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PE20061150A1 - Derivados de n-(n-sulfonilaminoarilmetil)ciclopropanocarboxamida sustituidos como antagonistas del receptor vainilloide tipo 1 (vdr1) - Google Patents

Derivados de n-(n-sulfonilaminoarilmetil)ciclopropanocarboxamida sustituidos como antagonistas del receptor vainilloide tipo 1 (vdr1)

Info

Publication number
PE20061150A1
PE20061150A1 PE2006000296A PE2006000296A PE20061150A1 PE 20061150 A1 PE20061150 A1 PE 20061150A1 PE 2006000296 A PE2006000296 A PE 2006000296A PE 2006000296 A PE2006000296 A PE 2006000296A PE 20061150 A1 PE20061150 A1 PE 20061150A1
Authority
PE
Peru
Prior art keywords
alkyl
cyclopropanocarboxamide
halogen
vainilloid
antagonists
Prior art date
Application number
PE2006000296A
Other languages
English (en)
Inventor
Takeshi Hanazawa
Misato Hirano
Tadashi Inoue
Satoshi Nagayama
Kazunari Nakao
Yuji Shishido
Hirotaka Tanaka
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PE20061150A1 publication Critical patent/PE20061150A1/es

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  • Organic Chemistry (AREA)
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  • Diabetes (AREA)
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  • Child & Adolescent Psychology (AREA)
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Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I DONDE A Y B SON CR12, N; CADA UNO DE D Y E SON CR9, N; R1 ES ALQUILO C1-C6; R2 ES H, HALOGENO, HIDROXI, ALQUILO C1- C6, ENTRE OTROS; R3 A R6, R10 Y R11 SON H, HALO, HIDROXI, ALQUILO C1-C6, ENTRE OTROS; R12 ES H, HALOGENO, ALQUILO C1-C6, HIDROXIALQUILO C1-C6; R7 Y R9 SON H, HALOGENO, ALQUILO C1-C6, ALQUIL(C1-C6)-TIO, ENTRE OTROS; R8 ES HALOGENO, ALQUILO C1-C6, HALOALQUILO C1-C6, ALCOXI C1-C6, ENTRE OTROS. SON COMPUESTOS PREFERIDOS 2-(4-TERC-BUTILFENIL)-N- {3-FLUORO-4-[(METILSULFONIL)AMINO]BENCIL}CICLOPROPANOCARBOXAMIDA; 2-(4-TERC-BUTIL-3-FLUOROFENIL)-N-((1R)-1- {3-METIL-4-[(METILSULFONIL)AMINO]FENIL}ETIL)CICLOPROPANOCARBOXAMIDA ; 2-[4-(1-HIDROXI-1-METILETIL)FENIL]-2-METIL-N-((1R)-1-{3-METIL-4-[(METILSULFONIL)AMINO]FENIL}ETIL)CICLOPROPANOCARBOXAMIDA. SE REFIERE A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO PREPARACION. LOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR VAINILLOIDE TIPO 1 (VR1) Y SON UTILES PARA EL TRATAMIENTO DE ISQUEMIA CEREBRAL AGUDA, DOLOR, DOLOR CRONICO, NEURALGIA, DOLOR AGUDO
PE2006000296A 2005-03-17 2006-03-17 Derivados de n-(n-sulfonilaminoarilmetil)ciclopropanocarboxamida sustituidos como antagonistas del receptor vainilloide tipo 1 (vdr1) PE20061150A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US66337405P 2005-03-17 2005-03-17
US69980005P 2005-07-15 2005-07-15
US73365105P 2005-11-04 2005-11-04

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PE20061150A1 true PE20061150A1 (es) 2006-11-08

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US (2) US7622589B2 (es)
EP (1) EP1861359B1 (es)
JP (1) JP4521463B2 (es)
KR (1) KR100927915B1 (es)
CN (1) CN101160285A (es)
AP (1) AP2007004157A0 (es)
AR (1) AR055878A1 (es)
AU (1) AU2006224295A1 (es)
BR (1) BRPI0608436A2 (es)
CA (1) CA2601508C (es)
CR (1) CR9375A (es)
DO (1) DOP2006000063A (es)
EA (1) EA200701745A1 (es)
GT (1) GT200600114A (es)
IL (1) IL185546A0 (es)
MA (1) MA29335B1 (es)
MX (1) MX2007011498A (es)
NL (1) NL1031385C2 (es)
NO (1) NO20075312L (es)
PE (1) PE20061150A1 (es)
TN (1) TNSN07349A1 (es)
TW (1) TW200716528A (es)
UY (1) UY29421A1 (es)
WO (1) WO2006097817A1 (es)
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