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UY26750A1 - Derivados de tiofeno útiles como agentes anticancerosos - Google Patents

Derivados de tiofeno útiles como agentes anticancerosos

Info

Publication number
UY26750A1
UY26750A1 UY26750A UY26750A UY26750A1 UY 26750 A1 UY26750 A1 UY 26750A1 UY 26750 A UY26750 A UY 26750A UY 26750 A UY26750 A UY 26750A UY 26750 A1 UY26750 A1 UY 26750A1
Authority
UY
Uruguay
Prior art keywords
useful
target agents
formula
compounds
thiophen derivatives
Prior art date
Application number
UY26750A
Other languages
English (en)
Inventor
Bingwei Vera Yang
Michael Joseph Luzzio
Matthew Arnold Marx
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of UY26750A1 publication Critical patent/UY26750A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

El invento se refiere a compuestos de fórmula 1: y a sales e hidratos farmacéuticamente aceptables de los mismos, fórmula en la que X, Y, R1, R2 y R11 son como aquí se definen. El invento se refiere también a composiciones farmacéuticas que contienen los compuestos de fórmula 1, y a métodos para tratar trastornos hiperproliferativos en un mamífero mediante la administración de los compuestos de fórmula 1.
UY26750A 2000-06-06 2001-06-05 Derivados de tiofeno útiles como agentes anticancerosos UY26750A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20968600P 2000-06-06 2000-06-06

Publications (1)

Publication Number Publication Date
UY26750A1 true UY26750A1 (es) 2002-01-31

Family

ID=22779830

Family Applications (1)

Application Number Title Priority Date Filing Date
UY26750A UY26750A1 (es) 2000-06-06 2001-06-05 Derivados de tiofeno útiles como agentes anticancerosos

Country Status (22)

Country Link
US (1) US6964961B2 (es)
EP (1) EP1287001B1 (es)
JP (1) JP2003535867A (es)
AR (1) AR032621A1 (es)
AT (1) ATE277933T1 (es)
AU (1) AU2001252463A1 (es)
BR (1) BR0111377A (es)
CA (1) CA2411084A1 (es)
DE (1) DE60106022T2 (es)
DO (1) DOP2001000170A (es)
EC (1) ECSP014097A (es)
ES (1) ES2223827T3 (es)
GT (1) GT200100104A (es)
MX (1) MXPA02012034A (es)
PA (1) PA8518701A1 (es)
PE (1) PE20011373A1 (es)
PT (1) PT1287001E (es)
SV (1) SV2002000478A (es)
TN (1) TNSN01082A1 (es)
TR (1) TR200402656T4 (es)
UY (1) UY26750A1 (es)
WO (1) WO2001094353A1 (es)

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US7101898B2 (en) 2002-02-01 2006-09-05 Novo Nordisk A/S Amides of aminoalkyl-substituted azetidines, pyrrolidines, piperidines and azepanes
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UA77303C2 (en) 2002-06-14 2006-11-15 Pfizer Derivatives of thienopyridines substituted by benzocondensed heteroarylamide useful as therapeutic agents, pharmaceutical compositions and methods for their use
US7488823B2 (en) 2003-11-10 2009-02-10 Array Biopharma, Inc. Cyanoguanidines and cyanoamidines as ErbB2 and EGFR inhibitors
CL2003002287A1 (es) 2002-11-25 2005-01-14 Wyeth Corp COMPUESTOS DERIVADOS DE TIENO[3,2-b]-PIRIDINA-6-CARBONITRILOS Y TIENEO[2,3-b]-PIRIDINA-5-CARBONITRILOS, COMPOSICION FARMACEUTICA, PROCEDIMIENTO DE PREPARACION Y COMPUESTOS INTERMEDIARIOS, Y SU USO EN EL TRATAMIENTO DEL CANCER, APOPLEJIA, OSTEOPOROSIS
US7276519B2 (en) 2002-11-25 2007-10-02 Wyeth Thieno[3,2-b]pyridine-6-carbonitriles and thieno[2,3-b]pyridine-5-carbonitriles as protein kinase inhibitors
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US7592352B2 (en) * 2003-05-06 2009-09-22 Smithkline Beecham Corporation Substituted thieno and furo-pyridines
JP4828421B2 (ja) 2003-08-14 2011-11-30 アレイ バイオファーマ、インコーポレイテッド 受容体チロシンキナーゼ阻害剤としてのキナゾリン誘導体
US7501427B2 (en) 2003-08-14 2009-03-10 Array Biopharma, Inc. Quinazoline analogs as receptor tyrosine kinase inhibitors
US7459562B2 (en) 2004-04-23 2008-12-02 Bristol-Myers Squibb Company Monocyclic heterocycles as kinase inhibitors
TW200538453A (en) 2004-04-26 2005-12-01 Bristol Myers Squibb Co Bicyclic heterocycles as kinase inhibitors
US7439246B2 (en) 2004-06-28 2008-10-21 Bristol-Myers Squibb Company Fused heterocyclic kinase inhibitors
US7432373B2 (en) 2004-06-28 2008-10-07 Bristol-Meyers Squibb Company Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors
US7173031B2 (en) 2004-06-28 2007-02-06 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
CA2573538C (en) 2004-07-30 2014-11-25 Methylgene Inc. Inhibitors of vegf receptor and hgf receptor signaling
AU2006343808B2 (en) 2005-05-20 2012-03-29 Mirati Therapeutics, Inc. Inhibitors of VEGF receptor and HGF receptor signaling
CA2608726C (en) 2005-05-20 2013-07-09 Methylgene Inc. Inhibitors of vegf receptor and hgf receptor signaling
WO2007035428A1 (en) 2005-09-15 2007-03-29 Bristol-Myers Squibb Company Met kinase inhibitors
PE20070619A1 (es) * 2005-09-27 2007-07-02 Wyeth Corp TIENO(2,3-b)PIRIDIN-5-CARBONITRILOS COMO INHIBIDORES DE PROTEINAS QUINASA
US7547782B2 (en) 2005-09-30 2009-06-16 Bristol-Myers Squibb Company Met kinase inhibitors
DK1971601T3 (da) 2005-11-15 2010-02-08 Array Biopharma Inc N4-phenyl-quinazolin-4-aminderivater og beslægtede forbindelser som ERBB Type 1-receptortyrosinkinase-inhibitorer til behandling af hyperproliferative sygdomme
US8003662B2 (en) * 2006-01-30 2011-08-23 Array Biopharma, Inc. Heterobicyclic thiophene compounds and methods of use
EP2137177B1 (en) 2007-04-05 2014-05-07 Amgen, Inc Aurora kinase modulators and method of use
KR20100137495A (ko) 2008-03-05 2010-12-30 메틸진 인코포레이티드 단백질 티로신 키나아제 활성의 억제제
AU2009226024B2 (en) 2008-03-20 2012-07-12 Amgen Inc. Aurora kinase modulators and method of use
WO2010019473A1 (en) 2008-08-14 2010-02-18 Amgen Inc. Aurora kinase modulators and methods of use
MY173229A (en) 2008-11-19 2020-01-07 Forum Pharmaceuticals Inc Treatment of cognitive disorders with (r)-7-chloro-n-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide and pharmaceutically acceptable salts thereof
RU2011150248A (ru) * 2009-05-11 2013-06-20 Энвиво Фармасьютикалз, Инк. Лечение когнитивных расстройств с определенными рецепторами альфа-7 никотиновой кислоты в комбинации с ингибиторами ацетилхолинэстеразы
PT3029039T (pt) 2010-05-17 2017-11-28 Forum Pharmaceuticals Inc Formulações farmacêuticas que compreendem formas cristalinas de cloridrato de (r)-7-cloro-n-(quinuclidin-3-il)benzo(b)tiofeno-2-carboxamida mono-hidratado
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Also Published As

Publication number Publication date
ATE277933T1 (de) 2004-10-15
ECSP014097A (es) 2003-02-06
PA8518701A1 (es) 2002-09-17
US20020042409A1 (en) 2002-04-11
MXPA02012034A (es) 2003-04-25
CA2411084A1 (en) 2001-12-13
TNSN01082A1 (fr) 2005-11-10
BR0111377A (pt) 2003-06-03
DE60106022D1 (de) 2004-11-04
JP2003535867A (ja) 2003-12-02
DOP2001000170A (es) 2002-05-15
WO2001094353A1 (en) 2001-12-13
EP1287001B1 (en) 2004-09-29
GT200100104A (es) 2002-01-31
PE20011373A1 (es) 2002-01-18
US6964961B2 (en) 2005-11-15
SV2002000478A (es) 2002-07-03
PT1287001E (pt) 2004-12-31
EP1287001A1 (en) 2003-03-05
DE60106022T2 (de) 2006-03-09
AU2001252463A1 (en) 2001-12-17
ES2223827T3 (es) 2005-03-01
TR200402656T4 (tr) 2004-11-22
AR032621A1 (es) 2003-11-19

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Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20140128