ZA200200094B - Nitrogen containing heterobicycles as factor xa inhibitors. - Google Patents

Nitrogen containing heterobicycles as factor xa inhibitors.

Info

Publication number: ZA200200094B
Authority: ZA; South Africa
Prior art keywords: inhibitors; nitrogen containing; factor; heterobicycles; same
Prior art date: 1999-07-16

Application number

ZA200200094A

Other languages

English (en)

Inventor

Irina C Jacobson

Mimi L Quan

Original Assignee

Bristol Meyers Squibb Pharma C

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-07-16

Filing date

2002-01-04

Publication date

2003-04-30

2002-01-04 Application filed by Bristol Meyers Squibb Pharma C filed Critical Bristol Meyers Squibb Pharma C

2003-04-30 Publication of ZA200200094B publication Critical patent/ZA200200094B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

ZA200200094A 1999-07-16 2002-01-04 Nitrogen containing heterobicycles as factor xa inhibitors. ZA200200094B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US14434499P	1999-07-16	1999-07-16

Publications (1)

Publication Number	Publication Date
ZA200200094B true ZA200200094B (en)	2003-04-30

Family

ID=22508178

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200200094A ZA200200094B (en)	1999-07-16	2002-01-04	Nitrogen containing heterobicycles as factor xa inhibitors.

Country Status (18)

Country	Link
US (2)	US6429205B1 (xx)
EP (1)	EP1196412B1 (xx)
JP (1)	JP2004507439A (xx)
KR (1)	KR20030011268A (xx)
CN (1)	CN1454211A (xx)
AT (1)	ATE268766T1 (xx)
AU (1)	AU2481501A (xx)
BR (1)	BR0013200A (xx)
CA (1)	CA2380727A1 (xx)
DE (1)	DE60011430T2 (xx)
ES (1)	ES2222257T3 (xx)
HK (1)	HK1045502B (xx)
IL (1)	IL147317A0 (xx)
MX (1)	MXPA02000537A (xx)
NO (1)	NO20020217L (xx)
PL (1)	PL357108A1 (xx)
WO (1)	WO2001005784A1 (xx)
ZA (1)	ZA200200094B (xx)

