[go: up one dir, main page]

PE20011373A1 - Derivados de tiofeno de formula (i) - Google Patents

Derivados de tiofeno de formula (i)

Info

Publication number
PE20011373A1
PE20011373A1 PE2001000510A PE2001000510A PE20011373A1 PE 20011373 A1 PE20011373 A1 PE 20011373A1 PE 2001000510 A PE2001000510 A PE 2001000510A PE 2001000510 A PE2001000510 A PE 2001000510A PE 20011373 A1 PE20011373 A1 PE 20011373A1
Authority
PE
Peru
Prior art keywords
alkyl
methyl
indol
pyridin
thiophene derivatives
Prior art date
Application number
PE2001000510A
Other languages
English (en)
Inventor
Marx Matthew Arnold Arnold
Bingwei Vera Yang
Michael Joseph Luzzio
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE20011373A1 publication Critical patent/PE20011373A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

SE REFIERE A DERIVADOS DE TIOFENO DE FORMULA I DONDE X ES N, CH, C(CN); Y ES N, CH, CF, N-O; R1 ES H, ALQUILO C1-C6; R2 ES HETEROCICLO DE 5 A 13 MIEMBROS, GRUPO R2 CON 1 A 5 SUSTITUYENTES R5; R5 ES HALO, CIANO, TRIFLUOROMETOXILO, TRIFLUOROMETILO, -C(O)R8, -NR6-C(O)R7, -C(O)NR6R7, -NR6R7, ENTRE OTROS; R6 Y R7 SON H, ALQUILO C1-C6, -(CH2)t(ARILO C6-C10), -(CH2)t(HETEROCICLO DE 5 A 10 MIEMBROS), -(CH2)tO(CH2)qOR9, ENTRE OTROS; R8 ES H, ALQUILO C1-C10, -(CH2)t(ARILO C6-C10), (CH2)t(HETEROCICLO DE 5 A 10 MIEMBROS; t ES 0-6; q ES 2-6; R9 Y R10 SON H, ALQUILO C1-C6; R11 ES -C(O)NR12R13, -(CH2)tNR12R13, -NR12C(=O)R13, -SO2-R12, ENTRE OTROS; R12 Y R13 SON H, ALQUILO C1-C6, ENTRE OTROS; R12 Y R13 JUNTO A N FORMAN UN ANILLO AZABICICLICO C5-C9, AZIRIDINILO, AZETIDINILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS METIL-PIRIDIN-3-ILMETIL-AMIDA DEL ACIDO 7-(2-METIL-1H-INDOL-5-ILAMINO)-TIENO[3,2-b]PIRIDINA-2-CARBOXILICO, AZETIDIN-1-IL-{7-(2-METIL-1H-INDOL-5-ILAMINO)-TIENO-[3,2-b]PIRIDIN-2-IL}-METANONA, {7-(2-METIL-1H-INDOL-5-ILAMINO)-TIENO-[3,2-b]PIRIDIN-2-IL}-PIRROLIDIN-1-IL-METANONA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE DERIVADOS DE TIOFENO Y SON UTILES PARA EL TRATAMIENTO DE UN TRASTORNO HIPERPROLIFERATIVO, COMO CANCER
PE2001000510A 2000-06-06 2001-06-01 Derivados de tiofeno de formula (i) PE20011373A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20968600P 2000-06-06 2000-06-06

Publications (1)

Publication Number Publication Date
PE20011373A1 true PE20011373A1 (es) 2002-01-18

Family

ID=22779830

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001000510A PE20011373A1 (es) 2000-06-06 2001-06-01 Derivados de tiofeno de formula (i)

Country Status (22)

