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MXPA02000537A - Heterobiciclos que contienen nitrogeno como inhibidores del factor xa. - Google Patents

Heterobiciclos que contienen nitrogeno como inhibidores del factor xa.

Info

Publication number
MXPA02000537A
MXPA02000537A MXPA02000537A MXPA02000537A MXPA02000537A MX PA02000537 A MXPA02000537 A MX PA02000537A MX PA02000537 A MXPA02000537 A MX PA02000537A MX PA02000537 A MXPA02000537 A MX PA02000537A MX PA02000537 A MXPA02000537 A MX PA02000537A
Authority
MX
Mexico
Prior art keywords
inhibitors
nitrogen containing
factor
heterobicycles
same
Prior art date
Application number
MXPA02000537A
Other languages
English (en)
Inventor
Mimi L Quan
Original Assignee
Bristol Myers Squibb Pharma Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Pharma Co filed Critical Bristol Myers Squibb Pharma Co
Publication of MXPA02000537A publication Critical patent/MXPA02000537A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Esta invencion se refiere generalmente a heterobiciclos que contienen hidrogeno de las formulas A y B: (Ver formulas A y B) los cuales son inhibidores de las enzimas de serina proteasa similares a la tripsina, especialmente el factor Xa, composiciones farmaceuticas que contienen los mismos, y metodos del uso de los mismos como agentes anticoagulantes para el tratamiento y prevencion de trastornos tromboembolicos.
MXPA02000537A 1999-07-16 2000-07-12 Heterobiciclos que contienen nitrogeno como inhibidores del factor xa. MXPA02000537A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14434499P 1999-07-16 1999-07-16
PCT/US2000/018903 WO2001005784A1 (en) 1999-07-16 2000-07-12 NITROGEN CONTAINING HETEROBICYCLES AS FACTOR Xa INHIBITORS

Publications (1)

Publication Number Publication Date
MXPA02000537A true MXPA02000537A (es) 2004-09-10

Family

ID=22508178

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA02000537A MXPA02000537A (es) 1999-07-16 2000-07-12 Heterobiciclos que contienen nitrogeno como inhibidores del factor xa.

Country Status (18)

Country Link
US (2) US6429205B1 (es)
EP (1) EP1196412B1 (es)
JP (1) JP2004507439A (es)
KR (1) KR20030011268A (es)
CN (1) CN1454211A (es)
AT (1) ATE268766T1 (es)
AU (1) AU2481501A (es)
BR (1) BR0013200A (es)
CA (1) CA2380727A1 (es)
DE (1) DE60011430T2 (es)
ES (1) ES2222257T3 (es)
HK (1) HK1045502B (es)
IL (1) IL147317A0 (es)
MX (1) MXPA02000537A (es)
NO (1) NO20020217L (es)
PL (1) PL357108A1 (es)
WO (1) WO2001005784A1 (es)
ZA (1) ZA200200094B (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6339099B1 (en) * 1997-06-20 2002-01-15 Dupont Pharmaceuticals Company Guanidine mimics as factor Xa inhibitors
EP1192132B1 (en) 1999-06-14 2005-09-07 Eli Lilly And Company Serine protease inhibitors
AU2001234690A1 (en) 2000-02-01 2001-08-14 Cor Therapeutics, Inc. 2-(1h)-quinolone and 2-(1h)-quinoxalone inhibitors of factor xa
EP1255743A1 (en) * 2000-02-01 2002-11-13 Millenium Pharmaceuticals, Inc. 3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE INHIBITORS OF FACTOR Xa
CA2408913A1 (en) 2000-05-16 2001-11-22 Takeda Chemical Industries, Ltd. Melanin-concentrating hormone antagonist
CN1439008A (zh) 2000-06-23 2003-08-27 布里斯托尔-迈尔斯斯奎布药品公司 作为因子xa抑制剂的1－(杂芳环基－苯基)－稠合吡唑衍生物
AU2001268711A1 (en) 2000-06-23 2002-01-08 Bristol-Myers Squibb Pharma Company Heteroaryl-phenyl substituted factor xa inhibitors
GEP20074098B (en) 2001-09-21 2007-05-10 Bristol Myers Squibb Co Lactam-containing compounds and derivatives thereof as factor xa inhibitors
TWI331526B (en) 2001-09-21 2010-10-11 Bristol Myers Squibb Pharma Co Lactam-containing compounds and derivatives thereof as factor xa inhibitors
TW200302225A (en) 2001-12-04 2003-08-01 Bristol Myers Squibb Co Substituted amino methyl factor Xa inhibitors
AU2002350217A1 (en) 2001-12-04 2003-06-17 Bristol-Myers Squibb Company Glycinamides as factor xa inhibitors
BR0307178A (pt) * 2002-01-22 2004-12-07 Du Pont Composto, composição e método para controle de pragas invertebradas
WO2003082280A1 (en) 2002-03-26 2003-10-09 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
US7312214B2 (en) 2002-05-10 2007-12-25 Bristol-Myers Squibb Company 1, 1-disubstituted cycloalkyl derivatives as factor Xa inhibitors
ATE403648T1 (de) * 2002-08-21 2008-08-15 Boehringer Ingelheim Pharma Substituierte dihydrochinoline als glucocorticoid-mmimetika,verfahren zu deren herstellung, pharmazeutische zubereitungen und deren verwendung
PT1569912E (pt) 2002-12-03 2015-09-15 Pharmacyclics Llc Derivados 2-(2-hidroxibifenil-3-il)-1h-benzoimidazole-5- carboxamidina como inibidores do fator viia
EP1479678A1 (en) * 2003-05-19 2004-11-24 Aventis Pharma Deutschland GmbH Pyrazole-derivatives as factor xa inhibitors
US7429581B2 (en) 2002-12-23 2008-09-30 Sanofi-Aventis Deutschland Gmbh Pyrazole-derivatives as factor Xa inhibitors
ATE444292T1 (de) * 2002-12-23 2009-10-15 Sanofi Aventis Deutschland Pyrazolderivate als faktor-xa-inhibitoren
US7122557B2 (en) 2003-03-18 2006-10-17 Bristol-Myers Squibb Company Sulfonyl-amidino-containing and tetrahydropyrimidino-containing compounds as factor Xa inhibitors
US7129264B2 (en) * 2003-04-16 2006-10-31 Bristol-Myers Squibb Company Biarylmethyl indolines and indoles as antithromboembolic agents
UY28526A1 (es) 2003-09-24 2005-04-29 Boehringer Ingelheim Pharma Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos
US20050124664A1 (en) * 2003-10-30 2005-06-09 Eric Sartori Urea thiadiazole inhibitors of plasminogen activator inhibior-1
US7795272B2 (en) 2004-03-13 2010-09-14 Boehringer Ingelheim Pharmaceutical, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof
JP4912314B2 (ja) * 2004-10-26 2012-04-11 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 因子Ｘａ化合物
CA2592514A1 (en) 2004-12-27 2006-07-06 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
GT200600042A (es) * 2005-02-10 2006-09-27 Aventis Pharma Inc Compuestos de bis arilo y heteroarilo sustituido como antagonistas selectivos de 5ht2a
DE102005038947A1 (de) * 2005-05-18 2006-11-30 Grünenthal GmbH Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln
KR20090097908A (ko) 2006-12-06 2009-09-16 베링거 인겔하임 인터내셔날 게엠베하 글루코코르티코이드 모사물, 이의 제조 방법, 이의 약제학적 조성물 및 용도
US9096546B2 (en) * 2007-05-10 2015-08-04 Albany Molecular Research, Inc. Aryl- and heteroaryl-substituted tetrahydrobenzo-1,4-diazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
CN102112476A (zh) 2008-06-06 2011-06-29 贝林格尔.英格海姆国际有限公司 糖皮质激素模拟物、其制备方法、药物组合物及其用途
EP2865671B1 (en) * 2012-06-22 2017-11-01 Sumitomo Chemical Company, Ltd Fused heterocyclic compound
KR102282673B1 (ko) * 2016-05-23 2021-07-27 더 락커펠러 유니버시티 자가면역 질병의 치료를 위한 아미노아실인다졸 면역조절제

