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PE20030694A1 - 2-tio-3,5-diciano-4-fenil-6-aminopiridinas substituidas como ligandos de receptores a1 de adenosina - Google Patents

2-tio-3,5-diciano-4-fenil-6-aminopiridinas substituidas como ligandos de receptores a1 de adenosina

Info

Publication number
PE20030694A1
PE20030694A1 PE2002001187A PE2002001187A PE20030694A1 PE 20030694 A1 PE20030694 A1 PE 20030694A1 PE 2002001187 A PE2002001187 A PE 2002001187A PE 2002001187 A PE2002001187 A PE 2002001187A PE 20030694 A1 PE20030694 A1 PE 20030694A1
Authority
PE
Peru
Prior art keywords
phenyl
diciane
thio
amino
adenosine
Prior art date
Application number
PE2002001187A
Other languages
English (en)
Inventor
Ulrich Rosentreter
Thomas Kramer
Mitsuyuki Shimada
Kerstin Henninger
Nicole Diedrichs
Ralf Wischnat
Walter Hubsch
Thomas Krahn
Johannes-Peter Stasch
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of PE20030694A1 publication Critical patent/PE20030694A1/es

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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
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    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
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    • A61P17/00—Drugs for dermatological disorders
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    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
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  • Immunology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A 2-TIO-3,5-DICIANO-4-FENIL-6-AMINOPIRIDINAS SUSTITUIDAS DE FORMULA I DONDE n ES 2-4; R1 ES H, ALQUILO; R2 ES PIRIDILO, TIAZOLILO OPCIONALMENTE SUSTITUIDO CON ALQUILO, HALOGENO, AMINO, DIMETILAMINO, ACETILAMINO, GUANIDINO, PIRIDILAMINO, TIENILO, FURILO, ENTRE. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. SON COMPUESTOS PREFERIDOS 2-AMINO-6-({[2-(4-CLOROFENIL)-1,3-TIAZOL-4-IL)METIL}SULFANIL)-4-[4-(2-HIDROXIETOXI)FENIL]-3,5-PIRIDINCARBONITRILO; 2-AMINO-4-(4-(2-METOXIFENIL)FENIL]-6-[(3-PIRIDINILMETIL)SULFANIL]-3,5-PIRIDINDICARBONITRILO; ENTRE OTROS. LOS COMPUESTOS SON LIGANDOS DE RECEPTORES A1 DE ADENOSINA Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE ENFERMEDADES DEL SISTEMA CARDIOCIRCULATORIO, UROGENITAL, CANCER, INFLAMATORIAS, NEUROINFLAMATORIAS, NEURODEGENERATIVAS, ESTADO DE DOLOR
PE2002001187A 2001-12-11 2002-12-10 2-tio-3,5-diciano-4-fenil-6-aminopiridinas substituidas como ligandos de receptores a1 de adenosina PE20030694A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10160661 2001-12-11
DE10238113A DE10238113A1 (de) 2001-12-11 2002-08-21 Substituierte 2-Thio-3,5-dicyano-4-phenyl-6-aminopyridine und ihre Verwendung

Publications (1)

Publication Number Publication Date
PE20030694A1 true PE20030694A1 (es) 2003-09-22

Family

ID=26010753

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PE2002001187A PE20030694A1 (es) 2001-12-11 2002-12-10 2-tio-3,5-diciano-4-fenil-6-aminopiridinas substituidas como ligandos de receptores a1 de adenosina

Country Status (33)

Country Link
US (2) US7109218B2 (es)
EP (1) EP1455785B1 (es)
JP (1) JP4542778B2 (es)
KR (1) KR100958474B1 (es)
CN (1) CN100522945C (es)
AR (2) AR037477A1 (es)
AT (1) ATE424202T1 (es)
AU (1) AU2002358055B2 (es)
BR (1) BR0214870A (es)
CA (1) CA2469586C (es)
CO (1) CO5590927A2 (es)
CY (1) CY1109063T1 (es)
DE (2) DE10238113A1 (es)
DK (1) DK1455785T3 (es)
ES (1) ES2321387T3 (es)
HR (1) HRP20040618B1 (es)
HU (1) HU230059B1 (es)
IL (2) IL162266A0 (es)
MA (1) MA26348A1 (es)
MX (1) MXPA04005624A (es)
MY (1) MY134892A (es)
NZ (1) NZ533384A (es)
PE (1) PE20030694A1 (es)
PL (1) PL208627B1 (es)
PT (1) PT1455785E (es)
RU (1) RU2315757C9 (es)
SI (1) SI1455785T1 (es)
SV (1) SV2004001432A (es)
TW (1) TWI333487B (es)
UA (1) UA77730C2 (es)
UY (1) UY27571A1 (es)
WO (1) WO2003053441A1 (es)
ZA (1) ZA200404566B (es)

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