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PE20090655A1 - Derivados de 2-aza-biciclo[2.2.2]octano para prevencion o tratamiento de psicosis - Google Patents

Derivados de 2-aza-biciclo[2.2.2]octano para prevencion o tratamiento de psicosis

Info

Publication number
PE20090655A1
PE20090655A1 PE2008001248A PE2008001248A PE20090655A1 PE 20090655 A1 PE20090655 A1 PE 20090655A1 PE 2008001248 A PE2008001248 A PE 2008001248A PE 2008001248 A PE2008001248 A PE 2008001248A PE 20090655 A1 PE20090655 A1 PE 20090655A1
Authority
PE
Peru
Prior art keywords
psychosis
aza
octane
bicycle
treatment
Prior art date
Application number
PE2008001248A
Other languages
English (en)
Inventor
Jeffrey Scott Albert
Cristobal Alhambra
Todd Andrew Brugel
Jeffrey Gilbert Varnes
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of PE20090655A1 publication Critical patent/PE20090655A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

REFERIDA A COMPUESTOS DERIVADOS DE 2-AZA-BICICLO[2.2.2]OCTANO DE FORMULA (I) DONDE R1 ES H O ALQUILO(C1-C6); R2 ES HALOGENO, -CN, ALQUENILO(C2-C6), -S-ALQUILO(C1-C6), -SO2NR3R4, ENTRE OTROS, DONDE R3 Y R4 SON CADA UNO H O ALQUILO(C1-C6); n ES DE 1 A 3. SON COMPUESTOS PREFERIDOS: N-(2-AZABICICLO[2,2,2]OCTAN-1-IL(FENIL)METIL)-2,6-DIMETILBENZAMIDA, N-(2-AZABICICLO[2,2,2]OCTAN-1-IL(FENIL)METIL)-2,3-DICLOROBENZAMIDA, N-(2-AZABICICLO[2,2,2]OCTAN-1-IL(FENIL)METIL)-2-CLORO-3-(TRIFLUOROMETIL)BENZAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DEL TRANSPORTADOR DE GLICINA SIENDO UTILES EN EL TRATAMIENTO DE PSICOSIS TALES COMO TRASTORNOS DE ESQUIZOFRENIA, TRASTORNO BIPOLAR, DEPRESION MANIACA, ANSIEDAD
PE2008001248A 2007-07-23 2008-07-23 Derivados de 2-aza-biciclo[2.2.2]octano para prevencion o tratamiento de psicosis PE20090655A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95136507P 2007-07-23 2007-07-23

Publications (1)

Publication Number Publication Date
PE20090655A1 true PE20090655A1 (es) 2009-07-02

Family

ID=39846187

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008001248A PE20090655A1 (es) 2007-07-23 2008-07-23 Derivados de 2-aza-biciclo[2.2.2]octano para prevencion o tratamiento de psicosis

Country Status (6)

Country Link
US (1) US20090030033A1 (es)
AR (1) AR067648A1 (es)
PE (1) PE20090655A1 (es)
TW (1) TW200911808A (es)
UY (1) UY31243A1 (es)
WO (1) WO2009013535A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010087761A1 (en) * 2009-01-28 2010-08-05 Astrazeneca Ab 2-aza-bicyclo[2.2.2]octane compounds and uses thereof
US20120094995A1 (en) * 2009-01-28 2012-04-19 Astrazeneca Ab 2-aza-bicyclo[2.2.1]heptane compounds and uses thereof
FR2941954B1 (fr) * 2009-02-10 2011-04-08 Sanofi Aventis Derives de n-°(6-aza-bicyclo°3.2.1!oct-1-yl)-aryl-methyl! benzamide, leur preparation et leur application en therapeutique
FR2941953B1 (fr) * 2009-02-10 2011-04-08 Sanofi Aventis Derives de n-°(2-aza-bicyclo°2.1.1!hex-1-yl)-benzamide, leur preparation et leur application en therapeutique
FR2944283B1 (fr) * 2009-04-14 2011-05-06 Sanofi Aventis Derives de n-°(2-aza-bicyclo°2.1.1!hex-1-yl)-aryl-methyl!- heterobenzamide, leur preparation et leur application en therapeutique
FR2943059A1 (fr) * 2009-03-16 2010-09-17 Sanofi Aventis Derives de n-°6-aza-bicyclo°3.2.1!oct-5-yl)-aryl-methyl!- heterobenzamide,leur preparation et leur application en therapeutique
JP2012520345A (ja) * 2009-03-16 2012-09-06 サノフイ Ｎ−［（２−アザ−ビシクロ［２．１．１］ヘキス−１−イル）−アリール−）メチル］−ヘテロベンズアミドの誘導体、その調製および治療におけるその用途
FR2943056A1 (fr) * 2009-03-16 2010-09-17 Sanofi Aventis Derives de n-°2-aza-bicyclo°2.1.1!hex-1-yl)-aryl-methyl!- heterobenzamide, leur preparation et leur application en therapeutique
FR2944284A1 (fr) * 2009-04-14 2010-10-15 Sanofi Aventis Derives de n-°7-aza-bicyclo°2.2.1!hept-1-yl)-aryl-methyl! -benzamide, leur preparation et leur application en therapeutique
EP2575815A4 (en) 2010-06-04 2013-12-25 Albany Molecular Res Inc GLYCIN TRANSPORTER 1 INHIBITORS, METHODS OF MAKING THE SAME, AND USES THEREOF
US8227961B2 (en) 2010-06-04 2012-07-24 Cree, Inc. Lighting device with reverse tapered heatsink

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9600683D0 (sv) * 1996-02-23 1996-02-23 Astra Ab Azabicyclic esters of carbamic acids useful in therapy
SE0000540D0 (sv) * 2000-02-18 2000-02-18 Astrazeneca Ab New compounds
FR2838739B1 (fr) * 2002-04-19 2004-05-28 Sanofi Synthelabo Derives de n-[phenyl(piperidin-2-yl)methyl)benzamide, leur preparation et leur application en therapeutique
FR2842804B1 (fr) * 2002-07-29 2004-09-03 Sanofi Synthelabo Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
FR2861074B1 (fr) * 2003-10-17 2006-04-07 Sanofi Synthelabo Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
FR2861076B1 (fr) * 2003-10-17 2006-01-06 Sanofi Synthelabo Derives de n-heterocyclymethylbenzamide, leur preparation et leur application en therapeutique
FR2861071B1 (fr) * 2003-10-17 2006-01-06 Sanofi Synthelabo Derives de n-[phenyl(alkylpiperidin-2-yl) methyl]benzamide, leur prepartation et leur application en therapeutique

Also Published As

Publication number Publication date
TW200911808A (en) 2009-03-16
UY31243A1 (es) 2009-03-02
US20090030033A1 (en) 2009-01-29
AR067648A1 (es) 2009-10-21
WO2009013535A1 (en) 2009-01-29

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