Country Link
US (1) US6964961B2 (es)
EP (1) EP1287001B1 (es)
JP (1) JP2003535867A (es)
AR (1) AR032621A1 (es)
AT (1) ATE277933T1 (es)
AU (1) AU2001252463A1 (es)
BR (1) BR0111377A (es)
CA (1) CA2411084A1 (es)
DE (1) DE60106022T2 (es)
DO (1) DOP2001000170A (es)
EC (1) ECSP014097A (es)
ES (1) ES2223827T3 (es)
GT (1) GT200100104A (es)
MX (1) MXPA02012034A (es)
PA (1) PA8518701A1 (es)
PE (1) PE20011373A1 (es)
PT (1) PT1287001E (es)
SV (1) SV2002000478A (es)
TN (1) TNSN01082A1 (es)
TR (1) TR200402656T4 (es)
UY (1) UY26750A1 (es)
WO (1) WO2001094353A1 (es)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1372548A (zh) * 1999-07-01 2002-10-02 味之素株式会社 杂环化合物及其医药用途
AU2001279938B2 (en) * 2000-08-09 2007-01-25 Astrazeneca Ab Indole, azaindole and indazole derivatives having VEGF inhibiting activity
DE10164139A1 (de) 2001-12-27 2003-07-10 Bayer Ag 2-Heteroarylcarbonsäureamide
RU2366652C2 (ru) * 2002-02-01 2009-09-10 ХАЙ ПОЙНТ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи Амиды аминоалкилзамещенных азетидинов, пирролидинов, пиперидинов и азепанов
US7101898B2 (en) 2002-02-01 2006-09-05 Novo Nordisk A/S Amides of aminoalkyl-substituted azetidines, pyrrolidines, piperidines and azepanes
BR0308162A (pt) * 2002-03-01 2004-12-07 Pfizer Derivados de indolil-uréia de tienopiridinas úteis como agentes antiangiogênicos e métodos para o seu uso
ES2318141T3 (es) * 2002-06-06 2009-05-01 Boehringer Ingelheim Pharmaceuticals Inc. Compuestos de amida de acido 3-amino-tieno(2,3-b)piridina-2-carboxilico y procedimiento de preparacion y sus usos.
UA77303C2 (en) 2002-06-14 2006-11-15 Pfizer Derivatives of thienopyridines substituted by benzocondensed heteroarylamide useful as therapeutic agents, pharmaceutical compositions and methods for their use
US7488823B2 (en) * 2003-11-10 2009-02-10 Array Biopharma, Inc. Cyanoguanidines and cyanoamidines as ErbB2 and EGFR inhibitors
US7276519B2 (en) * 2002-11-25 2007-10-02 Wyeth Thieno[3,2-b]pyridine-6-carbonitriles and thieno[2,3-b]pyridine-5-carbonitriles as protein kinase inhibitors
CL2003002287A1 (es) * 2002-11-25 2005-01-14 Wyeth Corp COMPUESTOS DERIVADOS DE TIENO[3,2-b]-PIRIDINA-6-CARBONITRILOS Y TIENEO[2,3-b]-PIRIDINA-5-CARBONITRILOS, COMPOSICION FARMACEUTICA, PROCEDIMIENTO DE PREPARACION Y COMPUESTOS INTERMEDIARIOS, Y SU USO EN EL TRATAMIENTO DEL CANCER, APOPLEJIA, OSTEOPOROSIS
RU2359971C2 (ru) 2003-02-27 2009-06-27 Палау Фарма, С.А. Производные пиразолопиридина
JP2006528685A (ja) * 2003-05-06 2006-12-21 スミスクライン ビーチャム コーポレーション 新規化合物
KR101028952B1 (ko) 2003-08-14 2011-04-12 어레이 바이오파마 인크. 수용체 티로신 키나아제 억제제로서의 퀴나졸린 유사체
US7501427B2 (en) 2003-08-14 2009-03-10 Array Biopharma, Inc. Quinazoline analogs as receptor tyrosine kinase inhibitors
US7459562B2 (en) 2004-04-23 2008-12-02 Bristol-Myers Squibb Company Monocyclic heterocycles as kinase inhibitors
TW200538453A (en) 2004-04-26 2005-12-01 Bristol Myers Squibb Co Bicyclic heterocycles as kinase inhibitors
US7439246B2 (en) 2004-06-28 2008-10-21 Bristol-Myers Squibb Company Fused heterocyclic kinase inhibitors
US7173031B2 (en) 2004-06-28 2007-02-06 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
US7432373B2 (en) 2004-06-28 2008-10-07 Bristol-Meyers Squibb Company Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors
CA2573538C (en) 2004-07-30 2014-11-25 Methylgene Inc. Inhibitors of vegf receptor and hgf receptor signaling
US7790729B2 (en) 2005-05-20 2010-09-07 Methylgene Inc. Inhibitors of VEGF receptor and HGF receptor signaling
