RU2006118033A - Замещенные имидазо кольцевые системы и способы - Google Patents
Замещенные имидазо кольцевые системы и способы Download PDFInfo
- Publication number
- RU2006118033A RU2006118033A RU2006118033/04A RU2006118033A RU2006118033A RU 2006118033 A RU2006118033 A RU 2006118033A RU 2006118033/04 A RU2006118033/04 A RU 2006118033/04A RU 2006118033 A RU2006118033 A RU 2006118033A RU 2006118033 A RU2006118033 A RU 2006118033A
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- Russia
- Prior art keywords
- alkyl
- aryl
- alkylene
- group
- heteroaryl
- Prior art date
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- 238000000034 method Methods 0.000 title claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 57
- 125000003118 aryl group Chemical group 0.000 claims 46
- 125000001072 heteroaryl group Chemical group 0.000 claims 36
- 229910052739 hydrogen Inorganic materials 0.000 claims 30
- 239000001257 hydrogen Substances 0.000 claims 30
- 239000000126 substance Substances 0.000 claims 29
- 125000005275 alkylenearyl group Chemical group 0.000 claims 24
- 125000005218 alkyleneheteroaryl group Chemical group 0.000 claims 24
- 150000003839 salts Chemical class 0.000 claims 23
- 125000001188 haloalkyl group Chemical group 0.000 claims 21
- 229910052736 halogen Inorganic materials 0.000 claims 21
- 150000002367 halogens Chemical group 0.000 claims 21
- 150000002431 hydrogen Chemical class 0.000 claims 21
- 125000003545 alkoxy group Chemical group 0.000 claims 19
- 125000002947 alkylene group Chemical group 0.000 claims 18
- 125000001424 substituent group Chemical group 0.000 claims 18
- 125000004414 alkyl thio group Chemical group 0.000 claims 15
- 125000004093 cyano group Chemical group *C#N 0.000 claims 15
- 125000004663 dialkyl amino group Chemical group 0.000 claims 15
- 125000003342 alkenyl group Chemical group 0.000 claims 12
- 125000002877 alkyl aryl group Chemical group 0.000 claims 12
- 125000004994 halo alkoxy alkyl group Chemical group 0.000 claims 12
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 12
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 9
- 125000000623 heterocyclic group Chemical group 0.000 claims 9
- 241001465754 Metazoa Species 0.000 claims 6
- 125000004450 alkenylene group Chemical group 0.000 claims 6
- 125000000304 alkynyl group Chemical group 0.000 claims 6
- 125000004419 alkynylene group Chemical group 0.000 claims 6
- 125000000732 arylene group Chemical group 0.000 claims 6
- 125000005549 heteroarylene group Chemical group 0.000 claims 6
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 5
- 125000005741 alkyl alkenyl group Chemical group 0.000 claims 5
- 229910052731 fluorine Inorganic materials 0.000 claims 5
- 239000011737 fluorine Substances 0.000 claims 5
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 5
- -1 nitro, hydroxy, mercapto Chemical class 0.000 claims 4
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 3
- 125000003282 alkyl amino group Chemical group 0.000 claims 3
- 125000005213 alkyl heteroaryl group Chemical group 0.000 claims 3
- 125000005532 aryl alkyleneoxy group Chemical group 0.000 claims 3
- 125000004104 aryloxy group Chemical group 0.000 claims 3
- 125000004438 haloalkoxy group Chemical group 0.000 claims 3
- 125000005553 heteroaryloxy group Chemical group 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 229920006395 saturated elastomer Polymers 0.000 claims 3
- 125000005055 alkyl alkoxy group Chemical group 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 2
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 1
- 125000004201 2,4-dichlorophenyl group Chemical group [H]C1=C([H])C(*)=C(Cl)C([H])=C1Cl 0.000 claims 1
- 125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000005745 ethoxymethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])* 0.000 claims 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 230000000771 oncological effect Effects 0.000 claims 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
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Claims (23)
1. Вещество, соответствующее формуле (I-1)
в которой Х представляет собой алкилен, факультативно прерываемый одной или несколькими -О- группами;
Z представляет собой -С(O)-;
R1-1 выбирается из группы, включающей
водород,
алкил,
арил,
алкилен-арил,
гетероарил,
алкилен-гетероарил,
-N(СН3)(ОСН3), и
алкил, арил, алкилен-арил, гетероарил, или алкилен-гетероарил, замещенный одним или несколькими заместителями, выбираемыми из группы, содержащей
галоген,
циано,
нитро,
алкокси,
диалкиламино,
алкилтио,
галоалкил,
галоалкокси,
алкил,
-NH-SO2-R1-4,
-NH-C(O)-R1-4,
-NH-C(O)-NH2,
-NH-C(O)-NH-R1-4, и
-N3;
R1-4 выбирается из группы, включающей
алкил,
арил,
алкилен-арил,
гетероарил,
алкилен-гетероарил, и
алкил, арил, алкилен-арил, гетероарил, или алкилен-гетероарил, замещенный одним или несколькими заместителями, выбираемыми из группы, содержащей
галоген,
циано,
нитро,
алкокси,
диалкиламино,
алкилтио,
галоалкил,
галоалкокси,
алкил и
-N3; и
R2 выбирается из группы, включающей
-R4,
-X'-R4,
-X'-Y'-R4, и
-X'-R5;
X' выбирается из группы, включающей алкилен, алкенилен, алкинилен, арилен и гетероарилен, причем такая алкиленовая, алкениленовая и алкиниленовая группа может быть факультативно прервана или терминирована ариленом или гетероариленом и факультативно прервана одной или несколькими -O-группами;
Y' выбирается из группы, включающей
-S(O)0-2-,
-S(O)2-N(R8)-,
-C(R6)-,
-С(R6)-O-,
-O-C(R6)-,
-O-С(O)-O-,
-N(R8)-Q'-,
-C(R6)-N(R8)-,
-O-C(R6)-N(R8)-,
-C(R6)-N(OR9)-,
R4 выбирается из группы, включающей водород, алкил, алкенил, алкинил, арил, арилалкиленил, арилоксиалкиленил, алкилариленил, гетероарил, гетероарилалкиленил, гетероарилоксиалкиленил и алкилгетероариленил, причем алкильная, алкенильная, алкинильная, арильная, арилалкиленильная, арилоксиалкиленильная, алкилариленильная, гетероарильная, гетероарилалкиленильная, гетероарилоксиалкиленильная и алкилгетероариленильная группы могут быть незамещенными или замещенными одним или несколькими заместителями, независимо выбранными из группы, содержащей алкил, алкокси, гидроксиалкил, галоалкил, галоалкокси, галоген, нитро, гидрокси, меркапто, циано, арил, арилокси, арилалкиленокси, гетероарил, гетероарилокси, гетероарилалкиленокси, гетероциклил, амино, алкиламино, диалкиламино, (диалкиламино)-алкиленокси, и в случае алкила, алкенила и алкинила-оксо;
R5 выбирается из группы, включающей
R6 выбирается из группы, включающей =O и =S;
R7 представляет собой C2-7 алкилен;
R8 выбирается из группы, включающей водород, алкил, алкоксиалкиленил и арилалкиленил;
R9 выбирается из группы, включающей водород и алкил;
R10 представляет собой С3-8 алкилен;
А выбирается из группы, включающей -O-, -С(O)-, -S(O)0-2-, -CH2-, и
-N(R4)-;
Q' выбирается из группы, включающей ковалентную связь, -С(R6)-, -С(R6)-С(R6)-, -S(O)2-, и -S(O)2-N(R8)-;
V выбирается из группы, включающей -С(R6)-, -O-C(R6)-, и -S(O)2-;
а и b являются независимо выбранными целыми числами от 1 до 6 при условии, что а+b≤7;
каждая из групп RA и RB независимо выбирается из группы, содержащей
водород,
галоген,
алкил,
алкенил,
алкокси,
алкилтио и
-N(R9)2;
или RA и RB, взятые вместе, образуют или слитое арильное кольцо, которое является незамещенным или замещенным одной или несколькими R-группами, или слитое 5-7-членное насыщенное кольцо, которое является незамещенным или замещенным одним или несколькими Ra-заместителями;
R выбирается из группы, включающей
фтор,
алкил,
галоалкил,
алкокси и
-N(R9)2;
Ra выбирается из группы, включающей
галоген,
гидрокси,
алкил,
алкенил,
галоалкил,
алкокси,
алкилтио, и
-N(R9)2
или фармацевтически приемлемая соль одного из этих веществ.
2. Вещество, соответствующее формуле (I-2)
в которой Х представляет собой алкилен, факультативно прерываемый одной или несколькими -О- группами;
n является целым числом от 0 до 4;
Z представляет собой -С(O)-;
R1-1 выбирается из группы, включающей
водород,
алкил,
арил,
алкилен-арил,
гетероарил,
алкилен-гетероарил,
-N(СН3)(ОСН3), и
алкил, арил, алкилен-арил, гетероарил, или алкилен-гетероарил, замещенный одним или несколькими заместителями, выбираемыми из группы, содержащей
галоген,
циано,
нитро,
алкокси,
диалкиламино,
алкилтио,
галоалкил,
галоалкокси,
алкил,
-NH-SO2-R1-4,
-NH-C(O)-R1-4,
-NH-C(O)-NH2,
-NH-C(O)-NH-R1-4, и
-N3;
R1-4 выбирается из группы, включающей
алкил,
арил,
алкилен-арил,
гетероарил,
алкилен-гетероарил, и
алкил, арил, алкилен-арил, гетероарил, или алкилен-гетероарил, замещенный одним или несколькими заместителями, выбираемыми из группы, содержащей
галоген,
циано,
нитро,
алкокси,
диалкиламино,
алкилтио,
галоалкил,
галоалкокси,
алкил и
-N3; и
R выбирается из группы, включающей
фтор,
алкил,
галоалкил,
алкокси и
-N(R9)2;
R2 выбирается из группы, включающей
-R4,
-X'-R4,
-X'-Y'-R4, и
-X'-R5;
X' выбирается из группы, включающей алкилен, алкенилен, алкинилен, арилен и гетероарилен, причем такая алкиленовая, алкениленовая и алкиниленовая группа может быть факультативно прервана или терминирована ариленом или гетероариленом и факультативно прервана одной или несколькими -O-группами;
Y' выбирается из группы, включающей
-S(O)0-2-,
-S(O)2-N(R8)-,
-C(R6)-,
-C(R6)-O-,
-O-C(R6)-,
-O-С(O)-O-,
-N(R8)-Q'-,
-C(R6)-N(R8)-,
-O-C(R6)-N(R8)-,
-C(R6)-N(OR9)-,
R4 выбирается из группы, включающей водород, алкил, алкенил, алкинил, арил, арилалкиленил, арилоксиалкиленил, алкилариленил, гетероарил, гетероарилалкиленил, гетероарилоксиалкиленил и алкилгетероариленил, причем алкильная, алкенильная, алкинильная, арильная, арилалкиленильная, арилоксиалкиленильная, алкилариленильная, гетероарильная, гетероарилалкиленильная, гетероарилоксиалкиленильная и алкилгетероариленильная группы могут быть незамещенными или замещенными одним или несколькими заместителями, независимо выбранными из группы, содержащей алкил, алкокси, гидроксиалкил, галоалкил, галоалкокси, галоген, нитро, гидрокси, меркапто, циано, арил, арилокси, арилалкиленокси, гетероарил, гетероарилокси, гетероарилалкиленокси, гетероциклил, амино, алкиламино, диалкиламино, (диалкиламино)-алкиленокси, и в случае алкила, алкенила и алкинила-оксо;
R5 выбирается из группы, включающей
R6 выбирается из группы, включающей =O и =S;
R7 представляет собой C2-7 алкилен;
R8 выбирается из группы, включающей водород, алкил, алкоксиалкиленил и арилалкиленил;
R9 выбирается из группы, включающей водород и алкил;
R10 представляет собой С3-8 алкилен;
А выбирается из группы, включающей -O-, -С(O)-, -S(O)0-2-, -СН2-, и -N(R4)-;
Q' выбирается из группы, включающей ковалентную связь, -С(R6)-, -С(R6)-С(R6)-, -S(O)2-, и -S(O)2-N(R8)-;
V выбирается из группы, включающей -С(R6)-, -O-C(R6)-, и -S(O)2-; и
а и b являются независимо выбранными целыми числами от 1 до 6 при условии, что а+b≤7;
или фармацевтически приемлемая соль одного из этих веществ.
