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PE20000432A1 - Compuestos triciclicos sustituidos - Google Patents

Compuestos triciclicos sustituidos

Info

Publication number
PE20000432A1
PE20000432A1 PE1999000314A PE00031499A PE20000432A1 PE 20000432 A1 PE20000432 A1 PE 20000432A1 PE 1999000314 A PE1999000314 A PE 1999000314A PE 00031499 A PE00031499 A PE 00031499A PE 20000432 A1 PE20000432 A1 PE 20000432A1
Authority
PE
Peru
Prior art keywords
carbamoylcarbazol
methyl
acid
oxyacetic
oxyacetic acid
Prior art date
Application number
PE1999000314A
Other languages
English (en)
Inventor
Alan Hite Gary
David Mihelich Edward
Anne Bastian Jolie
James Bach Nicholas
Jon Sall Daniel
Theodore Vasileff Robert
Dean Kinnick Michael
Michael Morin Junior John
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PE20000432A1 publication Critical patent/PE20000432A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A COMPUESTOS TRICICLICOS DERIVADOS DE CARBAZOL TALES COMO: ACIDO {9-[(FENIL)METIL]-5-CARBAMOILCARBAZOL-4-IL}OXIACETICO; ACIDO [9-BENCIL-5-CARBAMOIL-1-FLUOROCARBAZOL-4-IL]OXIACETICO; ACIDO {9-[(3-FLUOROFENIL)METIL]-5-CARBAMOILCARBAZOL-4-IL}OXIACETICO; ACIDO {9-[(3-CLOROFENIL)METIL]-5-CARBAMOILCARBAZOL-4-IL}OXIACETICO; SAL SODICA DEL ACIDO {9-[(3-TRIFLUOROMETILFENIL)METIL]-5-CARBAMOILCARBAZOL-4-IL}OXIACETICO; SAL SODICA DEL ACIDO {9-[(2-METILFENIL)METIL]-5-CARBAMOILCARBAZOL-4-IL}OXIACETICO, SAL SODICA DEL ACIDO {9-[(3-METILFENIL)METIL]-5-CARBAMOILCARBAZOL-4-IL}OXIACETICO, SAL SODICA DEL ACIDO {9-[(3-TRIFLUOROMETOXIFENIL)METIL]-5-CARBAMOILCARBAZOL-4-IL}OXIACETICO, ACIDO [9-BENCIL-5-CARBAMOIL-1-CLOROCARBAZOL-4-IL]OXIACETICO, ACIDO [9-[(CICLOHEXIL)METIL]-5-CARBAMOILCARBAZOL-4-IL]OXIACETICO, ACIDO [9-[(CICLOPENTIL)METIL]-5-CARBAMOILCARBAZOL-4-IL]OXIACETICO; LOS QUE INHIBEN LA LIBERACION DE ACIDOS GRASOS INDUCIDA POR FOSFOLIPASA A2 SECRETORA NO PANCREATICA HUMANA (sPLA2) INHIBIENDO ASI LA CASCADA DE ACIDO ARAQUIDONICO POR LO QUE PUEDEN SER UTILES PARA EL TRATAMIENTO DE SEPTICEMIA, CHOQUE SEPTICO, ARTRITIS REUMATOIDE, OSTEOARTRITIS, APOPLEJIA, APOPTOSIS, ASMA, BRONQUITIS CRONICA, BRONQUITIS AGUDA, FIBROSIS QUISTICA, ENFERMEDAD INFLAMATORIA DEL INTESTINO
PE1999000314A 1998-04-17 1999-04-16 Compuestos triciclicos sustituidos PE20000432A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6232898A 1998-04-17 1998-04-17

Publications (1)

Publication Number Publication Date
PE20000432A1 true PE20000432A1 (es) 2000-05-23

Family

ID=22041763

Family Applications (2)

Application Number Title Priority Date Filing Date
PE1999000320A PE20000476A1 (es) 1998-04-17 1999-04-16 Compuestos triciclicos sustituidos
PE1999000314A PE20000432A1 (es) 1998-04-17 1999-04-16 Compuestos triciclicos sustituidos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PE1999000320A PE20000476A1 (es) 1998-04-17 1999-04-16 Compuestos triciclicos sustituidos

Country Status (30)

Country Link
EP (2) EP0952149B1 (es)
JP (2) JPH11322713A (es)
KR (2) KR19990083232A (es)
CN (1) CN1149193C (es)
AR (2) AR018186A1 (es)
AT (2) ATE271037T1 (es)
AU (2) AU753547B2 (es)
BR (2) BR9902365A (es)
CA (2) CA2269246C (es)
CO (2) CO5011054A1 (es)
CZ (2) CZ137099A3 (es)
DE (2) DE69918590T2 (es)
DK (1) DK0950657T3 (es)
DZ (1) DZ2769A1 (es)
EA (2) EA002816B1 (es)
ES (2) ES2226286T3 (es)
HU (2) HUP9901221A3 (es)
ID (2) ID23761A (es)
IL (2) IL129485A0 (es)
NO (2) NO314400B1 (es)
NZ (3) NZ507564A (es)
PE (2) PE20000476A1 (es)
PL (2) PL332566A1 (es)
PT (1) PT950657E (es)
SG (2) SG81977A1 (es)
SI (1) SI0950657T1 (es)
TR (2) TR199900843A2 (es)
TW (1) TWI238160B (es)
YU (2) YU18999A (es)
ZA (2) ZA992772B (es)

Families Citing this family (27)

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Publication number Priority date Publication date Assignee Title
AU9123198A (en) * 1997-08-28 1999-03-16 Eli Lilly And Company Method for treatment of non-rheumatoid athritis
DZ2769A1 (fr) * 1998-04-17 2003-12-01 Lilly Co Eli Composés tricycliques substitués.
WO2000037022A2 (en) * 1998-12-21 2000-06-29 Eli Lilly And Company Combination therapy for the treatment of sepsis
US6706752B1 (en) 1999-07-19 2004-03-16 Eli Lilly And Company sPLA2 inhibitors
DE60032774D1 (de) * 1999-07-19 2007-02-15 Lilly Co Eli Spla2 inhibitoren
WO2002000257A1 (en) * 2000-06-29 2002-01-03 Shionogi & Co., Ltd. Remedies for alzheimer's disease
ES2294003T3 (es) * 2000-06-29 2008-04-01 Anthera Pharmaceuticals, Inc. Remedios contra el cancer.
WO2002000256A1 (fr) * 2000-06-29 2002-01-03 Shionogi & Co., Ltd. Remedes contre la cirrhose
CN1450893A (zh) * 2000-07-14 2003-10-22 伊莱利利公司 治疗脓毒症的方法
WO2002050034A2 (en) * 2000-12-18 2002-06-27 Eli Lilly And Company Tetracyclic carbazole derivates and their use as spla2 inhibitors
ATE353876T1 (de) * 2001-03-28 2007-03-15 Lilly Co Eli Substituierte carbazole als inhibitoren von spla2
AUPS282602A0 (en) 2002-06-07 2002-06-27 Garvan Institute Of Medical Research Method of inhibiting cell proliferation
DE10249055A1 (de) 2002-10-22 2004-05-06 Bayer Cropscience Ag 2-Phenyl-2-substituierte-1,3-diketone
JO3598B1 (ar) 2006-10-10 2020-07-05 Infinity Discovery Inc الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
EP1988098A1 (en) * 2007-04-27 2008-11-05 AEterna Zentaris GmbH Novel Tetrahydrocarbazole Derivatives as Ligands of G-protein Coupled Receptors
CN101981012A (zh) 2008-03-26 2011-02-23 第一三共株式会社 新的四氢异喹啉衍生物
CA2721060A1 (en) 2008-04-09 2009-10-15 Infinity Pharmaceuticals, Inc. Inhibitors of fatty acid amide hydrolase
US8580795B2 (en) 2009-01-22 2013-11-12 Orchid Chemicals & Pharmaceuticals Limited Heterocyclic compounds as phosphodiesterase inhibitors
JP2012523425A (ja) 2009-04-07 2012-10-04 インフイニトイ プハルマセウトイカルス インコーポレイテッド 脂肪酸アミドヒドロラーゼの阻害薬
JP2012523424A (ja) 2009-04-07 2012-10-04 インフイニトイ プハルマセウトイカルス インコーポレイテッド 脂肪酸アミドヒドロラーゼの阻害薬
RU2569061C2 (ru) 2010-02-03 2015-11-20 Инфинити Фармасьютикалз, Инк. Ингибиторы амид-гидролазы жирных кислот
AR088377A1 (es) 2011-10-20 2014-05-28 Siena Biotech Spa Proceso para la preparacion de 6-cloro-2,3,4,9-tetrahidro-1h-carbazol-1-carboxamida y compuestos intermedios de esta
CN102816107B (zh) * 2012-08-20 2015-06-03 东南大学 咔唑衍生物及其制备方法与用途
MX2015006871A (es) 2012-11-30 2015-09-16 Ge Healthcare Ltd Proceso de cristalizacion de derivados de indoles triciclicos.
WO2014083163A1 (en) * 2012-11-30 2014-06-05 Ge Healthcare Limited Zinc halide mediated cyclization process leading to tricyclic indoles
WO2016116527A1 (de) * 2015-01-20 2016-07-28 Cynora Gmbh Organische moleküle, insbesondere zur verwendung in optoelektronischen bauelementen
CN108707104A (zh) * 2018-08-07 2018-10-26 北京恒信卓元科技有限公司 2-氯-1h-咔唑-1,4(9h)-二酮的合成方法

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US3579534A (en) * 1969-05-09 1971-05-18 American Cyanamid Co Tetrahydrocarbazolecarboxylates
US3979391A (en) * 1972-11-22 1976-09-07 Sterling Drug Inc. 1,2,3,4-Tetrahydrocarbazoles
US3939177A (en) * 1972-11-22 1976-02-17 Sterling Drug Inc. 4-Aminomethyl-9-benzyl-1,2,3,4-tetrahydrocarbazoles
US5420289A (en) * 1989-10-27 1995-05-30 American Home Products Corporation Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase
PT95692A (pt) * 1989-10-27 1991-09-13 American Home Prod Processo para a preparacao de derivados de acidos indole-,indeno-,piranoindole- e tetra-hidrocarbazole-alcanoicos, ou quais sao uteis como inibidores de pla2 e da lipoxigenase
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IL109311A0 (en) * 1993-04-16 1994-07-31 Lilly Co Eli 1H-indole-3-acetamide sPla2 inhibitors
IL109309A (en) * 1993-04-16 2000-06-29 Lilly Co Eli 1-H-indole-3-acetic acid hydrazide SPLA2 inhibitors and pharmaceutical compositions containing them
ES2151993T3 (es) * 1995-06-23 2001-01-16 Lilly Co Eli 1,2,3,4-tetrahidro-9h-carbazoles 6-sustituidos y 10h-ciclohepta(7,6-b)indoles 7-sustituidos.
AU1289797A (en) * 1995-12-13 1997-07-03 Eli Lilly And Company Naphthyl acetamides as spla2 inhibitors
AU734096B2 (en) * 1996-10-30 2001-06-07 Eli Lilly And Company Substituted tricyclics
JP2001517707A (ja) * 1997-09-26 2001-10-09 イーライ・リリー・アンド・カンパニー 嚢胞性繊維症の処置方法
EP1043991A4 (en) * 1997-11-14 2005-02-02 Lilly Co Eli TREATMENT OF ALZHEIMER DISEASE
DZ2769A1 (fr) * 1998-04-17 2003-12-01 Lilly Co Eli Composés tricycliques substitués.

