PE20091398A1 - Compuestos biciclicos conteniendo nitrogeno activos en condiciones de dolor cronicas - Google Patents
Compuestos biciclicos conteniendo nitrogeno activos en condiciones de dolor cronicasInfo
- Publication number
- PE20091398A1 PE20091398A1 PE2009000262A PE2009000262A PE20091398A1 PE 20091398 A1 PE20091398 A1 PE 20091398A1 PE 2009000262 A PE2009000262 A PE 2009000262A PE 2009000262 A PE2009000262 A PE 2009000262A PE 20091398 A1 PE20091398 A1 PE 20091398A1
- Authority
- PE
- Peru
- Prior art keywords
- chronic pain
- compounds containing
- containing active
- pain conditions
- active nitrogen
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 208000000094 Chronic Pain Diseases 0.000 title abstract 2
- 208000002193 Pain Diseases 0.000 title abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 title 2
- 229910052757 nitrogen Inorganic materials 0.000 title 1
- 208000001640 Fibromyalgia Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000002981 neuropathic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
SE REFIERE A COMPUESTOS BICICLICOS QUE CONTIENEN N DE FORMULA (I) DONDE R ES H, ALQUILO(C1-C6), CF3 O ARILO; Y ES CH2 O C=O; X ES UN ENLACE, C=O, SO2 O C=N-CN; A ES UN HETEROCICLO O UN COMPUESTO DE FORMULA (i), EN DONDE R1, R2, R4 Y R5 SON CADA UNO H, HALOGENO, ALQUILO(C1-C6), ALCOXI(C1-C6), ENTRE OTROS; R3 ES H, CN, ALQUILO(C1-C6), HIDROXI, ENTRE OTROS; m Y n SON CADA UNO 0 O 1. SON COMPUESTOS PREFERIDOS: (S)-(-)2-(2-FLUOROFENILSULFONIL)HEXAHIDROPIRROLO[1,2-a]PIRAZIN-6(7H)-UNO, (S)-(-)2-(3-FLUOROFENILSULFONIL)HEXAHIDROPIRROLO[1,2-a]PIRAZIN-6(7H)-UNO, (R)-(+)-2-(3,4-DIFLUOROFENILSULFONIL)HEXAHIDROPIRROLO[1,2-a]PIRAZIN-6(7H)-UNO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON UTILES PARA EL TRATAMIENTO DEL DOLOR CRONICO DE ORIGEN NEUROPATICO O INFLAMATORIO TALES COMO MIGRANA, FIBROMIALGIA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08101879.8A EP2098526B1 (en) | 2008-02-22 | 2008-02-22 | Nitrogen-containing bicyclic compounds active on chronic pain conditions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20091398A1 true PE20091398A1 (es) | 2009-10-13 |
Family
ID=39472460
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2009000262A PE20091398A1 (es) | 2008-02-22 | 2009-02-23 | Compuestos biciclicos conteniendo nitrogeno activos en condiciones de dolor cronicas |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8334286B2 (es) |
| EP (1) | EP2098526B1 (es) |
| JP (1) | JP5400804B2 (es) |
| CN (1) | CN101945876B (es) |
| AR (1) | AR070465A1 (es) |
| AU (1) | AU2009217201B2 (es) |
| BR (1) | BRPI0908495A2 (es) |
| CA (1) | CA2716230C (es) |
| CL (1) | CL2009000388A1 (es) |
| EA (1) | EA017737B1 (es) |
| ES (1) | ES2454366T3 (es) |
| IL (1) | IL207669A (es) |
| MX (1) | MX2010009228A (es) |
| PE (1) | PE20091398A1 (es) |
| PL (1) | PL2098526T3 (es) |
| WO (1) | WO2009103176A1 (es) |
| ZA (1) | ZA201005704B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9125898B2 (en) | 2008-11-14 | 2015-09-08 | Neurotune Ag | Acetam derivatives for pain relief |
| US8933132B2 (en) * | 2011-01-19 | 2015-01-13 | Convergence Pharmaceuticals Limited | Tricyclic substituted benzenesulfonamide piperazine derivatives as CAV2.2 calcium channel blockers |
| WO2013049164A1 (en) | 2011-09-29 | 2013-04-04 | Abbvie Inc. | SUBSTITUTED OCTAHYDROPYRROLO[1,2-a]PYRAZINES AS CALCIUM CHANNEL BLOCKERS |
| AR088064A1 (es) | 2011-09-29 | 2014-05-07 | Abbvie Inc | Octahidropirrolo[1,2-a]pirazina sulfonamidas sustituidas como bloqueadores de canales de calcio |
| JP2016503007A (ja) | 2012-12-12 | 2016-02-01 | アッヴィ・インコーポレイテッド | 疼痛治療におけるカルシウムチャネル遮断薬として有用なジアゼピン誘導体 |
| CA2935811C (en) | 2014-03-07 | 2018-09-18 | F. Hoffmann-La Roche Ag | 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection |
| KR102139708B1 (ko) | 2015-03-16 | 2020-07-31 | 에프. 호프만-라 로슈 아게 | Tlr7 작용제 및 hbv 캡시드 조립 억제제를 사용하는 병용 치료 |
| JP7101663B2 (ja) | 2016-09-13 | 2022-07-15 | エフ．ホフマン－ラ ロシュ アーゲー | Ｔｌｒ７アゴニストとｈｂｖキャプシドアセンブリ阻害剤の併用療法 |
| JOP20190251A1 (ar) | 2017-05-31 | 2019-10-21 | Metys Pharmaceuticals AG | تركيبات تآزرية تشتمل على (r)-ديميراسيتام (1) و(s)-ديميراسيتام (2) بنسبة غير راسيمية |
| PL3890833T3 (pl) | 2018-12-04 | 2023-09-18 | Metys Pharmaceuticals AG | Synergistyczne kompozycje zawierające (r)-2-(2-oksopirolidyn-1-ylo)butanoamid i (s)-2-(2-oksopirolidyn-1-ylo)butanoamid w stosunku nieracemicznym |
| MX2021006248A (es) * | 2018-12-04 | 2021-08-11 | Metys Pharmaceuticals AG | Composiciones sinergicas que comprenden r-2-(sulfonil sustituido)-hexahidro-pirrolo[1,2-a]pirazin-6(2h)-onas y s-2-(sulfonil sustituido)-hexahidro-pirrolo[1,2-a]pirazin-6(2h)-on as en una proporcion no racemica. |
| EP3947383B1 (en) | 2019-03-25 | 2024-10-02 | F. Hoffmann-La Roche AG | Solid forms of a compound of hbv core protein allosteric modifier |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3225077A (en) | 1963-03-05 | 1965-12-21 | American Cyanamid Co | N-cyanoimidates and processes for preparing same |
| JP3058945B2 (ja) * | 1990-10-26 | 2000-07-04 | 三共株式会社 | Ｎ−（３，３−ジ置換アクリロイル）ピペラジン誘導体 |
| US5925648A (en) | 1997-07-29 | 1999-07-20 | Schering Corporation | Tricyclic N-cyanoimines useful as inhibitors of a farnesyl-protein transferase |
| EP1118612A1 (en) | 2000-01-21 | 2001-07-25 | Universita Degli Studi di Firenze | Piperazine derivatives possesing nootropic activity |
| CN1984901B (zh) * | 2004-05-18 | 2011-02-09 | 先灵公司 | 用作pde4抑制剂的取代的2-喹啉基-*唑 |
| US7683056B2 (en) * | 2005-09-09 | 2010-03-23 | Glaxosmithkline Llc | Pyridine derivatives and their use in the treatment of psychotic disorders |
| AR057828A1 (es) * | 2005-09-29 | 2007-12-19 | Astrazeneca Ab | Compuestos derivados de azetidina, su preparacion y composicion farmaceuutica |
-
2008
- 2008-02-22 ES ES08101879.8T patent/ES2454366T3/es active Active
- 2008-02-22 EP EP08101879.8A patent/EP2098526B1/en active Active
- 2008-02-22 PL PL08101879T patent/PL2098526T3/pl unknown
-
2009
- 2009-02-17 US US12/918,718 patent/US8334286B2/en not_active Expired - Fee Related
- 2009-02-17 BR BRPI0908495A patent/BRPI0908495A2/pt not_active IP Right Cessation
- 2009-02-17 CN CN200980105813.4A patent/CN101945876B/zh not_active Expired - Fee Related
- 2009-02-17 AU AU2009217201A patent/AU2009217201B2/en not_active Ceased
- 2009-02-17 CA CA2716230A patent/CA2716230C/en active Active
- 2009-02-17 JP JP2010547016A patent/JP5400804B2/ja active Active
- 2009-02-17 MX MX2010009228A patent/MX2010009228A/es active IP Right Grant
- 2009-02-17 WO PCT/CH2009/000064 patent/WO2009103176A1/en not_active Ceased
- 2009-02-17 EA EA201001344A patent/EA017737B1/ru not_active IP Right Cessation
- 2009-02-20 CL CL2009000388A patent/CL2009000388A1/es unknown
- 2009-02-20 AR ARP090100617A patent/AR070465A1/es unknown
- 2009-02-23 PE PE2009000262A patent/PE20091398A1/es not_active Application Discontinuation
-
2010
- 2010-08-10 ZA ZA2010/05704A patent/ZA201005704B/en unknown
- 2010-08-18 IL IL207669A patent/IL207669A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| US8334286B2 (en) | 2012-12-18 |
| CA2716230A1 (en) | 2009-08-27 |
| BRPI0908495A2 (pt) | 2019-09-24 |
| EP2098526A1 (en) | 2009-09-09 |
| JP2011512365A (ja) | 2011-04-21 |
| EP2098526B1 (en) | 2014-01-15 |
| AU2009217201B2 (en) | 2013-06-20 |
| PL2098526T3 (pl) | 2014-06-30 |
| US20110015200A1 (en) | 2011-01-20 |
| CA2716230C (en) | 2016-11-01 |
| CL2009000388A1 (es) | 2010-02-19 |
| AU2009217201A1 (en) | 2009-08-27 |
| MX2010009228A (es) | 2010-11-12 |
| AR070465A1 (es) | 2010-04-07 |
| EA017737B1 (ru) | 2013-02-28 |
| CN101945876A (zh) | 2011-01-12 |
| ES2454366T3 (es) | 2014-04-10 |
| JP5400804B2 (ja) | 2014-01-29 |
| EA201001344A1 (ru) | 2011-02-28 |
| ZA201005704B (en) | 2013-01-30 |
| CN101945876B (zh) | 2014-04-30 |
| IL207669A0 (en) | 2010-12-30 |
| IL207669A (en) | 2014-08-31 |
| WO2009103176A1 (en) | 2009-08-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |