PE20091444A1 - Derivados de isoxazolo-pirazina - Google Patents
Derivados de isoxazolo-pirazinaInfo
- Publication number
- PE20091444A1 PE20091444A1 PE2008002001A PE2008002001A PE20091444A1 PE 20091444 A1 PE20091444 A1 PE 20091444A1 PE 2008002001 A PE2008002001 A PE 2008002001A PE 2008002001 A PE2008002001 A PE 2008002001A PE 20091444 A1 PE20091444 A1 PE 20091444A1
- Authority
- PE
- Peru
- Prior art keywords
- compound
- formula
- phenyl
- methyl
- isoxazol
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 7
- 239000002253 acid Substances 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- HWDVTQAXQJQROO-UHFFFAOYSA-N cyclopropylazanide Chemical compound [NH-]C1CC1 HWDVTQAXQJQROO-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000004702 methyl esters Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
REFERIDO A UN COMPUESTO DERIVADO DE ISOXAZOLO-PIRAZINA DE FORMULA I, DONDE X ES O o NH, R1 ES FENILO O PIRIDIN-2-ILO, OPCIONALMENTE SUSTITUIDO CON UNO, DOS O TRES HALO, R2 ES H, O ALQUILO C1-4, R3 Y R4 SON CADA UNO H, CN, HALO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: ESTER METILICO DEL ACIDO 5-(5-METIL-3-FENIL-ISOXAZOL-4-IL-METOXI)-PIRAZIN-2-CARBOXILICO, CICLOPROPILAMIDA DEL ACIDO 5-(5-METIL-3-FENIL-ISOXAZOL-4-IL-METOXI)-PIRAZIN-2-CARBOXILICO, 2-(5-METIL-3-FENIL-ISOXAZOL-4-ILMETOXI)-QUINOXALINA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE AL COMPUESTO DE FORMULA I Y A UN PROCEDIMIENTO DE PREPARACION PARA OBTENER DICHO COMPUESTO, QUE CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA VIII-a CON UN COMPUESTO DE FORMULA IX, EN PRESENCIA DE UNA BASE, EN UN DISOLVENTE. DICHO COMPUESTO PRESENTAN UNA AFINIDAD POR EL RECEPTOR GABA A ?5, SIENDO UTIL PARA EL TRATAMIENTO DE LOS TRASTORNOS COGNITIVOS COMO LA ENFERMEDAD DE ALZHEIMER
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07122271 | 2007-12-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20091444A1 true PE20091444A1 (es) | 2009-09-24 |
Family
ID=40256991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008002001A PE20091444A1 (es) | 2007-12-04 | 2008-12-01 | Derivados de isoxazolo-pirazina |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US7618973B2 (es) |
| EP (1) | EP2229383B1 (es) |
| JP (1) | JP5301556B2 (es) |
| KR (1) | KR101175859B1 (es) |
| CN (1) | CN101883769B (es) |
| AR (1) | AR069524A1 (es) |
| AU (1) | AU2008333320B2 (es) |
| BR (1) | BRPI0820649A2 (es) |
| CA (1) | CA2706990C (es) |
| CL (1) | CL2008003592A1 (es) |
| IL (1) | IL205755A0 (es) |
| MX (1) | MX2010005753A (es) |
| PE (1) | PE20091444A1 (es) |
| TW (1) | TW200924769A (es) |
| WO (1) | WO2009071464A1 (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ585308A (en) | 2007-12-04 | 2012-03-30 | Hoffmann La Roche | Isoxazolo-pyridine derivatives |
| AR073949A1 (es) * | 2008-10-21 | 2010-12-15 | Metabolex Inc | Agonistas del receptor aril-gpr120 y usos de los mismos |
| US8227461B2 (en) * | 2009-04-30 | 2012-07-24 | Hoffmann-La Roche Inc. | Isoxazoles |
| CA2759598C (en) * | 2009-05-05 | 2017-09-12 | F. Hoffmann-La Roche Ag | Isoxazole-thiazole derivatives as gaba a receptor inverse agonists for use in the treatment of cognitive disorders |
| US8415379B2 (en) * | 2009-05-05 | 2013-04-09 | Hoffmann-La Roche Inc. | Pyridines |
| EP2427455B1 (en) * | 2009-05-05 | 2020-01-15 | F.Hoffmann-La Roche Ag | Isoxazole-pyrazole derivatives |
| US8466181B2 (en) * | 2010-12-10 | 2013-06-18 | Hoffmann-La Roche Inc. | 1,2,3-triazole-imidazole compounds |
| US8604062B2 (en) | 2011-10-20 | 2013-12-10 | Hoffman-La Roche Inc. | Process for the preparation of isoxazolyl-methoxy nicotinic acids |
| US8785435B2 (en) | 2011-10-20 | 2014-07-22 | Hoffmann-La Roche Inc. | Solid forms |
| US20150374705A1 (en) | 2012-02-14 | 2015-12-31 | Shanghai Institues for Biological Sciences | Substances for treatment or relief of pain |
| WO2014001280A1 (en) | 2012-06-26 | 2014-01-03 | Aniona Aps | A phenyl triazole derivative and its use for modulating the gabaa receptor complex |
| WO2014001279A1 (en) | 2012-06-26 | 2014-01-03 | Aniona Aps | A phenyl triazole derivative and its use for modulating the gabaa receptor complex |
| KR20150033679A (ko) | 2012-06-26 | 2015-04-01 | 사니오나 에이피에스 | 페닐 트리아졸 유도체 및 이의 gabaa 수용체 복합체 조절용 용도 |
| AU2013283487C1 (en) | 2012-06-26 | 2018-01-18 | Saniona Aps | A phenyl triazole derivative and its use for modulating the GABAA receptor complex |
| WO2014001278A1 (en) | 2012-06-26 | 2014-01-03 | Aniona Aps | A phenyl triazole derivative and its use for modulating the gabaa receptor complex |
| BR102019014802A2 (pt) | 2018-07-20 | 2020-02-04 | Boehringer Ingelheim Int | difluorometil-fenil triazóis |
| HU231223B1 (hu) * | 2018-09-28 | 2022-01-28 | Richter Gedeon Nyrt. | GABAA A5 receptor modulátor hatású biciklusos vegyületek |
| US20240043418A1 (en) | 2020-03-26 | 2024-02-08 | Richter Gedeon Nyrt. | 1,3-dihydro-2h-pyrrolo[3,4-c]pyridine derivatives as gabaa a5 receptor modulators |
| AU2022270411A1 (en) | 2021-05-05 | 2023-11-23 | Draig Therapeutics Ltd | Heteroaryl compounds useful in the treatment of cognitive disorders |
| CN116854680A (zh) * | 2022-03-28 | 2023-10-10 | 上海赛默罗生物科技有限公司 | 异噁唑-杂环类衍生物、药物组合物和用途 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3525205A1 (de) * | 1984-09-11 | 1986-03-20 | Hoechst Ag, 6230 Frankfurt | Pflanzenschuetzende mittel auf basis von 1,2,4-triazolderivaten sowie neue derivate des 1,2,4-triazols |
| GB9808663D0 (en) | 1998-04-23 | 1998-06-24 | Merck Sharp & Dohme | Therapeutic agents |
| ES2255294T3 (es) * | 1998-08-07 | 2006-06-16 | Chiron Corporation | Derivados de isoxazol sustituidos como moduladores del receptor de estrogenos. |
| US6660753B2 (en) * | 1999-08-19 | 2003-12-09 | Nps Pharmaceuticals, Inc. | Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists |
| IT1314191B1 (it) | 1999-10-18 | 2002-12-06 | Recordati Chem Pharm | Derivati isossazolcarbossamidici |
| WO2001034603A2 (en) | 1999-11-12 | 2001-05-17 | Neurogen Corporation | Bicyclic and tricyclic heteroaromatic compounds |
| PA8535601A1 (es) | 2000-12-21 | 2002-11-28 | Pfizer | Derivados benzimidazol y piridilimidazol como ligandos para gabaa |
| GB0108475D0 (en) | 2001-04-04 | 2001-05-23 | Merck Sharp & Dohme | New compounds |
| IL159697A0 (en) | 2001-07-05 | 2004-06-20 | Synaptic Pharma Corp | Substituted anilinic piperidines as mch selective antagonists |
| ATE381542T1 (de) | 2001-08-13 | 2008-01-15 | Phenex Pharmaceuticals Ag | Nr1h4-kern-rezeptor-bindende verbindungen |
| ATE386740T1 (de) | 2001-11-20 | 2008-03-15 | Lilly Co Eli | Beta-3 adrenergische agonisten |
| GB0128160D0 (en) * | 2001-11-23 | 2002-01-16 | Merck Sharp & Dohme | Novel compounds |
| US7319109B2 (en) | 2002-11-22 | 2008-01-15 | Smith Kline Beecham Corporation | Farnesoid X receptor agonists |
| GB0318447D0 (en) | 2003-08-05 | 2003-09-10 | Merck Sharp & Dohme | Therapeutic agents |
| JP2007537286A (ja) * | 2004-05-14 | 2007-12-20 | アイアールエム・リミテッド・ライアビリティ・カンパニー | Ｐｐａｒモジュレーターとしての化合物および組成物 |
| CN1960984B (zh) | 2004-06-01 | 2010-05-12 | 弗·哈夫曼-拉罗切有限公司 | 作为mglu5受体拮抗剂的吡啶-4-基-乙炔基-咪唑和吡唑 |
| WO2005123672A2 (en) | 2004-06-14 | 2005-12-29 | Takeda San Diego, Inc. | Kinase inhibitors |
| RU2383524C2 (ru) | 2004-10-01 | 2010-03-10 | Ф.Хоффманн-Ля Рош Аг | Гексафторизопропанол-замещенные производные простых эфиров |
| WO2006044617A1 (en) | 2004-10-15 | 2006-04-27 | The Scripps Research Institute | Oxadiazole ketone inhibitors of fatty acid amide hydrolase |
| US20070060589A1 (en) | 2004-12-21 | 2007-03-15 | Purandare Ashok V | Inhibitors of protein arginine methyl transferases |
| ATE485269T1 (de) * | 2005-06-27 | 2010-11-15 | Bristol Myers Squibb Co | C-verknüpfte zyklische antagonisten des p2y1- rezeptors mit eignung bei der behandlung thrombotischer leiden |
| DE502006008095D1 (de) | 2005-07-20 | 2010-11-25 | Prospective Concepts Ag | Pneumatisch verstellbare seitenwangen für fahrzeugsitze |
| WO2007039389A1 (en) * | 2005-09-19 | 2007-04-12 | F. Hoffmann-La Roche Ag | Isoxazolo derivatives as gaba a alpha5 inverse agonists |
| WO2007052843A1 (ja) | 2005-11-04 | 2007-05-10 | Takeda Pharmaceutical Company Limited | 複素環アミド化合物およびその用途 |
| EP1962838B1 (en) | 2005-12-19 | 2011-09-28 | GlaxoSmithKline LLC | Farnesoid x receptor agonists |
| ES2452031T3 (es) | 2006-02-03 | 2014-03-31 | Eli Lilly & Company | Compuestos y procedimientos para modular receptores FX |
| JP2007230909A (ja) | 2006-03-01 | 2007-09-13 | Univ Of Tokyo | 置換イソキサゾール誘導体 |
| EP1894928A1 (en) | 2006-08-29 | 2008-03-05 | PheneX Pharmaceuticals AG | Heterocyclic fxr binding compounds |
| EP1894924A1 (en) | 2006-08-29 | 2008-03-05 | Phenex Pharmaceuticals AG | Heterocyclic FXR binding compounds |
-
2008
- 2008-11-25 AU AU2008333320A patent/AU2008333320B2/en not_active Expired - Fee Related
- 2008-11-25 CA CA2706990A patent/CA2706990C/en not_active Expired - Fee Related
- 2008-11-25 KR KR1020107012189A patent/KR101175859B1/ko not_active Expired - Fee Related
- 2008-11-25 US US12/277,326 patent/US7618973B2/en not_active Expired - Fee Related
- 2008-11-25 CN CN2008801186072A patent/CN101883769B/zh not_active Expired - Fee Related
- 2008-11-25 BR BRPI0820649-0A patent/BRPI0820649A2/pt not_active Application Discontinuation
- 2008-11-25 MX MX2010005753A patent/MX2010005753A/es active IP Right Grant
- 2008-11-25 EP EP08856804.3A patent/EP2229383B1/en not_active Not-in-force
- 2008-11-25 WO PCT/EP2008/066127 patent/WO2009071464A1/en not_active Ceased
- 2008-11-25 JP JP2010536405A patent/JP5301556B2/ja not_active Expired - Fee Related
- 2008-12-01 TW TW097146619A patent/TW200924769A/zh unknown
- 2008-12-01 PE PE2008002001A patent/PE20091444A1/es not_active Application Discontinuation
- 2008-12-02 CL CL2008003592A patent/CL2008003592A1/es unknown
- 2008-12-02 AR ARP080105243A patent/AR069524A1/es unknown
-
2009
- 2009-10-19 US US12/581,192 patent/US20100041886A1/en not_active Abandoned
-
2010
- 2010-05-13 IL IL205755A patent/IL205755A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP5301556B2 (ja) | 2013-09-25 |
| CN101883769B (zh) | 2012-08-08 |
| EP2229383A1 (en) | 2010-09-22 |
| MX2010005753A (es) | 2010-06-15 |
| JP2011505399A (ja) | 2011-02-24 |
| AR069524A1 (es) | 2010-01-27 |
| US20100041886A1 (en) | 2010-02-18 |
| CL2008003592A1 (es) | 2010-01-04 |
| CA2706990C (en) | 2016-05-10 |
| WO2009071464A1 (en) | 2009-06-11 |
| EP2229383B1 (en) | 2017-01-18 |
| US7618973B2 (en) | 2009-11-17 |
| CA2706990A1 (en) | 2009-06-11 |
| US20090143407A1 (en) | 2009-06-04 |
| KR101175859B1 (ko) | 2012-08-24 |
| CN101883769A (zh) | 2010-11-10 |
| AU2008333320A1 (en) | 2009-06-11 |
| AU2008333320B2 (en) | 2012-12-20 |
| IL205755A0 (en) | 2010-11-30 |
| BRPI0820649A2 (pt) | 2015-06-16 |
| TW200924769A (en) | 2009-06-16 |
| KR20100075674A (ko) | 2010-07-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |