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ES2179088T3 - Inhibidores de flsa2 1h-indol-3-glioxilamida. - Google Patents

Inhibidores de flsa2 1h-indol-3-glioxilamida.

Info

Publication number
ES2179088T3
ES2179088T3 ES95302166T ES95302166T ES2179088T3 ES 2179088 T3 ES2179088 T3 ES 2179088T3 ES 95302166 T ES95302166 T ES 95302166T ES 95302166 T ES95302166 T ES 95302166T ES 2179088 T3 ES2179088 T3 ES 2179088T3
Authority
ES
Spain
Prior art keywords
indol
glioxylamide
flsa2
inhibitors
glicoxilamidas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95302166T
Other languages
English (en)
Inventor
Nicholas James Bach
Robert Delane Dillard
Susan Elizabeth Draheim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2179088T3 publication Critical patent/ES2179088T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

SE PRESENTA UNA NUEVA CLASE DE 1H-INDOL-3-GLICOXILAMIDAS JUNTO CON EL USO DE TALES COMPUESTOS DE INDOL, PARA INHIBIR LA LIBERACION MEDIADA POR SPLA2 DE ACIDOS GRASOS PARA EL TRATAMIENTO DE ESTADOS COMO EL CHOQUE SEPTICO.
ES95302166T 1994-04-01 1995-03-31 Inhibidores de flsa2 1h-indol-3-glioxilamida. Expired - Lifetime ES2179088T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22191694A 1994-04-01 1994-04-01

Publications (1)

Publication Number Publication Date
ES2179088T3 true ES2179088T3 (es) 2003-01-16

Family

ID=22829963

Family Applications (2)

Application Number Title Priority Date Filing Date
ES08001265T Expired - Lifetime ES2377223T3 (es) 1994-04-01 1995-03-31 Éster metílico de ácido [[3-(2-amino-1,2-dioxoetil)-2-etil-1-(fenilmetil)-11H-indol-4-IL]oxi]acético como inhibidor de sPLA2
ES95302166T Expired - Lifetime ES2179088T3 (es) 1994-04-01 1995-03-31 Inhibidores de flsa2 1h-indol-3-glioxilamida.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES08001265T Expired - Lifetime ES2377223T3 (es) 1994-04-01 1995-03-31 Éster metílico de ácido [[3-(2-amino-1,2-dioxoetil)-2-etil-1-(fenilmetil)-11H-indol-4-IL]oxi]acético como inhibidor de sPLA2

Country Status (29)

Country Link
US (6) US5654326A (es)
EP (5) EP0675110B1 (es)
JP (1) JP3109974B2 (es)
KR (1) KR100368707B1 (es)
CN (1) CN1067054C (es)
AT (2) ATE540923T1 (es)
AU (1) AU688458B2 (es)
BR (1) BR9501404A (es)
CA (1) CA2146097C (es)
CO (1) CO4370099A1 (es)
CZ (1) CZ82295A3 (es)
DE (1) DE69527322T2 (es)
DK (2) DK0675110T3 (es)
ES (2) ES2377223T3 (es)
FI (1) FI114793B (es)
HU (1) HUT72048A (es)
IL (1) IL113210A (es)
MX (1) MX9501608A (es)
MY (1) MY112897A (es)
NO (1) NO304186B1 (es)
NZ (1) NZ270848A (es)
PE (1) PE18696A1 (es)
PL (1) PL180523B1 (es)
PT (1) PT675110E (es)
RU (1) RU2128169C1 (es)
SI (1) SI0675110T1 (es)
TW (1) TW383302B (es)
UA (1) UA47387C2 (es)
ZA (1) ZA952693B (es)

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JPH08193074A (ja) * 1994-11-18 1996-07-30 Nippon Bayeragrochem Kk 除草性１−シクロプロピルテトラゾリノン類
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ATE540923T1 (de) 2012-01-15
US5733923A (en) 1998-03-31
EP1081135A3 (en) 2003-11-05
EP1950200A1 (en) 2008-07-30
RU95104885A (ru) 1997-04-27
FI114793B (fi) 2004-12-31
MX9501608A (es) 1997-02-28
US5919810A (en) 1999-07-06
ZA952693B (en) 1996-09-30
MY112897A (en) 2001-10-31
NO304186B1 (no) 1998-11-09
EP1081135A2 (en) 2001-03-07
IL113210A (en) 2001-01-28
US6433001B1 (en) 2002-08-13
PT675110E (pt) 2002-11-29
JP3109974B2 (ja) 2000-11-20
EP2341045A1 (en) 2011-07-06
EP0675110B1 (en) 2002-07-10
US5654326A (en) 1997-08-05
NZ270848A (en) 1997-05-26
DE69527322D1 (de) 2002-08-14
JPH07285933A (ja) 1995-10-31
UA47387C2 (uk) 2002-07-15
HU9500957D0 (en) 1995-05-29
CA2146097C (en) 2000-03-21
ES2377223T3 (es) 2012-03-23
KR100368707B1 (ko) 2003-06-02
FI951553A0 (fi) 1995-03-31
DK0675110T3 (da) 2002-10-07
CN1114310A (zh) 1996-01-03
PL307951A1 (en) 1995-10-02
US5919943A (en) 1999-07-06
EP0675110A1 (en) 1995-10-04
DE69527322T2 (de) 2003-02-27
CZ82295A3 (en) 1995-12-13
EP1197484A2 (en) 2002-04-17
IL113210A0 (en) 1995-06-29
CO4370099A1 (es) 1996-10-07
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AU1621795A (en) 1995-10-12
RU2128169C1 (ru) 1999-03-27
BR9501404A (pt) 1996-03-05
EP1950200B1 (en) 2012-01-11
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AU688458B2 (en) 1998-03-12
NO951252L (no) 1995-10-02
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ATE220394T1 (de) 2002-07-15
FI951553L (fi) 1995-10-02
US6175021B1 (en) 2001-01-16
TW383302B (en) 2000-03-01
PE18696A1 (es) 1996-05-30
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PL180523B1 (pl) 2001-02-28
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