Also Published As

Publication number Publication date
CA2269262A1 (en) 1999-10-17
CZ137099A3 (cs) 1999-11-17
CN1253948A (zh) 2000-05-24
YU18999A (sh) 2002-08-12
NO314400B1 (no) 2003-03-17
NO312240B1 (no) 2002-04-15
ZA992771B (en) 2002-04-18
NO991822L (no) 1999-10-18
HUP9901221A3 (en) 2001-11-28
EP0952149A3 (en) 2001-08-16
DK0950657T3 (da) 2004-11-22
DE69917833T2 (de) 2005-07-14
PL332565A1 (en) 1999-10-25
NO991821D0 (no) 1999-04-16
HU9901220D0 (en) 1999-06-28
BR9902365A (pt) 2001-04-24
CZ136999A3 (cs) 1999-11-17
TR199900853A3 (tr) 1999-11-22
CO5031247A1 (es) 2001-04-27
PT950657E (pt) 2004-11-30
JP4435330B2 (ja) 2010-03-17
TR199900843A2 (xx) 2000-02-21
AU753436B2 (en) 2002-10-17
DE69918590D1 (de) 2004-08-19
ZA992772B (en) 2002-07-16
NZ335253A (en) 2000-11-24
ID23287A (id) 2000-04-05
CA2269246A1 (en) 1999-10-17
HU9901221A (hu) 2000-04-28
JP2000026416A (ja) 2000-01-25
JPH11322713A (ja) 1999-11-24
EA199900303A3 (ru) 2000-04-24
ES2222663T3 (es) 2005-02-01
YU19199A (sh) 2002-08-12
HUP9901220A3 (en) 2001-11-28
SG81977A1 (en) 2001-07-24
DE69918590T2 (de) 2005-07-21
AU2381799A (en) 1999-10-28
NO991822D0 (no) 1999-04-16
HU9901220A (hu) 2000-04-28
EP0952149B1 (en) 2004-06-09
EP0950657A3 (en) 2001-08-16
DE69917833D1 (de) 2004-07-15
KR19990083232A (ko) 1999-11-25
CO5011054A1 (es) 2001-02-28
ATE268756T1 (de) 2004-06-15
ID23761A (id) 2000-05-11
CN1149193C (zh) 2004-05-12
EP0950657B1 (en) 2004-07-14
ES2226286T3 (es) 2005-03-16
TR199900853A2 (xx) 1999-11-22
AR018593A1 (es) 2001-11-28
BR9901279A (pt) 2000-05-02
PE20000476A1 (es) 2000-06-02
HU9901221D0 (en) 1999-06-28
EA002816B1 (ru) 2002-10-31
NO991821L (no) 1999-10-18
NZ507564A (en) 2002-10-25
EA199900301A2 (ru) 1999-10-28
AR018186A1 (es) 2001-10-31
PL332566A1 (en) 1999-10-25
KR100586761B1 (ko) 2006-06-08
SG81976A1 (en) 2001-07-24
ATE271037T1 (de) 2004-07-15
AU2381999A (en) 1999-10-28
NZ335251A (en) 2000-11-24
TWI238160B (en) 2005-08-21
AU753547B2 (en) 2002-10-24
EP0952149A2 (en) 1999-10-27
DZ2769A1 (fr) 2003-12-01
KR19990083233A (ko) 1999-11-25
SI0950657T1 (en) 2005-02-28
EA199900303A2 (ru) 1999-10-28
IL129483A0 (en) 2000-02-29
EA002347B1 (ru) 2002-04-25
IL129485A0 (en) 2000-02-29
EA199900301A3 (ru) 2000-04-24
CA2269246C (en) 2009-08-25
EP0950657A2 (en) 1999-10-20

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