KR101378716B1 (ko) 2005-05-20 2014-04-10 메틸진 인코포레이티드 Ｖｅｇｆ 수용체 및 ｈｇｆ 수용체 신호전달의 억제제
US7880004B2 (en) 2005-09-15 2011-02-01 Bristol-Myers Squibb Company Met kinase inhibitors
PE20070619A1 (es) * 2005-09-27 2007-07-02 Wyeth Corp TIENO(2,3-b)PIRIDIN-5-CARBONITRILOS COMO INHIBIDORES DE PROTEINAS QUINASA
US7547782B2 (en) 2005-09-30 2009-06-16 Bristol-Myers Squibb Company Met kinase inhibitors
CN101356171A (zh) 2005-11-15 2009-01-28 阿雷生物药品公司 作为erbbi型受体酪氨酸激酶抑制剂用于治疗增殖性疾病的n4-苯基-喹唑啉-4-胺衍生物和相关化合物
EP1989211A2 (en) * 2006-01-30 2008-11-12 Array Biopharma, Inc. Heterobicyclic thiophene compounds for the treatment of cancer
JP5516397B2 (ja) 2007-04-05 2014-06-11 アムジエン・インコーポレーテツド オーロラキナーゼ調節物質及び使用方法
NZ589336A (en) 2008-03-05 2011-12-22 Methylgene Inc Pyridine derivatives as inhibitors of protein tyrosine kinase activity
MX2010010151A (es) 2008-03-20 2010-10-25 Amgen Inc Moduladores de cinasa aurora y metodo de uso.
US9126935B2 (en) 2008-08-14 2015-09-08 Amgen Inc. Aurora kinase modulators and methods of use
PL2540297T3 (pl) 2008-11-19 2015-12-31 Forum Pharmaceuticals Inc Leczenie zaburzeń funkcji poznawczych(R)-7-chloro-N-(chinuklidyn-3-ylo)benzo[b]tiofeno-2-karboksyamidem i jego farmaceutyczne dopuszczalnymi solami
CN102802620A (zh) * 2009-05-11 2012-11-28 英维沃医药有限公司 使用某种α-7烟酸受体与乙酰胆碱酯酶抑制剂结合治疗认知障碍
KR101698250B1 (ko) 2010-05-17 2017-01-19 포럼 파마슈티칼즈 인크. (R)-7-클로로-N-(퀴누클리딘-3-일)벤조[b]티오펜-2-카르복사미드 히드로클로리드 모노히드레이트의 결정질 형태
RU2635522C2 (ru) 2012-05-08 2017-11-13 Форум Фармасьютикалз, Инк. Способы поддержания, лечения или улучшения когнитивной функции
FR3080620B1 (fr) * 2018-04-27 2021-11-12 Univ Paris Sud Composes a activite inhibitrice de la polymerisation de la tubuline et aux proprietes immunomodulatrices
CN113648307B (zh) * 2021-09-23 2022-09-30 河南大学 MII-tt-DTT及其在制备抗结直肠癌药物中的应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3277623D1 (en) 1981-07-31 1987-12-17 Sloan Kettering Inst Cancer Anti-leukemic beta-glycosyl c-nucleosides
EP0364598A4 (en) 1988-03-02 1992-01-15 Yoshitomi Pharmaceutical Industries, Ltd. 3,4-dihydrothieno 2,3-d¨pyrimidine compounds and pharmaceutical application thereof
JPH02256667A (ja) * 1988-12-27 1990-10-17 Masatoshi Yamato 縮合キノリン系化合物およびその製造方法
AU651337B2 (en) 1990-03-30 1994-07-21 Dowelanco Thienopyrimidine derivatives
US5187168A (en) 1991-10-24 1993-02-16 American Home Products Corporation Substituted quinazolines as angiotensin II antagonists
US5583137A (en) 1992-02-19 1996-12-10 Pfizer Inc. Heterocyclic compounds for enhancing antitumor activity
US5654307A (en) 1994-01-25 1997-08-05 Warner-Lambert Company Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family
IL112249A (en) 1994-01-25 2001-11-25 Warner Lambert Co Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
DK0831829T3 (da) 1995-06-07 2003-12-15 Pfizer Heterocykliske, ringkondenserede pyrimidinderivater
AR004010A1 (es) 1995-10-11 1998-09-30 Glaxo Group Ltd Compuestos heterociclicos
DE69628804T2 (de) 1995-12-08 2003-12-18 Pfizer Inc., New York Substitutierte heterozyclische Derivate als CRF Antagonisten
WO1997029110A1 (en) 1996-02-07 1997-08-14 Janssen Pharmaceutica N.V. Thiophenopyrimidines
BR9713552A (pt) 1996-11-27 2000-01-25 Pfizer Derivados de pirimidina bicìclicos condensados
ZA986729B (en) * 1997-07-29 1999-02-02 Warner Lambert Co Irreversible inhibitors of tyrosine kinases
PL340589A1 (en) * 1997-11-11 2001-02-12 Pfizer Prod Inc Derivatives of thienepyrimidine and thienepyridine useful as anticarcinogenic agents

