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UY27685A1 - Indolil-urea derivados de tienopiridinas útiles como agentes antiangiogénicos, y procedimientos para su uso - Google Patents

Indolil-urea derivados de tienopiridinas útiles como agentes antiangiogénicos, y procedimientos para su uso

Info

Publication number
UY27685A1
UY27685A1 UY27685A UY27685A UY27685A1 UY 27685 A1 UY27685 A1 UY 27685A1 UY 27685 A UY27685 A UY 27685A UY 27685 A UY27685 A UY 27685A UY 27685 A1 UY27685 A1 UY 27685A1
Authority
UY
Uruguay
Prior art keywords
tienopiridins
antiangiogen
indolil
procedures
agents
Prior art date
Application number
UY27685A
Other languages
English (en)
Inventor
Ru Zhou
Robert S Kania
William H Romines Iii
Stephan J Cripps
Mingyeng He
Jihong Lou
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of UY27685A1 publication Critical patent/UY27685A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La invención se refiere a compuestos representados por la fórmula I y profármacos de los mismos, sales o solvatos farmacéuticamente aceptables de dichos compuestos y de dichos profármacos, en la que X, R1 y R11 son como se han definido en este documento. La invención tambíen se refiere a composiciones farmacéuticas que contienen los compuestos de fórmula I y a procedimientos de tratamiento de trastornos hiperproliferativos en un mamífero por la administración de compuestos de fórmula I.
UY27685A 2002-03-01 2003-02-27 Indolil-urea derivados de tienopiridinas útiles como agentes antiangiogénicos, y procedimientos para su uso UY27685A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US36095202P 2002-03-01 2002-03-01

Publications (1)

Publication Number Publication Date
UY27685A1 true UY27685A1 (es) 2003-10-31

Family

ID=27789048

Family Applications (1)

Application Number Title Priority Date Filing Date
UY27685A UY27685A1 (es) 2002-03-01 2003-02-27 Indolil-urea derivados de tienopiridinas útiles como agentes antiangiogénicos, y procedimientos para su uso

Country Status (15)

Country Link
US (1) US6833456B2 (es)
EP (1) EP1483268A2 (es)
JP (1) JP2005527511A (es)
AR (1) AR040398A1 (es)
AU (1) AU2003206068A1 (es)
BR (1) BR0308162A (es)
CA (1) CA2478050A1 (es)
GT (1) GT200300046A (es)
HN (1) HN2003000080A (es)
MX (1) MXPA04008403A (es)
PA (1) PA8568101A1 (es)
PE (1) PE20030944A1 (es)
TW (1) TW200306193A (es)
UY (1) UY27685A1 (es)
WO (1) WO2003074529A2 (es)

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US20070149607A1 (en) * 2003-12-26 2007-06-28 Daichi Paharmaceutical Co., Ltd. Method for producing pyrrolidine derivative
GB0412467D0 (en) * 2004-06-04 2004-07-07 Astrazeneca Ab Chemical compounds
CA2573538C (en) 2004-07-30 2014-11-25 Methylgene Inc. Inhibitors of vegf receptor and hgf receptor signaling
US7790729B2 (en) 2005-05-20 2010-09-07 Methylgene Inc. Inhibitors of VEGF receptor and HGF receptor signaling
KR101378716B1 (ko) 2005-05-20 2014-04-10 메틸진 인코포레이티드 Ｖｅｇｆ 수용체 및 ｈｇｆ 수용체 신호전달의 억제제
MX2008001838A (es) * 2005-08-08 2008-04-09 Pfizer Sales y polimorfos de un inhibidor de vegf-r.
EP1989211A2 (en) * 2006-01-30 2008-11-12 Array Biopharma, Inc. Heterobicyclic thiophene compounds for the treatment of cancer
US20080064718A1 (en) * 2006-03-22 2008-03-13 Saavedra Oscar M Inhibitors of protein tyrosine kinase activity
WO2007146824A2 (en) * 2006-06-08 2007-12-21 Array Biopharma Inc. Quinoline compounds and methods of use
NZ589336A (en) 2008-03-05 2011-12-22 Methylgene Inc Pyridine derivatives as inhibitors of protein tyrosine kinase activity
KR101126736B1 (ko) * 2008-11-27 2012-04-12 주식회사 레고켐 바이오사이언스 티로신 키나아제 저해 화합물, 이의 이성질체 또는 이의 약학적으로 허용가능한 염 및 이를 포함하는 약학적 조성물
WO2012015324A1 (en) * 2010-07-29 2012-02-02 Bial - Portela & Ca, S.A. Process for the synthesis of substituted urea compounds
MX2014000648A (es) 2011-07-19 2014-09-25 Infinity Pharmaceuticals Inc Compuestos heterociclicos y sus usos.
CA2929742C (en) 2013-12-04 2022-09-20 Evotec International Gmbh Sulfoximine substituted quinazolines for pharmaceutical compositions
CA2946471C (en) 2014-04-25 2018-08-07 Pfizer Inc. Fused bicyclic heteroaromatic compounds and their use as dopamine d1 ligands
CN115746017B (zh) * 2022-11-30 2024-06-07 英维沃化工科技(广州)有限公司 一种噻吩并嘧啶类化合物及其制备方法和应用
CN116082214A (zh) * 2023-02-24 2023-05-09 常州大学 一种2-芳基-3-叔丁基吲哚类化合物、制备方法及其应用

