PE20091427A1 - Derivados de amidas del acido 6,7-dihidro-5h-imidazo[1,2-alfa]imidazol-3-carboxilico - Google Patents
Derivados de amidas del acido 6,7-dihidro-5h-imidazo[1,2-alfa]imidazol-3-carboxilicoInfo
- Publication number
- PE20091427A1 PE20091427A1 PE2008001991A PE2008001991A PE20091427A1 PE 20091427 A1 PE20091427 A1 PE 20091427A1 PE 2008001991 A PE2008001991 A PE 2008001991A PE 2008001991 A PE2008001991 A PE 2008001991A PE 20091427 A1 PE20091427 A1 PE 20091427A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- cycloalkyl
- halogen
- imidazo
- imidazol
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 150000001408 amides Chemical class 0.000 title 1
- -1 4-CYANO-BENZYL Chemical class 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- ZBNZAJFNDPPMDT-UHFFFAOYSA-N 1h-imidazole-5-carboxamide Chemical compound NC(=O)C1=CNC=N1 ZBNZAJFNDPPMDT-UHFFFAOYSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 150000001721 carbon Chemical class 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical compound C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 abstract 1
- 150000002430 hydrocarbons Chemical group 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 208000010125 myocardial infarction Diseases 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000005801 respiratory difficulty Effects 0.000 abstract 1
- 229930195734 saturated hydrocarbon Natural products 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Communicable Diseases (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Ophthalmology & Optometry (AREA)
- Transplantation (AREA)
- Toxicology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
REFERIDO A UN COMPUESTO DE FORMULA I, DONDE R1 ES -CN, -OCF3, HALOGENO, ENTRE OTROS, OPCIONALMENTE SUSTITUIDO CON HALOGENO O ALQUILO C1-3, R2 ES H, CICLOALQUILO C3-6, ALQUILO C1-3 OPCIONALMENTE SUSTITUIDO CON UNO O DOS GRUPOS SELECCIONADOS DE CICLOALQUILO C3-6, -OR9, ENTRE OTROS, R3 ES H O ALQUILO C1-3 O R2 Y R3 FORMAN UN ANILLO HIDROCARBONADO SATURADO DE 3 A 7 ATOMOS DE CARBONO, DONDE UN ATOMO DE CARBONO ESTA OPCIONALMENTE REEMPLAZADO POR -O-, -S-, -S(O)-, ENTRE OTROS, R4 ES ALQUILO C1-5, CICLOALQUILO C3-6, HETEROARILO, OPCIONALMENTE SUSTITUIDO CON DE --NR9R10, -OR9, ENTRE OTROS, R5 ES H, ALQUILO C1-3, -(CH2)2OH Y -(CH2)2OCH3, R6 ES H O HALOGENO, R7 ES HALOGENO O -CF3, R9 ES H, CICLOALQUILO C3-4 O ALQUILO C1-5 EL CUAL ESTA OPCIONALMENTE SUSTITUIDO CON -OH, R10 ES H O -CH3. SON COMPUESTOS PREFERIDOS: ((S)-1-BENCILCARBAMOIL-ETIL)-AMIDA DEL ACIDO (R)-5-(4-CIANO-BENCIL)-7-(3,5-DICLORO-FENIL)-5-METIL-6-OXO-6,7-DIHIDRO-5H-IMIDAZO[1,2-a]IMIDAZOL-3-CARBOXILICO, (3R)-3-(4-BROMOBENCIL)-1-(3,5-DICLOROFENIL)-3-METIL-N-{(1S)-1-METIL-2-OXO-2-[(3R)-3(1H-TETRAZOL-5-IL)PIPERIDIN-1-IL]ETIL}-2-OXO-2,3-DIHIDRO-1H-IMIDAZO[1,2-a]IMIDAZOL-5-CARBOXAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS EXHIBEN UN EFECTO INHIBIDOR TRAS LA INTERACCION DE LAS ICAM CON LAS LEUCOINTEGRINAS, SIENDO UTILES PARA EL TRATAMIENTO DE SINDROME DE DIFICULTAD RESPIRATORIA AGUDA, TOXICIDAD POR OXIGENO, INFARTO DE MIOCARDIO, PSORIASIS, ENTRE OTROS
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99096007P | 2007-11-29 | 2007-11-29 | |
| US4795708P | 2008-04-25 | 2008-04-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20091427A1 true PE20091427A1 (es) | 2009-10-19 |
Family
ID=40193954
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008001991A PE20091427A1 (es) | 2007-11-29 | 2008-11-27 | Derivados de amidas del acido 6,7-dihidro-5h-imidazo[1,2-alfa]imidazol-3-carboxilico |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US8552205B2 (es) |
