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ES2065324T3 - N-(piridinil)-1h-indol-1-aminas, un procedimiento para su preparacion y su uso como medicamentos. - Google Patents

N-(piridinil)-1h-indol-1-aminas, un procedimiento para su preparacion y su uso como medicamentos.

Info

Publication number
ES2065324T3
ES2065324T3 ES88106121T ES88106121T ES2065324T3 ES 2065324 T3 ES2065324 T3 ES 2065324T3 ES 88106121 T ES88106121 T ES 88106121T ES 88106121 T ES88106121 T ES 88106121T ES 2065324 T3 ES2065324 T3 ES 2065324T3
Authority
ES
Spain
Prior art keywords
piridinil
indol
medicines
amines
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88106121T
Other languages
English (en)
Inventor
Richard Charles Effland
Joseph Thomas Klein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Roussel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharmaceuticals Inc filed Critical Hoechst Roussel Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2065324T3 publication Critical patent/ES2065324T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE DESCRIBEN COMPUESTOS DE FORMULA (I) EN LA QUE M ES 1 O 2; N ES 1 O 2; P ES 0 O 1; R, R1, R2 Y R3 TIENEN EL SIGNIFICADO QUE SE INDICA EN LA INVENCION. SE DESCRIBE UN PROCESO PARA SU OBTENCION. LOS COMPUESTOS SON UTILES PARA REFORZAR LA MEMORIA Y TAMBIEN COMO AGENTES ANALGESICOS Y ANTIDEPRESIVOS.
ES88106121T 1987-04-24 1988-04-18 N-(piridinil)-1h-indol-1-aminas, un procedimiento para su preparacion y su uso como medicamentos. Expired - Lifetime ES2065324T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4207987A 1987-04-24 1987-04-24

Publications (1)

Publication Number Publication Date
ES2065324T3 true ES2065324T3 (es) 1995-02-16

Family

ID=21919923

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88106121T Expired - Lifetime ES2065324T3 (es) 1987-04-24 1988-04-18 N-(piridinil)-1h-indol-1-aminas, un procedimiento para su preparacion y su uso como medicamentos.

Country Status (17)

Country Link
EP (1) EP0287982B1 (es)
JP (1) JP2683360B2 (es)
KR (1) KR960015003B1 (es)
AT (1) ATE115143T1 (es)
AU (1) AU594876B2 (es)
CA (1) CA1330661C (es)
DE (1) DE3852335T2 (es)
DK (1) DK172153B1 (es)
ES (1) ES2065324T3 (es)
FI (1) FI90978C (es)
IE (1) IE65349B1 (es)
IL (1) IL86154A (es)
NO (1) NO168104C (es)
NZ (1) NZ224338A (es)
PH (1) PH26127A (es)
PT (1) PT87308B (es)
ZA (1) ZA882810B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4868190A (en) * 1988-12-27 1989-09-19 Hoechst-Roussel Pharmaceuticals, Inc. N-pyridinyl-9H-carbazol-9-amines
US4983615A (en) * 1989-06-28 1991-01-08 Hoechst-Roussel Pharmaceuticals Inc. Heteroarylamino- and heteroaryloxypyridinamine compounds which are useful in treating skin disorders
US5006537A (en) * 1989-08-02 1991-04-09 Hoechst-Roussel Pharmaceuticals, Inc. 1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones
US5179099A (en) * 1989-08-02 1993-01-12 Hoechst-Roussel Pharmaceuticals Incorporated 2,3-dihydro-1-(pyridinylamino)-indoles
US5179119A (en) * 1989-08-02 1993-01-12 Hoechst-Roussel Pharmaceuticals Incorporated 1,3-dihydro-1-(pyridinylamino)-2H-indol-1-ones and intermediates for the preparation thereof
ES2068294T3 (es) * 1989-08-02 1995-04-16 Hoechst Roussel Pharma 2,3-dihidro-1-(piridinilamino)-indoles, un procedimiento para su preparacion y su uso como medicamentos.
US4983608A (en) * 1989-09-05 1991-01-08 Hoechst-Roussell Pharmaceuticals, Inc. N-substituted-4-pyrimidinamines and pyrimidinediamines
US5102891A (en) * 1990-07-23 1992-04-07 Hoechst-Roussel Pharmaceuticals Inc. 1-(substituted pyridinylamino)-1H-indol-5-yl substituted carbamates
US5214038A (en) * 1991-04-15 1993-05-25 Hoechst-Roussel Pharmaceuticals Inc. 1-(pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1H-indoles and intermediates for the preparation thereof
US5328920A (en) * 1991-04-17 1994-07-12 Hoechst-Roussel Pharmaceuticals Incorporated Substituted (pyridinylamino)-indoles
US5185350A (en) * 1991-09-23 1993-02-09 Hoechst-Roussel Pharmaceuticals Incorporated Substituted pyridinylamino-1h-indoles,1h-indazoles,2h-indazoles, benzo (b)thiophenes and 1,2-benzisothiazoles
US5356910A (en) 1993-07-19 1994-10-18 Hoechst-Roussel Pharmaceuticals Inc. Use of N-(pyridinyl)-1H-indol-1-amines for the treatment of obsessive-compulsive disorder
US5459274A (en) * 1994-05-13 1995-10-17 Hoechst-Roussel Pharmaceuticals Inc. Preparation of N-alkyl-N-pyridinyl-1H-indol-1-amines
PT840609E (pt) * 1995-07-27 2002-10-31 Aventis Pharma Inc Utilizacao de n-(pirrol-1-il)-pirimidinas insubstituidas e substituidas como agentes anticonvulsivos
US5776955A (en) * 1995-07-27 1998-07-07 Hoechst Marion Roussel, Inc. Use of unsubstituted and substituted n-(pyrrol-1-yl)pyridinamines as anticonvulsant agents
BR9714189A (pt) * 1996-12-27 2000-02-29 Hoechst Marion Roussel Inc N-(piridinilamino) isoindolinas e compostos relacionados
EP1035114B1 (en) 1999-03-10 2004-11-24 Tosoh Corporation Processes for the preparation of nitrogen-heterocyclic compounds
JP4779185B2 (ja) * 1999-03-10 2011-09-28 東ソー株式会社 含窒素複素環化合物及びその製造方法
JP4683166B2 (ja) * 1999-03-10 2011-05-11 東ソー株式会社 含窒素複素環化合物の製造方法
GB0119435D0 (en) * 2001-02-15 2001-10-03 Aventis Pharm Prod Inc Method of treating of demyelinating diseases or conditions
US7538227B2 (en) 2004-01-13 2009-05-26 Sanofi-Aventis Deutschland Gmbh Process for stabilizing 4-halopyridines
GT200500063A (es) * 2004-04-01 2005-10-14 Metodo para tratar la esquizofrenia y/o anormalidades glucoregulatorias
FR2888238B1 (fr) * 2005-07-07 2007-09-07 Servier Lab Nouveaux derives 1h-indole-pyridinecarboxamides et 1h-indole-piperidinecarboxamide, leur procede de preparation et les compositions pharceumatiques qui les contiennent.
FR2911780A1 (fr) * 2007-01-26 2008-08-01 Urogene Traitement de l'incontinence fecale.
AU2008238379A1 (en) * 2007-04-13 2008-10-23 Sanofi-Aventis A transition metal catalyzed synthesis of N-aminoindoles

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3242185A (en) * 1963-10-07 1966-03-22 Merck & Co Inc Lower aliphatic acids, salts and derivatives thereof
DE1670184A1 (de) * 1967-01-20 1971-01-21 Boehringer Sohn Ingelheim Verfahren zur Herstellung heterocyclisch substituierter Hydrazino-imidazoline-(2)
CH603581A5 (es) * 1974-03-29 1978-08-31 Siegfried Ag
US4260767A (en) * 1979-12-26 1981-04-07 American Cyanamid Company 2-Pyridylhydrazides
US4792562A (en) * 1985-12-04 1988-12-20 Hoechst-Roussel Pharmaceuticals, Inc. N-(pyrrol-1-yl)pyridinamines having memory enhancing activity

Also Published As

Publication number Publication date
IL86154A (en) 1992-03-29
PT87308A (pt) 1988-05-01
EP0287982A3 (en) 1991-03-27
FI881874A0 (fi) 1988-04-21
FI881874A7 (fi) 1988-10-25
PT87308B (pt) 1992-08-31
DE3852335D1 (de) 1995-01-19
NZ224338A (en) 1991-07-26
FI90978C (fi) 1994-04-25
AU1510088A (en) 1988-10-27
CA1330661C (en) 1994-07-12
KR880012591A (ko) 1988-11-28
DK172153B1 (da) 1997-12-01
IL86154A0 (en) 1988-11-15
NO168104B (no) 1991-10-07
EP0287982A2 (en) 1988-10-26
DE3852335T2 (de) 1995-05-11
KR960015003B1 (ko) 1996-10-23
AU594876B2 (en) 1990-03-15
NO881776D0 (no) 1988-04-22
EP0287982B1 (en) 1994-12-07
IE65349B1 (en) 1995-10-18
IE881213L (en) 1988-10-24
JP2683360B2 (ja) 1997-11-26
FI90978B (fi) 1994-01-14
DK223488A (da) 1988-10-25
ATE115143T1 (de) 1994-12-15
DK223488D0 (da) 1988-04-22
PH26127A (en) 1992-02-24
NO881776L (no) 1988-10-25
ZA882810B (en) 1988-10-20
JPS63280079A (ja) 1988-11-17
NO168104C (no) 1992-01-15

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