PE20060421A1 - Procedimiento para preparar un compuesto de pirrolotriazina anilina como inhibidores de cinasa - Google Patents
Procedimiento para preparar un compuesto de pirrolotriazina anilina como inhibidores de cinasaInfo
- Publication number
- PE20060421A1 PE20060421A1 PE2005000918A PE2005000918A PE20060421A1 PE 20060421 A1 PE20060421 A1 PE 20060421A1 PE 2005000918 A PE2005000918 A PE 2005000918A PE 2005000918 A PE2005000918 A PE 2005000918A PE 20060421 A1 PE20060421 A1 PE 20060421A1
- Authority
- PE
- Peru
- Prior art keywords
- compound
- preparing
- procedure
- kinase inhibitors
- ester
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- UBWMDGGQTGIGMI-UHFFFAOYSA-N NC1=CC=CC=C1.N1N=NC=C2N=CC=C21 Chemical compound NC1=CC=CC=C1.N1N=NC=C2N=CC=C21 UBWMDGGQTGIGMI-UHFFFAOYSA-N 0.000 title 1
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical compound [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- VIROYRDWRZNPKD-UHFFFAOYSA-N 1,2,4-triazine-6-carboxamide Chemical compound NC(=O)C1=CN=CN=N1 VIROYRDWRZNPKD-UHFFFAOYSA-N 0.000 abstract 1
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 abstract 1
- HTJDQJBWANPRPF-UHFFFAOYSA-N Cyclopropylamine Chemical compound NC1CC1 HTJDQJBWANPRPF-UHFFFAOYSA-N 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- CETVQRFGPOGIQJ-UHFFFAOYSA-N lithium;hexane Chemical compound [Li+].CCCCC[CH2-] CETVQRFGPOGIQJ-UHFFFAOYSA-N 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
SE REFIERE A UN PROCEDIMIENTO PARA PREPARAR UN COMPUESTO DE FORMULA I, DONDE R1 ES ALQUILO, ARILO INFERIOR; QUE COMPRENDE: A) PROPORCIONAR UNA MEZCLA DE UNA BASE ORGANOMETALICA FUERTE TAL COMO HEXIL LITIO O n-BUTIL LITIO Y UNA AMINA DE LA ESTRUCTURA R1NH2, DONDE R1 ES ALQUILO O ARILO INFERIOR, EN UN SOLVENTE ORGANICO; B) PROPORCIONAR UN ESTER DE ESTRUCTURA A EN UN SOLVENTE ORGANICO; C) HACER REACCIONAR LA MEZCLA DE LA ETAPA A Y EL ESTER DE LA ETAPA B PARA FORMAR EL PRODUCTO DE LA AMIDA. LA REACCION ES LLAVADA A CABO A UNA TEMPERATURA ENTRE -10°C-110°C. UN COMPUESTO EMPLEANDO DICHO PROCESO ES 4[[5-[(CICLOPROPILAMINO)CARBONIL]-2-METILFENIL]AMINO]-5-METIL-N-PROPILPIRROLO[2,1-f][1,2,4]TRIAZINA-6-CARBOXAMIDA. DICHOS COMPUESTOS SON INHIBIDORES DE p38 CINASA SIENDO UTIL EN EL TRATAMIENTO DE ARTRITIS REUMATOIDE
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60093504P | 2004-08-12 | 2004-08-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20060421A1 true PE20060421A1 (es) | 2006-06-01 |
Family
ID=35907758
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2005000918A PE20060421A1 (es) | 2004-08-12 | 2005-08-09 | Procedimiento para preparar un compuesto de pirrolotriazina anilina como inhibidores de cinasa |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7148348B2 (es) |
| AR (1) | AR050519A1 (es) |
| PE (1) | PE20060421A1 (es) |
| TW (1) | TW200618803A (es) |
| WO (1) | WO2006020904A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1992344A1 (en) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation |
| TW201035100A (en) | 2008-12-19 | 2010-10-01 | Cephalon Inc | Pyrrolotriazines as ALK and JAK2 inhibitors |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
| CN111601593B (zh) | 2017-10-05 | 2022-04-15 | 弗尔康医疗公司 | P38激酶抑制剂降低dux4和下游基因表达以用于治疗fshd |
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| US4908056A (en) | 1986-04-25 | 1990-03-13 | E. I. Du Pont De Nemours And Company | Heterocyclic acyl sulfonamides |
| ATE159257T1 (de) | 1994-05-03 | 1997-11-15 | Ciba Geigy Ag | Pyrrolopyrimidinderivate mit antiproliferativer wirkung |
| CA2163399A1 (en) | 1994-11-24 | 1996-05-25 | Katsuhiro Kawano | Triazine derivative, chymase activity inhibitor and nitric oxide production inhibitor |
| IL118544A (en) | 1995-06-07 | 2001-08-08 | Smithkline Beecham Corp | History of imidazole, the process for their preparation and the pharmaceutical preparations containing them |
| DE69628804T2 (de) | 1995-12-08 | 2003-12-18 | Pfizer Inc., New York | Substitutierte heterozyclische Derivate als CRF Antagonisten |
