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PE20060374A1 - Inhibidores de cinasa heterociclicos fusionados - Google Patents

Inhibidores de cinasa heterociclicos fusionados

Info

Publication number
PE20060374A1
PE20060374A1 PE2005000752A PE2005000752A PE20060374A1 PE 20060374 A1 PE20060374 A1 PE 20060374A1 PE 2005000752 A PE2005000752 A PE 2005000752A PE 2005000752 A PE2005000752 A PE 2005000752A PE 20060374 A1 PE20060374 A1 PE 20060374A1
Authority
PE
Peru
Prior art keywords
iloxi
triazin
fluorophenyl
thiourea
methoxy
Prior art date
Application number
PE2005000752A
Other languages
English (en)
Inventor
Robert M Borzilleri
Zhong Chen
Tram N Huynh
Xiao Tao Chen
Zhen-Wei Cai
Kyoung S Kim
Wayne Vaccaro
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PE20060374A1 publication Critical patent/PE20060374A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07D495/04—Ortho-condensed systems

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Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I O II, DONDE R1 ES H, ALQUILO, CICLOALQUILO, FENILO, FLUOROFENILO, ENTRE OTROS; R2 ES H, HALOGENO, CIANO, NO2, ENTRE OTROS; B ES O, S, SO, ENTRE OTROS; V ES CH2, NH, ENTRE OTROS; W, X SON CADA UNO C, N; Y ES O, S, NH, N-HALOGENO; ENTRE OTROS; Z ES NH, CH2, ENTRE OTROS; n ES 0-4; A ES 6-METOXI-5-METIPIRROLO[2,1-f][1,2,4]TRIAZIN-4-ILOXI, 6-CLORO-1-METIL-1H-PIRAZOLO[3,4-d]PIRIMIDIN-4-ILOXI, 5-METILPIRROLO[2,1-f][1,2,4]TRIAZIN-6-CARBOXILATO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 1-(3-FLUORO-4-(6-METOXI-5-METILPIRROLO[2,1-f][1,2,4]TRIAZIN-4-ILOXI)FENIL)-3-(2-FENILACETIL)TIOUREA; 1-(3-FLUORO-4-(6-METOXI-5-METILPIRROLO[2,1-f][1,2,4]TRIAZIN-4-ILOXI)FENIL)-3-(2-(4-FLUOROFENIL)ACETIL)TIOUREA; 1-(4-(6-CLORO-1-METIL-1H-PIRAZOLO[3,4-d]PIRIMIDIN-4-ILOXI)-3-FLUOROFENIL)-3-(2-(4-FLUOROFENIL)ACETIL)TIOUREA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA ACTIVIDAD TIROSINA CINASA DE LOS RECEPTORES DEL FACTOR DE CRECIMIENTO TALES COMO C-MET, UTILES EN EL TRATAMIENTO DEL CANCER
PE2005000752A 2004-06-28 2005-06-28 Inhibidores de cinasa heterociclicos fusionados PE20060374A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58345904P 2004-06-28 2004-06-28
US61256304P 2004-09-23 2004-09-23

Publications (1)

Publication Number Publication Date
PE20060374A1 true PE20060374A1 (es) 2006-05-07

Family

ID=35457856

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2005000752A PE20060374A1 (es) 2004-06-28 2005-06-28 Inhibidores de cinasa heterociclicos fusionados
PE2005000754A PE20060524A1 (es) 2004-06-28 2005-06-28 Compuestos heterociclico fusionados como intermediarios en la preparacion de pirrolotriazinas inhibidoras de cinasa

Family Applications After (1)

Application Number Title Priority Date Filing Date
PE2005000754A PE20060524A1 (es) 2004-06-28 2005-06-28 Compuestos heterociclico fusionados como intermediarios en la preparacion de pirrolotriazinas inhibidoras de cinasa

Country Status (14)

Country Link
US (2) US7173031B2 (es)
EP (3) EP1761268A4 (es)
JP (3) JP2008504368A (es)
KR (3) KR20070026621A (es)
AR (2) AR050254A1 (es)
AU (2) AU2005259894C1 (es)
BR (1) BRPI0512722A (es)
CA (1) CA2571680A1 (es)
IL (1) IL180325A0 (es)
MX (2) MXPA06015192A (es)
NO (3) NO20070453L (es)
PE (2) PE20060374A1 (es)
TW (2) TW200604184A (es)
WO (3) WO2006004833A2 (es)

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WO2006004636A3 (en) 2006-05-26
JP4860609B2 (ja) 2012-01-25
EP1761268A4 (en) 2009-07-08
MXPA06015032A (es) 2007-02-08
AU2005260056B2 (en) 2009-08-27
KR20070037448A (ko) 2007-04-04
BRPI0512722A (pt) 2008-04-01
US20050288290A1 (en) 2005-12-29
TW200607505A (en) 2006-03-01
JP2008504368A (ja) 2008-02-14
JP4782117B2 (ja) 2011-09-28
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IL180325A0 (en) 2007-07-04
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EP1771177A2 (en) 2007-04-11
US7173031B2 (en) 2007-02-06
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