LTC2620436I2 - Pakeistojo policiklinio karbamoilpiridono darinio provaistas - Google Patents
Pakeistojo policiklinio karbamoilpiridono darinio provaistasInfo
- Publication number
- LTC2620436I2 LTC2620436I2 LTPA2021505C LTPA2021505C LTC2620436I2 LT C2620436 I2 LTC2620436 I2 LT C2620436I2 LT PA2021505 C LTPA2021505 C LT PA2021505C LT PA2021505 C LTPA2021505 C LT PA2021505C LT C2620436 I2 LTC2620436 I2 LT C2620436I2
- Authority
- LT
- Lithuania
- Prior art keywords
- substituted polycyclic
- polycyclic carbamoylpyridone
- carbamoylpyridone derivative
- derivative
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
- C07D253/10—Condensed 1,2,4-triazines; Hydrogenated condensed 1,2,4-triazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010213012 | 2010-09-24 | ||
| PCT/JP2011/071446 WO2012039414A1 (ja) | 2010-09-24 | 2011-09-21 | 置換された多環性カルバモイルピリドン誘導体のプロドラッグ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| LTPA2021505I1 LTPA2021505I1 (lt) | 2021-04-12 |
| LTC2620436I2 true LTC2620436I2 (lt) | 2023-08-10 |
Family
ID=45873898
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEP11826859.8T LT2620436T (lt) | 2010-09-24 | 2011-09-21 | Pakeistojo policiklinio karbamoilpiridono darinio provaistas |
| LTPA2021505C LTC2620436I2 (lt) | 2010-09-24 | 2021-03-19 | Pakeistojo policiklinio karbamoilpiridono darinio provaistas |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEP11826859.8T LT2620436T (lt) | 2010-09-24 | 2011-09-21 | Pakeistojo policiklinio karbamoilpiridono darinio provaistas |
Country Status (24)
| Country | Link |
|---|---|
| US (6) | US8987441B2 (lt) |
| EP (1) | EP2620436B1 (lt) |
| JP (2) | JP5553393B2 (lt) |
| KR (1) | KR101773226B1 (lt) |
| CN (1) | CN103228653B (lt) |
| AU (1) | AU2011307087B2 (lt) |
| BR (1) | BR112013006722B1 (lt) |
| CA (1) | CA2812363C (lt) |
| DK (1) | DK2620436T3 (lt) |
| ES (1) | ES2683153T3 (lt) |
| FR (1) | FR21C1012I2 (lt) |
| HR (1) | HRP20181250T1 (lt) |
| HU (2) | HUE039859T2 (lt) |
| LT (2) | LT2620436T (lt) |
| MX (1) | MX2013003139A (lt) |
| NO (2) | NO2021011I1 (lt) |
| PL (1) | PL2620436T3 (lt) |
| PT (1) | PT2620436T (lt) |
| RS (1) | RS57490B1 (lt) |
| RU (1) | RU2608519C2 (lt) |
| SI (1) | SI2620436T1 (lt) |
| TR (1) | TR201810736T4 (lt) |
| TW (1) | TWI518085B (lt) |
| WO (1) | WO2012039414A1 (lt) |
Families Citing this family (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS57244B1 (sr) * | 2009-06-15 | 2018-07-31 | Shionogi & Co | Supstituisani policiklički derivati karbamoilpiridona |
