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PE20081159A1 - Inhibidores de las quinasas y metodos para su utilizacion - Google Patents

Inhibidores de las quinasas y metodos para su utilizacion

Info

Publication number
PE20081159A1
PE20081159A1 PE2007001532A PE2007001532A PE20081159A1 PE 20081159 A1 PE20081159 A1 PE 20081159A1 PE 2007001532 A PE2007001532 A PE 2007001532A PE 2007001532 A PE2007001532 A PE 2007001532A PE 20081159 A1 PE20081159 A1 PE 20081159A1
Authority
PE
Peru
Prior art keywords
alkyl
methyl
hetero
halo
pyran
Prior art date
Application number
PE2007001532A
Other languages
English (en)
Inventor
Tobias Gabriel
Kin-Chuns Thomas Luk
Joel Mcintosh
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20081159A1 publication Critical patent/PE20081159A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE R1 ES C1-C6 ALQUILO, HALO, C1-C6 ALCOXI, HALO-C1-C6-ALQUILO, HETERO-C1-C6-ALQUILO; R2 ES CIANO, HETEROCICLO MONOCICLO DE 5 MIEMBROS; R3 ES C1-C6 ALQUILO, C3-C6 CICLOALQUILO, (C3-C6 CICLOALQUIL)-(C1-C6 ALQUILO), HETERO-C1-C6 ALQUILO; R4 ES C1-C6 ALQUILO, HALO-C1-C6 ALQUILO, HETERO-C1-C6 ALQUILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 4-METIL-3-[8-METIL-7-OXO-2-(TETRAHIDRO-PIRAN-4-ILAMINO)-7,8-DIHIDRO-PIRIDO[2,3-d]PIRIMIDIN-6-IL]-BENZONITRILO; 8-METIL-6-[2-METIL-5-(3-METIL-ISOXAZOL-5-IL)FENIL]-2- (TETRAHIDRO-PIRAN-4-ILAMINO)-8H-PIRIDO[2,3-d]PIRIMIDIN-7-ONA; ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO DE PREPARACION Y COMPOSICIONES FARMACEUTICAS. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES MEDIDAS POR LAS MAP QUINASA p38 Y LA QUINASA Raf, TALES COMO, SINDROME DE COLON IRRITABLE, TRASTORNOS PROLIFERATIVOS, PSORIASIS, ENTRE OTROS
PE2007001532A 2006-11-09 2007-11-07 Inhibidores de las quinasas y metodos para su utilizacion PE20081159A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US85820306P 2006-11-09 2006-11-09

Publications (1)

Publication Number Publication Date
PE20081159A1 true PE20081159A1 (es) 2008-08-15

Family

ID=38961448

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007001532A PE20081159A1 (es) 2006-11-09 2007-11-07 Inhibidores de las quinasas y metodos para su utilizacion

Country Status (10)

Country Link
US (1) US7645764B2 (es)
EP (1) EP2094698A1 (es)
JP (1) JP2010509265A (es)
CN (1) CN101535308A (es)
AR (1) AR063637A1 (es)
CA (1) CA2668731A1 (es)
CL (1) CL2007003191A1 (es)
PE (1) PE20081159A1 (es)
TW (1) TW200829251A (es)
WO (1) WO2008055842A1 (es)

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AR095464A1 (es) 2013-03-15 2015-10-21 Celgene Avilomics Res Inc Compuestos de heteroarilo y usos de los mismos
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WO2016015597A1 (en) 2014-07-26 2016-02-04 Sunshine Lake Pharma Co., Ltd. Compounds as cdk small-molecule inhibitors and uses thereof
US11471538B2 (en) 2017-02-10 2022-10-18 INSERM (Institut National de la Santéet de la Recherche Medicale) Methods and pharmaceutical compositions for the treatment of cancers associated with activation of the MAPK pathway
US11725185B2 (en) 2017-12-28 2023-08-15 University Of Houston System Stem cell culture systems for columnar epithelial stem cells, and uses related thereto
CN108440278B (zh) * 2018-03-07 2021-01-12 中国计量大学 一种二羧基查尔酮类化合物及其在制备抗炎药物中的应用
TWI831829B (zh) 2018-09-12 2024-02-11 美商建南德克公司 苯氧基-吡啶基-嘧啶化合物及使用方法
EP3941919A1 (en) * 2019-01-03 2022-01-26 Genentech, Inc. Pyrido-pyrimidinone and pteridinone compounds as inhibitors of endoribonuclease inositol requiring enzyme i (ire i alpha) for the treatment of cancer diseases
WO2021122645A1 (en) 2019-12-20 2021-06-24 Syngenta Crop Protection Ag Pesticidally active azole-amide compounds
CN113416197B (zh) * 2021-08-25 2021-12-28 北京鑫开元医药科技有限公司 甲酰胺类衍生物、制备方法、药物组合物及应用

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