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GB8827305D0 (en) 1988-11-23 1988-12-29 British Bio Technology Compounds
US6177401B1 (en) 1992-11-13 2001-01-23 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis
CZ288955B6 (cs) 1994-02-23 2001-10-17 Pfizer Inc. Substituované chinazolinové deriváty, jejich pouľití a farmaceutické prostředky na jejich bázi
US5863949A (en) 1995-03-08 1999-01-26 Pfizer Inc Arylsulfonylamino hydroxamic acid derivatives
EP3103799B1 (en) 1995-03-30 2018-06-06 OSI Pharmaceuticals, LLC Quinazoline derivatives
PT821671E (pt) * 1995-04-20 2001-04-30 Pfizer Derivados do acido arilsulfonil hidroxamico como inibidores de mmp e tnf
DK0831829T3 (da) 1995-06-07 2003-12-15 Pfizer Heterocykliske, ringkondenserede pyrimidinderivater
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AR004010A1 (es) 1995-10-11 1998-09-30 Glaxo Group Ltd Compuestos heterociclicos
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IL125954A (en) 1996-03-05 2003-06-24 Zeneca Ltd Quinazoline derivatives, processes for their preparation, pharmaceutical compositions containing them and use thereof in the manufacture of medicaments having an antiangiogenic and/or vascular permeability reducing effect
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CA2259222A1 (en) * 1996-06-27 1997-12-31 Pfizer Inc. Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one and their use as farnesyl protein transferase inhibitors
TR199900048T2 (xx) 1996-07-13 1999-04-21 Glaxo Group Limited Protein tirozin kinaz inhibit�rleri olarak bisiklik heteroaromatik bile�ikler
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BR9713552A (pt) 1996-11-27 2000-01-25 Pfizer Derivados de pirimidina bicìclicos condensados
PT950059E (pt) 1997-01-06 2004-10-29 Pfizer Derivados de sulfona ciclicos
HUP0000852A2 (hu) 1997-02-03 2001-05-28 Pfizer Products Inc. Aril-szulfonil-amino-hidroxámsav-származékok, valamint e vegyületeket tartalmazó gyógyászati készítmények
EP0966438A1 (en) 1997-02-07 1999-12-29 Pfizer Inc. N-hydroxy-beta-sulfonyl-propionamide derivatives and their use as inhibitors of matrix metalloproteinases
JP3710489B2 (ja) 1997-02-11 2005-10-26 ファイザー・インク アリールスルホニルヒドロキサム酸誘導体
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PA8469501A1 (es) 1998-04-10 2000-09-29 Pfizer Prod Inc Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico
PA8469401A1 (es) 1998-04-10 2000-05-24 Pfizer Prod Inc Derivados biciclicos del acido hidroxamico
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AU2002345792A1 (en) * 2001-06-21 2003-01-08 Pfizer Inc. Thienopyridine and thienopyrimidine anticancer agents

Also Published As

Publication number Publication date
WO2003074529A2 (en) 2003-09-12
HN2003000080A (es) 2004-05-05
AR040398A1 (es) 2005-04-06
MXPA04008403A (es) 2004-11-26
EP1483268A2 (en) 2004-12-08
US20040019065A1 (en) 2004-01-29
GT200300046A (es) 2003-10-10
AU2003206068A8 (en) 2003-09-16
PA8568101A1 (es) 2003-11-12
BR0308162A (pt) 2004-12-07
US6833456B2 (en) 2004-12-21
PE20030944A1 (es) 2003-11-08
AU2003206068A1 (en) 2003-09-16
CA2478050A1 (en) 2003-09-12
TW200306193A (en) 2003-11-16
WO2003074529A3 (en) 2003-12-24
JP2005527511A (ja) 2005-09-15

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Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20150126