Also Published As

Publication number Publication date
DE60106022D1 (de) 2004-11-04
US6964961B2 (en) 2005-11-15
ECSP014097A (es) 2003-02-06
DOP2001000170A (es) 2002-05-15
DE60106022T2 (de) 2006-03-09
PA8518701A1 (es) 2002-09-17
CA2411084A1 (en) 2001-12-13
JP2003535867A (ja) 2003-12-02
US20020042409A1 (en) 2002-04-11
ATE277933T1 (de) 2004-10-15
EP1287001A1 (en) 2003-03-05
SV2002000478A (es) 2002-07-03
WO2001094353A1 (en) 2001-12-13
AR032621A1 (es) 2003-11-19
AU2001252463A1 (en) 2001-12-17
BR0111377A (pt) 2003-06-03
TNSN01082A1 (fr) 2005-11-10
EP1287001B1 (en) 2004-09-29
ES2223827T3 (es) 2005-03-01
UY26750A1 (es) 2002-01-31
PT1287001E (pt) 2004-12-31
MXPA02012034A (es) 2003-04-25
GT200100104A (es) 2002-01-31
TR200402656T4 (tr) 2004-11-22

Similar Documents

Publication Publication Date Title
PE20011373A1 (es) Derivados de tiofeno de formula (i)
AR046200A1 (es) Derivados de pirazina y su uso farmaceutico. procesos de preparacion y composiciones farmaceuticas
ES2525763T3 (es) Derivados del ácido fenilalcanoico sustituido y sus usos para el tratamiento de enfermedades respiratorias
AR017808A1 (es) Compuestos intermediarios de epotilona de anillo abierto, utiles para la preparacion de analogos de epotilona, un proceso para producir dichos analogos deepotilona, un proceso para producir dichos intermediarios de epotilona y los compuestos analogos de epotilona asi obtenidos
CO5170521A1 (es) Compuestos farmaceuticos de pirimidinona
PE20020228A1 (es) Compuestos organicos como inhibidores de 3',5' guanosin monofosfato ciclico fosfodiesterasa
GB0100621D0 (en) Chemical compounds VI
CO5320600A1 (es) Agentes antibacterianos de 3-aminoquinazolin-2,4-dionas
PE20040164A1 (es) Mimeticos de glucocorticoides, procedimientos para su preparacion y composiciones farmaceuticas
AR046781A1 (es) Derivados de imidazoquinolinas. composiciones farmaceuticas.
CO5251467A1 (es) Derivados de piperazina
PE13396A1 (es) Compuesto biciclico
AR042668A1 (es) Derivados de fosfonoxi quinazolinas y su uso farmaceutico
AR040031A1 (es) Compuestos de pirazol-pirimidina anilina utiles como inhibidores de cinasa y composiciones farmaceuticas que los contienen
PE20080144A1 (es) Compuestos de tetrahidropiridotienopirimidina con actividad antiproliferativa
ES2132373T3 (es) Benzocicloheptenos, benzoxepinas y benzotiepinas.
CO5590924A2 (es) Derivados de indolilalquilamina como ligandos de 5- hidroxitriptamina-6
KR880006247A (ko) 티에노피리디논 및 이의 제조방법
AR008296A1 (es) Compuestos derivados de tetrahidroquinolina, proceso para su preparacion, composiciones que los contienen y su uso en la preparacion de una composicion
AR043487A1 (es) Heterociclos fusionados de pirimidina y usos de los mismos
PE20050336A1 (es) Compuestos triciclicos como inhibidores de la proteina farnesil transferasa
PE20050160A1 (es) 3-aminopirrolidinas como inhibidores de la captacion de monoaminas
PE20220427A1 (es) Compuestos triciclicos
PE20021018A1 (es) DERIVADOS DE ß - CARBOLINA
AR006991A1 (es) Analogo hidrosoluble de 20(s)- camptotecina, una composicion farmaceutica que los contiene, una medicina para el tratamiento del cancer, leucemia oestados relacionados con el hiv, el uso de dichos compuestos y un procedimiento para su preparacion

Legal Events

Date Code Title Description
FC Refusal