PE20091446A1 - Derivados de isoxazolo-piridazina - Google Patents
Derivados de isoxazolo-piridazinaInfo
- Publication number
- PE20091446A1 PE20091446A1 PE2008002009A PE2008002009A PE20091446A1 PE 20091446 A1 PE20091446 A1 PE 20091446A1 PE 2008002009 A PE2008002009 A PE 2008002009A PE 2008002009 A PE2008002009 A PE 2008002009A PE 20091446 A1 PE20091446 A1 PE 20091446A1
- Authority
- PE
- Peru
- Prior art keywords
- compound
- pyridazine
- formula
- phenyl
- isoxazol
- Prior art date
Links
- LUNHCIBEAIKLQJ-UHFFFAOYSA-N [1,2]oxazolo[4,3-c]pyridazine Chemical class C1=CN=NC2=CON=C21 LUNHCIBEAIKLQJ-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 9
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- -1 PYRIMIDINYL Chemical group 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- FIULGFJIHJJXMT-UHFFFAOYSA-N [C]1[N]C=CC=C1 Chemical group [C]1[N]C=CC=C1 FIULGFJIHJJXMT-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- FAMRKDQNMBBFBR-BQYQJAHWSA-N diethyl azodicarboxylate Substances CCOC(=O)\N=N\C(=O)OCC FAMRKDQNMBBFBR-BQYQJAHWSA-N 0.000 abstract 1
- FAMRKDQNMBBFBR-UHFFFAOYSA-N ethyl n-ethoxycarbonyliminocarbamate Chemical compound CCOC(=O)N=NC(=O)OCC FAMRKDQNMBBFBR-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- XUWVIABDWDTJRZ-UHFFFAOYSA-N propan-2-ylazanide Chemical compound CC(C)[NH-] XUWVIABDWDTJRZ-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
REFERIDO A UN COMPUESTO DERIVADO DE ISOXAZOLO-PIRIDAZINA DE FORMULA I DONDE X ES O O NH, R1 ES FENILO, PIRIDINILO O PIRIMIDINILO, CADA UNO OPCIONALMENTE SUSTITUIDO CON UNO, DOS O TRES HALOGENOS, R2 ES ALQUILO C1-4, H O HALOALQUILO C1-4, R3, R4 Y R5 SON CADA UNO H, CN, NO2, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 3-CLORO-6-(5-METIL-3-FENIL-ISOXAZOL-4-ILMETOXI)-PIRIDAZINA, 6-(5-METIL-3-FENIL-ISOXAZOL-4-ILMETOXI)-PIRIDAZINA-3-CARBOXILATO DE ETILO, ISOPROPILAMIDA DEL ACIDO 6-(5-METIL-3-FENIL-ISOXAZOL-4-ILMETOXI)-PIRIDAZINA-3-CARBOXILICO. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE AL COMPUESTO DE FORMULA I Y A UN PROCEDIMIENTO DE PREPARACION PARA OBTENER DICHO COMPUESTO, QUE CONSISTE EN HACER REACCIONAR A) UN COMPUESTO DE FORMULA VIII, CON UN COMPUESTO DE FORMULA IX EN PRESENCIA DE UNA BASE O EN UN DISOLVENTE, O B) HACER REACCIONAR UN COMPUESTO DE FORMULA VIII, CON UN COMPUESTO DE FORMULA X EN PRESENCIA DE TRIFENILFOSFINA Y AZODICARBOXILATO DE DIETILO, EN UN DISOLVENTE. DICHO COMPUESTO PRESENTAN UNA AFINIDAD POR EL RECEPTOR GABA A ?5, SIENDO UTIL PARA EL TRATAMIENTO DE LOS TRASTORNOS COGNITIVOS COMO LA ENFERMEDAD DE ALZHEIMER
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07122293 | 2007-12-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20091446A1 true PE20091446A1 (es) | 2009-09-24 |
Family
ID=40328910
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008002009A PE20091446A1 (es) | 2007-12-04 | 2008-12-02 | Derivados de isoxazolo-piridazina |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7943619B2 (es) |
| EP (1) | EP2231651B1 (es) |
| JP (1) | JP5301558B2 (es) |
| KR (1) | KR101175855B1 (es) |
| CN (1) | CN101868458B (es) |
| AR (1) | AR069525A1 (es) |
| AU (1) | AU2008333327B2 (es) |
| BR (1) | BRPI0820113A2 (es) |
| CA (1) | CA2707821C (es) |
| CL (1) | CL2008003593A1 (es) |
| IL (1) | IL205753A0 (es) |
| MX (1) | MX2010006182A (es) |
| PE (1) | PE20091446A1 (es) |
| TW (1) | TW200924775A (es) |
| WO (1) | WO2009071477A1 (es) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ585308A (en) | 2007-12-04 | 2012-03-30 | Hoffmann La Roche | Isoxazolo-pyridine derivatives |
| AR073949A1 (es) * | 2008-10-21 | 2010-12-15 | Metabolex Inc | Agonistas del receptor aril-gpr120 y usos de los mismos |
| US8227461B2 (en) * | 2009-04-30 | 2012-07-24 | Hoffmann-La Roche Inc. | Isoxazoles |
| EP2427455B1 (en) * | 2009-05-05 | 2020-01-15 | F.Hoffmann-La Roche Ag | Isoxazole-pyrazole derivatives |
| CA2759598C (en) * | 2009-05-05 | 2017-09-12 | F. Hoffmann-La Roche Ag | Isoxazole-thiazole derivatives as gaba a receptor inverse agonists for use in the treatment of cognitive disorders |
| AU2010244545A1 (en) | 2009-05-05 | 2011-10-13 | F. Hoffmann-La Roche Ag | Isoxazole-pyridazine derivatives |
| US8415379B2 (en) * | 2009-05-05 | 2013-04-09 | Hoffmann-La Roche Inc. | Pyridines |
| AR081626A1 (es) | 2010-04-23 | 2012-10-10 | Cytokinetics Inc | Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos |
| AR081331A1 (es) | 2010-04-23 | 2012-08-08 | Cytokinetics Inc | Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos |
| US9133123B2 (en) | 2010-04-23 | 2015-09-15 | Cytokinetics, Inc. | Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use |
| BR112013011265A2 (pt) * | 2010-11-09 | 2016-11-01 | Hoffmann La Roche | derivados de triazol como ligantes para receptores gaba |
| WO2012068161A1 (en) * | 2010-11-15 | 2012-05-24 | Agenebio, Inc. | Pyridazine derivatives, compositions and methods for treating cognitive impairment |
| CN104024259B (zh) | 2011-09-27 | 2017-09-26 | 基恩菲特公司 | 作为Rev‑Erb激动剂的6‑取代的三唑并哒嗪类衍生物 |
| US8604062B2 (en) | 2011-10-20 | 2013-12-10 | Hoffman-La Roche Inc. | Process for the preparation of isoxazolyl-methoxy nicotinic acids |
| IN2014DN03063A (es) * | 2011-10-28 | 2015-05-15 | Inhibitaxin Ltd | |
| US20150374705A1 (en) | 2012-02-14 | 2015-12-31 | Shanghai Institues for Biological Sciences | Substances for treatment or relief of pain |
| WO2014001280A1 (en) | 2012-06-26 | 2014-01-03 | Aniona Aps | A phenyl triazole derivative and its use for modulating the gabaa receptor complex |
| AU2013283487C1 (en) | 2012-06-26 | 2018-01-18 | Saniona Aps | A phenyl triazole derivative and its use for modulating the GABAA receptor complex |
| WO2014001279A1 (en) | 2012-06-26 | 2014-01-03 | Aniona Aps | A phenyl triazole derivative and its use for modulating the gabaa receptor complex |
| KR20150033679A (ko) | 2012-06-26 | 2015-04-01 | 사니오나 에이피에스 | 페닐 트리아졸 유도체 및 이의 gabaa 수용체 복합체 조절용 용도 |
| WO2014001278A1 (en) | 2012-06-26 | 2014-01-03 | Aniona Aps | A phenyl triazole derivative and its use for modulating the gabaa receptor complex |
| CA3123897C (en) | 2013-12-20 | 2024-02-06 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
| MA42624A (fr) | 2015-06-19 | 2021-04-28 | Agenebio Inc | Dérivés de benzodiazépine, compositions et méthodes de traitement de la déficience cognitive |
| CN107344939A (zh) * | 2016-05-06 | 2017-11-14 | 如东赛默罗生物科技有限公司 | 咪唑[2,1-a]酞嗪类衍生物、其制备方法、药物组合物和用途 |
| HUE058355T2 (hu) * | 2016-12-08 | 2022-07-28 | Hoffmann La Roche | Új izoxazolil-éter származékok, mint a gaba a alfa5 pam |
| US11505555B2 (en) | 2016-12-19 | 2022-11-22 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
| CA3102101A1 (en) * | 2018-06-13 | 2019-12-19 | F. Hoffmann-La Roche Ag | New isoxazolyl ether derivatives as gaba a alpha5 pam |
| EA202190076A1 (ru) | 2018-06-19 | 2021-09-22 | Эйджинбайо, Инк. | Производные бензодиазепина, композиции и способы лечения когнитивных нарушений |
| BR102019014802A2 (pt) | 2018-07-20 | 2020-02-04 | Boehringer Ingelheim Int | difluorometil-fenil triazóis |
| HU231223B1 (hu) | 2018-09-28 | 2022-01-28 | Richter Gedeon Nyrt. | GABAA A5 receptor modulátor hatású biciklusos vegyületek |
| EP4003978B1 (en) | 2019-07-22 | 2024-05-01 | Boehringer Ingelheim International GmbH | N-methyl, n-(6-(methoxy)pyridazin-3-yl) amine derivatives as autotaxin (atx) modulators for the treatment of inflammatory airway or fibrotic diseases |
| CN112979655A (zh) * | 2019-12-16 | 2021-06-18 | 上海赛默罗生物科技有限公司 | 三唑并哒嗪类衍生物、其制备方法、药物组合物和用途 |
| AU2021244926A1 (en) | 2020-03-26 | 2022-11-03 | Richter Gedeon Nyrt. | Naphthyridine and pyrido(3,4-c)pyridazine derivatives as GABAA a5 receptor modulators |
| US20240043418A1 (en) | 2020-03-26 | 2024-02-08 | Richter Gedeon Nyrt. | 1,3-dihydro-2h-pyrrolo[3,4-c]pyridine derivatives as gabaa a5 receptor modulators |
| AU2022270411A1 (en) | 2021-05-05 | 2023-11-23 | Draig Therapeutics Ltd | Heteroaryl compounds useful in the treatment of cognitive disorders |
| HU231691B1 (hu) | 2021-09-29 | 2025-10-28 | Richter Gedeon Nyrt | GABAA ALFA5 receptor modulátor hatású biciklusos aminszármazékok |
| CN116854680A (zh) * | 2022-03-28 | 2023-10-10 | 上海赛默罗生物科技有限公司 | 异噁唑-杂环类衍生物、药物组合物和用途 |
| IL319979A (en) * | 2022-10-25 | 2025-05-01 | Hoffmann La Roche | ALOGABAT production process |
| WO2024251133A1 (zh) * | 2023-06-05 | 2024-12-12 | 武汉人福创新药物研发中心有限公司 | 作为α5-GABAA受体调节剂的杂环化合物及其用途 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3525205A1 (de) * | 1984-09-11 | 1986-03-20 | Hoechst Ag, 6230 Frankfurt | Pflanzenschuetzende mittel auf basis von 1,2,4-triazolderivaten sowie neue derivate des 1,2,4-triazols |