| BR112014008896A2 (pt) * | 2011-10-12 | 2017-04-18 | Shionogi & Co | derivado de piridona policíclico tendo atividade inibidora de integrase |
| MX344879B (es) | 2012-12-21 | 2017-01-11 | Gilead Sciences Inc | Compuestos de carbamoilpiridona policiclicos y su uso farmaceutico. |
| CN104918942A (zh) * | 2013-01-08 | 2015-09-16 | 萨维拉制药有限公司 | 嘧啶酮衍生物和它们用于治疗、改善或预防病毒疾病的用途 |
| NO2865735T3 (lt) | 2013-07-12 | 2018-07-21 | ||
| LT3019503T (lt) | 2013-07-12 | 2017-11-27 | Gilead Sciences, Inc. | Policikliniai karbamoilpiridono junginiai ir jų panaudojimas živ infekcijų gydymui |
| EA037949B1 (ru) | 2013-09-12 | 2021-06-10 | Янссен Байофарма, Инк. | Азапиридоновые соединения и их применение |
| WO2015038660A1 (en) | 2013-09-12 | 2015-03-19 | Alios Biopharma, Inc. | Pyridazinone compounds and uses thereof |
| TWI744723B (zh) | 2014-06-20 | 2021-11-01 | 美商基利科學股份有限公司 | 多環型胺甲醯基吡啶酮化合物之合成 |
| NO2717902T3 (lt) | 2014-06-20 | 2018-06-23 | ||
| TW201613936A (en) | 2014-06-20 | 2016-04-16 | Gilead Sciences Inc | Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide |
| EP3166943A1 (en) * | 2014-07-07 | 2017-05-17 | Savira Pharmaceuticals GmbH | Pyridopyrazine compounds and their use in the treatment, amelioration or prevention of influenza |
| WO2016027879A1 (ja) * | 2014-08-22 | 2016-02-25 | 塩野義製薬株式会社 | インテグラーゼ阻害活性を有する多環性ピリドン誘導体 |
| TWI738321B (zh) * | 2014-12-23 | 2021-09-01 | 美商基利科學股份有限公司 | 多環胺甲醯基吡啶酮化合物及其醫藥用途 |
| JP6858712B2 (ja) | 2015-01-30 | 2021-04-14 | リーバー インスティテュート フォー ブレイン ディベロップメントＬｉｅｂｅｒ Ｉｎｓｔｉｔｕｔｅ Ｆｏｒ Ｂｒａｉｎ Ｄｅｖｅｌｏｐｍｅｎｔ | Ｃｏｍｔ阻害方法及び組成物 |
| CN107531614B (zh) * | 2015-02-06 | 2020-04-10 | 迈兰实验室有限公司 | 德罗格韦的制备方法 |
| EP3268368A4 (en) | 2015-03-11 | 2018-11-14 | Alios Biopharma, Inc. | Aza-pyridone compounds and uses thereof |
| CA2980362C (en) | 2015-04-02 | 2020-02-25 | Gilead Sciences, Inc. | Polycyclic-carbamoylpyridone compounds and their pharmaceutical use |
| LT3290424T (lt) * | 2015-04-28 | 2023-03-10 | Shionogi & Co., Ltd | Pakeisto policiklinio piridono dariniai ir jo provaistas |
| RU2712275C9 (ru) | 2015-04-28 | 2020-03-19 | Сионоги Энд Ко., Лтд. | Замещенные полициклические производные пиридона и их пролекарства |
| CN105030819B (zh) * | 2015-07-06 | 2019-04-05 | 中国科学技术大学 | 一种3-羟基-4-吡啶酮类高分子铁螯合剂的用途 |
| TW201726678A (zh) | 2015-10-30 | 2017-08-01 | 赫孚孟拉羅股份公司 | 嘧啶酮衍生物及其於治療、改善或預防病毒性疾病之用途 |
| PL3380471T3 (pl) * | 2015-11-25 | 2021-12-20 | Lieber Institute Inc. Dba Lieber Institute For Brain Development | Tetrahydro-8h-pirydo[1,2-a]pirazyn-8-ony jako inhibitory comt do leczenia chorób i zaburzeń neurodegeneracyjnych |
