[go: up one dir, main page]

PE20070833A1 - Compuestos de pirimidinil benzotiofeno - Google Patents

Compuestos de pirimidinil benzotiofeno

Info

Publication number
PE20070833A1
PE20070833A1 PE2006001456A PE2006001456A PE20070833A1 PE 20070833 A1 PE20070833 A1 PE 20070833A1 PE 2006001456 A PE2006001456 A PE 2006001456A PE 2006001456 A PE2006001456 A PE 2006001456A PE 20070833 A1 PE20070833 A1 PE 20070833A1
Authority
PE
Peru
Prior art keywords
halo
hydroxy
pyrimidinyl
alkyl
compounds
Prior art date
Application number
PE2006001456A
Other languages
English (en)
Inventor
Karl Robert Dahnke
Ho-Shen Lin
Chuan Shih
Q May Wang
Bo Zhang
Michael Enrico Richett
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PE20070833A1 publication Critical patent/PE20070833A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE R1 ES H, HIDROXI, HALO, METILTIO, ENTRE OTROS; R2 ES H, HIDROXI, HALO, CIANO, ENTRE OTROS; R3 ES H, HALO, METILO; R4 ES -NR6R7, AMINOMETILOCICLOHEXILO, PIPERIDINILO, ENTRE OTROS; R5 ES H CUANDO n ES 1-7, HIDROXI CUANDO n ES 2-7; R6 ES H, ALQUILO C1-C4; R7 ES H, ALQUILO C1-C4, PIPERIDIN-4-ILO, ENTRE OTROS; n ES 1-7. UN COMPUESTO PREFERIDO ES: CICLOPROPILAMIDA DEL ACIDO 2-{5-CLORO-2-[3-(4-METILPIPERAZIN-1-IL)-PROPILAMINO]-PIRIMIDIN-4-IL}BENZO[b]TIOFEN-4-CARBOXILICO. REFERIDA TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE CINASA IKKBETA Y SON UTILES EN EL TRATAMIENTO DE CANCER Y ENFERMEDADES INFLAMATORIAS
PE2006001456A 2005-11-18 2006-11-15 Compuestos de pirimidinil benzotiofeno PE20070833A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73809705P 2005-11-18 2005-11-18

Publications (1)

Publication Number Publication Date
PE20070833A1 true PE20070833A1 (es) 2007-08-27

Family

ID=38345605

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006001456A PE20070833A1 (es) 2005-11-18 2006-11-15 Compuestos de pirimidinil benzotiofeno

Country Status (27)

Country Link
US (1) US7547691B2 (es)
EP (1) EP1989200B1 (es)
JP (1) JP2009516697A (es)
KR (1) KR100990771B1 (es)
CN (1) CN101309918B (es)
AR (1) AR057911A1 (es)
AT (1) ATE437873T1 (es)
AU (1) AU2006337626B2 (es)
BR (1) BRPI0618245A2 (es)
CA (1) CA2629336A1 (es)
CR (1) CR9947A (es)
DE (1) DE602006008187D1 (es)
DK (1) DK1989200T3 (es)
EA (1) EA014426B1 (es)
EC (1) ECSP088456A (es)
ES (1) ES2329085T3 (es)
IL (1) IL190489A0 (es)
MA (1) MA30053B1 (es)
NO (1) NO20082594L (es)
PE (1) PE20070833A1 (es)
PL (1) PL1989200T3 (es)
PT (1) PT1989200E (es)
SI (1) SI1989200T1 (es)
TN (1) TNSN08227A1 (es)
TW (1) TW200800201A (es)
WO (1) WO2007092095A2 (es)
ZA (1) ZA200803940B (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5066175B2 (ja) 2006-03-31 2012-11-07 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ヒスタミンｈ４受容体のモジュレーターとしてのベンゾイミダゾール−２−イルピリミジンおよびピラジン
CA2658764A1 (en) * 2006-07-20 2008-01-24 Mehmet Kahraman Benzothiophene inhibitors of rho kinase
EA016178B1 (ru) 2006-12-21 2012-02-28 Эли Лилли Энд Компани Соединения имидазолидинониламинопиримидина
ATE479680T1 (de) 2006-12-21 2010-09-15 Lilly Co Eli Imidazolidinonylaminopyrimidinverbindungen zur behandlung von krebs
EP2155735A2 (en) 2007-05-16 2010-02-24 Eli Lilly And Company Triazolyl aminopyrimidine compounds
TW200908981A (en) 2007-05-16 2009-03-01 Lilly Co Eli Triazolyl aminopyrimidine compounds
US9371311B2 (en) 2008-06-30 2016-06-21 Janssen Pharmaceutica Nv Benzoimidazol-2-yl pyrimidine derivatives
TW201433568A (zh) 2008-06-30 2014-09-01 Janssen Pharmaceutica Nv 製備經取代之嘧啶衍生物的方法
KR101123178B1 (ko) * 2009-04-09 2012-06-13 (주)에스메디 2-아릴벤조싸이오펜 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 퇴행성 뇌질환의 진단 또는 치료용 약학적 조성물
CN102470127A (zh) 2009-08-19 2012-05-23 埃姆比特生物科学公司 联芳基化合物和其使用方法
AU2010351938B2 (en) 2010-04-27 2014-10-30 Hutchison Medipharma Limited Pyrimidinyl indole compounds
EP2694707B1 (en) 2011-04-07 2018-08-15 Cornell University Monomers capable of dimerizing in an aqueous solution, and methods of using same
US9245773B2 (en) 2011-09-02 2016-01-26 Taiwan Semiconductor Manufacturing Company, Ltd. Semiconductor device packaging methods and structures thereof
CN103159742B (zh) * 2011-12-16 2015-08-12 北京韩美药品有限公司 5-氯嘧啶类化合物及其作为egfr酪氨酸激酶抑制剂的应用
JP6250561B2 (ja) * 2012-02-08 2017-12-20 サノビオン ファーマシューティカルズ インクＳｕｎｏｖｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． ヘテロアリール化合物およびそれらの使用方法
US9227978B2 (en) 2013-03-15 2016-01-05 Araxes Pharma Llc Covalent inhibitors of Kras G12C
JO3805B1 (ar) 2013-10-10 2021-01-31 Araxes Pharma Llc مثبطات كراس جي12سي
CN105085434B (zh) * 2014-05-09 2018-02-09 上海特化医药科技有限公司 硫乙拉嗪或其中间体的制备方法
WO2017076888A1 (en) * 2015-11-03 2017-05-11 Janssen Pharmaceutica Nv 2-[3-(1-methyl-piperidin-4-yl)-propylamino]-pyrimidine-5-carboxylic acids and amides and methods of making the same
JP7187437B2 (ja) 2016-07-29 2022-12-12 サノビオン ファーマシューティカルズ インク 化合物および組成物ならびにそれらの使用
EP3490607A4 (en) 2016-07-29 2020-04-08 Sunovion Pharmaceuticals Inc. COMPOUNDS AND COMPOSITIONS, AND USES THEREOF
WO2018140514A1 (en) 2017-01-26 2018-08-02 Araxes Pharma Llc 1-(6-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)azetidin-1-yl)prop-2-en-1-one derivatives and similar compounds as kras g12c inhibitors for the treatment of cancer
US11274093B2 (en) 2017-01-26 2022-03-15 Araxes Pharma Llc Fused bicyclic benzoheteroaromatic compounds and methods of use thereof
WO2018140599A1 (en) * 2017-01-26 2018-08-02 Araxes Pharma Llc Benzothiophene and benzothiazole compounds and methods of use thereof
EP3573971A1 (en) 2017-01-26 2019-12-04 Araxes Pharma LLC 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1yl)prop-2-en-1-one derivatives and similar compounds as kras g12c modulators for treating cancer
JP2020521740A (ja) 2017-05-25 2020-07-27 アラクセス ファーマ エルエルシー 変異体ｋｒａｓ、ｈｒａｓまたはｎｒａｓの調節因子としてのキナゾリン誘導体
TW201900633A (zh) 2017-05-25 2019-01-01 美商亞瑞克西斯製藥公司 Kras之共價抑制劑
SG11202000669VA (en) 2017-08-02 2020-02-27 Sunovion Pharmaceuticals Inc Isochroman compounds and uses thereof
US12134620B2 (en) 2018-08-01 2024-11-05 Araxes Pharma Llc Heterocyclic spiro compounds and methods of use thereof for the treatment of cancer
KR20210139376A (ko) 2019-03-14 2021-11-22 선오비온 파마슈티컬스 인코포레이티드 이소크로마닐 화합물의 염, 및 이의 결정성 형태, 제조방법, 치료 용도 및 약제학적 조성물

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989011279A1 (en) * 1988-05-16 1989-11-30 Georgia State University Foundation, Inc. Nucleic acid interacting unfused heteropolycyclic compounds
GB0308466D0 (en) * 2003-04-11 2003-05-21 Novartis Ag Organic compounds
CN101115749B (zh) 2004-12-17 2011-06-22 安姆根有限公司 氨基嘧啶化合物和使用方法