| US6297235B1 (en) * | 1997-08-28 | 2001-10-02 | Merck Sharp & Dohme Ltd. | Triazolopyridazine derivatives for treating anxiety and enhancing cognition |
| GB9808663D0 (en) | 1998-04-23 | 1998-06-24 | Merck Sharp & Dohme | Therapeutic agents |
| ES2255294T3 (es) * | 1998-08-07 | 2006-06-16 | Chiron Corporation | Derivados de isoxazol sustituidos como moduladores del receptor de estrogenos. |
| US6660753B2 (en) * | 1999-08-19 | 2003-12-09 | Nps Pharmaceuticals, Inc. | Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists |
| IT1314191B1 (it) | 1999-10-18 | 2002-12-06 | Recordati Chem Pharm | Derivati isossazolcarbossamidici |
| WO2001034603A2 (en) | 1999-11-12 | 2001-05-17 | Neurogen Corporation | Bicyclic and tricyclic heteroaromatic compounds |
| PA8535601A1 (es) | 2000-12-21 | 2002-11-28 | Pfizer | Derivados benzimidazol y piridilimidazol como ligandos para gabaa |
| GB0108475D0 (en) | 2001-04-04 | 2001-05-23 | Merck Sharp & Dohme | New compounds |
| IL159697A0 (en) | 2001-07-05 | 2004-06-20 | Synaptic Pharma Corp | Substituted anilinic piperidines as mch selective antagonists |
| ATE381542T1 (de) | 2001-08-13 | 2008-01-15 | Phenex Pharmaceuticals Ag | Nr1h4-kern-rezeptor-bindende verbindungen |
| ATE386740T1 (de) | 2001-11-20 | 2008-03-15 | Lilly Co Eli | Beta-3 adrenergische agonisten |
| GB0128160D0 (en) * | 2001-11-23 | 2002-01-16 | Merck Sharp & Dohme | Novel compounds |
| US7319109B2 (en) | 2002-11-22 | 2008-01-15 | Smith Kline Beecham Corporation | Farnesoid X receptor agonists |
| GB0318447D0 (en) | 2003-08-05 | 2003-09-10 | Merck Sharp & Dohme | Therapeutic agents |
| JP2007537286A (ja) * | 2004-05-14 | 2007-12-20 | アイアールエム・リミテッド・ライアビリティ・カンパニー | Ｐｐａｒモジュレーターとしての化合物および組成物 |
| CN1960984B (zh) | 2004-06-01 | 2010-05-12 | 弗·哈夫曼-拉罗切有限公司 | 作为mglu5受体拮抗剂的吡啶-4-基-乙炔基-咪唑和吡唑 |
| WO2005123672A2 (en) | 2004-06-14 | 2005-12-29 | Takeda San Diego, Inc. | Kinase inhibitors |
| RU2383524C2 (ru) | 2004-10-01 | 2010-03-10 | Ф.Хоффманн-Ля Рош Аг | Гексафторизопропанол-замещенные производные простых эфиров |
| WO2006044617A1 (en) | 2004-10-15 | 2006-04-27 | The Scripps Research Institute | Oxadiazole ketone inhibitors of fatty acid amide hydrolase |
| US20070060589A1 (en) | 2004-12-21 | 2007-03-15 | Purandare Ashok V | Inhibitors of protein arginine methyl transferases |
| WO2006095882A1 (ja) | 2005-03-07 | 2006-09-14 | Pioneer Corporation | ホログラム装置及び記録方法 |
| WO2006095822A1 (ja) | 2005-03-11 | 2006-09-14 | Ono Pharmaceutical Co., Ltd. | スルホンアミド化合物およびその医薬 |
| ATE485269T1 (de) * | 2005-06-27 | 2010-11-15 | Bristol Myers Squibb Co | C-verknüpfte zyklische antagonisten des p2y1- rezeptors mit eignung bei der behandlung thrombotischer leiden |
| DE502006008095D1 (de) | 2005-07-20 | 2010-11-25 | Prospective Concepts Ag | Pneumatisch verstellbare seitenwangen für fahrzeugsitze |