3. Вещество, соответствующее формуле (I-3)
в которой Х представляет собой алкилен, факультативно прерываемый одной или несколькими -О- группами;
Z представляет собой -С(O)-, -С(O)O-, или -C(-Q-R1-3)2-;
R1-1 выбирается из группы, включающей
водород,
алкил,
арил,
алкилен-арил,
гетероарил,
алкилен-гетероарил, и
алкил, арил, алкилен-арил, гетероарил, или алкилен-гетероарил, замещенный одним или несколькими заместителями, выбираемыми из группы, содержащей
галоген,
циано,
нитро,
алкокси,
диалкиламино,
алкилтио,
галоалкил,
галоалкокси,
алкил,
-NH-SO2-R1-4,
-NH-C(O)-R1-4,
-NH-C(O)-NH2,
-NH-C(O)-NH-R1-4, и
-N3;
при условии, что если Z представляет собой -С(O)-, то R1-1 может также быть группой -N(СН3)(ОСН3);
при дополнительном условии, что если Z представляет собой -С(O)O-, то R1-1 не является водородом;
при дополнительном условии, что если Z представляет собой -С(O)O-, то Х не включает -О- группы;
Q - это О или S;
R1-3 выбирается из группы, включающей
алкил,
арил,
алкилен-арил,
гетероарил,
алкилен-гетероарил, и
алкил, арил, алкилен-арил, гетероарил, или алкилен-гетероарил, замещенный одним или несколькими заместителями, выбираемыми из группы, содержащей
галоген,
циано,
нитро,
алкокси,
диалкиламино,
алкилтио,
галоалкил,
галоалкокси,
алкил,
-NH-SO2-R1-4,
-NH-C(O)-R1-4,
-NH-C(O)-NH2,
-NH-C(O)-NH-R1-4, и
-N3;
или R1-3 группы могут объединяться друг с другом с образованием кольцевой системы, содержащей насыщенное или ненасыщенное 5-, 6- или 7-членное кольцо;
R1-4 выбирается из группы, включающей
алкил,
арил,
алкилен-арил,
гетероарил,
алкилен-гетероарил, и
алкил, арил, алкилен-арил, гетероарил, или алкилен-гетероарил, замещенный одним или несколькими заместителями, выбираемыми из группы, содержащей
галоген,
циано,
нитро,
алкокси,
диалкиламино,
алкилтио,
галоалкил,
галоалкокси,
алкил и
-N3; и
R2 выбирается из группы, включающей
-R4,
-X'-R4,
-X'-Y'-R4, и
-X'-R5;
X' выбирается из группы, включающей алкилен, алкенилен, алкинилен, арилен и гетероарилен, причем такая алкиленовая, алкениленовая и алкиниленовая группа может быть факультативно прервана или терминирована ариленом или гетероариленом и факультативно прервана одной или несколькими -O-группами;
Y' выбирается из группы, включающей
-S(O)0-2-,
-S(O)2-N(R8)-,
-С(R6)-,
-С(R6)-O-,
-O-C(R6)-,
-O-С(O)-O-,
-N(R8)-Q'-,
-C(R6)-N(R8)-,
-O-C(R6)-N(R8)-,
-C(R6)-N(OR9)-,
R4 выбирается из группы, включающей водород, алкил, алкенил, алкинил, арил, арилалкиленил, арилоксиалкиленил, алкилариленил, гетероарил, гетероарилалкиленил, гетероарилоксиалкиленил и алкилгетероариленил, причем алкильная, алкенильная, алкинильная, арильная, арилалкиленильная, арилоксиалкиленильная, алкилариленильная, гетероарильная, гетероарилалкиленильная, гетероарилоксиалкиленильная и алкилгетероариленильная группы могут быть незамещенными или замещенными одним или несколькими заместителями, независимо выбранными из группы, содержащей алкил, алкокси, гидроксиалкил, галоалкил, галоалкокси, галоген, нитро, гидрокси, меркапто, циано, арил, арилокси, арилалкиленокси, гетероарил, гетероарилокси, гетероарилалкиленокси, гетероциклил, амино, алкиламино, диалкиламино, (диалкиламино)-алкиленокси, и в случае алкила, алкенила и алкинила-оксо;
R5 выбирается из группы, включающей
R6 выбирается из группы, включающей =O и =S;
R7 представляет собой C2-7 алкилен;
R8 выбирается из группы, включающей водород, алкил, алкоксиалкиленил и арилалкиленил;
R9 выбирается из группы, включающей водород и алкил;
R10 представляет собой С3-8 алкилен;
А выбирается из группы, включающей -O-, -С(O)-, -S(O)0-2-, -CH2-, и -N(R4)-;
Q' выбирается из группы, включающей ковалентную связь, -C(R6)-, -C(R6)-C(R6)-, -S(O)2-, и -S(O)2-N(R8)-;
V выбирается из группы, включающей -С(R6)-, -О-С(R6)-, и -S(O)2-;
а и b являются независимо выбранными целыми числами от 1 до 6 при условии, что а+b≤7;
каждая из групп RA' и RB' независимо выбирается из группы, содержащей
водород,
галоген,
алкил,
алкенил,
алкокси,
алкилтио, и
-N(R9)2;
или фармацевтически приемлемая соль одного из этих веществ.
4. Вещество, соответствующее формуле (Ia)
в которой Х представляет собой алкилен, факультативно прерываемый одной или несколькими -О- группами;
n является целым числом от 0 до 4;
R1-1 выбирается из группы, включающей
водород,
алкил,
арил,
алкилен-арил,
гетероарил,
алкилен-гетероарил,
-N(СН3)(ОСН3), и
алкил, арил, алкилен-арил, гетероарил, или алкилен-гетероарил, замещенный одним или несколькими заместителями, выбираемыми из группы, содержащей
галоген,
циано,
нитро,
алкокси,
диалкиламино,
алкилтио,
галоалкил,
галоалкокси,
алкил,
-NH-SO2-R1-4,
-NH-C(O)-R1-4,
-NH-C(O)-NH2,
-NH-C(O)-NH-R1-4, и
-N3;
R1-4 выбирается из группы, включающей
алкил,
арил,
алкилен-арил,
гетероарил,
алкилен-гетероарил, и
алкил, арил, алкилен-арил, гетероарил, или алкилен-гетероарил, замещенный одним или несколькими заместителями, выбираемыми из группы, содержащей
галоген,
циано,
нитро,
алкокси,
диалкиламино,
алкилтио,
галоалкил,
галоалкокси,
алкил и
-N3;
R выбирается из группы, включающей
фтор,
алкил,
галоалкил,
алкокси и
-N(R9)2;
R2 выбирается из группы, включающей
водород,
алкил,
алкенил,
арил,
гетероарил,
гетероциклил,
алкилен-Y-алкил,
алкилен-Y-алкенил,
алкилен-Y-арил, и
алкил или алкенил, замещенный одним или несколькими заместителями, выбираемыми из группы, содержащей
гидрокси,
галоген,
-N(R3)2,
-С(O)-С1-10алкил,
-С(O)-O-С1-10алкил,
-N(R3)-С(O)-С1-10алкил,
-N3,
арил,
гетероарил,
гетероциклил,
-С(O)-арил, и
-С(O)-гетероарил;
где Y представляет собой -О- или -S(O)0-2-;
R3 выбирается из группы, включающей
водород,
С1-10алкил и
С2-10алкенил; и
R9 выбирается из группы, включающей водород и алкил;
или фармацевтически приемлемая соль одного из этих веществ.
5. Вещество, соответствующее формуле (Id)
в которой Х представляет собой алкилен, факультативно прерываемый одной или несколькими -О- группами;
n является целым числом от 0 до 4;
R1-1 выбирается из группы, включающей
водород,
алкил,
арил,
алкилен-арил,
гетероарил,
алкилен-гетероарил, и
алкил, арил, алкилен-арил, гетероарил, или алкилен-гетероарил, замещенный одним или несколькими заместителями, выбираемыми из группы, содержащей
галоген,
циано,
нитро,
алкокси,
диалкиламино,
алкилтио,
галоалкил,
галоалкокси,
алкил,
-NH-SO2-R1-4,
-NH-C(O)-R1-4,
-NH-C(O)-NH2,
-NH-C(O)-NH-R1-4, и
-N3;
Q - это О или S;
R1-3 выбирается из группы, включающей
алкил,
арил,
алкилен-арил,
гетероарил,
алкилен-гетероарил, и
алкил, арил, алкилен-арил, гетероарил, или алкилен-гетероарил, замещенный одним или несколькими заместителями, выбираемыми из группы, содержащей
галоген,
циано,
нитро,
алкокси,
диалкиламино,
алкилтио,
галоалкил,
галоалкокси,
алкил,
-NH-SO2-R1-4,
-NH-C(O)-R1-4,
-NH-C(O)-NH2,
-NH-C(O)-NH-R1-4, и
-N3;
или R1-3 группы могут объединяться друг с другом с образованием кольцевой системы, содержащей насыщенное или ненасыщенное 5-, 6- или 7-членное кольцо;
R1-4 выбирается из группы, включающей
алкил,
арил,
алкилен-арил,
гетероарил,
алкилен-гетероарил, и
алкил, арил, алкилен-арил, гетероарил, или алкилен-гетероарил, замещенный одним или несколькими заместителями, выбираемыми из группы, содержащей
галоген,
циано,
нитро,
алкокси,
диалкиламино,
алкилтио,
галоалкил,
галоалкокси,
алкил и
-N3;
R выбирается из группы, включающей
фтор,
алкил,
алкокси,
галоалкил и
-N(R9)2;
R2 выбирается из группы, включающей
водород,
алкил,
алкенил,
арил,
гетероарил,
гетероциклил,
алкилен-Y-алкил,
алкилен-Y-алкенил,
алкилен-Y-арил, и
алкил или алкенил, замещенный одним или несколькими заместителями, выбираемыми из группы, содержащей
гидрокси,
галоген,
-N(R3)2,
-С(O)-С1-10алкил,
-С(O)-O-С1-10алкил,
-N(R3)-С(O)-С1-10алкил,
-N3,
арил,
гетероарил,
гетероциклил,
-С(O)-арил, и
-С(O)-гетероарил;
где Y представляет собой -О- или -S(O)0-2-; и
R3 выбирается из группы, включающей
водород,
С1-10алкил и
С2-10алкенил; и
R9 выбирается из группы, включающей водород и алкил;
или фармацевтически приемлемая соль одного из этих веществ.
6. Вещество, соответствующее формуле (Ie)
в которой Х представляет собой алкилен, факультативно прерываемый одной или несколькими -О- группами;
n является целым числом от 0 до 4;
R выбирается из группы, включающей
фтор,
алкил,
алкокси,
галоалкил и
-N(R9)2;
R2 выбирается из группы, включающей
водород,
алкил,
алкенил,
арил,
гетероарил,
гетероциклил,
алкилен-Y-алкил,
алкилен-Y-алкенил,
алкилен-Y-арил, и
алкил или алкенил, замещенный одним или несколькими заместителями, выбираемыми из группы, содержащей
гидрокси,
галоген,
-N(R3)2,
-С(O)-С1-10алкил,
-С(O)-O-С1-10алкил,
-N(R3)-С(O)-С1-10алкил,
-N3,
арил,
гетероарил,
гетероциклил,
-С(O)-арил, и
-С(O)-гетероарил;
где Y представляет собой -О- или -S(O)0-2-; и
R3 выбирается из группы, включающей
водород,
С1-10алкил и
С2-10алкенил; и
R9 выбирается из группы, включающей водород и алкил;
или фармацевтически приемлемая соль одного из этих веществ.
7. Вещество по п.3 или его соль, отличающиеся тем, что RA' и RB'независимо выбираются из группы, содержащей водород и алкил.
8. Вещество по п.3 или его соль, отличающиеся тем, что Z представляет собой -С(O)-.
9. Вещество по любому из пп.2, 4, 5 и 6, или его соль, отличающиеся тем, что n равняется 0.
10. Вещество по п.3 или 5, или его соль, отличающиеся тем, что R1-3 представляет собой алкил или R1-3 группы объединяются друг с другом с образованием 5-членного кольца.
11. Вещество по п.3 или 5, или его соль, отличающиеся тем, что каждая из групп Q представляет собой -O-.
12. Вещество по любому из пп.1-4, 7 и 8, или его соль, отличающиеся тем, что R1-1 выбирается из группы, включающей арил, алкил и -N(СН3)ОСН3.
13. Вещество по любому из пп.1-5, 7 и 8, или его соль, отличающиеся тем, что R1-1 выбирается из группы, включающей алкил, арил и водород.
14. Вещество по любому из пп.1-8, или его соль, отличающиеся тем, что Х представляет собой С1-6алкилен или -(CH2)2-4-O-(CH2)1-3-.
15. Вещество по п.14, или его соль, отличающиеся тем, что Х выбирается из группы, включающей -(CH2)1-6-, -СН2-С(СН3)2-, -(СН2)2-O-СН2-, -(СН2)3-O-СН2- и
-СН2-С(СН3)2-СН2-.
16. Вещество по любому из пп.1-5, 7 и 8, или его соль, отличающиеся тем, что R1-1 выбирается из группы, включающей алкил и арил.
17. Вещество по п.16, или его соль, отличающиеся тем, что R1-1 выбирается из группы, включающей метил, этил, н-пропил, изопропил, циклопропил, н-бутил, втор-бутил, изобутил, трет-бутил, н-пентил, циклопентил, и-гексил, циклогексил, фенил, 4-хлорфенил и 2,4-дихлорфенил.
18. Вещество по любому из пп.1-8, или его соль, отличающиеся тем, что R2 выбирается из группы, включающей водород, алкил, гидроксиалкил и алкоксиалкил.
19. Вещество по п.18, или его соль, отличающиеся тем, что R2 выбирается из группы, включающей водород, гидроксиметил, метил, этил, н-пропил, н-бутил, этоксиметил, и 2-метоксиэтил.
20. Фармацевтическая композиция, содержащая терапевтически эффективное количество вещества по одному из пп.1-8, или его соли в комбинации с фармацевтически приемлемым носителем или наполнителем.
21. Способ индукции биосинтеза цитокинов у животных, включающий введение эффективного количества любого вещества, указанного в пп.1-8, или его соли в организм животного.