| EP (1) | EP2225238B1 (es) |
| JP (1) | JP5485164B2 (es) |
| KR (1) | KR20100101095A (es) |
| CN (1) | CN101889011B (es) |
| AR (1) | AR069513A1 (es) |
| AU (1) | AU2008329909B2 (es) |
| BR (1) | BRPI0819831A2 (es) |
| CA (1) | CA2705583A1 (es) |
| CL (1) | CL2008003576A1 (es) |
| CO (1) | CO6210701A2 (es) |
| CY (1) | CY1115857T1 (es) |
| DK (1) | DK2225238T3 (es) |
| EA (1) | EA017688B1 (es) |
| EC (1) | ECSP10010196A (es) |
| ES (1) | ES2525237T3 (es) |
| HR (1) | HRP20141171T1 (es) |
| IL (1) | IL205189A (es) |
| MA (1) | MA31905B1 (es) |
| MX (1) | MX2010004995A (es) |
| MY (1) | MY151004A (es) |
| NZ (1) | NZ585640A (es) |
| PE (1) | PE20091427A1 (es) |
| PL (1) | PL2225238T3 (es) |
| PT (1) | PT2225238E (es) |
| RS (1) | RS53602B1 (es) |
| SI (1) | SI2225238T1 (es) |
| TN (1) | TN2010000240A1 (es) |
| TW (2) | TWI475990B (es) |
| UY (1) | UY31493A1 (es) |
| WO (1) | WO2009070485A1 (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5384733B2 (ja) * | 2009-06-02 | 2014-01-08 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ６，７−ジヒドロ−５Ｈ−イミダゾ［１，２−ａ］イミダゾール−３−カルボン酸アミドの誘導体 |
| US8575360B2 (en) | 2009-06-02 | 2013-11-05 | Boehringer Ingelheim International Gmbh | Derivatives of 6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-carboxylic acid amides |
| PL2491028T3 (pl) | 2009-10-21 | 2014-05-30 | Boehringer Ingelheim Int | Związki indazolowe i pirazolopirydynowe jako antagoniści receptora CCR1 |
| US8912221B2 (en) * | 2010-12-27 | 2014-12-16 | Hoffmann-La Roche Inc. | Biaryl amide derivatives |
| CA2834429C (en) | 2011-04-27 | 2019-07-02 | Kyohei Hayashi | 5-membered ring aromatic heterocyclic derivative having npy y5 receptor antagonistic activity |
| EP2740730B1 (en) | 2011-08-03 | 2016-11-16 | Kyowa Hakko Kirin Co., Ltd. | Dibenzooxepin derivative |
| MX367774B (es) | 2011-10-03 | 2019-09-04 | Ogeda S A | N-ACIL-5,6,7, (8-SUSTITUIDO)-TETRAHIDRO- [1,2,4] TRIAZOLO [4,3-a] PIRAZINAS QUIRALES, NOVEDOSAS, COMO ANTAGONISTAS SELECTIVOS DE RECEPTOR DE NK-3; COMPOSICIÓN FARMACÉUTICA, MÉTODOS PARA USO EN TRASTORNOS MEDIADOS POR RECEPTOR DE NK-3 Y SU SÍNTESIS QUIRAL. |
| MX375839B (es) | 2014-10-14 | 2025-03-06 | Syngenta Participations Ag | Proceso para la preparación de 1-(3,5-dicloro-4-fluorofenil)-2,2,2-trifluoroetanona. |
| JOP20190024A1 (ar) | 2016-08-26 | 2019-02-19 | Gilead Sciences Inc | مركبات بيروليزين بها استبدال واستخداماتها |
| CN106631827B (zh) * | 2016-12-30 | 2018-10-23 | 上海毕得医药科技有限公司 | 一种(1-环丙基-1-甲基)乙基胺及其盐酸盐的合成方法 |
| CN109369432B (zh) * | 2018-11-02 | 2021-06-25 | 永农生物科学有限公司 | (s)-4-氯-2-氨基丁酸酯的制备方法 |
| EP4285723A3 (en) | 2019-12-20 | 2024-03-27 | Bayer Aktiengesellschaft | Substituted thiophene carboxamides, thiophene carboxylic acids and derivatives thereof |
| CN111848521A (zh) * | 2020-08-26 | 2020-10-30 | 韶远科技（上海)有限公司 | 一种2-取代-4-烷氧基咪唑化合物的制备方法 |
| IL318203A (en) * | 2022-07-12 | 2025-03-01 | Adama Makhteshim Ltd | Process for preparing modified benzamides |
| WO2025021943A1 (en) | 2023-07-26 | 2025-01-30 | Neuralis | Quinazolinone, benzoxazinone and benzoxazepinone derivatives as protein kinase inhibitors |
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| JPS5136332B1 (es) * | 1970-12-09 | 1976-10-07 | ||
| EP0091596B1 (de) * | 1982-04-08 | 1991-09-11 | Shell Internationale Researchmaatschappij B.V. | Neue Hydantoine, ihre Herstellung und Verwendung |
| JPS63270667A (ja) | 1987-04-30 | 1988-11-08 | Wakamoto Pharmaceut Co Ltd | １−ベンジルイミダゾ−ル誘導体 |
