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PE20010637A1 - Derivados del acido aminodicarboxilico como estimulantes de la guanilato ciclasa - Google Patents

Derivados del acido aminodicarboxilico como estimulantes de la guanilato ciclasa

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Publication number
PE20010637A1
PE20010637A1 PE2000000945A PE0009452000A PE20010637A1 PE 20010637 A1 PE20010637 A1 PE 20010637A1 PE 2000000945 A PE2000000945 A PE 2000000945A PE 0009452000 A PE0009452000 A PE 0009452000A PE 20010637 A1 PE20010637 A1 PE 20010637A1
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PE
Peru
Prior art keywords
alkyl
aryl
cycloalkyl
alkylene
alkenyl
Prior art date
Application number
PE2000000945A
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English (en)
Inventor
Elisabeth Perzborn
Klaus Dembowsky
Cristina Alonso-Alija
Johannes-Peter Stasch
Elke Stahl
Paul Naab
Josef Pernerstorfer
Markus Heil
Dietmar Flubacher
Frank Wunder
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of PE20010637A1 publication Critical patent/PE20010637A1/es

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    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07C237/12—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
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Abstract

SE REFIERE AL USO DE DERIVADOS DEL ACIDO AMINODICARBOXILICO DE FORMULA I, DONDE: V FALTA o ES O, NR4, NR4CONR4, NR4CO, NR4SO2, ENTRE OTROS; R4 ES ALQUILO C1-C8, CICLOALQUILO C3-C8, ARILO C6-C10, ENTRE OTROS; Q FALTA o ES ALQUILOC1-C12, ALQUENDIILO C1-C12, ALQUINDIILO C1-C12; Y ES H, NR8R9, ARILO C6-C10, HETEROCICLO AROMATICO C1-C9, CICLOALQUILO C3-C8 SUSTITUIDO CON ALQUILO, ALQUENILO, ALQUINILO, NR7COR10, CONR11R12, SR6, ENTRE OTROS; R6 ES H, ALQUILO C1-C8, ENTRE OTROS; R7 ES H, ALQUILO C1-C8, CICLOALQUILO C3-C8; R8, R9, R11, R12 SON H, ALQUILO, ALQUENILO C1-C8, ARILO C6-C10, HETEROCICLO C1-C9, ENTRE OTROS; R13 ES ALQUILO C1-C4, ARILO C6-C10, ENTRE OTROS; R10 ES H, ALQUILO C1-C12, ALQUENILO C1-C12, ARILO C6-C10, HETEROCICLO AROMATICO, CICLOALQUILO C3-C8, ENTRE OTROS; R3 ES H, HALO, ALQUILO, ALCOXI, ENTRE OTROS; m ES 1-4; W ES ALQUILENO C1-C6, ALQUENDIILO C1-C6, ENTRE OTROS; U ES ALQUILO C1-C4; A ES ARILO C6-C10, HETEROCICLO C1-C9, ENTRE OTROS; X ES ALQUILENO C1-C12, ALQUENDIILO C1-C12, ENTRE OTROS; R1 ES TETRAZOLILO, COOR30, ENTRE OTROS; R30 ES H, ALQUILO C1-C8, CICLOALQUILO C3-C8; R2 ES COOR24; R24 ES H, ALQUILO C1-C6. LOS COMPUESTOS ESTIMULAN A LA GUANILATO CICLASA SOLUBLE Y PUEDEN SER UTILES EN EL TRATAMIENTO DE ENFERMEDADES CARDIACAS, ANGINA DE PECHO, ISQUEMIAS, ARTERIOSCLEORSIS, HIPERTENSION, ENFERMEDADES FIBROTICAS
PE2000000945A 1999-09-13 2000-09-13 Derivados del acido aminodicarboxilico como estimulantes de la guanilato ciclasa PE20010637A1 (es)

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DE19943635A DE19943635A1 (de) 1999-09-13 1999-09-13 Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften

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