22. Способ лечения вирусного заболевания в организме животного, при необходимости в таком лечении, включающий введение терапевтически эффективного количества любого вещества, указанного в одном из пп.1-8, или его соли в организм животного.
23. Способ лечения того или иного онкологического заболевания в организме животного, при необходимости в таком лечении, включающий введение терапевтически эффективного количества любого вещества, указанного в одном из пп.1-8, или его соли в организм животного.
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| US58013904P | 2004-06-16 | 2004-06-16 | |
| US60/580,139 | 2004-06-16 |
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Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6677347B2 (en) * | 2000-12-08 | 2004-01-13 | 3M Innovative Properties Company | Sulfonamido ether substituted imidazoquinolines |
| US6797718B2 (en) | 2002-06-07 | 2004-09-28 | 3M Innovative Properties Company | Ether substituted imidazopyridines |
| US20040265351A1 (en) | 2003-04-10 | 2004-12-30 | Miller Richard L. | Methods and compositions for enhancing immune response |
| US20040214851A1 (en) * | 2003-04-28 | 2004-10-28 | 3M Innovative Properties Company | Compositions and methods for induction of opioid receptors |
| US20050070460A1 (en) | 2003-08-05 | 2005-03-31 | 3M Innovative Properties Company | Infection prophylaxis using immune response modifier compounds |
| AU2004266658A1 (en) * | 2003-08-12 | 2005-03-03 | 3M Innovative Properties Company | Hydroxylamine substituted imidazo-containing compounds |
| US7897597B2 (en) * | 2003-08-27 | 2011-03-01 | 3M Innovative Properties Company | Aryloxy and arylalkyleneoxy substituted imidazoquinolines |
| JP2007504269A (ja) | 2003-09-05 | 2007-03-01 | スリーエム イノベイティブ プロパティズ カンパニー | Ｃｄ５＋ｂ細胞リンパ腫の治療方法 |
| AU2004315876B2 (en) | 2003-10-03 | 2011-05-26 | 3M Innovative Properties Company | Pyrazolopyridines and analogs thereof |
| US7544697B2 (en) * | 2003-10-03 | 2009-06-09 | Coley Pharmaceutical Group, Inc. | Pyrazolopyridines and analogs thereof |
| US20090075980A1 (en) * | 2003-10-03 | 2009-03-19 | Coley Pharmaceutical Group, Inc. | Pyrazolopyridines and Analogs Thereof |
| US8871782B2 (en) | 2003-10-03 | 2014-10-28 | 3M Innovative Properties Company | Alkoxy substituted imidazoquinolines |
| EP1682544A4 (en) * | 2003-11-14 | 2009-05-06 | 3M Innovative Properties Co | HYDROXYLAMINE SUBSTITUTED IMIDAZO RING COMPOUNDS |
| AU2004291101A1 (en) | 2003-11-14 | 2005-06-02 | 3M Innovative Properties Company | Oxime substituted imidazo ring compounds |
| AU2004293078B2 (en) | 2003-11-25 | 2012-01-19 | 3M Innovative Properties Company | Substituted imidazo ring systems and methods |
| EP1701955A1 (en) * | 2003-12-29 | 2006-09-20 | 3M Innovative Properties Company | Arylalkenyl and arylalkynyl substituted imidazoquinolines |
| EP1699788A2 (en) * | 2003-12-30 | 2006-09-13 | 3M Innovative Properties Company | Imidazoquinolinyl, imidazopyridinyl and imidazonaphthyridinyl sulfonamides |
| EP1730143A2 (en) * | 2004-03-24 | 2006-12-13 | 3M Innovative Properties Company | Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines |
| US8017779B2 (en) * | 2004-06-15 | 2011-09-13 | 3M Innovative Properties Company | Nitrogen containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines |
| US8541438B2 (en) | 2004-06-18 | 2013-09-24 | 3M Innovative Properties Company | Substituted imidazoquinolines, imidazopyridines, and imidazonaphthyridines |
| US7897609B2 (en) * | 2004-06-18 | 2011-03-01 | 3M Innovative Properties Company | Aryl substituted imidazonaphthyridines |
| US8026366B2 (en) * | 2004-06-18 | 2011-09-27 | 3M Innovative Properties Company | Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines |
| WO2006009832A1 (en) * | 2004-06-18 | 2006-01-26 | 3M Innovative Properties Company | Substituted imidazo ring systems and methods |
| WO2006065280A2 (en) | 2004-06-18 | 2006-06-22 | 3M Innovative Properties Company | Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and methods |
| WO2006026760A2 (en) * | 2004-09-02 | 2006-03-09 | 3M Innovative Properties Company | 1-amino imidazo-containing compounds and methods |
| WO2006028962A2 (en) | 2004-09-02 | 2006-03-16 | 3M Innovative Properties Company | 1-alkoxy 1h-imidazo ring systems and methods |
| WO2006063072A2 (en) * | 2004-12-08 | 2006-06-15 | 3M Innovative Properties Company | Immunomodulatory compositions, combinations and methods |
| US8034938B2 (en) | 2004-12-30 | 2011-10-11 | 3M Innovative Properties Company | Substituted chiral fused [1,2]imidazo[4,5-c] ring compounds |
| SI1830876T1 (sl) | 2004-12-30 | 2015-08-31 | Meda Ab | Uporaba imikvimoda za zdravljenje kožnih metastaz, ki izhajajo iz rakavega tumorja dojke |
| AU2005322898B2 (en) | 2004-12-30 | 2011-11-24 | 3M Innovative Properties Company | Chiral fused (1,2)imidazo(4,5-c) ring compounds |
| WO2006084251A2 (en) | 2005-02-04 | 2006-08-10 | Coley Pharmaceutical Group, Inc. | Aqueous gel formulations containing immune reponse modifiers |
| CA2597324C (en) | 2005-02-09 | 2015-06-30 | Coley Pharmaceutical Group, Inc. | Alkyloxy substituted thiazoloquinolines and thiazolonaphthyridines |
| EP1877056A2 (en) | 2005-02-09 | 2008-01-16 | Coley Pharmaceutical Group, Inc. | Oxime and hydroxylamine substituted thiazoloý4,5-c¨ring compounds and methods |
| AU2006213746A1 (en) * | 2005-02-11 | 2006-08-17 | Coley Pharmaceutical Group, Inc. | Oxime and hydroxylamine substituted imidazo(4,5-c) ring compounds and methods |
| EP1845988A2 (en) * | 2005-02-11 | 2007-10-24 | 3M Innovative Properties Company | Substituted imidazoquinolines and imidazonaphthyridines |
| EP1851220A2 (en) | 2005-02-23 | 2007-11-07 | 3M Innovative Properties Company | Hydroxyalkyl substituted imidazonaphthyridines |
| WO2006091647A2 (en) * | 2005-02-23 | 2006-08-31 | Coley Pharmaceutical Group, Inc. | Method of preferentially inducing the biosynthesis of interferon |
| JP2008531567A (ja) * | 2005-02-23 | 2008-08-14 | コーリー ファーマシューティカル グループ，インコーポレイテッド | ヒドロキシアルキル置換イミダゾキノリン化合物および方法 |
| EP1851224A2 (en) * | 2005-02-23 | 2007-11-07 | 3M Innovative Properties Company | Hydroxyalkyl substituted imidazoquinolines |
| CA2602683A1 (en) | 2005-04-01 | 2006-10-12 | Coley Pharmaceutical Group, Inc. | Pyrazolopyridine-1,4-diamines and analogs thereof |
| AU2006232375A1 (en) | 2005-04-01 | 2006-10-12 | Coley Pharmaceutical Group, Inc. | 1-substituted pyrazolo (3,4-c) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases |
| CN101253173A (zh) * | 2005-09-02 | 2008-08-27 | 辉瑞有限公司 | 羟基取代的1h-咪唑并吡啶和方法 |
| AU2006287270A1 (en) * | 2005-09-09 | 2007-03-15 | Coley Pharmaceutical Group, Inc. | Amide and carbamate derivatives of N-{2-[4-amino-2- (ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-1,1-dimethylethyl}methanesulfonamide and methods |
| ZA200803029B (en) | 2005-09-09 | 2009-02-25 | Coley Pharm Group Inc | Amide and carbamate derivatives of alkyl substituted /V-[4-(4-amino-1H-imidazo[4,5-c] quinolin-1-yl)butyl] methane-sulfonamides and methods |
| WO2007035935A1 (en) * | 2005-09-23 | 2007-03-29 | Coley Pharmaceutical Group, Inc. | METHOD FOR 1H-IMIDAZO[4,5-c]PYRIDINES AND ANALOGS THEREOF |
| EP1948173B1 (en) * | 2005-11-04 | 2013-07-17 | 3M Innovative Properties Company | Hydroxy and alkoxy substituted 1h-imidazoquinolines and methods |
| MX2008010611A (es) | 2006-02-17 | 2008-11-12 | Pfizer Ltd | Derivados de 3-desazapurina como moduladores de receptores similares a toll. |
| US8951528B2 (en) | 2006-02-22 | 2015-02-10 | 3M Innovative Properties Company | Immune response modifier conjugates |
| WO2007106854A2 (en) * | 2006-03-15 | 2007-09-20 | Coley Pharmaceutical Group, Inc. | Hydroxy and alkoxy substituted 1h-imidazonaphthyridines and methods |
| WO2008008432A2 (en) | 2006-07-12 | 2008-01-17 | Coley Pharmaceutical Group, Inc. | Substituted chiral fused( 1,2) imidazo (4,5-c) ring compounds and methods |
| US8178539B2 (en) * | 2006-09-06 | 2012-05-15 | 3M Innovative Properties Company | Substituted 3,4,6,7-tetrahydro-5H-1,2a,4a,8-tetraazacyclopenta[cd]phenalenes and methods |
| US20080149123A1 (en) | 2006-12-22 | 2008-06-26 | Mckay William D | Particulate material dispensing hairbrush with combination bristles |
| RS55819B1 (sr) * | 2010-08-17 | 2017-08-31 | 3M Innovative Properties Co | Kompozicije sa lipidiranim modifikatorom imuno-odgovora, formulacije, i postupci |
| MX347240B (es) | 2011-06-03 | 2017-04-20 | 3M Innovative Properties Co | Ligadores heterobifuncionales con segmentos polietilenglicol y conjugados modificadores de la respuesta inmunitaria elaborados a partir de los mismos. |
| MX355623B (es) | 2011-06-03 | 2018-04-25 | 3M Innovative Properties Co | Hidrazino-1h-imidazoquinolin-4-aminas y conjugados elaborados a partir de las mismas. |
| SI2941233T1 (sl) | 2013-01-07 | 2021-01-29 | The Trustees Of The University Of Pennsylvania | Sestavki in postopki za zdravljenje kutanega T celičnega limfoma |
| US9920052B2 (en) | 2013-12-09 | 2018-03-20 | Ucb Biopharma Sprl | Imidazopyridine derivatives as modulators of TNF activity |
| WO2016183371A1 (en) | 2015-05-13 | 2016-11-17 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Methods for the treatment or prevention of ischemic tissue damage |
| WO2017040233A1 (en) | 2015-08-31 | 2017-03-09 | 3M Innovative Properties Company | GUANIDINE SUBSTITUTED IMIDAZO[4,5-c] RING COMPOUNDS |
| CN107922416B (zh) | 2015-08-31 | 2021-07-02 | 3M创新有限公司 | 含有取代的胍基团的咪唑并[4,5-c]环化合物 |
| WO2017184735A1 (en) * | 2016-04-19 | 2017-10-26 | Ifm Therapeutics, Inc | Nlrp3 modulators |
| CN109071535B (zh) | 2016-04-19 | 2021-10-08 | 先天肿瘤免疫公司 | Nlrp3调节剂 |
| EP3504215B1 (en) | 2016-08-26 | 2022-04-06 | 3M Innovative Properties Company | Fused [1,2]imidazo[4,5-c]ring compounds substituted with guanidino groups |
| TWI674261B (zh) | 2017-02-17 | 2019-10-11 | 美商英能腫瘤免疫股份有限公司 | Nlrp3 調節劑 |
| WO2018160552A1 (en) | 2017-03-01 | 2018-09-07 | 3M Innovative Properties Company | IMIDAZO[4,5-c] RING COMPOUNDS CONTAINING GUANIDINE SUBSTITUTED BENZAMIDE GROUPS |
| JP7197244B2 (ja) | 2017-12-20 | 2022-12-27 | スリーエム イノベイティブ プロパティズ カンパニー | 免疫応答調節剤として使用するための分岐鎖連結基を有するアミド置換イミダゾ［４，５－ｃ］キノリン化合物 |
| WO2019166946A1 (en) | 2018-02-28 | 2019-09-06 | Pfizer Inc. | Il-15 variants and uses thereof |
| EP3759107B1 (en) | 2018-02-28 | 2024-12-04 | Solventum Intellectual Properties Company | Substituted imidazo[4,5-c]quinoline compounds with an n-1 branched group |
| EP3797121B1 (en) | 2018-05-23 | 2024-06-19 | Pfizer Inc. | Antibodies specific for cd3 and uses thereof |
| TWI803637B (zh) | 2018-05-23 | 2023-06-01 | 美商輝瑞大藥廠 | 特異性針對gucy2c之抗體及其用途 |
| WO2019224765A1 (en) | 2018-05-24 | 2019-11-28 | 3M Innovative Properties Company | N-1 branched cycloalkyl substituted imidazo[4,5-c]quinoline compounds, compositions, and methods |
| WO2020109898A1 (en) | 2018-11-26 | 2020-06-04 | 3M Innovative Properties Company | N-1 branched alkyl ether substituted imidazo[4,5-c]quinoline compounds, compositions, and methods |
| US20220370606A1 (en) | 2018-12-21 | 2022-11-24 | Pfizer Inc. | Combination Treatments Of Cancer Comprising A TLR Agonist |
| WO2020245706A1 (en) | 2019-06-06 | 2020-12-10 | 3M Innovative Properties Company | N-1 branched alkyl substituted imidazo[4,5-c]quinoline compounds, compositions, and methods |
| US20220194935A1 (en) | 2019-06-12 | 2022-06-23 | 3M Innovative Properties Company | Phenethyl substituted imidazo[4,5-c]quinoline compounds with an n-1 branched group |
| KR20220114049A (ko) | 2019-12-17 | 2022-08-17 | 화이자 인코포레이티드 | Cd47, pd-l1에 특이적인 항체, 및 그의 용도 |
| AU2021305193A1 (en) * | 2020-07-08 | 2023-02-09 | Purdue Research Foundation | Compounds, compositions, and methods for the treatment of fibrotic diseases and cancer |
| IL299939A (en) | 2020-07-17 | 2023-03-01 | Pfizer | Therapeutic antibodies and their uses |
| KR20240087695A (ko) * | 2021-08-30 | 2024-06-19 | 퍼듀 리서치 파운데이션 | Car t-세포의 재생을 위한 접합체, 조성물 및 방법 |
| WO2025104289A1 (en) | 2023-11-17 | 2025-05-22 | Medincell S.A. | Antineoplastic combinations |
Family Cites Families (366)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3314941A (en) * | 1964-06-23 | 1967-04-18 | American Cyanamid Co | Novel substituted pyridodiazepins |
| US3412093A (en) | 1965-12-21 | 1968-11-19 | Delmar Chem | New adenine derivatives and method for their preparation |
| DE1645976A1 (de) | 1966-06-18 | 1971-01-21 | Ajinomoto Kk | Verfahren zur Herstellung von Adenosin und 2',3'-O-Isopropylidenadenosin |
| ZA704419B (en) | 1969-07-21 | 1971-04-28 | Ici Australia Ltd | Injectable aqueous solutions of tetramisole |
| US3866508A (en) * | 1970-09-21 | 1975-02-18 | Elmer F Huslig | Stick for playing percussion instruments |
| US3692907A (en) | 1970-10-27 | 1972-09-19 | Richardson Merrell Inc | Treating viral infections with bis-basic ethers and thioethers of fluorenone and fluorene and pharmaceutical compositons of the same |
| US3917624A (en) | 1972-09-27 | 1975-11-04 | Pfizer | Process for producing 2-amino-nicotinonitrile intermediates |
| US4006237A (en) * | 1973-10-11 | 1977-02-01 | Beecham Group Limited | Tetrahydrocarbostyril derivatives for the prophylaxis of asthma, hayfever and rhinitis |
| US3891660A (en) | 1974-02-07 | 1975-06-24 | Squibb & Sons Inc | Derivatives of 1H-imidazo{8 4,5-c{9 pyridine-7-carboxylic acids and esters |
| US3899508A (en) | 1974-04-12 | 1975-08-12 | Lilly Co Eli | 5-(2-Aminophenyl)pyrazole-3-carboxylic acids and esters thereof |
| DE2423389A1 (de) | 1974-05-14 | 1975-12-04 | Hoechst Ag | Arzneimittel mit psychotroper wirkung und verfahren zu ihrer herstellung |
| JPS6016438B2 (ja) | 1976-10-14 | 1985-04-25 | ウェルファイド株式会社 | イミダゾキノリン誘導体 |
| US4381344A (en) * | 1980-04-25 | 1983-04-26 | Burroughs Wellcome Co. | Process for producing deoxyribosides using bacterial phosphorylase |
| DE3204126A1 (de) | 1982-02-06 | 1983-08-11 | Bayer Ag, 5090 Leverkusen | Pyrazoloxazine, -thiazine, -chinoline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| US4758574A (en) | 1982-05-03 | 1988-07-19 | Eli Lilly And Company | 2-phenylimidazio (4,5-c) pyridines |
| US4563525A (en) * | 1983-05-31 | 1986-01-07 | Ici Americas Inc. | Process for preparing pyrazolopyridine compounds |
| CA1271477A (en) | 1983-11-18 | 1990-07-10 | John F. Gerster | 1h-imidazo[4,5-c]quinolin-4-amines |
| IL73534A (en) | 1983-11-18 | 1990-12-23 | Riker Laboratories Inc | 1h-imidazo(4,5-c)quinoline-4-amines,their preparation and pharmaceutical compositions containing certain such compounds |
| ZA848968B (en) | 1983-11-18 | 1986-06-25 | Riker Laboratories Inc | 1h-imidazo(4,5-c)quinolines and 1h-imidazo(4,5-c)quinolin-4-amines |
| JPS61112075A (ja) | 1984-11-05 | 1986-05-30 | Shionogi & Co Ltd | チエニルピラゾロキノリン誘導体 |
| US4593821A (en) | 1985-04-25 | 1986-06-10 | Laros Equipment Company, Inc. | Belt separator for blow molding parts |
| US4668686A (en) | 1985-04-25 | 1987-05-26 | Bristol-Myers Company | Imidazoquinoline antithrombrogenic cardiotonic agents |
| US4698346A (en) | 1985-05-08 | 1987-10-06 | Usv Pharmaceutical Corporation | Thiazolo[5,4-h]quinoline compounds useful as anti-allergy agents |
| US4826830A (en) | 1985-07-31 | 1989-05-02 | Jui Han | Topical application of glyciphosphoramide |
| CA1306260C (en) | 1985-10-18 | 1992-08-11 | Shionogi & Co., Ltd. | Condensed imidazopyridine derivatives |
| HU197019B (en) * | 1985-11-12 | 1989-02-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing thiqzolo (4,5-c) quinoline derivatives and pharmaceuticals comprising same |
| US4837378A (en) | 1986-01-15 | 1989-06-06 | Curatek Pharmaceuticals, Inc. | Topical metronidazole formulations and therapeutic uses thereof |
| JPS6310787A (ja) | 1986-03-06 | 1988-01-18 | Takeda Chem Ind Ltd | ヌクレオシド類縁体、その製造法および抗ウイルス剤 |
| US4775674A (en) | 1986-05-23 | 1988-10-04 | Bristol-Myers Company | Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors |
| CA1287061C (en) * | 1986-06-27 | 1991-07-30 | Roche Holding Ltd. | Pyridine ethanolamine derivatives |
| US5500228A (en) * | 1987-05-26 | 1996-03-19 | American Cyanamid Company | Phase separation-microencapsulated pharmaceuticals compositions useful for alleviating dental disease |
| US4880779A (en) | 1987-07-31 | 1989-11-14 | Research Corporation Technologies, Inc. | Method of prevention or treatment of AIDS by inhibition of human immunodeficiency virus |
| US4774339A (en) | 1987-08-10 | 1988-09-27 | Molecular Probes, Inc. | Chemically reactive dipyrrometheneboron difluoride dyes |
| US5536743A (en) | 1988-01-15 | 1996-07-16 | Curatek Pharmaceuticals Limited Partnership | Intravaginal treatment of vaginal infections with buffered metronidazole compositions |
| US5225183A (en) | 1988-12-06 | 1993-07-06 | Riker Laboratories, Inc. | Medicinal aerosol formulations |
| US5736553A (en) * | 1988-12-15 | 1998-04-07 | Riker Laboratories, Inc. | Topical formulations and transdermal delivery systems containing 1-isobutyl-1H-imidazo 4,5-C!quinolin-4-amine |
| US5238944A (en) | 1988-12-15 | 1993-08-24 | Riker Laboratories, Inc. | Topical formulations and transdermal delivery systems containing 1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine |
| US5756747A (en) * | 1989-02-27 | 1998-05-26 | Riker Laboratories, Inc. | 1H-imidazo 4,5-c!quinolin-4-amines |
| DE69029212T2 (de) * | 1989-02-27 | 1997-05-22 | Riker Laboratories Inc | 4-Amino-1H-Imidazo(4,5-c)chinoline als antivirale Mittel |
| US5457183A (en) | 1989-03-06 | 1995-10-10 | Board Of Regents, The University Of Texas System | Hydroxylated texaphyrins |
| US4929624A (en) | 1989-03-23 | 1990-05-29 | Minnesota Mining And Manufacturing Company | Olefinic 1H-imidazo(4,5-c)quinolin-4-amines |
| US5037986A (en) | 1989-03-23 | 1991-08-06 | Minnesota Mining And Manufacturing Company | Olefinic 1H-imidazo[4,5-c]quinolin-4-amines |
| NZ232740A (en) | 1989-04-20 | 1992-06-25 | Riker Laboratories Inc | Solution for parenteral administration comprising a 1h-imidazo(4,5-c) quinolin-4-amine derivative, an acid and a tonicity adjuster |
| US4988815A (en) * | 1989-10-26 | 1991-01-29 | Riker Laboratories, Inc. | 3-Amino or 3-nitro quinoline compounds which are intermediates in preparing 1H-imidazo[4,5-c]quinolines |
| EP0452331A1 (de) | 1989-11-02 | 1991-10-23 | PFEIFER & LANGEN | Verfahren und vorrichtung zur verhinderung der krustenbildung in kontinuierlich arbeitenden zucker-kristallisationsapparaten |
| US5750134A (en) | 1989-11-03 | 1998-05-12 | Riker Laboratories, Inc. | Bioadhesive composition and patch |
| JPH05503517A (ja) | 1989-12-18 | 1993-06-10 | バージニア・コモンウェルス・ユニバーシティ | シグマレセプターリガンド及びその用途 |
| US5274113A (en) | 1991-11-01 | 1993-12-28 | Molecular Probes, Inc. | Long wavelength chemically reactive dipyrrometheneboron difluoride dyes and conjugates |
| BR9106391A (pt) | 1990-04-30 | 1993-04-27 | Isis Pharmaceuticals Inc | Oligonucleotideo ou analogo de oligonucleotideo,processo para modular o metaboslismo do acido araquidonico em um animal,e,processo para tratar um anumal suspeito de ter uma doenca que e modulada por mudancas na sintese ou no metabolismo do acido arquidonico |
| EP0461040A1 (fr) | 1990-06-08 | 1991-12-11 | Roussel Uclaf | Dérivés de l'imidazole, leur procédé de préparation, les intermédiaires obtenus, leur application à titre de médicaments et les compositions pharmaceutiques les renfermant |
| CA2093132C (en) | 1990-10-05 | 2002-02-26 | John F. Gerster | Process for the preparation of imidazo[4,5-c]quinolin-4-amines |
| MX9203481A (es) | 1990-10-18 | 1992-07-01 | Minnesota Mining & Mfg | Formulaciones. |
| US5248782A (en) | 1990-12-18 | 1993-09-28 | Molecular Probes, Inc. | Long wavelength heteroaryl-substituted dipyrrometheneboron difluoride dyes |
| US5175296A (en) | 1991-03-01 | 1992-12-29 | Minnesota Mining And Manufacturing Company | Imidazo[4,5-c]quinolin-4-amines and processes for their preparation |
| WO1992015582A1 (en) | 1991-03-01 | 1992-09-17 | Minnesota Mining And Manufacturing Company | 1-SUBSTITUTED, 2-SUBSTITUTED 1H-IMIDAZO[4,5-c]QUINOLIN-4-AMINES |
| US5389640A (en) * | 1991-03-01 | 1995-02-14 | Minnesota Mining And Manufacturing Company | 1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines |
| US5342784A (en) | 1991-04-12 | 1994-08-30 | Mitsubishi Paper Mills Limited | Electrophotographic lithographic printing plate |
| JPH04327587A (ja) | 1991-04-26 | 1992-11-17 | Asahi Chem Ind Co Ltd | ６’−ｃ−アルキル−３−デアザネプラノシンａ誘導体、その製造法およびその用途 |
| US5187288A (en) * | 1991-05-22 | 1993-02-16 | Molecular Probes, Inc. | Ethenyl-substituted dipyrrometheneboron difluoride dyes and their synthesis |
| US5268376A (en) | 1991-09-04 | 1993-12-07 | Minnesota Mining And Manufacturing Company | 1-substituted 1H-imidazo[4,5-c]quinolin-4-amines |
| TW300219B (ru) | 1991-09-14 | 1997-03-11 | Hoechst Ag | |
| PH31245A (en) | 1991-10-30 | 1998-06-18 | Janssen Pharmaceutica Nv | 1,3-Dihydro-2H-imidazoÄ4,5-BÜ-quinolin-2-one derivatives. |
| US5266575A (en) | 1991-11-06 | 1993-11-30 | Minnesota Mining And Manufacturing Company | 2-ethyl 1H-imidazo[4,5-ciquinolin-4-amines |
| US5378848A (en) * | 1992-02-12 | 1995-01-03 | Shionogi & Co., Ltd. | Condensed imidazopyridine derivatives |
| IL105325A (en) | 1992-04-16 | 1996-11-14 | Minnesota Mining & Mfg | Immunogen/vaccine adjuvant composition |
| ATE155681T1 (de) | 1992-05-18 | 1997-08-15 | Minnesota Mining & Mfg | Einrichtung zur transmucosalen wirkstoffabgabe |
| US5352680A (en) | 1992-07-15 | 1994-10-04 | Regents Of The University Of Minnesota | Delta opioid receptor antagonists to block opioid agonist tolerance and dependence |
| US6608201B2 (en) | 1992-08-28 | 2003-08-19 | 3M Innovative Properties Company | Process for preparing 1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines |
| TW251284B (ru) | 1992-11-02 | 1995-07-11 | Pfizer | |
| US5395937A (en) * | 1993-01-29 | 1995-03-07 | Minnesota Mining And Manufacturing Company | Process for preparing quinoline amines |
| CA2156408C (en) | 1993-03-17 | 2005-02-15 | Daniel C. Duan | Aerosol formulation containing a polyester dispersing aid |
| DE4309969A1 (de) | 1993-03-26 | 1994-09-29 | Bayer Ag | Substituierte heteroanellierte Imidazole |
| DE69314318T2 (de) | 1993-04-27 | 1998-04-09 | Agfa Gevaert Nv | Verfahren zum Einfügen von einer Wasserumlöslichen Verbindung in eine hydrophile Schicht |
| ES2149276T3 (es) | 1993-07-15 | 2000-11-01 | Minnesota Mining & Mfg | Imidazo(4,5-c)piridin-4-aminas. |
| US5648516A (en) | 1994-07-20 | 1997-07-15 | Minnesota Mining And Manufacturing Company | Fused cycloalkylimidazopyridines |
| US5352784A (en) | 1993-07-15 | 1994-10-04 | Minnesota Mining And Manufacturing Company | Fused cycloalkylimidazopyridines |
| CA2131680C (en) | 1993-09-17 | 2006-11-07 | Gerhard Stucky | Process for preparing imidazopyridine derivatives |
| US5837809A (en) | 1995-08-11 | 1998-11-17 | Oregon Health Sciences University | Mammalian opioid receptor ligand and uses |
| JPH07163368A (ja) * | 1993-12-15 | 1995-06-27 | Hayashibara Biochem Lab Inc | 組換えｄｎａとその組換えｄｎａを含む形質転換体 |
| TW574214B (en) | 1994-06-08 | 2004-02-01 | Pfizer | Corticotropin releasing factor antagonists |
| US6110923A (en) | 1994-06-22 | 2000-08-29 | Biochem Pharma Inc. | Method for treating cancer using novel substituted purinyl derivatives with immunomodulating activity |
| DE69535036T3 (de) * | 1994-07-15 | 2011-07-07 | The University of Iowa Research Foundation, IA | Immunomodulatorische oligonukleotide |
| US6239116B1 (en) | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6207646B1 (en) * | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US5612377A (en) * | 1994-08-04 | 1997-03-18 | Minnesota Mining And Manufacturing Company | Method of inhibiting leukotriene biosynthesis |
| US5644063A (en) | 1994-09-08 | 1997-07-01 | Minnesota Mining And Manufacturing Company | Imidazo[4,5-c]pyridin-4-amine intermediates |
| DE4432860A1 (de) * | 1994-09-15 | 1996-03-21 | Merck Patent Gmbh | Imidazopyridine |
| GB9420168D0 (en) | 1994-10-06 | 1994-11-23 | Boots Co Plc | Therapeutic agents |
| US5571819A (en) | 1994-11-22 | 1996-11-05 | Sabb; Annmarie L. | Imidazopyridines as muscarinic agents |
| US5482936A (en) | 1995-01-12 | 1996-01-09 | Minnesota Mining And Manufacturing Company | Imidazo[4,5-C]quinoline amines |
| US6071949A (en) | 1995-03-14 | 2000-06-06 | The United States Of America As Represented By The Department Of Health And Human Services | Use of lipoxygenase inhibitors as anti-cancer therapeutic and intervention agents |
| US5585612A (en) | 1995-03-20 | 1996-12-17 | Harp Enterprises, Inc. | Method and apparatus for voting |
| FR2732605B1 (fr) | 1995-04-07 | 1997-05-16 | Pasteur Merieux Serums Vacc | Composition destinee a l'induction d'une reponse immunitaire mucosale |
| US5766789A (en) | 1995-09-29 | 1998-06-16 | Energetics Systems Corporation | Electrical energy devices |
| DK0778277T3 (da) | 1995-12-08 | 2003-10-27 | Pfizer | Substituerede heterocycliske derivater som CRF antagonister |
| JPH09176116A (ja) | 1995-12-27 | 1997-07-08 | Toray Ind Inc | 複素環誘導体およびその医薬用途 |
| JPH09208584A (ja) | 1996-01-29 | 1997-08-12 | Terumo Corp | アミド誘導体、およびそれを含有する医薬製剤、および合成中間体 |
| US5939047A (en) | 1996-04-16 | 1999-08-17 | Jernberg; Gary R. | Local delivery of chemotherapeutic agents for treatment of periodontal disease |
| US5861268A (en) * | 1996-05-23 | 1999-01-19 | Biomide Investment Limited Partnership | Method for induction of tumor cell apoptosis with chemical inhibitors targeted to 12-lipoxygenase |
| US5741908A (en) * | 1996-06-21 | 1998-04-21 | Minnesota Mining And Manufacturing Company | Process for reparing imidazoquinolinamines |
| US5693811A (en) | 1996-06-21 | 1997-12-02 | Minnesota Mining And Manufacturing Company | Process for preparing tetrahdroimidazoquinolinamines |
| ATE283855T1 (de) * | 1996-07-03 | 2004-12-15 | Sumitomo Pharma | Neue purinderivate |
| US6387938B1 (en) | 1996-07-05 | 2002-05-14 | Mochida Pharmaceutical Co., Ltd. | Benzimidazole derivatives |
| US5955299A (en) | 1996-09-27 | 1999-09-21 | Incyte Pharmaceuticals, Inc. | snRNP Sm proteins |
| HUP9904665A3 (en) | 1996-10-25 | 2000-11-28 | Minnesota Mining And Mfg Co Sa | Immune response modifier compounds for treatment of th2 mediated and related diseases |
| US5939090A (en) * | 1996-12-03 | 1999-08-17 | 3M Innovative Properties Company | Gel formulations for topical drug delivery |
| EP0894797A4 (en) | 1997-01-09 | 2001-08-16 | Terumo Corp | NEW AMID DERIVATIVES AND INTERMEDIATES ON YOUR SYNTHESIS |
| US6406705B1 (en) | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
| JPH10298181A (ja) | 1997-04-25 | 1998-11-10 | Sumitomo Pharmaceut Co Ltd | タイプ２ヘルパーｔ細胞選択的免疫応答抑制剤 |
| US6426334B1 (en) | 1997-04-30 | 2002-07-30 | Hybridon, Inc. | Oligonucleotide mediated specific cytokine induction and reduction of tumor growth in a mammal |
| CN1935840A (zh) | 1997-05-07 | 2007-03-28 | 先灵公司 | 人Toll样受体蛋白、相关试剂和方法 |
| US6113918A (en) | 1997-05-08 | 2000-09-05 | Ribi Immunochem Research, Inc. | Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors |
| US6303347B1 (en) | 1997-05-08 | 2001-10-16 | Corixa Corporation | Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors |
| EP1003531B1 (en) * | 1997-05-20 | 2007-08-22 | Ottawa Health Research Institute | Processes for preparing nucleic acid constructs |
| CA2291487A1 (en) | 1997-05-29 | 1998-12-03 | New Zealand Pastoral Agriculture Research Institute Limited | Processes for production of immunoglobulin a in milk |
| US6123957A (en) | 1997-07-16 | 2000-09-26 | Jernberg; Gary R. | Delivery of agents and method for regeneration of periodontal tissues |
| KR100528112B1 (ko) | 1997-08-20 | 2006-03-17 | 소니 가부시끼 가이샤 | 원반형 기록 매체의 제조 장치 및 방법 |
| JPH1180156A (ja) | 1997-09-04 | 1999-03-26 | Hokuriku Seiyaku Co Ltd | １−（置換アリール）アルキル−１ｈ−イミダゾピリジン−４−アミン誘導体 |
| US6309623B1 (en) | 1997-09-29 | 2001-10-30 | Inhale Therapeutic Systems, Inc. | Stabilized preparations for use in metered dose inhalers |
| AU1066499A (en) | 1997-10-07 | 1999-04-27 | Ortho-Mcneil Pharmaceutical, Inc. | Dipyridoimidazolderivatives useful in treating central nervous system disorders |
| CA2311742C (en) | 1997-11-28 | 2009-06-16 | Sumitomo Pharmaceuticals Co., Ltd. | 6-amino-9-benzyl-8-hydroxypurine derivatives |
| US6121323A (en) | 1997-12-03 | 2000-09-19 | 3M Innovative Properties Company | Bishydroxyureas |
| UA67760C2 (ru) | 1997-12-11 | 2004-07-15 | Міннесота Майнінг Енд Мануфакчурінг Компані | Имидазонафтиридины и их применение для индуцирования биосинтеза цитокинов |
| TW572758B (en) * | 1997-12-22 | 2004-01-21 | Sumitomo Pharma | Type 2 helper T cell-selective immune response inhibitors comprising purine derivatives |
| JPH11222432A (ja) | 1998-02-03 | 1999-08-17 | Terumo Corp | インターフェロンを誘起するアミド誘導体を含有する外用剤 |
| US6011253A (en) * | 1998-03-31 | 2000-01-04 | Lucent Technologies Inc. | Methods and apparatus for analyzing polarization mode dispersion of an optical device |
| US6114058A (en) | 1998-05-26 | 2000-09-05 | Siemens Westinghouse Power Corporation | Iron aluminide alloy container for solid oxide fuel cells |
| US6110929A (en) * | 1998-07-28 | 2000-08-29 | 3M Innovative Properties Company | Oxazolo, thiazolo and selenazolo [4,5-c]-quinolin-4-amines and analogs thereof |
| US5962636A (en) | 1998-08-12 | 1999-10-05 | Amgen Canada Inc. | Peptides capable of modulating inflammatory heart disease |
| JP2000119271A (ja) * | 1998-08-12 | 2000-04-25 | Hokuriku Seiyaku Co Ltd | １ｈ―イミダゾピリジン誘導体 |
| CA2345808A1 (en) | 1998-10-02 | 2000-04-13 | 3M Innovative Properties Company | Mucosal originated drug delivery systems and animal applications |
| US6518280B2 (en) * | 1998-12-11 | 2003-02-11 | 3M Innovative Properties Company | Imidazonaphthyridines |
| US6486168B1 (en) | 1999-01-08 | 2002-11-26 | 3M Innovative Properties Company | Formulations and methods for treatment of mucosal associated conditions with an immune response modifier |
| NZ512628A (en) * | 1999-01-08 | 2004-03-26 | 3M Innovative Properties Co | Formulations and methods for treatment of mucosal associated conditions with an immune response modifier |
| US20020058674A1 (en) * | 1999-01-08 | 2002-05-16 | Hedenstrom John C. | Systems and methods for treating a mucosal surface |
| EP1495758A3 (en) | 1999-01-08 | 2005-04-13 | 3M Innovative Properties Company | Formulations and methods for treatment of mucosal associated conditions with an immune response modifier |
| US6558951B1 (en) | 1999-02-11 | 2003-05-06 | 3M Innovative Properties Company | Maturation of dendritic cells with immune response modifying compounds |
| US6294271B1 (en) | 1999-02-12 | 2001-09-25 | Shin-Etsu Chemical Co., Ltd. | Flip-chip type semiconductor device sealing material and flip-chip type semiconductor device |
| JP2000247884A (ja) | 1999-03-01 | 2000-09-12 | Sumitomo Pharmaceut Co Ltd | アラキドン酸誘発皮膚疾患治療剤 |
| EP1171609B1 (en) | 1999-04-12 | 2008-06-25 | Lexicon Pharmaceuticals, Inc. | Lipoxygenase proteins and polynucleotides encoding the same |
| EP1196558A1 (fr) | 1999-06-08 | 2002-04-17 | Aventis Pasteur | Oligonucleotide immunostimulant |
| US6756382B2 (en) | 1999-06-10 | 2004-06-29 | 3M Innovative Properties Company | Amide substituted imidazoquinolines |
| US6573273B1 (en) | 1999-06-10 | 2003-06-03 | 3M Innovative Properties Company | Urea substituted imidazoquinolines |
| US6331539B1 (en) | 1999-06-10 | 2001-12-18 | 3M Innovative Properties Company | Sulfonamide and sulfamide substituted imidazoquinolines |
| US6541485B1 (en) | 1999-06-10 | 2003-04-01 | 3M Innovative Properties Company | Urea substituted imidazoquinolines |
| US6451810B1 (en) | 1999-06-10 | 2002-09-17 | 3M Innovative Properties Company | Amide substituted imidazoquinolines |
| US6315985B1 (en) | 1999-06-18 | 2001-11-13 | 3M Innovative Properties Company | C-17/21 OH 20-ketosteroid solution aerosol products with enhanced chemical stability |
| ES2233426T3 (es) | 1999-08-13 | 2005-06-16 | Hybridon, Inc. | Modulacion de la estimulacion inmunitaria medida por cpg de oligonucleotido por modificacion de la posicion de los nucleosidos. |
| US6432989B1 (en) | 1999-08-27 | 2002-08-13 | Pfizer Inc | Use of CRF antagonists to treat circadian rhythm disorders |
| EP1666028B1 (en) * | 1999-10-29 | 2010-03-24 | Novartis AG | Dry powder compositions having improved dispersivity |
| CO5271670A1 (es) | 1999-10-29 | 2003-04-30 | Pfizer Prod Inc | Antagonistas del factor de liberacion de corticitropina y composiciones relacionadas |
| US6376669B1 (en) | 1999-11-05 | 2002-04-23 | 3M Innovative Properties Company | Dye labeled imidazoquinoline compounds |
| US6916925B1 (en) | 1999-11-05 | 2005-07-12 | 3M Innovative Properties Co. | Dye labeled imidazoquinoline compounds |
| US6313156B1 (en) | 1999-12-23 | 2001-11-06 | Icos Corporation | Thiazole compounds as cyclic-AMP-specific phosphodiesterase inhibitors |
| DE10001037C1 (de) | 2000-01-13 | 2001-12-13 | Byk Gulden Lomberg Chem Fab | Verfahren und Zwischenprodukte zur Herstellung von Imidazopyridinen |
| US20040023870A1 (en) * | 2000-01-21 | 2004-02-05 | Douglas Dedera | Methods of therapy and diagnosis using targeting of cells that express toll-like receptor proteins |
| GB0001704D0 (en) * | 2000-01-25 | 2000-03-15 | Glaxo Group Ltd | Protein |
| US6692745B2 (en) | 2000-01-28 | 2004-02-17 | Arogenics Pharmaceuticals, Inc. | Compositions and methods for inhibition of HIV-1 infection |
| KR20020073211A (ko) | 2000-02-09 | 2002-09-19 | 호쿠리쿠 세이야쿠 가부시키가이샤 | 1 에이치-이미다조피리딘유도체 |
| WO2001070663A2 (en) | 2000-03-17 | 2001-09-27 | Corixa Corporation | Novel amphipathic aldehydes and their use as adjuvants and immunoeffectors |
| US20010046968A1 (en) | 2000-03-23 | 2001-11-29 | Zagon Ian S. | Opioid growth factor modulates angiogenesis |
| US6894060B2 (en) * | 2000-03-30 | 2005-05-17 | 3M Innovative Properties Company | Method for the treatment of dermal lesions caused by envenomation |
| EP1270578A4 (en) | 2000-03-30 | 2004-11-03 | Shionogi & Co | NOVEL PROCESS FOR PRODUCING MOLTEN IMIDAZOPYRIDINE DERIVATIVE AND NOVEL CRYSTALLINE FORM |
| US20020137101A1 (en) | 2000-05-19 | 2002-09-26 | Meyers Rachel A. | 46638, a novel human lipoxygenase family member and uses thereof |
| DE10020465A1 (de) | 2000-04-26 | 2001-11-08 | Osram Opto Semiconductors Gmbh | Strahlungsemittierendes Halbleiterbauelement mit Lumineszenzkonversionselement |
| DE10029580C1 (de) * | 2000-06-15 | 2002-01-10 | Ferton Holding Sa | Vorrichtung zum Entfernen von Körpersteinen mit einem intrakorporalen Lithotripter |
| AU8054601A (en) | 2000-07-13 | 2002-02-05 | Alteon Inc | Cyanomethyl substituted thiazoliums and imidazoliums and treatments of disordersassociated with protein aging |
| US6387383B1 (en) | 2000-08-03 | 2002-05-14 | Dow Pharmaceutical Sciences | Topical low-viscosity gel composition |
| US6900016B1 (en) | 2000-09-08 | 2005-05-31 | Applera Corporation | Polymorphisms in known genes associated with inflammatory autoimmune disease, methods of detection and uses thereof |
| US20020055517A1 (en) | 2000-09-15 | 2002-05-09 | 3M Innovative Properties Company | Methods for delaying recurrence of herpes virus symptoms |
| WO2002022809A2 (en) | 2000-09-15 | 2002-03-21 | Coley Pharmaceutical Gmbh | PROCESS FOR HIGH THROUGHPUT SCREENING OF CpG-BASED IMMUNO-AGONIST/ANTAGONIST |
| GB0023008D0 (en) | 2000-09-20 | 2000-11-01 | Glaxo Group Ltd | Improvements in vaccination |
| JP2002145777A (ja) | 2000-11-06 | 2002-05-22 | Sumitomo Pharmaceut Co Ltd | アラキドン酸誘発皮膚疾患治療剤 |
| WO2002046479A1 (fr) * | 2000-12-07 | 2002-06-13 | Aoyama Seisakusho Co., Ltd. | Procede de cuisson d'element d'acier |
| US6664264B2 (en) | 2000-12-08 | 2003-12-16 | 3M Innovative Properties Company | Thioether substituted imidazoquinolines |
| US6545017B1 (en) | 2000-12-08 | 2003-04-08 | 3M Innovative Properties Company | Urea substituted imidazopyridines |
| US6660747B2 (en) | 2000-12-08 | 2003-12-09 | 3M Innovative Properties Company | Amido ether substituted imidazoquinolines |
| US20020110840A1 (en) * | 2000-12-08 | 2002-08-15 | 3M Innovative Properties Company | Screening method for identifying compounds that selectively induce interferon alpha |
| US6664265B2 (en) * | 2000-12-08 | 2003-12-16 | 3M Innovative Properties Company | Amido ether substituted imidazoquinolines |
| US6664260B2 (en) * | 2000-12-08 | 2003-12-16 | 3M Innovative Properties Company | Heterocyclic ether substituted imidazoquinolines |
| US6677348B2 (en) * | 2000-12-08 | 2004-01-13 | 3M Innovative Properties Company | Aryl ether substituted imidazoquinolines |
| US6545016B1 (en) | 2000-12-08 | 2003-04-08 | 3M Innovative Properties Company | Amide substituted imidazopyridines |
| US20020107262A1 (en) | 2000-12-08 | 2002-08-08 | 3M Innovative Properties Company | Substituted imidazopyridines |
| US6677347B2 (en) * | 2000-12-08 | 2004-01-13 | 3M Innovative Properties Company | Sulfonamido ether substituted imidazoquinolines |
| UA75622C2 (en) | 2000-12-08 | 2006-05-15 | 3M Innovative Properties Co | Aryl ether substituted imidazoquinolines, pharmaceutical composition based thereon |
| US6525064B1 (en) * | 2000-12-08 | 2003-02-25 | 3M Innovative Properties Company | Sulfonamido substituted imidazopyridines |
| UA74593C2 (en) | 2000-12-08 | 2006-01-16 | 3M Innovative Properties Co | Substituted imidazopyridines |
| US20060142202A1 (en) | 2000-12-08 | 2006-06-29 | 3M Innovative Properties Company | Compositions and methods for targeted delivery of immune response modifiers |
| US6660735B2 (en) | 2000-12-08 | 2003-12-09 | 3M Innovative Properties Company | Urea substituted imidazoquinoline ethers |
| US6667312B2 (en) | 2000-12-08 | 2003-12-23 | 3M Innovative Properties Company | Thioether substituted imidazoquinolines |
| US6464654B1 (en) * | 2001-01-22 | 2002-10-15 | Julia S. Montgomery | Massaging shoe device |
| KR100455713B1 (ko) | 2001-01-29 | 2004-11-06 | 호남석유화학 주식회사 | 올레핀 중합용 다중핵 메탈로센 촉매 및 이를 이용한중합방법 |
| US20020182274A1 (en) * | 2001-03-21 | 2002-12-05 | Kung-Ming Lu | Methods for inhibiting cancer growth, reducing infection and promoting general health with a fermented soy extract |
| DE60228229D1 (de) | 2001-04-17 | 2008-09-25 | Dainippon Sumitomo Pharma Co | Neue adeninderivate |
| ATE463505T1 (de) * | 2001-04-20 | 2010-04-15 | Inst Systems Biology | Toll-ähnlichen-rezeptor-5-liganden und verwendungsverfahren |
| US20020193729A1 (en) | 2001-04-20 | 2002-12-19 | Cormier Michel J.N. | Microprojection array immunization patch and method |
| US6627639B2 (en) | 2001-04-26 | 2003-09-30 | Wyeth | Uses for indoletetrahydropyridine derivatives of 2,3-dihydro-7H-[1,4]dioxino-[2,3-e]indole |
| CN1523987A (zh) | 2001-06-15 | 2004-08-25 | 3M创新有限公司 | 治疗牙周疾病的免疫反应调节剂 |
| US7226928B2 (en) | 2001-06-15 | 2007-06-05 | 3M Innovative Properties Company | Methods for the treatment of periodontal disease |
| US6756399B2 (en) | 2001-06-29 | 2004-06-29 | The United States Of America As Represented By The Department Of Health And Human Services | Use of lipoxygenase inhibitors and PPAR ligands as anti-cancer therapeutic and intervention agents |
| CN1250550C (zh) | 2001-07-16 | 2006-04-12 | 盐野义制药株式会社 | 脒衍生物的制备方法 |
| WO2003009852A1 (en) | 2001-07-24 | 2003-02-06 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| WO2003020889A2 (en) | 2001-08-30 | 2003-03-13 | 3M Innovative Properties Company | Methods of maturing plasmacytoid dendritic cells using immune response modifier molecules |
| WO2003030902A1 (en) | 2001-10-09 | 2003-04-17 | Tularik Inc. | Imidazole derivates as anti-inflammatory agents |
| US20030139364A1 (en) | 2001-10-12 | 2003-07-24 | University Of Iowa Research Foundation | Methods and products for enhancing immune responses using imidazoquinoline compounds |
| EP1719511B1 (en) * | 2001-11-16 | 2008-12-10 | 3M Innovative Properties Company | N-[4-(4-amino-2-ethyl-1H-imidazo[4,5-c]quinolin-1-yl)butyl]methanesulfonamide, a pharmaceutical composition comprising the same and use thereof |
| US20050009858A1 (en) * | 2001-11-17 | 2005-01-13 | Martinez-Colon Maria I | Imiquimod therapies |
| US7622479B2 (en) | 2001-11-26 | 2009-11-24 | Takeda Pharmaceutical Company Limited | Bicyclic derivative, its production and use |
| GEP20074099B (en) | 2001-11-27 | 2007-05-10 | Anadys Pharmaceuticals Inc | 3-β-D-RIBOFURANO-SYLTHIAZOLO[4,5-d]PYRIDIMINE NUCLEOSIDES AND USES THEREOF |
| DK1450804T3 (da) | 2001-11-29 | 2009-01-05 | 3M Innovative Properties Co | Farmaceutiske formulelringer, der omfatter et immunsvarmodificerende middel |
| US6677349B1 (en) * | 2001-12-21 | 2004-01-13 | 3M Innovative Properties Company | Sulfonamide and sulfamide substituted imidazoquinolines |
| US6775514B2 (en) | 2002-01-11 | 2004-08-10 | Xerox Corporation | Substrate size monitoring system for use in copier/printers |
| US6525028B1 (en) * | 2002-02-04 | 2003-02-25 | Corixa Corporation | Immunoeffector compounds |
| US20050281813A1 (en) | 2002-02-14 | 2005-12-22 | Nuvelo, Inc. | Methods of therapy and diagnosis using targeting of cells that express toll-like receptor proteins |
| EP1478327B1 (en) | 2002-02-22 | 2015-04-29 | Meda AB | Method of reducing and treating uvb-induced immunosuppression |
| US20030185835A1 (en) | 2002-03-19 | 2003-10-02 | Braun Ralph P. | Adjuvant for vaccines |
| ATE491471T1 (de) | 2002-03-19 | 2011-01-15 | Powderject Res Ltd | Adjuvantien für dns impstoffe basierend auf imidazochinoline |
| GB0206461D0 (en) | 2002-03-19 | 2002-05-01 | Glaxo Group Ltd | Improvements in vaccination |
| RU2302865C2 (ru) | 2002-04-04 | 2007-07-20 | Коли Фармасьютикал Гмбх | Иммуностимулирующие g, u-содержащие олигорибонуклеотиды |
| GB0207906D0 (en) | 2002-04-05 | 2002-05-15 | 3M Innovative Properties Co | Formoterol and mometasone aerosol formulations |
| AU2003225054A1 (en) | 2002-04-19 | 2003-11-03 | Yale University | Toll-like receptor 11 and toll-like receptor 12 |
| CA2484192C (en) | 2002-04-30 | 2012-10-02 | Unigen Pharmaceuticals, Inc. | Formulation of a mixture of free-b-ring flavonoids and flavans as a therapeutic agent |
| GB0211649D0 (en) | 2002-05-21 | 2002-07-03 | Novartis Ag | Organic compounds |
