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PE20090218A1 - Compuestos mimeticos de glucocorticoides, metodos de preparacion y composiciones farmaceuticas - Google Patents

Compuestos mimeticos de glucocorticoides, metodos de preparacion y composiciones farmaceuticas

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Publication number
PE20090218A1
PE20090218A1 PE2008001806A PE2008001806A PE20090218A1 PE 20090218 A1 PE20090218 A1 PE 20090218A1 PE 2008001806 A PE2008001806 A PE 2008001806A PE 2008001806 A PE2008001806 A PE 2008001806A PE 20090218 A1 PE20090218 A1 PE 20090218A1
Authority
PE
Peru
Prior art keywords
alkyl
diabetes
hydroxy
optionally substituted
ona
Prior art date
Application number
PE2008001806A
Other languages
English (en)
Inventor
Pingrong Liu
Younes Bekkali
Michel J Emmanuel
Christian H J J Harcken
Daniel Kuzmich
Usha R Patel
Doris Riether
Ji Wang
John Robert Proudfoot
Hidenori Takahashi
Rajashekhar Betageri
Thomas M Kirrane
Thomas Wai-Ho Lee
Hossein Razavi
David S Thomson
Renee Zindell
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of PE20090218A1 publication Critical patent/PE20090218A1/es

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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
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Abstract

SE REFIERE A COMPUESTOS DE FORMULA (IC) DONDE R1 ES ARILO O HETEROARILO, OPCIONALMENTE SUSTITUIDO CON ALQUILO C1-C5, ALQUENILO C2-C5, ALQUINILO C2-C5, ENTRE OTROS; R2 Y R3 SON CADA UNO ALQUILO C1-C5; R4 ES ALQUILO C1-C5, ALQUENILO C2-C5, ALQUINILO C2-C5, OPCIONALMENTE SUSTITUIDO CON ALQUILO C1-C3, HIDROXI, HALOGENO, AMINO, OXO; R5 ES HETEROARILO OPCIONALMENTE SUSTITUIDO CON HETEROCICLILCARBONILO, AROILO, AMINOCARBONILO, ENTRE OTROS; R6 ES H, ALQUILO C1-C8, TRIFLUOROMETILO, ENTRE OTROS, OPCIONALMENTE SUSTITUIDO CON ALQUILO C1-C5, ALQUENILO C2-C5, ALQUINILO C2-C5, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 1-[4-(5-FLUORO-2-METOXIFENIL)-2-HIDROXI-4-METIL-2-TRIFLUOROMETILPENTIL]-1,5,6,7-TETRAHIDROINDOL-4-ONA, 1-[4-(2,3-DIHIDROBENZOFURAN-7-IL)-2-HIDROXI-4-METIL-2-TRIFLUOROMETILPENTIL]-1,5,6,7-TETRAHIDROINDOL-4-ONA, 1-[2-HIDROXI-4-(5-METANSULFONIL-2,3-DIHIDROBENZOFURAN-7-IL)-4-METIL-2-TRIFLUOROMETILPENTIL]-1,5,6,7-TETRAHIDROINDOL-4-ONA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON MODULADORES DEL RECEPTOR DE GLUCOCORTICOIDES SIENDO UTILES PARA EL TRATAMIENTO DE ENFERMEDADES PULMONARES, REUMATICAS, ALERGICAS, RENALES, HEPATICAS, CARDIOVASCULARES, NEUROLOGICAS, DIABETES TIPO I y II, OBESIDAD, ENFERMEDAD DE ALZHEIMER, ARTERIOESCLEROSIS, OSTEOARTRITIS, DOLOR GRAVE Y CRONICO
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AU2004275757A1 (en) 2005-04-07
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