DE60032774D1 - Spla2 inhibitoren - Google Patents
Spla2 inhibitorenInfo
- Publication number
- DE60032774D1 DE60032774D1 DE60032774T DE60032774T DE60032774D1 DE 60032774 D1 DE60032774 D1 DE 60032774D1 DE 60032774 T DE60032774 T DE 60032774T DE 60032774 T DE60032774 T DE 60032774T DE 60032774 D1 DE60032774 D1 DE 60032774D1
- Authority
- DE
- Germany
- Prior art keywords
- spla2 inhibitors
- class
- compounds
- treatment
- fatty acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003112 inhibitor Substances 0.000 title 1
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 abstract 2
- 102000005473 Secretory Phospholipases A2 Human genes 0.000 abstract 1
- 108010031873 Secretory Phospholipases A2 Proteins 0.000 abstract 1
- 206010040070 Septic Shock Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 abstract 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 230000036303 septic shock Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14450299P | 1999-07-19 | 1999-07-19 | |
| PCT/US2000/016319 WO2001005761A1 (en) | 1999-07-19 | 2000-07-11 | sPLA2 INHIBITORS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60032774D1 true DE60032774D1 (de) | 2007-02-15 |
Family
ID=22508894
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60032774T Expired - Lifetime DE60032774D1 (de) | 1999-07-19 | 2000-07-11 | Spla2 inhibitoren |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1202963B1 (de) |
| JP (1) | JP2003505372A (de) |
| AT (1) | ATE350367T1 (de) |
| AU (1) | AU5873400A (de) |
| CA (1) | CA2379208A1 (de) |
| DE (1) | DE60032774D1 (de) |
| WO (1) | WO2001005761A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001066111A1 (en) * | 2000-03-09 | 2001-09-13 | Eli Lilly And Company | Compositions containing potential spla2 inhibitors for the treatment of pain |
| CA2431023A1 (en) | 2000-12-18 | 2002-06-27 | Eli Lilly And Company | Substituted benzoindoles as spla2 inhibitors |
| DE102004017599A1 (de) | 2004-04-07 | 2005-11-03 | TransMIT Gesellschaft für Technologietransfer mbH | Vorrichtung zur intraperitonealen Applikation eines Ozon oder ozonisierten Sauerstoff aufweisenden Fluids in einem menschlichen oder tierischen Körper und Verwendung hierfür |
| AU2006311761A1 (en) * | 2005-11-03 | 2007-05-18 | Ilypsa, Inc. | Indole compounds having C4-amide substituents and use thereof as phospholipase-A2 inhibitors |
| US7666898B2 (en) | 2005-11-03 | 2010-02-23 | Ilypsa, Inc. | Multivalent indole compounds and use thereof as phospholipase-A2 inhibitors |
| GB201014633D0 (en) * | 2010-09-02 | 2010-10-13 | Avexxin As | Rheumatoid arthritis treatment |
| GB201604316D0 (en) | 2016-03-14 | 2016-04-27 | Avexxin As | Combination therapy |
| CA3037582A1 (en) | 2016-09-21 | 2018-03-29 | Avexxin As | Pharmaceutical composition |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT95692A (pt) * | 1989-10-27 | 1991-09-13 | American Home Prod | Processo para a preparacao de derivados de acidos indole-,indeno-,piranoindole- e tetra-hidrocarbazole-alcanoicos, ou quais sao uteis como inibidores de pla2 e da lipoxigenase |
| IL109311A0 (en) * | 1993-04-16 | 1994-07-31 | Lilly Co Eli | 1H-indole-3-acetamide sPla2 inhibitors |
| RU2128169C1 (ru) * | 1994-04-01 | 1999-03-27 | Эли Лилли Энд Компани | Iн-индол-3-глиоксиламиды, ингибирующие spla2-медиируемое выделение жирных кислот, фармацевтическая композиция |
| US5604253A (en) * | 1995-05-22 | 1997-02-18 | Merck Frosst Canada, Inc. | N-benzylindol-3-yl propanoic acid derivatives as cyclooxygenase inhibitors |
| DE69830335T2 (de) * | 1997-10-27 | 2006-02-02 | Eli Lilly And Co., Indianapolis | MORPHOLINO-N-ETHYL ESTER PRODROGEN VON INDOL sPLA 2 HEMMER |
| AU1279899A (en) * | 1997-10-27 | 1999-05-17 | Eli Lilly And Company | N,n-diethylglycolamido ester prodrugs of indole spla2 inhibitors |
| DZ2769A1 (fr) * | 1998-04-17 | 2003-12-01 | Lilly Co Eli | Composés tricycliques substitués. |
| US6391908B1 (en) * | 1998-12-22 | 2002-05-21 | Eli Lilly And Company | Oxime amide indole type sPLA2 inhibitors |
-
2000
- 2000-07-11 DE DE60032774T patent/DE60032774D1/de not_active Expired - Lifetime
- 2000-07-11 AT AT00944673T patent/ATE350367T1/de not_active IP Right Cessation
- 2000-07-11 JP JP2001511422A patent/JP2003505372A/ja not_active Withdrawn
- 2000-07-11 EP EP00944673A patent/EP1202963B1/de not_active Expired - Lifetime
- 2000-07-11 CA CA002379208A patent/CA2379208A1/en not_active Abandoned
- 2000-07-11 AU AU58734/00A patent/AU5873400A/en not_active Abandoned
- 2000-07-11 WO PCT/US2000/016319 patent/WO2001005761A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CA2379208A1 (en) | 2001-01-25 |
| JP2003505372A (ja) | 2003-02-12 |
| EP1202963A1 (de) | 2002-05-08 |
| ATE350367T1 (de) | 2007-01-15 |
| WO2001005761A1 (en) | 2001-01-25 |
| EP1202963B1 (de) | 2007-01-03 |
| AU5873400A (en) | 2001-02-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
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| ATE326963T1 (de) | Indolverbindungen als spla2 inhibitoren | |
| DE69720034D1 (de) | PHENYLGLYOXAMIDE ALS sPLA2-INHIBITOREN | |
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| WO2002012249A3 (en) | Substituted pyrrole compounds and their use as spla2 inhibitors | |
| AU7053700A (en) | Novel spla2 inhibitors | |
| WO2002050028A3 (en) | Substituted benzoindoles as spla2 inhibitors | |
| WO2001049662A3 (en) | Carbazole derivatives as inhibitors of spla2 | |
| DE60126831D1 (de) | Benz(g)indole und deren verwendung als spla2 inhibitoren | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8332 | No legal effect for de |