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US6339099B1 (en) *	1997-06-20	2002-01-15	Dupont Pharmaceuticals Company	Guanidine mimics as factor Xa inhibitors
CA2375920A1 (en)	1999-06-14	2000-12-21	Eli Lilly And Company	Compounds
AU2001234690A1 (en)	2000-02-01	2001-08-14	Cor Therapeutics, Inc.	2-(1h)-quinolone and 2-(1h)-quinoxalone inhibitors of factor xa
EP1255743A1 (en) *	2000-02-01	2002-11-13	Millenium Pharmaceuticals, Inc.	3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE INHIBITORS OF FACTOR Xa
AU2001256733A1 (en) *	2000-05-16	2001-11-26	Takeda Chemical Industries Ltd.	Melanin-concentrating hormone antagonist
CA2409762A1 (en)	2000-06-23	2002-01-03	Donald J.P. Pinto	Heteroaryl-phenyl substituted factor xa inhibitors
WO2002000655A1 (en)	2000-06-23	2002-01-03	Bristol-Myers Squibb Pharma Company	1 - (heteroaryl-phenyl) - condensed pyrazol derivatives as factor xa inhibitors
TWI331526B (en)	2001-09-21	2010-10-11	Bristol Myers Squibb Pharma Co	Lactam-containing compounds and derivatives thereof as factor xa inhibitors
SI1427415T1 (sl)	2001-09-21	2009-12-31	Bristol Myers Squibb Co	Sestavine, ki vsebujejo laktame in njihovi derivati kot inhibitorji faktorja xa
WO2003048081A2 (en)	2001-12-04	2003-06-12	Bristol-Myers Squibb Company	Glycinamides as factor xa inhibitors
TW200302225A (en)	2001-12-04	2003-08-01	Bristol Myers Squibb Co	Substituted amino methyl factor Xa inhibitors
EP1569912B1 (en)	2002-12-03	2015-04-29	Pharmacyclics, Inc.	2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors
EP1467988B1 (en) *	2002-01-22	2013-07-17	E.I. Du Pont De Nemours And Company	Quinazoline(di)ones for invertebrate pest control
DE60318188T2 (de)	2002-03-26	2008-12-11	Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield	Glucocorticoid-mimetika, deren herstellung, pharmazeutische zusammensetzungen und verwendung
US7312214B2 (en)	2002-05-10	2007-12-25	Bristol-Myers Squibb Company	1, 1-disubstituted cycloalkyl derivatives as factor Xa inhibitors
WO2004018429A2 (en) *	2002-08-21	2004-03-04	Boehringer Ingelheim Pharmaceuticals, Inc.	Substituted hihydroquinolines as glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
JP4585448B2 (ja) *	2002-12-23	2010-11-24	サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング	第Ｘａ因子阻害剤としてのピラゾール−誘導体
US7429581B2 (en)	2002-12-23	2008-09-30	Sanofi-Aventis Deutschland Gmbh	Pyrazole-derivatives as factor Xa inhibitors
EP1479678A1 (en) *	2003-05-19	2004-11-24	Aventis Pharma Deutschland GmbH	Pyrazole-derivatives as factor xa inhibitors
US7122557B2 (en)	2003-03-18	2006-10-17	Bristol-Myers Squibb Company	Sulfonyl-amidino-containing and tetrahydropyrimidino-containing compounds as factor Xa inhibitors
US7129264B2 (en) *	2003-04-16	2006-10-31	Bristol-Myers Squibb Company	Biarylmethyl indolines and indoles as antithromboembolic agents
UY28526A1 (es)	2003-09-24	2005-04-29	Boehringer Ingelheim Pharma	Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos
US20050124664A1 (en) *	2003-10-30	2005-06-09	Eric Sartori	Urea thiadiazole inhibitors of plasminogen activator inhibior-1
US7795272B2 (en)	2004-03-13	2010-09-14	Boehringer Ingelheim Pharmaceutical, Inc.	Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof
AU2005299693B2 (en) *	2004-10-26	2012-07-05	Janssen Pharmaceutica, N.V.	Factor Xa compounds
ES2326907T3 (es)	2004-12-27	2009-10-21	Boehringer Ingelheim Pharmaceuticals Inc.	Mimeticos de glucocorticoides, metodos para su preparacion, composiciones farmaceuticas y su uso.
GT200600042A (es) *	2005-02-10	2006-09-27	Aventis Pharma Inc	Compuestos de bis arilo y heteroarilo sustituido como antagonistas selectivos de 5ht2a
DE102005038947A1 (de)	2005-05-18	2006-11-30	Grünenthal GmbH	Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln
BRPI0720131A2 (pt)	2006-12-06	2014-02-04	Boehringer Ingelheim Int	Glicocorticoides miméticos, métodos para fazê-los, composições farmacêuticas e usos dos mesmos.
EP2146722A4 (en) *	2007-05-10	2011-08-03	Amr Technology Inc	ARYL AND HETEROARYL SUBSTITUTED TETRAHYDROBENZO-1,4-DIAZEPINES AND THEIR USE FOR BLOCKING THE RECOVERY OF NOREPINEPHRIN, DOPAMINE AND SEROTONINE
KR20110020902A (ko)	2008-06-06	2011-03-03	베링거 인겔하임 인터내셔날 게엠베하	글루코코르티코이드 유사체, 이의 제조방법, 약제학적 조성물 및 이의 용도
CN104395298A (zh) *	2012-06-22	2015-03-04	住友化学株式会社	稠合杂环化合物
MX385138B (es) *	2016-05-23	2025-03-14	Univ Rockefeller	Inmunomoduladores de aminoacilindazol para el tratamiento de enfermedades autoinmunes.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2001502655A (ja)	1995-12-21	2001-02-27	デュポンファーマシューティカルズカンパニー	Ｘａ因子阻害薬であるイソオキサゾリン、イソチアゾリンおよびピラゾリン
EP0946508B1 (en) *	1996-12-23	2009-09-23	Bristol-Myers Squibb Pharma Company	NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS
DE69720773T2 (de)	1996-12-23	2004-01-29	Bristol Myers Squibb Pharma Co	SAUERSTOFF ODER SCHWEFEL ENTHALTENDE 5-GLIEDRIGE HETEROAROMATISHE DERIVATIVE ALS FACTOR Xa HEMMER
PT991625E (pt)	1997-06-19	2005-10-31	Bristol Myers Squibb Pharma Co	Inibidores de factor xa com um grupo de especificidade p1 neutro
ZA985247B (en) *	1997-06-19	1999-12-17	Du Pont Merck Pharma	Guanidine mimics as factor Xa inhibitors.
JP2001526268A (ja)	1997-12-22	2001-12-18	デュポンファーマシューティカルズカンパニー	Ｘａ因子阻害剤としての、オルト−置換Ｐ１を有する、窒素含有複素環式芳香族化合物