| BR112018011103A2 (pt) * | 2015-12-15 | 2018-11-21 | Shionogi & Co., Ltd. | medicamento para tratar a gripe caracterizada por combinação de inibidor de endonuclease dependente de cap e de fármaco antigripe |
| WO2017109088A1 (en) | 2015-12-23 | 2017-06-29 | Savira Pharmaceuticals Gmbh | Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease |
| JP6806413B2 (ja) * | 2016-02-03 | 2021-01-06 | 塩野義製薬株式会社 | 多環性ピリドン誘導体およびそのプロドラッグ |
| JP6918819B2 (ja) | 2016-03-08 | 2021-08-11 | ノバルティス アーゲー | オルトミクソウイルス感染の処置に有用な三環式化合物 |
| WO2017158151A1 (en) | 2016-03-18 | 2017-09-21 | Savira Pharmaceuticals Gmbh | Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease |
| WO2017158147A1 (en) | 2016-03-18 | 2017-09-21 | Savira Pharmaceuticals Gmbh | Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease |
| JP6212678B1 (ja) | 2016-06-20 | 2017-10-11 | 塩野義製薬株式会社 | 置換された多環性ピリドン誘導体の製造方法およびその結晶 |
| AU2017310774B2 (en) | 2016-08-10 | 2023-01-19 | Shionogi & Co., Ltd. | Substituted polycyclic pyridone derivative and pharmaceutical composition containing prodrug thereof |
| JOP20170169A1 (ar) | 2016-08-29 | 2019-01-30 | Novartis Ag | مركبات بيريدازين ثلاثية الحلقة مندمجة تفيد في علاج العدوى بفيروس أورثوميكسو |
| WO2019010094A1 (en) * | 2017-07-06 | 2019-01-10 | Promega Corporation | STERILE SERIES PRO-COELENTERAZINE ANALOGS |
| TWI785116B (zh) * | 2017-09-18 | 2022-12-01 | 大陸商廣東東陽光藥業有限公司 | 流感病毒複製抑制劑及其用途 |
| CN111386276B (zh) | 2017-10-06 | 2023-06-23 | 盐野义制药株式会社 | 制备取代的多环吡啶酮衍生物的立体选择性方法 |
| KR102477187B1 (ko) * | 2018-01-17 | 2022-12-12 | 장시 카이시 파마슈티컬 테크놀로지 컴퍼니 리미티드 | 피리돈 유도체, 이의 입체 이성질체 및 항인플루엔자 바이러스 약물로서의 응용 |
| CN111303147B (zh) * | 2018-12-12 | 2024-07-02 | 江西彩石医药科技有限公司 | 吡啶酮衍生物、其组合物及作为抗流感病毒药物的应用 |
| CN110041327B (zh) * | 2018-01-17 | 2022-01-21 | 江西彩石医药科技有限公司 | 吡啶酮衍生物、其组合物及作为抗流感病毒药物的应用 |
| CN109503625A (zh) * | 2018-01-19 | 2019-03-22 | 赵蕾 | 一种多环吡啶酮化合物及其药物组合和用途 |
| US10596171B2 (en) * | 2018-01-22 | 2020-03-24 | Taigen Biotechnology Co., Ltd. | Cap-dependent endonuclease inhibitors |
| AU2019227250B2 (en) | 2018-02-28 | 2021-11-04 | Novartis Ag | 10-(di(phenyl)methyl)-4-hydroxy-8,9,9a,10-tetrahydro-7H-pyrrolo[1 ',2':4,5]pyrazino[1,2-b]pyridazine-3,5-dione derivatives and related compounds as inhibitors of the orthomyxovirus replication for treating influenza |
| CN108440564B (zh) | 2018-04-11 | 2019-08-06 | 安帝康（无锡）生物科技有限公司 | 被取代的多环氨基甲酰基吡啶酮衍生物及其前药 |
| WO2020004443A1 (ja) | 2018-06-27 | 2020-01-02 | 国立大学法人北海道大学 | 多環性カルバモイルピリドン誘導体を含有するアレナウイルス増殖阻害剤 |
| WO2020015669A1 (zh) * | 2018-07-17 | 2020-01-23 | 南京明德新药研发有限公司 | 抗流感病毒三并环衍生物 |
| CN110317211B (zh) * | 2018-07-27 | 2022-05-13 | 深圳市塔吉瑞生物医药有限公司 | 一种取代的多环性吡啶酮化合物及其前药 |
| MX2021004182A (es) | 2018-10-10 | 2021-09-08 | Janssen Biopharma Inc | Inhibidores macrocíclicos de endonucleasa de la gripe. |
| MY207622A (en) | 2018-10-22 | 2025-03-06 | Univ Nebraska | Antiviral prodrugs and nanoformulations thereof |
| CN109134428A (zh) * | 2018-10-25 | 2019-01-04 | 南京科技职业学院 | 一种巴洛沙韦中间体的制备方法 |
| WO2020112716A1 (en) * | 2018-11-26 | 2020-06-04 | Cocrystal Pharma, Inc. | Inhibitors of influenza virus replication |
| CN118873676A (zh) | 2018-11-29 | 2024-11-01 | 内布拉斯加大学董事会 | 抗病毒前药及其纳米制剂 |
| CN113614085B (zh) * | 2019-03-05 | 2022-12-23 | 广东东阳光药业有限公司 | 流感病毒复制抑制剂及其用途 |
| JP7158808B2 (ja) | 2019-03-12 | 2022-10-24 | 塩野義製薬株式会社 | インフルエンザ及び合併症リスク因子を有する対象における置換多環式ピリドン誘導体及びそのプロドラッグを用いたインフルエンザの処置 |
| EP3714889A1 (en) | 2019-03-29 | 2020-09-30 | F. Hoffmann-La Roche AG | Baloxavir for the prevention of transmission of influenza virus |
| EP3946614A1 (en) * | 2019-04-01 | 2022-02-09 | Nikang Therapeutics, Inc. | Fused polycyclic pyridone compounds as influenza virus replication inhibitors |
| RU2720305C1 (ru) * | 2019-05-07 | 2020-04-28 | Андрей Александрович Иващенко | Замещенный 3,4,12,12а-тетрагидро-1Н-[1,4]оксазино[3,4-c]пиридо[2,1-f] [1,2,4]триазин-6,8-дион, фармацевтическая композиция, способы их получения и применения |
| CN111909174B (zh) * | 2019-05-08 | 2022-01-21 | 江西彩石医药科技有限公司 | 吡啶酮衍生物的晶型及制备方法和应用 |
| CN112174956B (zh) * | 2019-07-05 | 2023-01-13 | 广州南鑫药业有限公司 | 一种2-取代-5-六氢哒嗪酮-4-羧酸酯衍生物及其用途 |
| CN112174955B (zh) * | 2019-07-05 | 2023-01-13 | 广州南鑫药业有限公司 | 一种2-取代-5-六氢哒嗪酮-4-羧酸胺衍生物及其用途 |
| CA3149588A1 (en) * | 2019-08-27 | 2021-03-04 | Oliver Planz | Combinations of mek inhibitors with cap-dependent endonuclease inhibitors |
| CN112521386B (zh) * | 2019-09-19 | 2023-05-26 | 周雨恬 | 具有抗病毒作用的多环吡啶酮化合物及其药物组合和用途 |
| CN112574170A (zh) * | 2019-09-29 | 2021-03-30 | 江西东邦药业有限公司 | 一种二苯并七元环衍生物及其制备方法和应用 |
| WO2021129602A1 (zh) * | 2019-12-23 | 2021-07-01 | 石家庄迪斯凯威医药科技有限公司 | 取代的多环化合物及其药物组合物和用途 |
| CN111233891B (zh) * | 2020-03-04 | 2021-05-04 | 江苏柯菲平医药股份有限公司 | 一种稠环吡啶酮衍生物及其制备方法和用途 |
| WO2021191872A1 (en) * | 2020-03-26 | 2021-09-30 | Janssen Biopharma, Inc. | Heteroaryl-substituted macrocyclic flu endonuclease inhibitors |
| CN113620948B (zh) * | 2020-05-06 | 2022-11-25 | 太景医药研发(北京)有限公司 | 帽依赖性核酸内切酶抑制剂 |
| RU2745985C1 (ru) * | 2020-05-07 | 2021-04-05 | Андрей Александрович Иващенко | Антикоронавирусный терапевтический агент - замещенный 7-гидрокси-3,4,12,12а-тетрагидро-1H-[1,4]оксазино[3,4-c]пиридо[2,1-f][1,2,4]триазин-6,8-дион для профилактики и лечения COVID-19 |
