816A1 (es) | Derivados de pirrolopirimidinona como agentes ligandos de los receptores p2x3 | |
| PE20120031A1 (es) | Compuestos aril metil benzoquinazolinona como moduladores alostericos positivos del receptor m1 | |
| PE20081755A1 (es) | Nuevas 2-aminooxazolinas como ligandos taar1 | |
| AR060651A1 (es) | Derivados de 1,2,4-triazol como moduladores de mglur5 i, intermediarios para su sintesis, composiciones farmaceuticas que los contienen y su uso en la preparacion de medicamentos para el tratamiento del dolor y de trastornos gastrointestinales | |
| PE20071152A1 (es) | Compuestos derivados de azabiciclo[3.1.0]hex como moduladores de receptores de dopamina d3 | |
| AR061486A1 (es) | Derivados de 2-pirazinacarboxamida | |
| PE20071254A1 (es) | Derivados de sulfonamidas como agentes moduladores de los receptores de orexina y su preparacion | |
| PE20081665A1 (es) | Antagonistas del receptor de dopamina 2 de rapida disociacion | |
| AR060593A1 (es) | 5-amido-2-carboxiamida-indoles | |
| PE20090592A1 (es) | Nuevos derivados de piperazina-amida | |
| PE20141169A1 (es) | Derivados de etinilo | |
| PE20030610A1 (es) | Derivados de 3-azabiciclo[3.1.0]hexano con afinidad a los receptores opioides | |
| PE20081375A1 (es) | Derivados octahidro-pirrolo[3,4-c]pirrol como antagonistas del receptor ccr5 | |
| AR073565A1 (es) | Derivados de bencimidazol, procesos de preparacion y composiciones farmaceuticas que los contienen | |
| PE20040828A1 (es) | Benzoxazinonas como modulares de 5-hidroxitriptamina (5-ht) | |
| PE20081152A1 (es) | Azaciclilaminas n-sustituidas como antagonistas de histamina-3 | |
| PE20061038A1 (es) | Derivados del 1,5-difenil-1h-pirazol-3-il) oxadiazol como agentes antagonistas cb1 y su preparacion | |
| PE20081489A1 (es) | Derivados de espiro-piperidina |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |