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AR046781A1 - Derivados de imidazoquinolinas. composiciones farmaceuticas. - Google Patents

Derivados de imidazoquinolinas. composiciones farmaceuticas.

Info

Publication number
AR046781A1
AR046781A1 ARP040104350A ARP040104350A AR046781A1 AR 046781 A1 AR046781 A1 AR 046781A1 AR P040104350 A ARP040104350 A AR P040104350A AR P040104350 A ARP040104350 A AR P040104350A AR 046781 A1 AR046781 A1 AR 046781A1
Authority
AR
Argentina
Prior art keywords
group
alkylene
aryl
heteroaryl
alkyl
Prior art date
Application number
ARP040104350A
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English (en)
Original Assignee
3M Innovative Properties Co
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Publication date
Application filed by 3M Innovative Properties Co filed Critical 3M Innovative Properties Co
Publication of AR046781A1 publication Critical patent/AR046781A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
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    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
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    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
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    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
    • C07D255/02—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
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  • Tropical Medicine & Parasitology (AREA)
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  • Diabetes (AREA)
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  • Psychiatry (AREA)
  • AIDS & HIV (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Composiciones farmacéuticas que contienen los compuestos. Reivindicación 1: Un compuesto de fórmula (1), en la cual: X es alquileno opcionalmente interrumpido por uno o más grupos -O-; Z es -C(O)-, -C(O)O- o -C(-Q-R1-3)2-; R1-1 se selecciona del grupo integrado por: hidrógeno; alquilo; arilo; alquilen-arilo; heteroarilo; alquilen-heteroarilo; y alquilo, arilo, alquilen-arilo, heteroarilo o alquilen-heteroarilo sustituido con uno o más sustituyentes seleccionados del grupo integrado por: halógeno; ciano; nitro; alcoxi; dialquilamino; alquiltio; haloalquilo; haloalcoxi; alquilo; -NH-S(O)2-R1-4; -NH-C(O)-R1-4; -NH-C(O)-NH2; -NH-C(O)-NH-R1-4; y -N3; siempre que si Z es -C(O)-, entonces R1-1 pueden ser también -N(CH3)(OCH3); siempre que además si Z es -C(O)O-, entonces R1-1 no es hidrógeno; siempre que además si Z es -C(O)O-, entonces X no incluye grupos -O-; Q es O o S; R1-3 se selecciona del grupo integrado por: alquilo; arilo; alquilen-arilo; heteroarilo; alquilen-heteroarilo; y alquilo, arilo, alquilen-arilo, heteroarilo o alquilen-heteroarilo sustituido con uno o más sustituyentes seleccionados del grupo integrado por: halógeno; ciano; nitro; alcoxi; dialquilamino; alquiltio; haloalquilo; haloalcoxi; alquilo; -NH-S(O)2-R1- 4; -NH-C(O)-R1-4; -NH-C(O)-NH2; -NH-C(O)-NH-R1-4; y -N3; o los grupos R1-3 pueden unirse para formar un sistema de anillo que comprende un anillo saturado o insaturado de 5, 6 ó 7 miembros; R1-4 se selecciona del grupo integrado por: alquilo; arilo; alquilen-arilo; heteroarilo; alquilen-heteroarilo; y alquilo, arilo, alquilen-arilo, heteroarilo o alquilen-heteroarilo sustituido con uno o más sustituyentes seleccionados del grupo integrado por: halógeno; ciano; nitro; alcoxi; dialquilamino; alquiltio; haloalquilo; haloalcoxi; alquilo; y-N3; y R2 se selecciona del grupo integrado por: -R4; -X'-R4; -X'-Y'-R4; y -X'-R5; X' se selecciona del grupo integrado por alquileno, alquenileno, alquinileno, arileno y heteroarileno, donde los grupos alquileno, alquenileno, y alquinileno pueden estar opcionalmente interrumpidos o terminados con arileno, o heteroarileno, y opcionalmente interrumpido con uno o más grupos -O-; Y' se selecciona del grupo integrado por: -S(O)0-2-; -S(O)2-N(R8)-; - C(R6)-; -C(R6)-O-; -O-C(R6)-; -O-C(O)-O-; -N(R8)-Q'-; -C(R6)-N(R8)-; -O-C(R6)-N(R8)-; -C(R6)-N(OR9)-; o un resto de grupo de fórmula (2); R4 se selecciona del grupo integrado por hidrógeno, halógeno, alquilo, alquenilo, alquinilo, arilo, arilalquilenilo, ariloxialquilenilo, alquilarilenilo, heteroarilo, heteroarilalquilenilo, heteroariloxialquilenilo y alquilheteroarilenilo, donde los grupos alquilo, alquenilo, alquinilo, arilo, arilalquilenilo, ariloxialquilenilo, alquilarilenilo, heteroarilo, heteroarilalquilenilo, heteroariloxialquilenilo y alquilheteroarilenilo pueden ser no sustituidos o estar sustituidos con uno o más sustituyentes seleccionados en forma independiente del grupo integrado por alquilo, alcoxi, hidroxialquilo, haloalquilo, haloalcoxi, halógeno, nitro, hidroxi, mercapto, ciano, arilo, ariloxi, arilalquilenoxi, heteroarilo, heteroariloxi, heteroarilalquilenoxi, heterociclilo, amino, alquilamino, dialquilamino, (dialquilamino)alquilenoxi, y en el caso de alquilo, alquenilo, alquinilo, y oxo; R5 se selecciona del grupo integrado por las fórmulas (3); R6 se selecciona del grupo integrado por =O y =S; R7 es un alquileno C2-7; R8 se selecciona del grupo integrado por hidrógeno, alquilo, alcoxialquilenilo y arilalquilenilo; R9 se selecciona del grupo integrado por hidrógeno y alquilo; R10 es alquileno C3-8; A se selecciona del grupo integrado por -O-, -C(O)-, -S(O)0-2-, -CH2- y -N(R4)-; Q' se selecciona del grupo integrado por una unión, -C(R6)-, -C(R6)-C(R6)-, -S(O)2-, y -S(O)2-N(R8)-; V se selecciona del grupo integrado por -C(R6)-, -O-C(R6)- y -S(O)2-; a y b son en forma independiente números enteros del 1 a 6 siempre que a + b sea L 7; RA y RB se seleccionan cada uno de ellos en forma independiente del grupo integrado por: hidrógeno; halógeno; alquilo; alquenilo; alcoxi; alquiltio; y -N(R9)2 o RA y RB tomados juntos forman o un anillo arilo fusionado que es no sustituido o está sustituido con uno o más grupos R, o un anillo saturado de 5 a 7 miembros fusionado que es no sustituido o está sustituido con uno o más grupos Ra; R se selecciona del grupo integrado por; fluoro; alquilo; haloalquilo; alcoxi; y -N(R9)2; Ra se selecciona del grupo integrado por: halógeno; hidroxi; alquilo; alquenilo; haloalquilo; alcoxi; alquiltio; y -N(R9a)2; o su sal aceptable para uso farmacéutico.
ARP040104350A 2003-11-25 2004-11-24 Derivados de imidazoquinolinas. composiciones farmaceuticas. AR046781A1 (es)

