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PE20110122A1 - COMPUESTOS DERIVADOS DE 9H-PIRROLO[2,3-b:5,4-c]DIPIRIDIN-6-(PIRIDIN-3-IL) COMO INHIBIDORES DE LAS CINASA Pim - Google Patents

COMPUESTOS DERIVADOS DE 9H-PIRROLO[2,3-b:5,4-c]DIPIRIDIN-6-(PIRIDIN-3-IL) COMO INHIBIDORES DE LAS CINASA Pim

Info

Publication number
PE20110122A1
PE20110122A1 PE2010001118A PE2010001118A PE20110122A1 PE 20110122 A1 PE20110122 A1 PE 20110122A1 PE 2010001118 A PE2010001118 A PE 2010001118A PE 2010001118 A PE2010001118 A PE 2010001118A PE 20110122 A1 PE20110122 A1 PE 20110122A1
Authority
PE
Peru
Prior art keywords
pyridin
pirrolo
inhibitors
dipiridin
compounds derived
Prior art date
Application number
PE2010001118A
Other languages
English (en)
Inventor
Christopher Arendt
Didier Babin
Olivier Bedel
Thierry Gouyon
Mikhail Levit
Serge Mignani
Neil David Moorcroft
David Papin
Li Ronghua
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of PE20110122A1 publication Critical patent/PE20110122A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE R3 Y R4 SON CADA UNO H, HALOGENO, CF3, OXI SUSTITUIDO, AMIDA OPCIONALMENTE SUSTITUIDA, ENTRE OTROS; R6 ES PIRIDINA, 1-METIL-1H-PIRAZOL-4-IL, FURANO, 6-FLUORO-PIRIDINA-3-IL, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 6-PIRIDIN-3-IL-9H-PIRROLO[2,3-b:5,4-c']DIPIRIDINA; N,N-DIETIL-6-(PIRIDIN-3-IL)-9H-PIRROLO[2,3-b:5,4-c']DIPIRIDIN-3-AMINA; 5-[3-FLUORO-6-(PIRIDIN-3-IL)-9H-PIRROLO[2,3-b:5,4-c']DIPIRIDIN-4-IL]PIRIDIN-2-AMINA; ENTRE OTROS. REFERIDA TAMBIEN A UNA COMPOSICION FARMACEUTICA.DICHOS COMPUESTOS SON INHIBIDORES DE PROTEINAS CINASAS UTILES EN EL TRATAMIENTO DE CANCER
PE2010001118A 2008-06-12 2009-06-11 COMPUESTOS DERIVADOS DE 9H-PIRROLO[2,3-b:5,4-c]DIPIRIDIN-6-(PIRIDIN-3-IL) COMO INHIBIDORES DE LAS CINASA Pim PE20110122A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0803262 2008-06-12

Publications (1)

Publication Number Publication Date
PE20110122A1 true PE20110122A1 (es) 2011-03-07

Family

ID=40445526

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2010001118A PE20110122A1 (es) 2008-06-12 2009-06-11 COMPUESTOS DERIVADOS DE 9H-PIRROLO[2,3-b:5,4-c]DIPIRIDIN-6-(PIRIDIN-3-IL) COMO INHIBIDORES DE LAS CINASA Pim

Country Status (26)