| JP7407976B2 (ja) * | 2020-05-21 | 2024-01-04 | シーセン ファーマシューティカル カンパニー リミテッド | 縮合環誘導体及びその薬学的用途 |
| TWI796701B (zh) * | 2020-05-28 | 2023-03-21 | 太景生物科技股份有限公司 | 用於製備雜環化合物的中間體立體選擇性合成 |
| WO2021249522A1 (zh) * | 2020-06-12 | 2021-12-16 | 上海翰森生物医药科技有限公司 | 含吡啶酮稠环类衍生物抑制剂、其制备方法和应用 |
| US12129265B2 (en) | 2020-07-21 | 2024-10-29 | Ankh Life Sciences Limited | Therapeutic agents and uses thereof |
| CN116490190A (zh) * | 2020-07-27 | 2023-07-25 | 默沙东有限责任公司 | 用于治疗或预防流感的多环帽依赖性核酸内切酶抑制剂 |
| CN112062763B (zh) * | 2020-09-10 | 2021-11-05 | 浙江大学 | 羟基吡啶酮并[1,2-b][1,2,5]三氮卓平衍生物及制备和应用 |
| CN112047945B (zh) * | 2020-09-10 | 2021-11-12 | 浙江大学 | 螺环吡啶酮衍生物及应用 |
| WO2022105669A1 (zh) * | 2020-11-17 | 2022-05-27 | 南京明德新药研发有限公司 | 含Se大环类化合物 |
| CN112480007B (zh) * | 2020-12-08 | 2022-11-18 | 宿迁市科莱博生物化学有限公司 | 一种1，3-二甲基-1h-吡唑-4-羧酸的合成方法 |
| CN112724156B (zh) * | 2020-12-30 | 2022-05-10 | 深圳市坤健创新药物研究院 | 一种多环吡啶酮衍生物和药物组合物及其应用 |
| CN114907365B (zh) * | 2021-02-09 | 2023-12-01 | 扬子江药业集团有限公司 | 一种流感病毒抑制剂及其用途 |
| JP2024507788A (ja) * | 2021-02-16 | 2024-02-21 | メルク・シャープ・アンド・ドーム・エルエルシー | Ｈｉｖインテグラーゼ阻害剤として有用な四環式複素環化合物 |
| WO2022237710A1 (zh) * | 2021-05-10 | 2022-11-17 | 南京征祥医药有限公司 | 治疗流感化合物的晶型及应用 |
| WO2023088370A1 (zh) * | 2021-11-17 | 2023-05-25 | 辰欣药业股份有限公司 | 一种稠环衍生物的晶型及其制备方法 |
| CN117924325A (zh) * | 2022-11-09 | 2024-04-26 | 石家庄迪斯凯威医药科技有限公司 | 一种抗流感病毒衍生物及其用途 |
| WO2024109707A1 (zh) * | 2022-11-21 | 2024-05-30 | 合肥医工医药股份有限公司 | 稠环吡啶酮衍生物及其制备方法和用途 |
| JPWO2024190907A1 (lt) * | 2023-03-15 | 2024-09-19 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2280435A (en) | 1993-07-29 | 1995-02-01 | Merck & Co Inc | Anti-viral agent |
| KR100663147B1 (ko) * | 2002-02-19 | 2007-02-28 | 오노 야꾸힝 고교 가부시키가이샤 | 축합 피리다진 유도체 화합물 및 이를 유효 성분으로서함유하는 약제 |
| AU2003267098B2 (en) | 2002-09-11 | 2008-11-20 | Merck & Co., Inc. | Dihydroxypyridopyrazine-1,6-dione compounds useful as HIV integrase inhibitors |
| JP3879729B2 (ja) * | 2003-06-04 | 2007-02-14 | 株式会社ノーリツ | ガス燃焼装置 |
| TW200510425A (en) * | 2003-08-13 | 2005-03-16 | Japan Tobacco Inc | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor |
| AU2005227258A1 (en) | 2004-03-09 | 2005-10-06 | Merck & Co., Inc. | HIV integrase inhibitors |
| CA2557926A1 (en) | 2004-03-09 | 2005-09-22 | Monica Donghi | Hiv integrase inhibitors |
| JP2006088173A (ja) * | 2004-09-21 | 2006-04-06 | Sumitomo Light Metal Ind Ltd | ダブルスキン形材の摩擦撹拌接合方法 |
| WO2006066414A1 (en) | 2004-12-23 | 2006-06-29 | Virochem Pharma Inc. | Hydroxydihydropyridopy razine-1,8-diones and methods for inhibiting hiv integrase |
| JP5317257B2 (ja) | 2005-02-21 | 2013-10-16 | 塩野義製薬株式会社 | Ｈｉｖインテグラーゼ阻害活性を有する２環性カルバモイルピリドン誘導体 |