| WO2003101949A2 (en) | 2002-05-29 | 2003-12-11 | 3M Innovative Properties Company | Process for imidazo[4,5-c]pyridin-4-amines |
| US6797718B2 (en) | 2002-06-07 | 2004-09-28 | 3M Innovative Properties Company | Ether substituted imidazopyridines |
| PT1543002E (pt) * | 2002-07-23 | 2006-11-30 | Teva Gyogyszergyar Zartkoeruen | Preparação de intermediários 1h-imidazo ( 4,5-c )quinolin-4-aminas via 1h- imidazo (4,5-c ) quinolina-4-ftalimida |
| JP2004060458A (ja) * | 2002-07-25 | 2004-02-26 | Denso Corp | 内燃機関用スタータ |
| JP2005537287A (ja) * | 2002-07-26 | 2005-12-08 | テバ ジョジセルジャール レースベニュタールシャシャーグ | 新規１Ｈ−イミダゾ［４，５−ｃ］キノリン−４−シアノ及び１Ｈ−イミダゾ［４，５−ｃ］キノリン−４−カルボキサミド中間体による１Ｈ−イミダゾ［４，５−ｃ］キノリン−４−アミン類の製造 |
| ATE488246T1 (de) | 2002-08-15 | 2010-12-15 | 3M Innovative Properties Co | Immunstimulatorische zusammensetzungen und verfahren zur stimulierung einer immunantwort |
| EP1542688A4 (en) | 2002-09-26 | 2010-06-02 | 3M Innovative Properties Co | 1H-imidazo dimers |
| US7199119B2 (en) | 2002-10-31 | 2007-04-03 | Amgen Inc. | Antiinflammation agents |
| WO2004043913A2 (en) | 2002-11-08 | 2004-05-27 | Trimeris, Inc. | Hetero-substituted benzimidazole compounds and antiviral uses thereof |
| AU2003287316A1 (en) | 2002-12-11 | 2004-06-30 | 3M Innovative Properties Company | Assays relating to toll-like receptor activity |
| AU2003287324A1 (en) | 2002-12-11 | 2004-06-30 | 3M Innovative Properties Company | Gene expression systems and recombinant cell lines |
| US7091214B2 (en) | 2002-12-20 | 2006-08-15 | 3M Innovative Properties Co. | Aryl substituted Imidazoquinolines |
| EP1578419A4 (en) | 2002-12-30 | 2008-11-12 | 3M Innovative Properties Co | IMMUNOSTIMULATING COMBINATIONS |
| US7375180B2 (en) | 2003-02-13 | 2008-05-20 | 3M Innovative Properties Company | Methods and compositions related to IRM compounds and Toll-like receptor 8 |
| EP1599726A4 (en) * | 2003-02-27 | 2009-07-22 | 3M Innovative Properties Co | SELECTIVE MODULATION OF TLR-MEDIATED BIOLOGICAL ACTIVITY |
| WO2004078138A2 (en) | 2003-03-04 | 2004-09-16 | 3M Innovative Properties Company | Prophylactic treatment of uv-induced epidermal neoplasia |
| US20040176367A1 (en) | 2003-03-07 | 2004-09-09 | 3M Innovative Properties Company | 1-Amino 1H-imidazoquinolines |
| US7163947B2 (en) * | 2003-03-07 | 2007-01-16 | 3M Innovative Properties Company | 1-Amino 1H-imidazoquinolines |
| AU2004220466A1 (en) | 2003-03-13 | 2004-09-23 | 3M Innovative Properties Company | Methods for diagnosing skin lesions |
| BRPI0408476A (pt) | 2003-03-13 | 2006-04-04 | 3M Innovative Properties Co | métodos para melhorar a qualidade da pele |
| US7179253B2 (en) * | 2003-03-13 | 2007-02-20 | 3M Innovative Properties Company | Method of tattoo removal |
| US20040192585A1 (en) | 2003-03-25 | 2004-09-30 | 3M Innovative Properties Company | Treatment for basal cell carcinoma |
| EP1613956A2 (en) | 2003-03-25 | 2006-01-11 | 3M Innovative Properties Company | Selective activation of cellular activities mediated through a common toll-like receptor |
| US7893096B2 (en) | 2003-03-28 | 2011-02-22 | Novartis Vaccines And Diagnostics, Inc. | Use of small molecule compounds for immunopotentiation |
| WO2004108072A2 (en) | 2003-04-10 | 2004-12-16 | 3M Innovative Properties Company | Delivery of immune response modifier compounds using metal-containing particulate support materials |
| US20040265351A1 (en) | 2003-04-10 | 2004-12-30 | Miller Richard L. | Methods and compositions for enhancing immune response |
| US20040214851A1 (en) | 2003-04-28 | 2004-10-28 | 3M Innovative Properties Company | Compositions and methods for induction of opioid receptors |
| US7731967B2 (en) | 2003-04-30 | 2010-06-08 | Novartis Vaccines And Diagnostics, Inc. | Compositions for inducing immune responses |
| US20050032829A1 (en) * | 2003-06-06 | 2005-02-10 | 3M Innovative Properties Company | Process for imidazo[4,5-c]pyridin-4-amines |
| US6943255B2 (en) | 2003-06-06 | 2005-09-13 | 3M Innovative Properties Company | Process for imidazo[4,5-c]pyridin-4-amines |
| EA200600069A1 (ru) | 2003-06-20 | 2006-08-25 | Коли Фармасьютикал Гмбх | Низкомолекулярные антагонисты toll-подобных рецепторов (tlr) |
| MY157827A (en) | 2003-06-27 | 2016-07-29 | 3M Innovative Properties Co | Sulfonamide substituted imidazoquinolines |
| US20050106300A1 (en) | 2003-06-30 | 2005-05-19 | Purdue Research Foundation | Method for producing a material having an increased solubility in alcohol |
| BRPI0413143A (pt) | 2003-07-31 | 2006-10-03 | 3M Innovative Properties Co | composições para encapsulação e liberação controlada |
| US20050070460A1 (en) * | 2003-08-05 | 2005-03-31 | 3M Innovative Properties Company | Infection prophylaxis using immune response modifier compounds |
| AU2004266658A1 (en) * | 2003-08-12 | 2005-03-03 | 3M Innovative Properties Company | Hydroxylamine substituted imidazo-containing compounds |
| PL1653959T3 (pl) | 2003-08-14 | 2015-10-30 | 3M Innovative Properties Co | Modyfikatory odpowiedzi immunologicznej modyfikowane lipidami |
| JP2007503268A (ja) | 2003-08-25 | 2007-02-22 | スリーエム イノベイティブ プロパティズ カンパニー | 免疫応答修飾化合物の送達 |
| AU2004266162A1 (en) * | 2003-08-25 | 2005-03-03 | 3M Innovative Properties Company | Immunostimulatory combinations and treatments |
| US7897597B2 (en) | 2003-08-27 | 2011-03-01 | 3M Innovative Properties Company | Aryloxy and arylalkyleneoxy substituted imidazoquinolines |
| AU2004268665A1 (en) | 2003-09-02 | 2005-03-10 | 3M Innovative Properties Company | Methods related to the treatment of mucosal associated conditions |
| WO2005025583A2 (en) * | 2003-09-05 | 2005-03-24 | Anadys Pharmaceuticals, Inc. | Tlr7 ligands for the treatment of hepatitis c |
| JP2007504269A (ja) * | 2003-09-05 | 2007-03-01 | スリーエム イノベイティブ プロパティズ カンパニー | Ｃｄ５＋ｂ細胞リンパ腫の治療方法 |
| GB0321615D0 (en) | 2003-09-15 | 2003-10-15 | Glaxo Group Ltd | Improvements in vaccination |
| WO2005029037A2 (en) | 2003-09-17 | 2005-03-31 | 3M Innovative Properties Company | Selective modulation of tlr gene expression |
| US7687628B2 (en) | 2003-10-01 | 2010-03-30 | Taro Pharmaceuticals U.S.A., Inc. | Method of preparing 4-amino-1H-imidazo(4,5-c)quinolines and acid addition salts thereof |
| US20090075980A1 (en) * | 2003-10-03 | 2009-03-19 | Coley Pharmaceutical Group, Inc. | Pyrazolopyridines and Analogs Thereof |
| US7544697B2 (en) | 2003-10-03 | 2009-06-09 | Coley Pharmaceutical Group, Inc. | Pyrazolopyridines and analogs thereof |
| US8871782B2 (en) * | 2003-10-03 | 2014-10-28 | 3M Innovative Properties Company | Alkoxy substituted imidazoquinolines |
| AU2004315876B2 (en) | 2003-10-03 | 2011-05-26 | 3M Innovative Properties Company | Pyrazolopyridines and analogs thereof |
| US20050239733A1 (en) | 2003-10-31 | 2005-10-27 | Coley Pharmaceutical Gmbh | Sequence requirements for inhibitory oligonucleotides |
| WO2005041891A2 (en) | 2003-10-31 | 2005-05-12 | 3M Innovative Properties Company | Neutrophil activation by immune response modifier compounds |
| ITMI20032121A1 (it) | 2003-11-04 | 2005-05-05 | Dinamite Dipharma Spa In Forma Abbr Eviata Dipharm | Procedimento per la preparazione di imiquimod e suoi intermedi |
| AU2004291101A1 (en) * | 2003-11-14 | 2005-06-02 | 3M Innovative Properties Company | Oxime substituted imidazo ring compounds |
| EP1682544A4 (en) | 2003-11-14 | 2009-05-06 | 3M Innovative Properties Co | HYDROXYLAMINE SUBSTITUTED IMIDAZO RING COMPOUNDS |
| CU23404A1 (es) | 2003-11-19 | 2009-08-04 | Ct Ingenieria Genetica Biotech | Polisacáridos capsulares de neisseria meningitidis como inmunopotenciadores mucosales y formulaciones resultantes |
| AR046845A1 (es) | 2003-11-21 | 2005-12-28 | Novartis Ag | Derivados de 1h-imidazo[4,5-c]quinolina para tratamiento de enfermedades dependientes de las proteino-quinasas |
| KR20060117329A (ko) | 2003-11-21 | 2006-11-16 | 노파르티스 아게 | 단백질 키나제 저해제로서의 1ｈ-이미다조퀴놀린 유도체 |
| WO2005051324A2 (en) * | 2003-11-25 | 2005-06-09 | 3M Innovative Properties Company | Hydroxylamine and oxime substituted imidazoquinolines, imidazopyridines, and imidazonaphthyridines |
| AU2004293078B2 (en) | 2003-11-25 | 2012-01-19 | 3M Innovative Properties Company | Substituted imidazo ring systems and methods |
| US20050226878A1 (en) | 2003-12-02 | 2005-10-13 | 3M Innovative Properties Company | Therapeutic combinations and methods including IRM compounds |
| EP1689361A4 (en) | 2003-12-02 | 2009-06-17 | 3M Innovative Properties Co | THERAPEUTIC COMBINATIONS AND PROCESSES WITH IRM COMPOUNDS |
| JP2007513170A (ja) | 2003-12-04 | 2007-05-24 | スリーエム イノベイティブ プロパティズ カンパニー | スルホン置換イミダゾ環エーテル |
| EP1701955A1 (en) | 2003-12-29 | 2006-09-20 | 3M Innovative Properties Company | Arylalkenyl and arylalkynyl substituted imidazoquinolines |
| CA2552101A1 (en) | 2003-12-29 | 2005-07-21 | 3M Innovative Properties Company | Piperazine, [1,4]diazepane, [1,4]diazocane, and [1,5]diazocane fused imidazo ring compounds |
| WO2005065678A1 (en) | 2003-12-30 | 2005-07-21 | 3M Innovative Properties Company | Immunomodulatory combinations |
| EP1699398A4 (en) | 2003-12-30 | 2007-10-17 | 3M Innovative Properties Co | IMPROVING THE IMMUNE RESPONSE |
| EP1699788A2 (en) | 2003-12-30 | 2006-09-13 | 3M Innovative Properties Company | Imidazoquinolinyl, imidazopyridinyl and imidazonaphthyridinyl sulfonamides |
| US20070167479A1 (en) | 2004-03-15 | 2007-07-19 | Busch Terri F | Immune response modifier formulations and methods |
| EP1730143A2 (en) | 2004-03-24 | 2006-12-13 | 3M Innovative Properties Company | Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines |
| WO2005110013A2 (en) | 2004-04-09 | 2005-11-24 | 3M Innovative Properties Company | Methods, compositions, and preparations for delivery of immune response modifiers |
| EP1755665A4 (en) | 2004-04-28 | 2010-03-03 | 3M Innovative Properties Co | COMPOSITIONS AND METHODS FOR MUCOSAL VACCINATION |
| US20050267145A1 (en) | 2004-05-28 | 2005-12-01 | Merrill Bryon A | Treatment for lung cancer |
| US20080015184A1 (en) * | 2004-06-14 | 2008-01-17 | 3M Innovative Properties Company | Urea Substituted Imidazopyridines, Imidazoquinolines, and Imidazonaphthyridines |
| US8017779B2 (en) | 2004-06-15 | 2011-09-13 | 3M Innovative Properties Company | Nitrogen containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines |
| WO2006065280A2 (en) | 2004-06-18 | 2006-06-22 | 3M Innovative Properties Company | Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and methods |
| US8026366B2 (en) | 2004-06-18 | 2011-09-27 | 3M Innovative Properties Company | Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines |
| EP1765348B1 (en) | 2004-06-18 | 2016-08-03 | 3M Innovative Properties Company | Substituted imidazoquinolines, imidazopyridines, and imidazonaphthyridines |
| WO2006009832A1 (en) | 2004-06-18 | 2006-01-26 | 3M Innovative Properties Company | Substituted imidazo ring systems and methods |
| WO2006093514A2 (en) | 2004-06-18 | 2006-09-08 | 3M Innovative Properties Company | Aryl and arylalkylenyl substituted thiazoloquinolines and thiazolonaphthyridines |
| US7897609B2 (en) | 2004-06-18 | 2011-03-01 | 3M Innovative Properties Company | Aryl substituted imidazonaphthyridines |
| US20060045885A1 (en) | 2004-08-27 | 2006-03-02 | Kedl Ross M | Method of eliciting an immune response against HIV |
| WO2006026470A2 (en) | 2004-08-27 | 2006-03-09 | 3M Innovative Properties Company | Hiv immunostimulatory compositions |
| WO2006026760A2 (en) | 2004-09-02 | 2006-03-09 | 3M Innovative Properties Company | 1-amino imidazo-containing compounds and methods |
| WO2006028962A2 (en) | 2004-09-02 | 2006-03-16 | 3M Innovative Properties Company | 1-alkoxy 1h-imidazo ring systems and methods |
| CA2578975A1 (en) | 2004-09-02 | 2006-03-16 | 3M Innovative Properties Company | 2-amino 1h imidazo ring systems and methods |
| WO2006028451A1 (en) | 2004-09-03 | 2006-03-16 | 3M Innovative Properties Company | 1-amino 1-h-imidazoquinolines |
| US20080193468A1 (en) | 2004-09-08 | 2008-08-14 | Children's Medical Center Corporation | Method for Stimulating the Immune Response of Newborns |
| CN101056877B (zh) | 2004-09-14 | 2010-06-09 | 诺华疫苗和诊断公司 | 咪唑并喹啉化合物 |
| US20070243215A1 (en) | 2004-10-08 | 2007-10-18 | Miller Richard L | Adjuvant for Dna Vaccines |
| JP2008523084A (ja) | 2004-12-08 | 2008-07-03 | スリーエム イノベイティブ プロパティズ カンパニー | 免疫賦活用合剤および方法 |
| WO2006063072A2 (en) | 2004-12-08 | 2006-06-15 | 3M Innovative Properties Company | Immunomodulatory compositions, combinations and methods |
| US8080560B2 (en) | 2004-12-17 | 2011-12-20 | 3M Innovative Properties Company | Immune response modifier formulations containing oleic acid and methods |
| ZA200706251B (en) | 2004-12-30 | 2008-11-26 | Coley Pharm Group Inc | Immune response modifier formulations and methods |
| US8436176B2 (en) | 2004-12-30 | 2013-05-07 | Medicis Pharmaceutical Corporation | Process for preparing 2-methyl-1-(2-methylpropyl)-1H-imidazo[4,5-c][1,5]naphthyridin-4-amine |
| US8034938B2 (en) | 2004-12-30 | 2011-10-11 | 3M Innovative Properties Company | Substituted chiral fused [1,2]imidazo[4,5-c] ring compounds |
| SI1830876T1 (sl) | 2004-12-30 | 2015-08-31 | Meda Ab | Uporaba imikvimoda za zdravljenje kožnih metastaz, ki izhajajo iz rakavega tumorja dojke |
| US20080188513A1 (en) | 2004-12-30 | 2008-08-07 | Taked Pharmaceutical Company Limited | 1-(2-Methylpropyl)-1H-Imidazo[4,5-C](1,5]Naphthyridin-4-Amine Ethanesulfonate and 1-(2-Methylpropyl)-1H-Imidazo[4,5-C](1,5]Naphthyridin-4-Amine Methanesulfonate |
| AU2005322898B2 (en) | 2004-12-30 | 2011-11-24 | 3M Innovative Properties Company | Chiral fused (1,2)imidazo(4,5-c) ring compounds |
| CN101160518B (zh) | 2005-02-02 | 2010-08-04 | 膜康公司 | 探测和报告气密包装中泄漏大小的仪器和方法 |
| WO2006084251A2 (en) | 2005-02-04 | 2006-08-10 | Coley Pharmaceutical Group, Inc. | Aqueous gel formulations containing immune reponse modifiers |
| CA2597324C (en) | 2005-02-09 | 2015-06-30 | Coley Pharmaceutical Group, Inc. | Alkyloxy substituted thiazoloquinolines and thiazolonaphthyridines |
| EP1877056A2 (en) | 2005-02-09 | 2008-01-16 | Coley Pharmaceutical Group, Inc. | Oxime and hydroxylamine substituted thiazoloý4,5-c¨ring compounds and methods |
| EP1845988A2 (en) | 2005-02-11 | 2007-10-24 | 3M Innovative Properties Company | Substituted imidazoquinolines and imidazonaphthyridines |
| AU2006213746A1 (en) | 2005-02-11 | 2006-08-17 | Coley Pharmaceutical Group, Inc. | Oxime and hydroxylamine substituted imidazo(4,5-c) ring compounds and methods |
| CA2597595A1 (en) * | 2005-02-11 | 2006-08-17 | Coley Pharmaceutical Group, Inc. | Substituted fused [1,2]imidazo[4,5-c] ring compounds and methods |
| JP2008531567A (ja) | 2005-02-23 | 2008-08-14 | コーリー ファーマシューティカル グループ，インコーポレイテッド | ヒドロキシアルキル置換イミダゾキノリン化合物および方法 |
| EP1851220A2 (en) | 2005-02-23 | 2007-11-07 | 3M Innovative Properties Company | Hydroxyalkyl substituted imidazonaphthyridines |
| WO2006091647A2 (en) | 2005-02-23 | 2006-08-31 | Coley Pharmaceutical Group, Inc. | Method of preferentially inducing the biosynthesis of interferon |
| EP1851224A2 (en) | 2005-02-23 | 2007-11-07 | 3M Innovative Properties Company | Hydroxyalkyl substituted imidazoquinolines |
| WO2006099275A2 (en) | 2005-03-14 | 2006-09-21 | 3M Innovative Properties Company | Method of treating actinic keratosis |
| WO2006107771A2 (en) | 2005-04-01 | 2006-10-12 | Coley Pharmaceutical Group, Inc. | PYRAZOLO[3,4-c]QUINOLINES, PYRAZOLO[3,4-c]NAPHTHYRIDINES, ANALOGS THEREOF, AND METHODS |
| CA2602683A1 (en) | 2005-04-01 | 2006-10-12 | Coley Pharmaceutical Group, Inc. | Pyrazolopyridine-1,4-diamines and analogs thereof |
| AU2006232375A1 (en) | 2005-04-01 | 2006-10-12 | Coley Pharmaceutical Group, Inc. | 1-substituted pyrazolo (3,4-c) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases |
| AU2006244635A1 (en) | 2005-04-01 | 2006-11-16 | Coley Pharmaceutical Group, Inc. | Ring closing and related methods and intermediates |
| EP1874345B1 (en) | 2005-04-25 | 2012-08-15 | 3M Innovative Properties Company | Immunostimulatory compositions |
| GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
| CN101253173A (zh) | 2005-09-02 | 2008-08-27 | 辉瑞有限公司 | 羟基取代的1h-咪唑并吡啶和方法 |
| AU2006287270A1 (en) | 2005-09-09 | 2007-03-15 | Coley Pharmaceutical Group, Inc. | Amide and carbamate derivatives of N-{2-[4-amino-2- (ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-1,1-dimethylethyl}methanesulfonamide and methods |
| ZA200803029B (en) | 2005-09-09 | 2009-02-25 | Coley Pharm Group Inc | Amide and carbamate derivatives of alkyl substituted /V-[4-(4-amino-1H-imidazo[4,5-c] quinolin-1-yl)butyl] methane-sulfonamides and methods |
| US8889154B2 (en) | 2005-09-15 | 2014-11-18 | Medicis Pharmaceutical Corporation | Packaging for 1-(2-methylpropyl)-1H-imidazo[4,5-c] quinolin-4-amine-containing formulation |
| WO2007035935A1 (en) | 2005-09-23 | 2007-03-29 | Coley Pharmaceutical Group, Inc. | METHOD FOR 1H-IMIDAZO[4,5-c]PYRIDINES AND ANALOGS THEREOF |
| EP1948173B1 (en) | 2005-11-04 | 2013-07-17 | 3M Innovative Properties Company | Hydroxy and alkoxy substituted 1h-imidazoquinolines and methods |
| WO2007062043A1 (en) | 2005-11-23 | 2007-05-31 | Coley Pharmaceutical Group Inc. | Method of activating murine toll-like receptor 8 |
| MX2008007864A (es) | 2005-12-16 | 2009-03-04 | Coley Pharm Group Inc | Imidazoquinolinas, imidazonaftiridinas, e imidazopiridinas sustituidas, composiciones y metodos. |
| WO2007079171A2 (en) | 2005-12-28 | 2007-07-12 | Coley Pharmaceutical Group, Inc. | Treatment for hodgkin's lymphoma |
| WO2007079202A2 (en) | 2005-12-28 | 2007-07-12 | Coley Pharmaceutical Group, Inc. | Treatment for acute lymhoblastic leukemia |
| WO2007079169A2 (en) | 2005-12-28 | 2007-07-12 | Coley Pharmaceutical Group, Inc. | Treatment for acute myeloid leukemia |
| WO2007079086A1 (en) | 2005-12-28 | 2007-07-12 | Coley Pharmaceutical Group, Inc. | Pyrazoloalkyl substituted imidazo ring compounds and methods |
| WO2007079146A1 (en) | 2005-12-28 | 2007-07-12 | Coley Pharmaceutical Group, Inc | Treatment for non-hodgkin's lymphoma |
| JP2009522296A (ja) | 2005-12-28 | 2009-06-11 | スリーエム イノベイティブ プロパティズ カンパニー | 皮膚のｔ細胞リンパ腫の治療 |
| US20090306388A1 (en) | 2006-02-10 | 2009-12-10 | Pfizer Inc. | Method for substituted ih-imidazo[4,5-c] pyridines |
| US8951528B2 (en) | 2006-02-22 | 2015-02-10 | 3M Innovative Properties Company | Immune response modifier conjugates |
| WO2007106854A2 (en) | 2006-03-15 | 2007-09-20 | Coley Pharmaceutical Group, Inc. | Hydroxy and alkoxy substituted 1h-imidazonaphthyridines and methods |
| WO2007106852A2 (en) | 2006-03-15 | 2007-09-20 | Coley Pharmaceutical Group, Inc. | Substituted fused[1,2]imidazo[4,5-c] ring compounds and methods |
| WO2007143526A2 (en) | 2006-06-05 | 2007-12-13 | Coley Pharmaceutical Group, Inc. | Substituted tetrahydroimidazonaphthyridines and methods |
| WO2007149802A2 (en) | 2006-06-19 | 2007-12-27 | 3M Innovative Properties Company | Formulation for delivery of immune response modifiers |
| WO2008008432A2 (en) | 2006-07-12 | 2008-01-17 | Coley Pharmaceutical Group, Inc. | Substituted chiral fused( 1,2) imidazo (4,5-c) ring compounds and methods |
| WO2008016475A2 (en) | 2006-07-31 | 2008-02-07 | 3M Innovative Properties Company | Immune response modifier compositions and methods |
| US8178539B2 (en) | 2006-09-06 | 2012-05-15 | 3M Innovative Properties Company | Substituted 3,4,6,7-tetrahydro-5H-1,2a,4a,8-tetraazacyclopenta[cd]phenalenes and methods |
| WO2008036312A1 (en) | 2006-09-19 | 2008-03-27 | Coley Pharmaceutical Group, Inc. | Fungicidal methods using immune response modifier compounds |
| WO2008045543A1 (en) | 2006-10-13 | 2008-04-17 | Coley Pharmaceutical Group, Inc. | Substituted 4h-imidazo [4, 5, 1-ij] [1, 6] naphthyridine-9-amines and their pharmaceutical use |
| US20080149123A1 (en) | 2006-12-22 | 2008-06-26 | Mckay William D | Particulate material dispensing hairbrush with combination bristles |
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Also Published As
| Publication number | Publication date |
|---|---|
| KR20060125818A (ko) | 2006-12-06 |
| KR101130928B1 (ko) | 2012-04-12 |
| JP2007512370A (ja) | 2007-05-17 |
| AU2004293078A1 (en) | 2005-06-09 |
| US9328110B2 (en) | 2016-05-03 |
| EP1687307A2 (en) | 2006-08-09 |
| CA2547020C (en) | 2014-03-25 |
| WO2005051317A2 (en) | 2005-06-09 |
| BRPI0416936A (pt) | 2007-01-16 |
| US8691837B2 (en) | 2014-04-08 |
| CA2547020A1 (en) | 2005-06-09 |
| US20070072893A1 (en) | 2007-03-29 |
| IL175915A0 (en) | 2006-10-05 |
| IL218494A0 (en) | 2012-04-30 |
| NZ547467A (en) | 2010-06-25 |
| MXPA06005910A (es) | 2006-08-23 |
| AR046781A1 (es) | 2005-12-21 |
| JP2012006976A (ja) | 2012-01-12 |
| EP1687307B1 (en) | 2016-01-06 |
| RU2409576C2 (ru) | 2011-01-20 |
| US20140194628A1 (en) | 2014-07-10 |
| JP4891088B2 (ja) | 2012-03-07 |
| SG148201A1 (en) | 2008-12-31 |
| US20160194322A1 (en) | 2016-07-07 |
| WO2005051317A3 (en) | 2006-05-11 |
| AU2004293078B2 (en) | 2012-01-19 |
| EP1687307A4 (en) | 2009-06-17 |
| US9765071B2 (en) | 2017-09-19 |
| MY161812A (en) | 2017-05-15 |
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