Country Link
US (1) US20110178053A1 (es)
EP (1) EP2303882A2 (es)
JP (1) JP2011522867A (es)
KR (1) KR20110016998A (es)
CN (1) CN102124007A (es)
AR (1) AR072084A1 (es)
AU (1) AU2009259114B2 (es)
BR (1) BRPI0915204A2 (es)
CA (1) CA2725093A1 (es)
CO (1) CO6280536A2 (es)
CR (1) CR11814A (es)
DO (1) DOP2010000366A (es)
EA (1) EA018945B1 (es)
EC (1) ECSP10010670A (es)
IL (1) IL209840A0 (es)
MA (1) MA32460B1 (es)
MX (1) MX2010013699A (es)
NI (1) NI201000210A (es)
NZ (1) NZ589839A (es)
PE (1) PE20110122A1 (es)
SV (1) SV2010003754A (es)
TW (1) TW201002711A (es)
UA (1) UA101668C2 (es)
UY (1) UY31895A (es)
WO (1) WO2009150381A2 (es)
ZA (1) ZA201008387B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8501765B2 (en) 2008-06-11 2013-08-06 Genentech, Inc. Diazacarbazoles and methods of use
KR101600278B1 (ko) 2008-06-12 2016-03-08 얀센 파마슈티카 엔.브이. 히스타민 ｈ4 수용체의 다이아미노-피리딘, 피리미딘, 및 피리다진 조절제
BRPI0924844A2 (pt) * 2009-03-24 2016-01-26 Sanofi Sa derivados de azacarbolinas 9h-pirrol[2,3-b:5,4-c']dipiridina, sua preparação e sua utilização terapêutica.
FR2950891B1 (fr) * 2009-10-06 2012-11-09 Sanofi Aventis Derives d'azacarbolines 9h-pyrrolo[2,3-b:5,4-c']dipyridine, leur preparation et leur utilisation therapeutique
FR2953838B1 (fr) * 2009-12-10 2012-02-24 Sanofi Aventis Derives de 9h-beta-carboline (ou 9h-pyridino[3,4-b]indole) trisubstitues, leur preparation et leur utilisation therapeutique
US20110183938A1 (en) * 2009-12-16 2011-07-28 Genentech, Inc. 1,7-diazacarbazoles and methods of use
CN105377851B (zh) * 2013-03-11 2018-07-20 密执安州立大学董事会 Bet布罗莫结构域抑制剂和使用这些抑制剂的治疗方法
KR101663864B1 (ko) * 2013-04-19 2016-10-07 영남대학교 산학협력단 아미도피리딘올 유도체 또는 이의 약제학적 허용가능한 염을 유효성분으로 함유하는 염증성 장질환의 예방 또는 치료용 약학조성물
CN103408573B (zh) * 2013-07-12 2015-12-23 上海工程技术大学 硼酸衍生物及其制备方法和应用
WO2018137655A1 (zh) * 2017-01-25 2018-08-02 江苏豪森药业集团有限公司 吡咯并吡啶类n-氧化衍生物及其制备方法和应用
AU2018312836B2 (en) * 2017-08-07 2022-12-08 Joint Stock Company "Biocad" Novel heterocyclic compounds as CDK8/19 inhibitors
SG11202010882XA (en) 2018-05-04 2020-11-27 Incyte Corp Salts of an fgfr inhibitor
EP3860996A4 (en) 2018-10-02 2022-08-31 Northwestern University BETA-CARBOLINES AS POSITIVE ALLOSTERIC MODULATORS OF HUMAN SEROTONIN RECEPTOR 2C (5-HT2C)
WO2021113462A1 (en) 2019-12-04 2021-06-10 Incyte Corporation Derivatives of an fgfr inhibitor
CN116693449A (zh) 2022-03-04 2023-09-05 上海致根医药科技有限公司 用作tyk2抑制剂的化合物、其制备方法及其在医药上的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8119655B2 (en) * 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
US8501765B2 (en) * 2008-06-11 2013-08-06 Genentech, Inc. Diazacarbazoles and methods of use

Also Published As

Publication number Publication date
CA2725093A1 (fr) 2009-12-17
EP2303882A2 (fr) 2011-04-06
CN102124007A (zh) 2011-07-13
AU2009259114A1 (en) 2009-12-17
AU2009259114B2 (en) 2013-05-23
IL209840A0 (en) 2011-02-28
JP2011522867A (ja) 2011-08-04
NZ589839A (en) 2012-07-27
UA101668C2 (ru) 2013-04-25
ECSP10010670A (es) 2011-01-31
WO2009150381A3 (fr) 2010-02-18
MA32460B1 (fr) 2011-07-03
WO2009150381A2 (fr) 2009-12-17
BRPI0915204A2 (pt) 2019-01-15
CO6280536A2 (es) 2011-05-20
CR11814A (es) 2011-01-10
KR20110016998A (ko) 2011-02-18
ZA201008387B (en) 2012-02-29
EA018945B1 (ru) 2013-11-29
UY31895A (es) 2010-01-29
SV2010003754A (es) 2011-03-15
TW201002711A (en) 2010-01-16
AR072084A1 (es) 2010-08-04
EA201170002A1 (ru) 2011-08-30
US20110178053A1 (en) 2011-07-21
NI201000210A (es) 2011-05-09
DOP2010000366A (es) 2010-12-31
MX2010013699A (es) 2011-02-23

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