| UA96568C2 (en) * | 2005-04-28 | 2011-11-25 | Глаксосмиткляйн Ллк | Polycyclic carbamoyl pyridone derivative as hiv-integrase inhibitor |
| US8129385B2 (en) * | 2005-04-28 | 2012-03-06 | Shionogi & Co., Ltd. | Substituted 5-hydroxy-3,4,6,9,9a, 10-hexanhydro-2h-1-oxa04a,8a-diaza-anthracene-6,10-dioness |
| JP4675828B2 (ja) * | 2005-07-15 | 2011-04-27 | 株式会社リコー | デジタルカメラ |
| CN101346376A (zh) * | 2005-10-27 | 2009-01-14 | 盐野义制药株式会社 | 具有hiv整合酶抑制活性的多环性氨基甲酰基吡啶酮衍生物 |
| AU2006307101A1 (en) * | 2005-10-27 | 2007-05-03 | Shionogi & Co., Ltd. | Polycyclic carbamoylpyridone derivative having inhibitory activity on HIV integrase |
| WO2010011815A1 (en) * | 2008-07-25 | 2010-01-28 | Smithkline Beecham Corporation | Chemical compounds |
| US8183372B2 (en) | 2008-07-25 | 2012-05-22 | Shionogi & Co., Ltd. | Substituted 9,11-dioxo-2,3,4a,5,9,11,13,13a-octahydor-1H-pyrido[1,2-a]pyrrolo[1′,2′:3,4]imidazo[1,2-d]pyrazines |
| ES2448766T3 (es) * | 2008-07-25 | 2014-03-17 | Viiv Healthcare Company | Profármacos de dolutegravir |
| WO2010011819A1 (en) | 2008-07-25 | 2010-01-28 | Smithkline Beecham Corporation | Chemical compounds |
| SG192550A1 (en) * | 2008-07-25 | 2013-08-30 | Viiv Healthcare Co | Chemical compounds |
| WO2010011818A1 (en) * | 2008-07-25 | 2010-01-28 | Smithkline Beecham Corporation | Chemical compounds |
| RS57244B1 (sr) | 2009-06-15 | 2018-07-31 | Shionogi & Co | Supstituisani policiklički derivati karbamoilpiridona |
| WO2011011483A1 (en) | 2009-07-22 | 2011-01-27 | Glaxosmithkline Llc | Chemical compounds |
-
2011
- 2011-09-21 CN CN201180056716.8A patent/CN103228653B/zh active Active
- 2011-09-21 WO PCT/JP2011/071446 patent/WO2012039414A1/ja not_active Ceased
- 2011-09-21 KR KR1020137010331A patent/KR101773226B1/ko active Active
- 2011-09-21 DK DK11826859.8T patent/DK2620436T3/en active
- 2011-09-21 AU AU2011307087A patent/AU2011307087B2/en active Active
- 2011-09-21 PL PL11826859T patent/PL2620436T3/pl unknown
- 2011-09-21 TR TR2018/10736T patent/TR201810736T4/tr unknown
- 2011-09-21 EP EP11826859.8A patent/EP2620436B1/en active Active
- 2011-09-21 RS RS20180908A patent/RS57490B1/sr unknown
- 2011-09-21 HU HUE11826859A patent/HUE039859T2/hu unknown
- 2011-09-21 BR BR112013006722-5A patent/BR112013006722B1/pt active IP Right Grant
- 2011-09-21 US US13/824,723 patent/US8987441B2/en active Active
- 2011-09-21 CA CA2812363A patent/CA2812363C/en active Active
- 2011-09-21 HR HRP20181250TT patent/HRP20181250T1/hr unknown
- 2011-09-21 LT LTEP11826859.8T patent/LT2620436T/lt unknown
