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BR9901279A - Triciclicos substituìdos - Google Patents

Triciclicos substituìdos

Info

Publication number
BR9901279A
BR9901279A BR9901279-0A BR9901279A BR9901279A BR 9901279 A BR9901279 A BR 9901279A BR 9901279 A BR9901279 A BR 9901279A BR 9901279 A BR9901279 A BR 9901279A
Authority
BR
Brazil
Prior art keywords
tricycles
replaced
tricyclics
compounds
treatment
Prior art date
Application number
BR9901279-0A
Other languages
English (en)
Inventor
Benjamin Alan Anderson
Michael Leroy Phillips
Nicholas James Bach
Michael Enrico Richett
Jolie Anne Bastian
Daniel Jon Sall
Nancy Kay Harn
Jason Scott Sawyer
Richard Waltz Harper
Richard Walter Schevitz
Gary Alan Hite
Robert Theodore Vasileff
Michael Dean Kinnnick
Ho-Shen Nmn Lin
Richard James Loncharich
John Mcneill Mcgill Iii
Edward David Mihelich
John Michael Junior Morin
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BR9901279A publication Critical patent/BR9901279A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Patente de Invenção: <B>''TRICìCLICOS SUBSTITUìDOS''<D>. Apresenta-se novos tricíclicos juntamente com o uso de tais compostos para inibir liberação de ácidos graxos mediada por sPLA2, para o tratamento de condições como choque séptico.
BR9901279-0A 1998-04-17 1999-04-16 Triciclicos substituìdos BR9901279A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6232898A 1998-04-17 1998-04-17

Publications (1)

Publication Number Publication Date
BR9901279A true BR9901279A (pt) 2000-05-02

Family

ID=22041763

Family Applications (2)

Application Number Title Priority Date Filing Date
BR9902365-2A BR9902365A (pt) 1998-04-17 1999-04-16 Tricìclicos substituìdos
BR9901279-0A BR9901279A (pt) 1998-04-17 1999-04-16 Triciclicos substituìdos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BR9902365-2A BR9902365A (pt) 1998-04-17 1999-04-16 Tricìclicos substituìdos

Country Status (30)

Country Link
EP (2) EP0952149B1 (pt)
JP (2) JPH11322713A (pt)
KR (2) KR19990083232A (pt)
CN (1) CN1149193C (pt)
AR (2) AR018186A1 (pt)
AT (2) ATE271037T1 (pt)
AU (2) AU753436B2 (pt)
BR (2) BR9902365A (pt)
CA (2) CA2269262A1 (pt)
CO (2) CO5011054A1 (pt)
CZ (2) CZ136999A3 (pt)
DE (2) DE69917833T2 (pt)
DK (1) DK0950657T3 (pt)
DZ (1) DZ2769A1 (pt)
EA (2) EA002347B1 (pt)
ES (2) ES2226286T3 (pt)
HU (2) HUP9901221A3 (pt)
ID (2) ID23761A (pt)
IL (2) IL129485A0 (pt)
NO (2) NO312240B1 (pt)
NZ (3) NZ507564A (pt)
PE (2) PE20000432A1 (pt)
PL (2) PL332566A1 (pt)
PT (1) PT950657E (pt)
SG (2) SG81977A1 (pt)
SI (1) SI0950657T1 (pt)
TR (2) TR199900843A2 (pt)
TW (1) TWI238160B (pt)
YU (2) YU19199A (pt)
ZA (2) ZA992772B (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999009978A1 (en) * 1997-08-28 1999-03-04 Eli Lilly And Company Method for treatment of non-rheumatoid athritis
DZ2769A1 (fr) * 1998-04-17 2003-12-01 Lilly Co Eli Composés tricycliques substitués.
CA2358492A1 (en) * 1998-12-21 2000-06-29 Eli Lilly And Company Combination therapy for the treatment of sepsis
JP2003505372A (ja) * 1999-07-19 2003-02-12 イーライ・リリー・アンド・カンパニー ｓＰＬＡ２インヒビター
US6706752B1 (en) 1999-07-19 2004-03-16 Eli Lilly And Company sPLA2 inhibitors
EP1300159B1 (en) * 2000-06-29 2007-10-10 Anthera Pharmaceuticals, Inc. Remedies for cancer
AU2001267825A1 (en) 2000-06-29 2002-01-08 Shionogi And Co., Ltd. Remedies for cirrhosis
US20040102442A1 (en) * 2000-06-29 2004-05-27 Kohji Hanasaki Remedies for alzheimer's disease
CA2413582A1 (en) * 2000-07-14 2002-01-24 Eli Lilly And Company Use of a spla2 inhibitor for the treatment of sepsis
EP1345898A2 (en) * 2000-12-18 2003-09-24 Eli Lilly And Company Teracyclic carbazole derivates and their use as spla2 inhibitors
US6933313B2 (en) 2001-03-28 2005-08-23 Eli Lilly And Company Substituted carbazoles as inhibitors of sPLA2
AUPS282602A0 (en) 2002-06-07 2002-06-27 Garvan Institute Of Medical Research Method of inhibiting cell proliferation
DE10249055A1 (de) 2002-10-22 2004-05-06 Bayer Cropscience Ag 2-Phenyl-2-substituierte-1,3-diketone
JO3598B1 (ar) 2006-10-10 2020-07-05 Infinity Discovery Inc الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
EP1988098A1 (en) * 2007-04-27 2008-11-05 AEterna Zentaris GmbH Novel Tetrahydrocarbazole Derivatives as Ligands of G-protein Coupled Receptors
CN101981012A (zh) 2008-03-26 2011-02-23 第一三共株式会社 新的四氢异喹啉衍生物
WO2009126691A1 (en) 2008-04-09 2009-10-15 Infinity Pharmaceuticals, Inc Inhibitors of fatty acid amide hydrolase
US8580795B2 (en) 2009-01-22 2013-11-12 Orchid Chemicals & Pharmaceuticals Limited Heterocyclic compounds as phosphodiesterase inhibitors
EP2416660B1 (en) 2009-04-07 2014-07-02 Infinity Pharmaceuticals, Inc. Inhibitors of fatty acid amide hydrolase
WO2010118159A1 (en) 2009-04-07 2010-10-14 Infinity Pharmaceuticals, Inc. Inhibitors of fatty acid amide hydrolase
AU2011213072C1 (en) 2010-02-03 2016-12-15 Infinity Pharmaceuticals, Inc. Fatty acid amide hydrolase inhibitors
AR088377A1 (es) 2011-10-20 2014-05-28 Siena Biotech Spa Proceso para la preparacion de 6-cloro-2,3,4,9-tetrahidro-1h-carbazol-1-carboxamida y compuestos intermedios de esta
CN102816107B (zh) * 2012-08-20 2015-06-03 东南大学 咔唑衍生物及其制备方法与用途
RU2647867C2 (ru) * 2012-11-30 2018-03-21 ДжиИ ХЕЛТКЕР ЛИМИТЕД Катализируемый галогенидом цинка способ циклизации, приводящий к образованию трициклических индолов
BR112015012138A2 (pt) 2012-11-30 2017-07-11 Ge Healthcare Ltd composição, método para obtenção de uma composição, método de formação de imagem in vivo, e, kit
EP3248230B1 (de) * 2015-01-20 2020-05-06 cynora GmbH Verwendung organischer moleküle in optoelektronischen bauelementen
CN108707104A (zh) * 2018-08-07 2018-10-26 北京恒信卓元科技有限公司 2-氯-1h-咔唑-1,4(9h)-二酮的合成方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3579534A (en) * 1969-05-09 1971-05-18 American Cyanamid Co Tetrahydrocarbazolecarboxylates
US3979391A (en) * 1972-11-22 1976-09-07 Sterling Drug Inc. 1,2,3,4-Tetrahydrocarbazoles
US3939177A (en) * 1972-11-22 1976-02-17 Sterling Drug Inc. 4-Aminomethyl-9-benzyl-1,2,3,4-tetrahydrocarbazoles
PT95692A (pt) * 1989-10-27 1991-09-13 American Home Prod Processo para a preparacao de derivados de acidos indole-,indeno-,piranoindole- e tetra-hidrocarbazole-alcanoicos, ou quais sao uteis como inibidores de pla2 e da lipoxigenase
US5420289A (en) * 1989-10-27 1995-05-30 American Home Products Corporation Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase
WO1993001169A2 (en) * 1991-07-05 1993-01-21 Merck Sharp & Dohme Limited Aromatic compounds, pharmaceutical compositions containing them and their use in therapy
MY110227A (en) * 1991-08-12 1998-03-31 Ciba Geigy Ag 1-acylpiperindine compounds.
IL109311A0 (en) * 1993-04-16 1994-07-31 Lilly Co Eli 1H-indole-3-acetamide sPla2 inhibitors
IL109309A (en) * 1993-04-16 2000-06-29 Lilly Co Eli 1-H-indole-3-acetic acid hydrazide SPLA2 inhibitors and pharmaceutical compositions containing them
ES2151993T3 (es) * 1995-06-23 2001-01-16 Lilly Co Eli 1,2,3,4-tetrahidro-9h-carbazoles 6-sustituidos y 10h-ciclohepta(7,6-b)indoles 7-sustituidos.
CA2240395A1 (en) * 1995-12-13 1997-06-19 David Kent Herron Naphthyl acetamides as spla2 inhibitors
PL332896A1 (en) * 1996-10-30 1999-10-25 Lilly Co Eli Substituted tricyclic compounds
WO1999016453A1 (en) * 1997-09-26 1999-04-08 Eli Lilly And Company Method for the treatment of cystic fibrosis
WO1999025340A1 (en) * 1997-11-14 1999-05-27 Eli Lilly And Company Treatment for alzheimer's disease
DZ2769A1 (fr) * 1998-04-17 2003-12-01 Lilly Co Eli Composés tricycliques substitués.