2000
- 2000-07-12 MX MXPA02000537A patent/MXPA02000537A/es unknown
- 2000-07-12 WO PCT/US2000/018903 patent/WO2001005784A1/en not_active Ceased
- 2000-07-12 BR BR0013200-4A patent/BR0013200A/pt not_active IP Right Cessation
- 2000-07-12 IL IL14731700A patent/IL147317A0/xx unknown
- 2000-07-12 PL PL00357108A patent/PL357108A1/xx not_active Application Discontinuation
- 2000-07-12 CA CA002380727A patent/CA2380727A1/en not_active Abandoned
- 2000-07-12 JP JP2001511443A patent/JP2004507439A/ja active Pending
- 2000-07-12 AU AU24815/01A patent/AU2481501A/en not_active Abandoned
- 2000-07-12 ES ES00982716T patent/ES2222257T3/es not_active Expired - Lifetime
- 2000-07-12 CN CN00819731A patent/CN1454211A/zh active Pending
- 2000-07-12 KR KR1020027000658A patent/KR20030011268A/ko not_active Withdrawn
- 2000-07-12 HK HK02106604.3A patent/HK1045502B/en not_active IP Right Cessation
- 2000-07-12 DE DE60011430T patent/DE60011430T2/de not_active Expired - Lifetime
- 2000-07-12 EP EP00982716A patent/EP1196412B1/en not_active Expired - Lifetime
- 2000-07-12 AT AT00982716T patent/ATE268766T1/de not_active IP Right Cessation
- 2000-07-13 US US09/615,465 patent/US6429205B1/en not_active Expired - Lifetime
2002
- 2002-01-04 ZA ZA200200094A patent/ZA200200094B/xx unknown
- 2002-01-15 NO NO20020217A patent/NO20020217L/no not_active Application Discontinuation
- 2002-07-26 US US10/205,792 patent/US6716841B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
IL147317A0 (en)	2002-08-14
US6429205B1 (en)	2002-08-06
ES2222257T3 (es)	2005-02-01
EP1196412B1 (en)	2004-06-09
ATE268766T1 (de)	2004-06-15
CN1454211A (zh)	2003-11-05
DE60011430D1 (de)	2004-07-15
NO20020217D0 (no)	2002-01-15
HK1045502B (en)	2004-12-10
CA2380727A1 (en)	2001-01-25
JP2004507439A (ja)	2004-03-11
EP1196412A1 (en)	2002-04-17
US6716841B2 (en)	2004-04-06
AU2481501A (en)	2001-02-05
PL357108A1 (en)	2004-07-12
KR20030011268A (ko)	2003-02-07
NO20020217L (no)	2002-03-15
US20030096820A1 (en)	2003-05-22
DE60011430T2 (de)	2005-07-07
WO2001005784A1 (en)	2001-01-25
MXPA02000537A (es)	2004-09-10
HK1045502A1 (en)	2002-11-29
BR0013200A (pt)	2002-05-07

Publication	Publication Date	Title
IL147317A0 (en)	2002-08-14	NITROGEN CONTAINING HETEROBICYCLES AS FACTOR Xa INHIBITORS
WO2002000651A3 (en)	2002-06-13	Factor xa inhibitors
BR9908280A (pt)	2000-10-31	Inibidores de enzimas de fosfolipase
PL350042A1 (en)	2002-10-21	Serine protease inhibitors
WO2000055124A3 (en)	2001-08-16	Novel compounds and compositions as protease inhibitors
GEP20074098B (en)	2007-05-10	Lactam-containing compounds and derivatives thereof as factor xa inhibitors
ATE244717T1 (de)	2003-07-15	Inhibitoren des impdh-enzyms
NO990855D0 (no)	1999-02-23	Substituerte sykliske amin-metallprotease-inhibitorer
EP1862457A3 (en)	2008-02-20	Fluoropyrrolidines as dipeptidyl peptidase inhibitors
DE60324183D1 (en)	2008-11-27	Aryl-, aryloxy- und alkyloxysubstituierte 1h-indol-3-yl-glyoxylsäurederivateals inhibitoren des plasminogenaktivatorinhibitors-1 (pai-1)
WO2005099709A3 (en)	2006-01-05	Bicyclic heterocycles useful as serine protease inhibitors
IS6069A (is)	2001-09-07	N-cýanómetýlamíð sem próteasalatar
NO983688L (no)	1998-10-12	Serin-protease-inhibitorer
WO2002020475A3 (en)	2003-08-14	Inhibitors of serine protease activity of matriptase or mtsp1
WO2002080853A3 (en)	2003-02-27	Fused heterocyclic inhibitors of factor xa
TW200514772A (en)	2005-05-01	Novel tetrahydropyridine derivatives
WO2001044172A8 (en)	2001-07-19	Salicylamides as serine protease and factor xa inhibitors
MY138303A (en)	2009-05-29	Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade
IL124883A0 (en)	1999-01-26	Amidino protease inhibitors and pharmaceutical compositions containing the same
WO2001070204A3 (de)	2002-08-01	Hochselektive inhibitoren des urokinase-plasminogenaktivators
WO2002002519A3 (en)	2002-07-25	THROMBIN OR FACTOR Xa INHIBITORS
WO2003015715A3 (en)	2003-11-20	Tetrahydroquinoline derivatives as antithrombotic agents
AU3864000A (en)	2000-09-21	Inhibitors of serine protease activity, methods and compositions for treatment of herpes viruses
AU8184301A (en)	2001-12-24	Inhibitors for the blood-clotting factor xa
AU3719100A (en)	2000-09-21	Inhibitors of serine protease activity, methods and compositions for treatment of viral infections