- 2011-09-21 ES ES11826859.8T patent/ES2683153T3/es active Active
- 2011-09-21 MX MX2013003139A patent/MX2013003139A/es active IP Right Grant
- 2011-09-21 PT PT118268598T patent/PT2620436T/pt unknown
- 2011-09-21 SI SI201131528T patent/SI2620436T1/en unknown
- 2011-09-21 RU RU2013114189A patent/RU2608519C2/ru active
- 2011-09-21 JP JP2012535048A patent/JP5553393B2/ja active Active
- 2011-09-23 TW TW100134256A patent/TWI518085B/zh active
-
2014
- 2014-05-20 JP JP2014104465A patent/JP5777077B2/ja active Active
- 2014-12-05 US US14/562,117 patent/US9758515B2/en active Active
-
2017
- 2017-08-14 US US15/676,540 patent/US10202379B2/en active Active
-
2018
- 2018-11-19 US US16/194,504 patent/US20190248785A1/en not_active Abandoned
-
2019
- 2019-11-15 US US16/684,870 patent/US20200339565A1/en not_active Abandoned
-
2021
- 2021-03-08 NO NO2021011C patent/NO2021011I1/no unknown
- 2021-03-15 FR FR21C1012C patent/FR21C1012I2/fr active Active
- 2021-03-19 LT LTPA2021505C patent/LTC2620436I2/lt unknown
- 2021-03-23 HU HUS2100010C patent/HUS2100010I1/hu unknown
-
2023
- 2023-08-04 US US18/230,392 patent/US20240182463A1/en active Pending
-
2025
- 2025-08-28 NO NO2025040C patent/NO2025040I1/no unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| LTC2620436I2 (lt) | Pakeistojo policiklinio karbamoilpiridono darinio provaistas | |
| EP2444400A4 (en) | SUBSTITUTED POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE | |
| PL2614063T3 (pl) | Podstawione imidazopirydazyny | |
| EP2684880A4 (en) | DISPIROPYRROLIDINDERIVAT | |
| EP2599771A4 (en) | naphthalene | |
| BR112013009935C8 (pt) | compostos | |
| BR112012028556A2 (pt) | Indóis | |
| DE102011100241A8 (de) | Nitridhalbleiterbauteil | |
| CR20130111A (es) | Triazina-oxidiazoles | |
| DE10170954T8 (de) | Mikrowellendruckgarer | |
| DK2648516T3 (da) | Substituerede pyridinon-pyridinylforbindelser | |
| DK2590974T3 (da) | Tetrahydropyridopyrimidinderivater | |
| DE112011104226A5 (de) | Käfigmutter | |
| CO6801726A2 (es) | Compuestos | |
| BR112013013695A2 (pt) | derivado de pirazol | |
| DE102011117046A8 (de) | Doppelkupplungswindungsgetriebe | |
| DK2649070T3 (da) | Triazolpyridinforbindelser | |
| DE112011101226A5 (de) | Linearwegmesssystem | |
| DE112011102080A5 (de) | Kupplungszentralausrücker | |
| EP2543670A4 (en) | Pyrazolopyrimidine DERIVATIVE | |
| DK2442899T3 (da) | Rotorskive | |
| DE102010038420A8 (de) | Reinigungungsvorrichtung | |
| DE102011002623A8 (de) | Ventilsteuerzeitversteller | |
| DE112011102711A5 (de) | Hydrostataktor | |
| DK2448659T3 (da) | Rotorskive |