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US52496103P 2003-11-25 2003-11-25
US58013904P 2004-06-16 2004-06-16

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AR046781A1 true AR046781A1 (es) 2005-12-21

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US (3) US8691837B2 (es)
EP (1) EP1687307B1 (es)
JP (2) JP4891088B2 (es)
KR (1) KR101130928B1 (es)
AR (1) AR046781A1 (es)
AU (1) AU2004293078B2 (es)
BR (1) BRPI0416936A (es)
CA (1) CA2547020C (es)
IL (2) IL175915A0 (es)
MX (1) MXPA06005910A (es)
MY (1) MY161812A (es)
NZ (1) NZ547467A (es)
RU (1) RU2409576C2 (es)
SG (1) SG148201A1 (es)
WO (1) WO2005051317A2 (es)

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US20040265351A1 (en) 2003-04-10 2004-12-30 Miller Richard L. Methods and compositions for enhancing immune response
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BRPI0413998A (pt) * 2003-08-27 2006-11-07 3M Innovative Properties Co imidazoquinolinas arilóxi e arilalquilenóxi substituìdas
US20050054665A1 (en) 2003-09-05 2005-03-10 3M Innovative Properties Company Treatment for CD5+ B cell lymphoma
US20090075980A1 (en) * 2003-10-03 2009-03-19 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and Analogs Thereof
US7544697B2 (en) * 2003-10-03 2009-06-09 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and analogs thereof
JP2007508305A (ja) 2003-10-03 2007-04-05 スリーエム イノベイティブ プロパティズ カンパニー ピラゾロピリジンおよびその類似物
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