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AR062125A1 - Compuestos que modulan el receptor cb2 y su utilizacion como medicamentos - Google Patents

Compuestos que modulan el receptor cb2 y su utilizacion como medicamentos

Info

Publication number
AR062125A1
AR062125A1 ARP070103333A ARP070103333A AR062125A1 AR 062125 A1 AR062125 A1 AR 062125A1 AR P070103333 A ARP070103333 A AR P070103333A AR P070103333 A ARP070103333 A AR P070103333A AR 062125 A1 AR062125 A1 AR 062125A1
Authority
AR
Argentina
Prior art keywords
optionally substituted
alkyl
halogen
halogen atoms
pyridinyl
Prior art date
Application number
ARP070103333A
Other languages
English (en)
Inventor
Chandana Chowdhury
Christopher Francis Palmer
James Edward Jenkins
Eugene Richard Hickey
Nigel Blumire
Doris Riether
Matthew S Thompson
Malcolm Taylor
Monika Ermann
Angela Berry
Pier Francesco Cirillo
Innocent Mushi
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38884541&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR062125(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of AR062125A1 publication Critical patent/AR062125A1/es

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    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

Son utiles para tratar la inflamacion. Los compuestos que son agonistas, son adicionalmente utiles para tratar el dolor. Reivindicacion 1: Un compuesto de formula (1) en la que: R1 es arilo o heteroarilo, cada uno de ellos opcionalmente sustituido independientemente con 1 a 3 sustituyentes elegidos entre alquilo C1-6 (que está opcionalmente sustituido con 1 a 3 átomos de halogeno), cicloalquilo C1-6, alcoxi C1-6 (que está opcionalmente sustituido con 1 a 3 átomos de halogeno), alquiltio C1-6, alquilsulfonilo C1-6, alcoxicarbonilo C1-6, alquilamino C1-6, cicloalquilamino C3-6, dialquilamino C1-6, alquilaminocarbonilo C1-6, acilamino, dialquilaminocarbonilo C1-6, hidroxilo, halogeno, ciano, nitro, oxo, heterociclilo, arilo y heteroarilo; R2 y R3 son independientemente hidrogeno o alquilo C1-6 o R2 y R3 junto con el de carbono al que están unidos forman un anillo cicloalquilo o heterocíclico de 3 a 6 miembros; R4 es hidrogeno o metilo; R5 es arilo o heteroarilo, cada uno de ellos opcionalmente sustituido independientemente con 1 a 3 sustituyentes elegidos entre alquilo C1-6 (que está opcionalmente sustituido con 1 a 3 átomos de halogeno o con un grupo heterociclilo), alcoxi C1-6 (que está opcionalmente sustituido con 1 a 3 átomos de halogeno), cicloalquilo C1-6, heterociclilo, fenoxi, halogeno, ciano, dimetilaminoalquilo, fenilo (que está opcionalmente sustituido con 1 a 2 átomos de halogeno o alquilo C1-4 opcionalmente sustituido con halogeno), tienilo (que está opcionalmente sustituido con 1 a 2 átomos de halogeno o alquilo C1-4 opcionalmente sustituido con halogeno) y piridinilo (que está opcionalmente sustituido con 1 a 2 grupos alquilo C1-4 opcionalmente sustituidos con halogeno); donde R2 y R3, junto con el átomo de carbono al que están unidos no forman un anillo ciclopropilo cuando R5 es 5-alcoxi-benzotiazolilo, 3-alquil-2-piridinilo, 3-piridinilo sin sustituir, 1-fenil-5-pirazolilo, 2-tiazolilo, 2,3-dihidro-benzo[1,4]dioxina y benzo[1,3]dioxol, y R1 es un fenilo, 4-clorofenilo o 4-metilfenilo; o un tautomero o una sal farmacéuticamente aceptable del mismo.
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