[go: up one dir, main page]

ZA992771B - Substituted tricyclics. - Google Patents

Substituted tricyclics.

Info

Publication number
ZA992771B
ZA992771B ZA9902771A ZA992771A ZA992771B ZA 992771 B ZA992771 B ZA 992771B ZA 9902771 A ZA9902771 A ZA 9902771A ZA 992771 A ZA992771 A ZA 992771A ZA 992771 B ZA992771 B ZA 992771B
Authority
ZA
South Africa
Prior art keywords
substituted tricyclics
tricyclics
substituted
Prior art date
Application number
ZA9902771A
Other languages
English (en)
Inventor
Nicholas James Bach
Jolie Anne Bastian
Gary Alan Hite
Michael Dean Kinnick
Edward David Mihelich
Junior John Michael Morin
Daniel Jon Sall
Robert Theodore Vasileff
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of ZA992771B publication Critical patent/ZA992771B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56Ring systems containing three or more rings
    • C07D209/80[b, c]- or [b, d]-condensed
    • C07D209/82Carbazoles; Hydrogenated carbazoles
    • C07D209/88Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56Ring systems containing three or more rings
    • C07D209/58[b]- or [c]-condensed
    • C07D209/70[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA9902771A 1998-04-17 1999-04-16 Substituted tricyclics. ZA992771B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6232898A 1998-04-17 1998-04-17

Publications (1)

Publication Number Publication Date
ZA992771B true ZA992771B (en) 2002-04-18

Family

ID=22041763

Family Applications (2)

Application Number Title Priority Date Filing Date
ZA9902772A ZA992772B (en) 1998-04-17 1999-04-16 Substituted tricyclics.
ZA9902771A ZA992771B (en) 1998-04-17 1999-04-16 Substituted tricyclics.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ZA9902772A ZA992772B (en) 1998-04-17 1999-04-16 Substituted tricyclics.

Country Status (30)