| WO2007039389A1 (en) | 2005-09-19 | 2007-04-12 | F. Hoffmann-La Roche Ag | Isoxazolo derivatives as gaba a alpha5 inverse agonists |
| WO2007052843A1 (ja) | 2005-11-04 | 2007-05-10 | Takeda Pharmaceutical Company Limited | 複素環アミド化合物およびその用途 |
| EP1962838B1 (en) | 2005-12-19 | 2011-09-28 | GlaxoSmithKline LLC | Farnesoid x receptor agonists |
| JP2007230909A (ja) | 2006-03-01 | 2007-09-13 | Univ Of Tokyo | 置換イソキサゾール誘導体 |
| EP1894924A1 (en) | 2006-08-29 | 2008-03-05 | Phenex Pharmaceuticals AG | Heterocyclic FXR binding compounds |
| EP1894928A1 (en) | 2006-08-29 | 2008-03-05 | PheneX Pharmaceuticals AG | Heterocyclic fxr binding compounds |
| EP2142551B1 (en) * | 2007-04-17 | 2015-10-14 | Bristol-Myers Squibb Company | Fused heterocyclic 11-beta-hydroxysteroid dehydrogenase type i inhibitors |
-
2008
- 2008-11-25 US US12/277,331 patent/US7943619B2/en active Active
- 2008-11-26 BR BRPI0820113 patent/BRPI0820113A2/pt not_active Application Discontinuation
- 2008-11-26 CA CA2707821A patent/CA2707821C/en not_active Expired - Fee Related
- 2008-11-26 JP JP2010536410A patent/JP5301558B2/ja not_active Expired - Fee Related
- 2008-11-26 MX MX2010006182A patent/MX2010006182A/es active IP Right Grant
- 2008-11-26 EP EP08855943.0A patent/EP2231651B1/en active Active
- 2008-11-26 CN CN2008801172173A patent/CN101868458B/zh not_active Expired - Fee Related
- 2008-11-26 KR KR1020107011907A patent/KR101175855B1/ko not_active Expired - Fee Related
- 2008-11-26 AU AU2008333327A patent/AU2008333327B2/en not_active Expired - Fee Related
- 2008-11-26 WO PCT/EP2008/066226 patent/WO2009071477A1/en not_active Ceased
- 2008-12-01 TW TW097146621A patent/TW200924775A/zh unknown
- 2008-12-02 CL CL2008003593A patent/CL2008003593A1/es unknown
- 2008-12-02 PE PE2008002009A patent/PE20091446A1/es not_active Application Discontinuation
- 2008-12-02 AR ARP080105244A patent/AR069525A1/es unknown
-
2010
- 2010-05-13 IL IL205753A patent/IL205753A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2231651B1 (en) | 2018-11-21 |
| AR069525A1 (es) | 2010-01-27 |
| KR101175855B1 (ko) | 2012-08-24 |
| KR20100074320A (ko) | 2010-07-01 |
| CL2008003593A1 (es) | 2010-01-04 |
| CN101868458B (zh) | 2012-11-28 |
| CA2707821A1 (en) | 2009-06-11 |
| CN101868458A (zh) | 2010-10-20 |
| EP2231651A1 (en) | 2010-09-29 |
| AU2008333327B2 (en) | 2012-12-06 |
| MX2010006182A (es) | 2010-07-01 |
| BRPI0820113A2 (pt) | 2015-05-05 |
| CA2707821C (en) | 2016-06-07 |
| JP2011505402A (ja) | 2011-02-24 |
| TW200924775A (en) | 2009-06-16 |
| AU2008333327A1 (en) | 2009-06-11 |
| JP5301558B2 (ja) | 2013-09-25 |
| WO2009071477A1 (en) | 2009-06-11 |
| US7943619B2 (en) | 2011-05-17 |
| IL205753A0 (en) | 2010-11-30 |
| US20090143385A1 (en) | 2009-06-04 |
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