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2240946C (en) 1995-12-21 2002-09-10 The Dupont Merck Pharmaceutical Company Isoxazoline, isothiazoline and pyrazoline factor xa inhibitors
ES2331860T3 (es) * 1996-12-23 2010-01-18 Bristol-Myers Squibb Pharma Company Compuestos heteroaromaticos que contienen nitrogeno como inhibidores del factor xa.
EP0946528B1 (en) 1996-12-23 2003-04-09 Bristol-Myers Squibb Pharma Company OXYGEN OR SULFUR CONTAINING 5-MEMBERED HETEROAROMATICS AS FACTOR Xa INHIBITORS
ZA985247B (en) * 1997-06-19 1999-12-17 Du Pont Merck Pharma Guanidine mimics as factor Xa inhibitors.
JP2002507968A (ja) 1997-06-19 2002-03-12 デュポン ファーマシューティカルズ カンパニー 中性のＰ１特異性基を有するＸａ因子阻害剤
BR9813835A (pt) 1997-12-22 2000-10-10 Du Pont Pharm Co Composto, composição farmacêutica e método de tratamento ou prevenção de uma desordem tromboembólica

Also Published As

Publication number Publication date
AU2481501A (en) 2001-02-05
NO20020217L (no) 2002-03-15
WO2001005784A1 (en) 2001-01-25
IL147317A0 (en) 2002-08-14
KR20030011268A (ko) 2003-02-07
US6716841B2 (en) 2004-04-06
ES2222257T3 (es) 2005-02-01
ZA200200094B (en) 2003-04-30
ATE268766T1 (de) 2004-06-15
EP1196412B1 (en) 2004-06-09
CN1454211A (zh) 2003-11-05
JP2004507439A (ja) 2004-03-11
DE60011430T2 (de) 2005-07-07
CA2380727A1 (en) 2001-01-25
HK1045502A1 (en) 2002-11-29
EP1196412A1 (en) 2002-04-17
US6429205B1 (en) 2002-08-06
DE60011430D1 (de) 2004-07-15
US20030096820A1 (en) 2003-05-22
HK1045502B (en) 2004-12-10
NO20020217D0 (no) 2002-01-15
PL357108A1 (en) 2004-07-12
BR0013200A (pt) 2002-05-07

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