Country Link
EP (2) EP0950657B1 (xx)
JP (2) JPH11322713A (xx)
KR (2) KR19990083232A (xx)
CN (1) CN1149193C (xx)
AR (2) AR018593A1 (xx)
AT (2) ATE271037T1 (xx)
AU (2) AU753436B2 (xx)
BR (2) BR9902365A (xx)
CA (2) CA2269262A1 (xx)
CO (2) CO5031247A1 (xx)
CZ (2) CZ136999A3 (xx)
DE (2) DE69917833T2 (xx)
DK (1) DK0950657T3 (xx)
DZ (1) DZ2769A1 (xx)
EA (2) EA002816B1 (xx)
ES (2) ES2222663T3 (xx)
HU (2) HUP9901220A3 (xx)
ID (2) ID23761A (xx)
IL (2) IL129483A0 (xx)
NO (2) NO312240B1 (xx)
NZ (3) NZ507564A (xx)
PE (2) PE20000432A1 (xx)
PL (2) PL332566A1 (xx)
PT (1) PT950657E (xx)
SG (2) SG81976A1 (xx)
SI (1) SI0950657T1 (xx)
TR (2) TR199900853A3 (xx)
TW (1) TWI238160B (xx)
YU (2) YU18999A (xx)
ZA (2) ZA992772B (xx)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1011670A4 (en) * 1997-08-28 2004-10-27 Lilly Co Eli PROCESS FOR TREATING NON-RHUMATOID POLYARTHRITIS
DZ2769A1 (fr) * 1998-04-17 2003-12-01 Lilly Co Eli Composés tricycliques substitués.
EP1214041A2 (en) * 1998-12-21 2002-06-19 Eli Lilly And Company Combination therapy for the treatment of sepsis
EP1202963B1 (en) * 1999-07-19 2007-01-03 Eli Lilly And Company Spla2 inhibitors
US6706752B1 (en) 1999-07-19 2004-03-16 Eli Lilly And Company sPLA2 inhibitors
WO2002000256A1 (fr) * 2000-06-29 2002-01-03 Shionogi & Co., Ltd. Remedes contre la cirrhose
AU2001267824A1 (en) * 2000-06-29 2002-01-08 Shionogi And Co., Ltd. Remedies for cancer
AU2001267826A1 (en) * 2000-06-29 2002-01-08 Shionogi And Co., Ltd. Remedies for alzheimer's disease
EP1303262A2 (en) * 2000-07-14 2003-04-23 Eli Lilly And Company Use of a spla2 inhibitor for the treatment of sepsis
CA2431028A1 (en) * 2000-12-18 2002-06-27 Ho-Shen Lin Tetracyclic carbazole derivates and their use as spla2 inhibitors
ATE353876T1 (de) 2001-03-28 2007-03-15 Lilly Co Eli Substituierte carbazole als inhibitoren von spla2
AUPS282602A0 (en) 2002-06-07 2002-06-27 Garvan Institute Of Medical Research Method of inhibiting cell proliferation
DE10249055A1 (de) 2002-10-22 2004-05-06 Bayer Cropscience Ag 2-Phenyl-2-substituierte-1,3-diketone
JO3598B1 (ar) 2006-10-10 2020-07-05 Infinity Discovery Inc الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
EP1988098A1 (en) * 2007-04-27 2008-11-05 AEterna Zentaris GmbH Novel Tetrahydrocarbazole Derivatives as Ligands of G-protein Coupled Receptors
RU2474575C2 (ru) 2008-03-26 2013-02-10 Дайити Санкио Компани, Лимитед Новое производное тетрагидроизохинолина, фармацевтическая композиция на его основе, применение его и способ лечения и/или предотвращения заболевания
JP5637982B2 (ja) 2008-04-09 2014-12-10 インフィニティー ファーマシューティカルズ, インコーポレイテッド 脂肪酸アミド加水分解酵素の阻害剤
WO2010084402A2 (en) * 2009-01-22 2010-07-29 Orchid Research Laboratories Ltd. Heterocyclic compounds as phosphodiesterase inhibitors
JP2012523425A (ja) 2009-04-07 2012-10-04 インフイニトイ プハルマセウトイカルス インコーポレイテッド 脂肪酸アミドヒドロラーゼの阻害薬
EP2416660B1 (en) 2009-04-07 2014-07-02 Infinity Pharmaceuticals, Inc. Inhibitors of fatty acid amide hydrolase
KR101888026B1 (ko) 2010-02-03 2018-08-13 인피니티 파마슈티컬스, 인코포레이티드 지방산 아미드 하이드롤라제 저해제
AR088377A1 (es) 2011-10-20 2014-05-28 Siena Biotech Spa Proceso para la preparacion de 6-cloro-2,3,4,9-tetrahidro-1h-carbazol-1-carboxamida y compuestos intermedios de esta
CN102816107B (zh) * 2012-08-20 2015-06-03 东南大学 咔唑衍生物及其制备方法与用途
CA2892485A1 (en) 2012-11-30 2014-06-05 Ge Healthcare Limited Crystallization process of tricyclic indole derivatives
EP2925723A1 (en) * 2012-11-30 2015-10-07 GE Healthcare Limited Zinc halide mediated cyclization process leading to tricyclic indoles
EP3248230B1 (de) * 2015-01-20 2020-05-06 cynora GmbH Verwendung organischer moleküle in optoelektronischen bauelementen
CN108707104A (zh) * 2018-08-07 2018-10-26 北京恒信卓元科技有限公司 2-氯-1h-咔唑-1,4(9h)-二酮的合成方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3579534A (en) * 1969-05-09 1971-05-18 American Cyanamid Co Tetrahydrocarbazolecarboxylates
US3979391A (en) * 1972-11-22 1976-09-07 Sterling Drug Inc. 1,2,3,4-Tetrahydrocarbazoles
US3939177A (en) * 1972-11-22 1976-02-17 Sterling Drug Inc. 4-Aminomethyl-9-benzyl-1,2,3,4-tetrahydrocarbazoles
PT95692A (pt) * 1989-10-27 1991-09-13 American Home Prod Processo para a preparacao de derivados de acidos indole-,indeno-,piranoindole- e tetra-hidrocarbazole-alcanoicos, ou quais sao uteis como inibidores de pla2 e da lipoxigenase
US5420289A (en) * 1989-10-27 1995-05-30 American Home Products Corporation Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase
CA2110514A1 (en) * 1991-07-05 1993-01-21 Raymond Baker Aromatic compounds, pharmaceutical compositions containing them and their use in therapy
MY110227A (en) * 1991-08-12 1998-03-31 Ciba Geigy Ag 1-acylpiperindine compounds.
IL109311A0 (en) * 1993-04-16 1994-07-31 Lilly Co Eli 1H-indole-3-acetamide sPla2 inhibitors
IL109309A (en) * 1993-04-16 2000-06-29 Lilly Co Eli 1-H-indole-3-acetic acid hydrazide SPLA2 inhibitors and pharmaceutical compositions containing them
CA2179678A1 (en) * 1995-06-23 1996-12-24 Michael Edward Flaugh 6-substituted-1,2,3,4-tetrahydro-9h-carbazoles and 7-substituted-10h-cyclohepta¬7,6-b| indoles
BR9612347A (pt) * 1995-12-13 1999-07-13 Lilly Co Eli Naftil acetamidas como inibidores de spla2
AU734096B2 (en) * 1996-10-30 2001-06-07 Eli Lilly And Company Substituted tricyclics
JP2001517707A (ja) * 1997-09-26 2001-10-09 イーライ・リリー・アンド・カンパニー 嚢胞性繊維症の処置方法
EP1043991A4 (en) * 1997-11-14 2005-02-02 Lilly Co Eli TREATMENT OF ALZHEIMER DISEASE
DZ2769A1 (fr) * 1998-04-17 2003-12-01 Lilly Co Eli Composés tricycliques substitués.

Also Published As

Publication number Publication date
PE20000432A1 (es) 2000-05-23
AR018593A1 (es) 2001-11-28
EA199900301A3 (ru) 2000-04-24
HUP9901221A3 (en) 2001-11-28
HU9901220D0 (en) 1999-06-28
EA199900301A2 (ru) 1999-10-28
BR9901279A (pt) 2000-05-02
NZ335251A (en) 2000-11-24
CO5011054A1 (es) 2001-02-28
CZ136999A3 (cs) 1999-11-17
YU18999A (sh) 2002-08-12
DE69918590T2 (de) 2005-07-21
NZ335253A (en) 2000-11-24
EP0950657A3 (en) 2001-08-16
AU2381799A (en) 1999-10-28
DE69917833D1 (de) 2004-07-15
DE69918590D1 (de) 2004-08-19
NO991821L (no) 1999-10-18
DE69917833T2 (de) 2005-07-14
NO314400B1 (no) 2003-03-17
IL129485A0 (en) 2000-02-29
DZ2769A1 (fr) 2003-12-01
KR100586761B1 (ko) 2006-06-08
JP2000026416A (ja) 2000-01-25
BR9902365A (pt) 2001-04-24
HU9901221A (hu) 2000-04-28
KR19990083232A (ko) 1999-11-25
JP4435330B2 (ja) 2010-03-17
EP0952149A3 (en) 2001-08-16
EA002816B1 (ru) 2002-10-31
HUP9901220A3 (en) 2001-11-28
ES2222663T3 (es) 2005-02-01
EA199900303A3 (ru) 2000-04-24
YU19199A (sh) 2002-08-12
ID23761A (id) 2000-05-11
TWI238160B (en) 2005-08-21
EP0952149A2 (en) 1999-10-27
CN1149193C (zh) 2004-05-12
ZA992772B (en) 2002-07-16
IL129483A0 (en) 2000-02-29
JPH11322713A (ja) 1999-11-24
AU2381999A (en) 1999-10-28
PE20000476A1 (es) 2000-06-02
CA2269246A1 (en) 1999-10-17
EP0950657B1 (en) 2004-07-14
ID23287A (id) 2000-04-05
AU753436B2 (en) 2002-10-17
AR018186A1 (es) 2001-10-31
HU9901220A (hu) 2000-04-28
NO312240B1 (no) 2002-04-15
EA199900303A2 (ru) 1999-10-28
EP0952149B1 (en) 2004-06-09
PL332565A1 (en) 1999-10-25
HU9901221D0 (en) 1999-06-28
NO991822D0 (no) 1999-04-16
TR199900843A2 (xx) 2000-02-21
CZ137099A3 (cs) 1999-11-17
CO5031247A1 (es) 2001-04-27
AU753547B2 (en) 2002-10-24
SG81976A1 (en) 2001-07-24
ES2226286T3 (es) 2005-03-16
NZ507564A (en) 2002-10-25
NO991822L (no) 1999-10-18
CA2269246C (en) 2009-08-25
EA002347B1 (ru) 2002-04-25
CN1253948A (zh) 2000-05-24
NO991821D0 (no) 1999-04-16
TR199900853A2 (xx) 1999-11-22
KR19990083233A (ko) 1999-11-25
CA2269262A1 (en) 1999-10-17
ATE268756T1 (de) 2004-06-15
PL332566A1 (en) 1999-10-25
ATE271037T1 (de) 2004-07-15
EP0950657A2 (en) 1999-10-20
PT950657E (pt) 2004-11-30
SI0950657T1 (en) 2005-02-28
SG81977A1 (en) 2001-07-24
TR199900853A3 (tr) 1999-11-22
DK0950657T3 (da) 2004-11-22

Similar Documents

Publication Publication Date Title
ZA992772B (en) Substituted tricyclics.
EG24814A (en) Novel compounds.
ZA996185B (en) Sulfanylsilanes.
ZA200005136B (en) Dihydropyrimides.
ZA99254B (en) Benzosulfone derivatives.
ZA991272B (en) Novel thiobenzamides.
ZA996133B (en) Substituted benzamides.
ZA992773B (en) Substituted tricyclics.
ZA992072B (en) Substituted pyrroles.
ZA981926B (en) Detergent--package combination.
ZA992443B (en) Hydroxy-methyl-hexanones.
ZA987058B (en) Substituted 4-benzoylpyrazoles.
ZA987055B (en) Substituted 4-benzoylpyrazoles.
ZA991550B (en) Cyclohexanediole derivatives.
ZA993123B (en) Trisresorcinyltriazines.
ZA992899B (en) Novel compound.
ZA995325B (en) Methylcyclotetradec-5-en-1-ones.
MXPA01011743A (es) Arilpirimidinas substituidas 5-.
ZA200006118B (en) Novel composition.
MXPA02000261A (es) Aminoindanos novedosos.
ZA987B (en) Substituted 4-benzoylpyrazoles.
ZA200000192B (en) Novel composition.
ZA983795B (en) Substituted 4-benzoyl-pyrazoles.
ZA996936B (en) Railbreak indicating arrangement.
ZA99925B (en) Composition.