| JPS63270665A (ja) | 1987-04-30 | 1988-11-08 | Wakamoto Pharmaceut Co Ltd | イミダゾ−ル誘導体 |
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| JPH05188631A (ja) | 1992-01-10 | 1993-07-30 | Mita Ind Co Ltd | 電子写真感光体 |
| TW521073B (en) | 1994-01-05 | 2003-02-21 | Hoechst Marion Roussel Inc | New optionally substituted phenylimidazolidines, their preparation process, their use as anti-androgenic agent and the pharmaceutical compositions containing them |
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| IL130931A0 (en) | 1997-03-03 | 2001-01-28 | Boehringer Ingelheim Pharma | Small molecules useful in the treatment of inflammatory disease |
| PT1007033E (pt) | 1997-08-28 | 2008-07-22 | Novartis Ag | Antagonistas do antigénio-1 da função de linfócitos |
| HUP0101587A3 (en) | 1998-03-27 | 2003-03-28 | Genentech Inc | Antagonists for treatment of cd11/cd18 adhesion receptor mediated disorders |
| WO2001007052A1 (en) * | 1999-07-21 | 2001-02-01 | Boehringer Ingelheim Pharmaceuticals, Inc. | Small molecules useful in the treatment of inflammatory disease |
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| ES2306665T3 (es) * | 1999-07-21 | 2008-11-16 | Boehringer Ingelheim Pharmaceuticals Inc. | Pequeñas moleculas utiles en el tratamiento de la enfermedad inflamatoria. |
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| US6844360B2 (en) * | 2002-10-30 | 2005-01-18 | Boehringer Ingelheim Pharmaceuticals, Inc. | Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonylamino]-propionamide |
| AU2005269634A1 (en) * | 2004-07-27 | 2006-02-09 | Boehringer Ingelheim International, Gmbh | Synthesis of 6,7-dihydro-5H-imidazo(1,2-a)imidazole-3-sulfonic acid amides |
| WO2006107923A1 (en) * | 2005-04-05 | 2006-10-12 | Boehringer Ingelheim International Gmbh | Substituted benzylimidazoles useful for the treatment of inflammatory diseases |
| CA2603214A1 (en) * | 2005-04-06 | 2006-10-12 | Steven Richard Brunette | Derivatives of[6,7-dihydro-5himidazo[1,2-alpha]imidazole-3-sulfonyl]-azetedine-carboxylic acids, esters and amides and use thereof as anti-inflammatory agents |
| BRPI0610354A2 (pt) * | 2005-05-19 | 2010-06-15 | Boehringer Ingelheim Internac | derivados de ácido 6,7-diidro-5h-imidazo[1,2-a]imidazol-3-slfÈnico, bem como composição farmacêutica e uso dos mesmos |
| TW200831488A (en) | 2006-11-29 | 2008-08-01 | Astrazeneca Ab | Novel compounds |
| EP2080758A3 (de) | 2007-11-29 | 2009-08-26 | Bayer CropScience AG | Halogen substituierte delta-1-Pyrroline |
| JP2009149609A (ja) | 2007-11-29 | 2009-07-09 | Sumitomo Chemical Co Ltd | アミド化合物及びその用途 |
| TWI361690B (en) | 2007-11-29 | 2012-04-11 | Actelion Pharmaceuticals Ltd | Phosphonic acid derivatives |
| US8063025B2 (en) | 2007-11-29 | 2011-11-22 | Metabasis Therapeutics, Inc. | Nucleoside prodrugs and uses thereof |
| US8575360B2 (en) * | 2009-06-02 | 2013-11-05 | Boehringer Ingelheim International Gmbh | Derivatives of 6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-carboxylic acid amides |
| JP5384733B2 (ja) * | 2009-06-02 | 2014-01-08 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ６，７−ジヒドロ−５Ｈ−イミダゾ［１，２−ａ］イミダゾール−３−カルボン酸アミドの誘導体 |
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2008
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- 2008-11-20 DK DK08853791.5T patent/DK2225238T3/en active
- 2008-11-20 RS RSP20140622 patent/RS53602B1/sr unknown
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- 2008-11-20 BR BRPI0819831A patent/BRPI0819831A2/pt not_active IP Right Cessation
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