| DE69724246T2 (de) | 1996-01-11 | 2004-06-03 | Smithkline Beecham Corp. | Neue substituierte imidazolverbindungen |
| GB9604361D0 (en) | 1996-02-29 | 1996-05-01 | Pharmacia Spa | 4-Substituted pyrrolopyrimidine compounds as tyrosine kinase inhibitors |
| US20010007867A1 (en) | 1999-12-13 | 2001-07-12 | Yuhpyng L. Chen | Substituted 6,5-hetero-bicyclic derivatives |
| EP0923582B1 (en) | 1996-08-28 | 2006-09-20 | Pfizer Inc. | Substituted 6,5-hetero-bicyclic derivatives |
| US6147080A (en) | 1996-12-18 | 2000-11-14 | Vertex Pharmaceuticals Incorporated | Inhibitors of p38 |
| US5945418A (en) | 1996-12-18 | 1999-08-31 | Vertex Pharmaceuticals Incorporated | Inhibitors of p38 |
| US6087496A (en) | 1998-05-22 | 2000-07-11 | G. D. Searle & Co. | Substituted pyrazoles suitable as p38 kinase inhibitors |
| IL132736A0 (en) | 1997-05-22 | 2001-03-19 | Searle & Co | 3(5)-Heteroaryl substituted pyrazoles as p38 kinase inhibitors |
| WO1999001452A1 (en) | 1997-07-02 | 1999-01-14 | Smithkline Beecham Corporation | Novel cycloalkyl substituted imidazoles |
| WO1999024033A1 (en) | 1997-11-12 | 1999-05-20 | Shionogi & Co., Ltd. | Method for the treatment of disorders associated with apoptosis using n-heterocyclic glyoxylamide compounds |
| US6130235A (en) | 1998-05-22 | 2000-10-10 | Scios Inc. | Compounds and methods to treat cardiac failure and other disorders |
| CN1261098C (zh) | 1998-08-28 | 2006-06-28 | 西奥斯股份有限公司 | p38－α激酶的抑制剂 |
| US6184226B1 (en) | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
| DK1117653T3 (da) | 1998-10-01 | 2003-05-26 | Astrazeneca Ab | Quinolin- og quinazolinderivater og deres anvendelse som inhibitorer af cykokin-merierede sygdomme |
| GB9906566D0 (en) | 1999-03-23 | 1999-05-19 | Zeneca Ltd | Chemical compounds |
| PL204437B1 (pl) | 1999-05-21 | 2010-01-29 | Bristol Myers Squibb Co | Pochodna pirolotriazyny i jej zastosowanie oraz kompozycja farmaceutyczna i jej zastosowanie |
| US6982265B1 (en) | 1999-05-21 | 2006-01-03 | Bristol Myers Squibb Company | Pyrrolotriazine inhibitors of kinases |
| AU6473600A (en) | 1999-08-23 | 2001-03-19 | Shionogi & Co., Ltd. | Pyrrolotriazine derivatives having spla2-inhibitory activities |
| GB9924092D0 (en) | 1999-10-13 | 1999-12-15 | Zeneca Ltd | Pyrimidine derivatives |
| IL139197A0 (en) | 1999-10-29 | 2001-11-25 | Pfizer Prod Inc | Use of corticotropin releasing factor antagonists and related compositions |
| SK9892001A3 (en) | 1999-11-10 | 2002-04-04 | Ortho Mcneil Pharm Inc | Substituted 2-aryl-3-(heteroaryl)-imidazo[1,2-a]pyrimidines, and related pharmaceutical compositions and methods |
| US20020065270A1 (en) | 1999-12-28 | 2002-05-30 | Moriarty Kevin Joseph | N-heterocyclic inhibitors of TNF-alpha expression |
| WO2001047897A1 (en) | 1999-12-28 | 2001-07-05 | Pharmacopeia, Inc. | Cytokine, especially tnf-alpha, inhibitors |
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| US7102002B2 (en) | 2004-06-16 | 2006-09-05 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
| US7173031B2 (en) | 2004-06-28 | 2007-02-06 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
| TW200600513A (en) | 2004-06-30 | 2006-01-01 | Bristol Myers Squibb Co | A method for preparing pyrrolotriazine compounds |
| US7253167B2 (en) | 2004-06-30 | 2007-08-07 | Bristol-Myers Squibb Company | Tricyclic-heteroaryl compounds useful as kinase inhibitors |
| US7102003B2 (en) | 2004-07-01 | 2006-09-05 | Bristol-Myers Squibb Company | Pyrrolotriazine compounds |
-
2005
- 2005-08-09 PE PE2005000918A patent/PE20060421A1/es not_active Application Discontinuation
- 2005-08-09 TW TW094126983A patent/TW200618803A/zh unknown
- 2005-08-09 US US11/199,746 patent/US7148348B2/en not_active Expired - Lifetime
- 2005-08-11 AR ARP050103338A patent/AR050519A1/es unknown
- 2005-08-11 WO PCT/US2005/028808 patent/WO2006020904A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006020904A1 (en) | 2006-02-23 |
| TW200618803A (en) | 2006-06-16 |
| US7148348B2 (en) | 2006-12-12 |
| AR050519A1 (es) | 2006-11-01 |
| US20060035886A1 (en) | 2006-02-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |