AR006991A1 - Analogo hidrosoluble de 20(s)- camptotecina, una composicion farmaceutica que los contiene, una medicina para el tratamiento del cancer, leucemia oestados relacionados con el hiv, el uso de dichos compuestos y un procedimiento para su preparacion - Google Patents
Analogo hidrosoluble de 20(s)- camptotecina, una composicion farmaceutica que los contiene, una medicina para el tratamiento del cancer, leucemia oestados relacionados con el hiv, el uso de dichos compuestos y un procedimiento para su preparacionInfo
- Publication number
- AR006991A1 AR006991A1 ARP970101799A ARP970101799A AR006991A1 AR 006991 A1 AR006991 A1 AR 006991A1 AR P970101799 A ARP970101799 A AR P970101799A AR P970101799 A ARP970101799 A AR P970101799A AR 006991 A1 AR006991 A1 AR 006991A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- lower alkyl
- amino
- alkyl
- unsubstituted
- Prior art date
Links
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 208000032839 leukemia Diseases 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 2
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000004429 atom Chemical group 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000001589 carboacyl group Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- -1 carboxy, carbonyloxy, amino, substituted amino Chemical group 0.000 abstract 2
- 125000004122 cyclic group Chemical group 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 229910052717 sulfur Chemical group 0.000 abstract 2
- 239000011593 sulfur Chemical group 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000003368 amide group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 abstract 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Un análogo soluble en agua de 20(S)-camptotecina, caracterizado porque comprende la fórmula 1 en la cual R1, R2, R3 y R4 son independientementeiguales o diferentes y representan: hidrógeno, hidroxi, alcoxi inferior, ariloxi, alcanoiloinf erior, nitro, ciano, halo, carboxi, carboniloxi, amino,amino sustituido, alquilo inferior, alquilo inferior sustituido o R2 y R3 combinadas entre sí representan-O-(CH2)n-O- donde n= 1 o 2; R5 reprentahidrógeno, alquilo inferior, alquiloinferio r sustituido, aralquilo inferior, hidroximetilo, carboximetilo, aminometilo, aminometilo sustituído donde elgrupo amino es mono o disustituido, en el cual ambos sustituyentes son independientes o combinados entre sí para formarun sistema de anillos cíclicosde 5 o 6 átomos que contienen carbono y optativamente uno o dos heteroátomos seleccinados entre oxígeno, nitrógeno y azufre y R representa hidrógeno,alquilo inferior, alquenilo inferior, alcanoilo inferior, alquiloinferior sustituido, alquenilo inferior sustituido, alcoxicarbonilo inferior o fenilo,bencilo o benoilo donde el grupo fenilo puede ser insustituido o sustituido; y R6 representa hidrógeno, hidroxi, alcoxi inferior; COOR donde R eshidrógeno,alquilo inferi or o aralquilo inferior; grupo amida o amino en donde el grupo alquilo puede ser insustituido, mono o disustituido en donde ambossustituyentes son inde pendientes o combinados entre sí para formar un sistema de anilloscíclicos de 3 a 8 átomos qu e contiene carbono y optativamentecontiene uno o dos heteroátomos seleccionados entre oxígeno, nitrógeno y azufre fenoxi, fenilo, benzoilo o bencilo donde el grupo fenilo puede ser insustituidoo sustituido con mono, di otrisustituyentes seleccionado s entre halógeno, hidroxi, alcoxi inferior, ciano, carboxi, nitro, amido, amino sustituido
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65525996A | 1996-06-05 | 1996-06-05 | |
| US08/771,390 US5972955A (en) | 1995-06-06 | 1996-12-19 | Water soluble C-ring analogues of 20(S)-camptothecin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR006991A1 true AR006991A1 (es) | 1999-10-13 |
Family
ID=27096938
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970101799A AR006991A1 (es) | 1996-06-05 | 1997-04-30 | Analogo hidrosoluble de 20(s)- camptotecina, una composicion farmaceutica que los contiene, una medicina para el tratamiento del cancer, leucemia oestados relacionados con el hiv, el uso de dichos compuestos y un procedimiento para su preparacion |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5972955A (es) |
| EP (1) | EP0906317A1 (es) |
| JP (1) | JP2000511556A (es) |
| CN (1) | CN1221421A (es) |
| AR (1) | AR006991A1 (es) |
| AU (1) | AU2812497A (es) |
| TW (1) | TW472058B (es) |
| WO (1) | WO1997046562A1 (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5972955A (en) * | 1995-06-06 | 1999-10-26 | Dr. Reddy's Research Foundation | Water soluble C-ring analogues of 20(S)-camptothecin |
| US7105492B2 (en) * | 1999-03-09 | 2006-09-12 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Camptothecin derivatives having antitumor activity |
| ATE216998T1 (de) * | 1999-03-09 | 2002-05-15 | Sigma Tau Ind Farmaceuti | Camptothecin-derivate mit antitumor-wirkung |
| AU775373B2 (en) | 1999-10-01 | 2004-07-29 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| EP1330444B1 (en) | 2000-11-01 | 2011-03-23 | Millennium Pharmaceuticals, Inc. | Nitrogenous heterocyclic compounds and process for making them |
| CZ20031515A3 (cs) | 2000-11-09 | 2003-09-17 | Neopharm, Inc. | Komplexy SN-38 s lipidem a způsob jejich použití |
| WO2003030864A1 (en) | 2001-05-29 | 2003-04-17 | Neopharm, Inc. | Liposomal formulation of irinotecan |
| US7908924B2 (en) * | 2003-06-18 | 2011-03-22 | Schnitta Bonnie S | Sound focusing mechanism and method of estimating acoustic leakage of an object and method of estimating transmission loss of an object |
| US20070269790A1 (en) * | 2003-12-01 | 2007-11-22 | Technion Research & Development | Methods of Generating Stem Cells and Embryonic Bodies Carrying Disease-Causing Mutations and Methods of Using same for Studying Genetic Disorders |
| JP4433918B2 (ja) * | 2004-07-15 | 2010-03-17 | コニカミノルタエムジー株式会社 | 画像形成方法 |
| KR100651728B1 (ko) * | 2004-11-10 | 2006-12-06 | 한국전자통신연구원 | 정착기를 갖는 전자 소자용 화합물 및 이를 포함하는 전자소자와 이들의 제조 방법 |
| ITMI20061473A1 (it) * | 2006-07-26 | 2008-01-27 | Indena Spa | Derivati della camptotecina ad attivita antitumorale |
| ITMI20061475A1 (it) * | 2006-07-26 | 2008-01-27 | Indena Spa | Derivati della camptotecina ad attivita antitumorale |
| ITMI20061474A1 (it) * | 2006-07-26 | 2008-01-27 | Indena Spa | Derivati della camptotecina ad attivita antitumorale |
| LU102067B1 (en) * | 2020-09-17 | 2022-03-18 | Narodowy Inst Lekow | 7-Ethyl-10-hydroxycamptothecin derivatives for use in the treatment of cancer |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4399282A (en) * | 1979-07-10 | 1983-08-16 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives |
| JPS5839685A (ja) * | 1981-09-04 | 1983-03-08 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体及びその製造法 |
| US4473692A (en) * | 1981-09-04 | 1984-09-25 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives and process for preparing same |
| JPS58154584A (ja) * | 1982-03-10 | 1983-09-14 | Yakult Honsha Co Ltd | ５位ヒドロキシ置換カンプトテシン誘導体の製造法 |
| JPS6019790A (ja) * | 1983-07-14 | 1985-01-31 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体 |
| US4981968A (en) * | 1987-03-31 | 1991-01-01 | Research Triangle Institute | Synthesis of camptothecin and analogs thereof |
| US5122526A (en) * | 1987-03-31 | 1992-06-16 | Research Triangle Institute | Camptothecin and analogs thereof and pharmaceutical compositions and method using them |
| US5053512A (en) * | 1987-04-14 | 1991-10-01 | Research Triangle Institute | Total synthesis of 20(S) and 20(R)-camptothecin and compthothecin derivatives |
| US5391745A (en) * | 1992-07-23 | 1995-02-21 | Sloan-Kettering Institute For Cancer Research | Methods of preparation of camptothecin analogs |
| US5446047A (en) * | 1992-07-23 | 1995-08-29 | Sloan-Kettering Institute For Cancer Research | Camptothecin analogues |
| US5468754A (en) * | 1994-04-19 | 1995-11-21 | Bionumerik Pharmaceuticals, Inc. | 11,7 substituted camptothecin derivatives and formulations of 11,7 substituted camptothecin derivatives and methods for uses thereof |
| US5972955A (en) * | 1995-06-06 | 1999-10-26 | Dr. Reddy's Research Foundation | Water soluble C-ring analogues of 20(S)-camptothecin |
| US6214836B1 (en) * | 1995-06-06 | 2001-04-10 | Dr. Reddy's Research Foundation | Water soluble analogues of 20(S)-camptothecin |
| CN1101818C (zh) * | 1996-06-05 | 2003-02-19 | 雷迪博士研究基金会 | 20(s)－喜树碱的水溶性C－环类似物,制备方法和用途 |
-
1996
- 1996-12-19 US US08/771,390 patent/US5972955A/en not_active Expired - Fee Related
-
1997
- 1997-04-22 CN CN97195256A patent/CN1221421A/zh active Pending
- 1997-04-22 WO PCT/US1997/006960 patent/WO1997046562A1/en not_active Ceased
- 1997-04-22 AU AU28124/97A patent/AU2812497A/en not_active Abandoned
- 1997-04-22 EP EP97922465A patent/EP0906317A1/en not_active Withdrawn
- 1997-04-22 JP JP10500567A patent/JP2000511556A/ja active Pending
- 1997-04-24 TW TW086105386A patent/TW472058B/zh not_active IP Right Cessation
- 1997-04-30 AR ARP970101799A patent/AR006991A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1221421A (zh) | 1999-06-30 |
| US5972955A (en) | 1999-10-26 |
| WO1997046562A1 (en) | 1997-12-11 |
| TW472058B (en) | 2002-01-11 |
| JP2000511556A (ja) | 2000-09-05 |
| EP0906317A1 (en) | 1999-04-07 |
| AU2812497A (en) | 1998-01-05 |
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| FB | Suspension of granting procedure |