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PE20081359A1 - Compuestos de azabenzotiofenil como inhibidores de la quinasa mek - Google Patents

Compuestos de azabenzotiofenil como inhibidores de la quinasa mek

Info

Publication number
PE20081359A1
PE20081359A1 PE2007001134A PE2007001134A PE20081359A1 PE 20081359 A1 PE20081359 A1 PE 20081359A1 PE 2007001134 A PE2007001134 A PE 2007001134A PE 2007001134 A PE2007001134 A PE 2007001134A PE 20081359 A1 PE20081359 A1 PE 20081359A1
Authority
PE
Peru
Prior art keywords
compounds
fluoro
pyridine
carboxyl
alkyl
Prior art date
Application number
PE2007001134A
Other languages
English (en)
Inventor
Stephen Price
Karen Williams
Pascal Pierre Savy
Hazel Joan Dyke
John Gary Montana
Mark S Stanley
Liang Bao
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38800915&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20081359(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of PE20081359A1 publication Critical patent/PE20081359A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4743—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Virology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A COMPUESTOS AZABENZOTIOFENIL DE FORMULA (I), EN DONDE Z1 ES CR1 O N; Z2 ES CR2 O N; Z3 ES CR3 O N; Z4 ES CR4 O N, DONDE UNO O DOS Z1, Z2, Z3, Z4 SON N; R1, R2, R3, R4 SON INDEPENDIENTEMENTE H, HALO, CN, CF3, -OF3, ALQUILO(C1-C12), HETEROCICLILO, ENTRE OTROS; W ES a); R5 Y R6 SON INDEPENDIENTEMENTE H O ALQUILO(C1-C12); X1 ES R11, -OR11, ENTRE OTROS, DONDE OR11 Y R5 SE UNEN PARA FORMAR UN ANILLO DE 4 A 7 SUBUNIDADES CON 0 A 2 HETEROATOMOS SELECCIONADO DE O, S O N; R11 ES H, ALQUILO(C1-C12), ARILO, ENTRE OTROS; X2 ES CARBOCICLILO, HETEROCICLILO, ARILO O HETEROARILO. SON SELECCIONADOS: ((R)-2,2-DIMETIL-[1,3]DIOXOLAN-4-ILMETOXI)-AMIDA DEL ACIDO 3-(4-BROMO-2-FLUORO-FENILAMINO)-TIENO[2,3-c]PIRIDINA-2-CARBOXILICO, ESTER ETILICO DEL ACIDO 3-(2FLUORO-4-YODO-FENILAMINO)TIENO[2,3-c]PIRIDINA-2-CARBOXILICO, ESTER ETILICO DEL ACIDO 3-AMINO-7-FLUORO-TIENO[3,2-c]PIRIDINA-2-CARBOXILICO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. ESTOS COMPUESTOS SON INHIBIDORES DE LA ACTIVIDAD DE LA QUINASA MEK, POR LO QUE INHIBEN EL CRECIMIENTO CELULAR ANOMALO, SIENDO UTILES EN EL TRATAMIENTO DE TRASTORNOS HIPERPROLIFERATIVOS O ENFERMEDAD INFLAMATORIA
PE2007001134A 2006-08-21 2007-08-21 Compuestos de azabenzotiofenil como inhibidores de la quinasa mek PE20081359A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US83916306P 2006-08-21 2006-08-21
US87160006P 2006-12-22 2006-12-22
US91762407P 2007-05-11 2007-05-11

Publications (1)

Publication Number Publication Date
PE20081359A1 true PE20081359A1 (es) 2008-11-27

Family

ID=38800915

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2007001134A PE20081359A1 (es) 2006-08-21 2007-08-21 Compuestos de azabenzotiofenil como inhibidores de la quinasa mek
PE2011001541A PE20120049A1 (es) 2006-08-21 2007-08-21 Derivados de 3-anilino-tieno[3, 2-c]piridina como inhibidores de quinasa mek

Family Applications After (1)

Application Number Title Priority Date Filing Date
PE2011001541A PE20120049A1 (es) 2006-08-21 2007-08-21 Derivados de 3-anilino-tieno[3, 2-c]piridina como inhibidores de quinasa mek

Country Status (16)

Country Link
US (1) US7893085B2 (es)
EP (1) EP2069359B1 (es)
JP (1) JP5349306B2 (es)
KR (1) KR101475088B1 (es)
AR (1) AR062469A1 (es)
AU (1) AU2007286807B2 (es)
BR (1) BRPI0714629A2 (es)
CA (1) CA2660963A1 (es)
CL (1) CL2007002431A1 (es)
ES (1) ES2528797T3 (es)
IL (1) IL197060A (es)
MX (1) MX2009001875A (es)
NO (1) NO20091198L (es)
PE (2) PE20081359A1 (es)
TW (1) TWI426078B (es)
WO (1) WO2008024724A1 (es)

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Also Published As

Publication number Publication date
WO2008024724A1 (en) 2008-02-28
TW200823222A (en) 2008-06-01
EP2069359B1 (en) 2014-11-12
EP2069359A1 (en) 2009-06-17
AR062469A1 (es) 2008-11-12
CA2660963A1 (en) 2008-02-28
AU2007286807A1 (en) 2008-02-28
IL197060A (en) 2014-12-31
NO20091198L (no) 2009-05-20
JP5349306B2 (ja) 2013-11-20
JP2010501584A (ja) 2010-01-21
MX2009001875A (es) 2009-03-02
PE20120049A1 (es) 2012-02-16
TWI426078B (zh) 2014-02-11
IL197060A0 (en) 2009-11-18
BRPI0714629A2 (pt) 2013-05-07
US7893085B2 (en) 2011-02-22
US20080081821A1 (en) 2008-04-03
KR101475088B1 (ko) 2014-12-23
KR20090047538A (ko) 2009-05-12
CL2007002431A1 (es) 2008-03-14
ES2528797T3 (es) 2015-02-12
AU2007286807B2 (en) 2013-03-21

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