Also Published As

Publication number Publication date
ATE271037T1 (de) 2004-07-15
HU9901220D0 (en) 1999-06-28
AU2381799A (en) 1999-10-28
CO5031247A1 (es) 2001-04-27
TWI238160B (en) 2005-08-21
EP0952149A3 (en) 2001-08-16
DE69918590T2 (de) 2005-07-21
CA2269246A1 (en) 1999-10-17
EA002347B1 (ru) 2002-04-25
NO312240B1 (no) 2002-04-15
ID23761A (id) 2000-05-11
EP0952149A2 (en) 1999-10-27
SI0950657T1 (en) 2005-02-28
IL129485A0 (en) 2000-02-29
NO991822D0 (no) 1999-04-16
HUP9901220A3 (en) 2001-11-28
HU9901221D0 (en) 1999-06-28
JP4435330B2 (ja) 2010-03-17
ES2222663T3 (es) 2005-02-01
NO991821L (no) 1999-10-18
DK0950657T3 (da) 2004-11-22
NO991822L (no) 1999-10-18
HU9901220A (hu) 2000-04-28
DZ2769A1 (fr) 2003-12-01
TR199900843A2 (xx) 2000-02-21
CO5011054A1 (es) 2001-02-28
SG81976A1 (en) 2001-07-24
PT950657E (pt) 2004-11-30
TR199900853A3 (tr) 1999-11-22
YU18999A (sh) 2002-08-12
CN1149193C (zh) 2004-05-12
EP0950657A2 (en) 1999-10-20
ES2226286T3 (es) 2005-03-16
CA2269246C (en) 2009-08-25
CZ136999A3 (cs) 1999-11-17
ATE268756T1 (de) 2004-06-15
ZA992771B (en) 2002-04-18
EP0952149B1 (en) 2004-06-09
JP2000026416A (ja) 2000-01-25
AU753436B2 (en) 2002-10-17
YU19199A (sh) 2002-08-12
TR199900853A2 (xx) 1999-11-22
CZ137099A3 (cs) 1999-11-17
IL129483A0 (en) 2000-02-29
EA199900303A2 (ru) 1999-10-28
EA199900301A2 (ru) 1999-10-28
PL332565A1 (en) 1999-10-25
HUP9901221A3 (en) 2001-11-28
ZA992772B (en) 2002-07-16
DE69917833D1 (de) 2004-07-15
AU2381999A (en) 1999-10-28
PE20000432A1 (es) 2000-05-23
BR9902365A (pt) 2001-04-24
NZ335253A (en) 2000-11-24
NO991821D0 (no) 1999-04-16
NZ335251A (en) 2000-11-24
EA002816B1 (ru) 2002-10-31
KR19990083232A (ko) 1999-11-25
EP0950657A3 (en) 2001-08-16
AR018186A1 (es) 2001-10-31
NZ507564A (en) 2002-10-25
CA2269262A1 (en) 1999-10-17
PE20000476A1 (es) 2000-06-02
AR018593A1 (es) 2001-11-28
DE69918590D1 (de) 2004-08-19
SG81977A1 (en) 2001-07-24
ID23287A (id) 2000-04-05
DE69917833T2 (de) 2005-07-14
EA199900303A3 (ru) 2000-04-24
NO314400B1 (no) 2003-03-17
PL332566A1 (en) 1999-10-25
KR19990083233A (ko) 1999-11-25
AU753547B2 (en) 2002-10-24
EA199900301A3 (ru) 2000-04-24
KR100586761B1 (ko) 2006-06-08
CN1253948A (zh) 2000-05-24
HU9901221A (hu) 2000-04-28
EP0950657B1 (en) 2004-07-14
JPH11322713A (ja) 1999-11-24

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Free format text: ALTERADA DA INT. CL: CO7D 209/88; A61K 31/40; C07D 209/82; A61K 31/403; A61K 31/44; A61K 31/4427; A61K 31/443; A61K 31/4439; A61P 1/00; A61P 7/00; A61P 9/00; A61P 11/00; A61P 11/06; A61P 19/02; A61P 31/00; A61P 31/04; A61P 35/00; A61P 43/00

Ipc: C07D 209/82 (2008.04), A61K 31/40 (2008.04)

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
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B08L Patent application lapsed because of non payment of annual fee [chapter 8.12 patent gazette]

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