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NO20070506L - Fremgangsmater og mellomprodukter nyttige for fremstilling av kondenserte heterocykliske kinase inhibitorer. - Google Patents

Fremgangsmater og mellomprodukter nyttige for fremstilling av kondenserte heterocykliske kinase inhibitorer.

Info

Publication number
NO20070506L
NO20070506L NO20070506A NO20070506A NO20070506L NO 20070506 L NO20070506 L NO 20070506L NO 20070506 A NO20070506 A NO 20070506A NO 20070506 A NO20070506 A NO 20070506A NO 20070506 L NO20070506 L NO 20070506L
Authority
NO
Norway
Prior art keywords
preparation
methods
kinase inhibitors
intermediates useful
condensed heterocyclic
Prior art date
Application number
NO20070506A
Other languages
English (en)
Inventor
Zhen-Wei Cai
Stephanie Barbosa
Junying Fan
Gerard Crispino
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of NO20070506L publication Critical patent/NO20070506L/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)

Abstract

Foreliggende oppfinnelse angår mellomprodukter som er anvendelige for fremstilling av pyrrolotriaziner og fremgangsmåter for fremstilling av slike mellomprodukter. Pyrrolotriaziner er funnet å være anvendelige ved behandling av kreft ved å hemme proteintyrosinkinase aktiviteten.
NO20070506A 2004-06-28 2007-01-26 Fremgangsmater og mellomprodukter nyttige for fremstilling av kondenserte heterocykliske kinase inhibitorer. NO20070506L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US58345904P 2004-06-28 2004-06-28
US61256304P 2004-09-23 2004-09-23
PCT/US2005/023198 WO2006004884A2 (en) 2004-06-28 2005-06-28 Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors

Publications (1)

Publication Number Publication Date
NO20070506L true NO20070506L (no) 2007-02-14

Family

ID=35457856

Family Applications (3)

Application Number Title Priority Date Filing Date
NO20070453A NO20070453L (no) 2004-06-28 2007-01-24 Kondenserte heterocykliske kinase inhibitorer
NO20070514A NO20070514L (no) 2004-06-28 2007-01-26 Pyrrolotriazin kinase inhibitorer
NO20070506A NO20070506L (no) 2004-06-28 2007-01-26 Fremgangsmater og mellomprodukter nyttige for fremstilling av kondenserte heterocykliske kinase inhibitorer.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
NO20070453A NO20070453L (no) 2004-06-28 2007-01-24 Kondenserte heterocykliske kinase inhibitorer
NO20070514A NO20070514L (no) 2004-06-28 2007-01-26 Pyrrolotriazin kinase inhibitorer

Country Status (14)

Country Link
US (2) US20050288290A1 (no)
EP (3) EP1768983A2 (no)
JP (3) JP4782117B2 (no)
KR (3) KR20070026621A (no)
AR (2) AR049536A1 (no)
AU (2) AU2005259894C1 (no)
BR (1) BRPI0512722A (no)
CA (1) CA2571680A1 (no)
IL (1) IL180325A0 (no)
MX (2) MXPA06015192A (no)
NO (3) NO20070453L (no)
PE (2) PE20060374A1 (no)
TW (2) TW200604184A (no)
WO (3) WO2006004833A2 (no)

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PE20060374A1 (es) 2006-05-07
JP2008504367A (ja) 2008-02-14
CA2571680A1 (en) 2006-01-12
WO2006004884A2 (en) 2006-01-12
AU2005260056B2 (en) 2009-08-27
KR20070026621A (ko) 2007-03-08
AR049536A1 (es) 2006-08-09
WO2006004636A2 (en) 2006-01-12
US7173031B2 (en) 2007-02-06
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KR20070028458A (ko) 2007-03-12
JP2008504368A (ja) 2008-02-14
EP1771177A2 (en) 2007-04-11
US20050288290A1 (en) 2005-12-29
NO20070453L (no) 2007-01-24
AU2005259894C1 (en) 2009-09-17
TW200604184A (en) 2006-02-01
WO2006004636A3 (en) 2006-05-26
AU2005260056A1 (en) 2006-01-12
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AU2005259894A1 (en) 2006-01-12
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