Also Published As

Publication number Publication date
JP2009516697A (ja) 2009-04-23
PT1989200E (pt) 2009-10-12
DE602006008187D1 (de) 2009-09-10
EA014426B1 (ru) 2010-12-30
AR057911A1 (es) 2007-12-26
ES2329085T3 (es) 2009-11-20
EA200801362A1 (ru) 2009-02-27
US7547691B2 (en) 2009-06-16
BRPI0618245A2 (pt) 2011-08-23
EP1989200A2 (en) 2008-11-12
CN101309918B (zh) 2010-12-29
EP1989200B1 (en) 2009-07-29
CN101309918A (zh) 2008-11-19
ATE437873T1 (de) 2009-08-15
TNSN08227A1 (en) 2009-10-30
NO20082594L (no) 2008-06-10
MA30053B1 (fr) 2008-12-01
KR20080059451A (ko) 2008-06-27
ECSP088456A (es) 2008-06-30
AU2006337626B2 (en) 2012-03-22
AU2006337626A1 (en) 2007-08-16
CA2629336A1 (en) 2007-08-16
IL190489A0 (en) 2008-11-03
TW200800201A (en) 2008-01-01
WO2007092095A2 (en) 2007-08-16
DK1989200T3 (da) 2009-11-09
CR9947A (es) 2008-11-28
KR100990771B1 (ko) 2010-10-29
WO2007092095A3 (en) 2007-11-08
SI1989200T1 (sl) 2009-12-31
PL1989200T3 (pl) 2009-12-31
US20080306082A1 (en) 2008-12-11
ZA200803940B (en) 2009-09-30
AU2006337626A8 (en) 2008-06-19

Similar Documents

Publication Publication Date Title
PE20070833A1 (es) Compuestos de pirimidinil benzotiofeno
MX2011012627A (es) Derivados aminobutiricos sustituidos como inhibidores de nepralisina.
PE20081845A1 (es) Nuevos derivados de aminopirimidina como inhibidores de plk1
PE20091486A1 (es) Derivado de pirrolopirimidina como inhibidor de la enzima pi3k
AR054560A1 (es) Espiropiperidina como inhibidores de beta-secretasa para el tratamiento de la enfermedad de alzheimer
NO20083427L (no) Cystoksiske midler omfattende nye tomaymycinderivater og deres terapeutiske anvendelse
MX2011012628A (es) Derivados amino-propionicos sustituidos como inhibidores de neprilisina.
PE20061439A1 (es) DERIVADOS DE 2-AMIDO-6-AMINO-8-OXO-PURINA COMO MODULADORES DEL RECEPTOR Toll (TLR)
PE20140918A1 (es) Compuestos de benzoxepina inhibidores de la pi3k
MX2010006421A (es) Compuestos organicos.
PE20081545A1 (es) Derivados de sulfonamida como inhibidores de acido graso sintasas
PE20081393A1 (es) Derivados de quinolina como inhibidores de csf-1r
PE20030062A1 (es) Derivados aralquilsulfonil-3-(pirrol-2-ilmetiliden)-2-indolinona como inhibidores de quinasas
MX2007003546A (es) Derivados de indozolona como inhibidores de 11-beta- hidroxiesteroide-deshidrogenasa.
UA94606C2 (ru) Производные тиоксантина, композиция, которая их содержит, и их применение в терапии
PE20060937A1 (es) Derivados de sulfonilbencimidazol como agonistas del receptor cannabinoide 2 (cb2)
PE20090880A1 (es) Compuestos heterociclicos como inhibidores de fosfatidilinositol 3-cinasa
PE20081831A1 (es) Derivados de heteroaril-pirrolidinil- y -piperidinil-cetona
PE20091330A1 (es) Derivados de 4-aminopirimidina como antagonistas de receptores de histamina h4
EA200801245A1 (ru) [4-(6-галоген-7-замещенные-2,4-диоксо-1,4-дигидро-2н-хиназолин-3-ил)фенил]-5-хлортиофен-2-илсульфонилмочевины и формы и способы, связанные с ними
MY143568A (en) 11b-hsd1 inhibitors for the treatment of diabetes
MX2008016358A (es) Derivados de tiazolil-urea como inhibidores de cinasa de fosfatidil-inositol-3.
EA200901474A1 (ru) Соли [4-(6-фтор-7-метиламино-2,4-диоксо-1,4-дигидро-2н-хиназолин-3-ил)фенил]-5-хлортиофен-2-илсульфонилмочевины в различных кристаллических формах и фармацевтические композиции на их основе
ATE492534T1 (de) 1h-indol-5-ylpiperazin-1-ylmethanonderivate
EA200870224A1 (ru) Бензо[f]изоиндол-2-илфенильные производные уксусной кислоты в качестве агонистов рецепторов ep

Legal Events

Date Code Title Description
FD Application declared void or lapsed