[go: up one dir, main page]

PL3380471T3 - Tetrahydro-8h-pirydo[1,2-a]pirazyn-8-ony jako inhibitory comt do leczenia chorób i zaburzeń neurodegeneracyjnych - Google Patents

Tetrahydro-8h-pirydo[1,2-a]pirazyn-8-ony jako inhibitory comt do leczenia chorób i zaburzeń neurodegeneracyjnych

Info

Publication number
PL3380471T3
PL3380471T3 PL16869342T PL16869342T PL3380471T3 PL 3380471 T3 PL3380471 T3 PL 3380471T3 PL 16869342 T PL16869342 T PL 16869342T PL 16869342 T PL16869342 T PL 16869342T PL 3380471 T3 PL3380471 T3 PL 3380471T3
Authority
PL
Poland
Prior art keywords
pyrido
pyrazine
tetrahydro
ones
treatment
Prior art date
Application number
PL16869342T
Other languages
English (en)
Inventor
James Barrow
Glen Ernst
Dominique Swinnen
Florian MONTEL
Sabine Defays
Yifang Huang
Pablo DE LÉON
Michael Steven Poslusney
Original Assignee
Lieber Institute Inc. Dba Lieber Institute For Brain Development
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lieber Institute Inc. Dba Lieber Institute For Brain Development filed Critical Lieber Institute Inc. Dba Lieber Institute For Brain Development
Publication of PL3380471T3 publication Critical patent/PL3380471T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL16869342T 2015-11-25 2016-11-25 Tetrahydro-8h-pirydo[1,2-a]pirazyn-8-ony jako inhibitory comt do leczenia chorób i zaburzeń neurodegeneracyjnych PL3380471T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562260067P 2015-11-25 2015-11-25
PCT/US2016/063779 WO2017091818A1 (en) 2015-11-25 2016-11-25 Comt inhibiting methods and compositions
EP16869342.2A EP3380471B8 (en) 2015-11-25 2016-11-25 Tetrahydro-8h-pyrido[1,2-a]pyrazine-8-ones as comt inhibitors for the treatment of neurodegenerative disorders

Publications (1)

Publication Number Publication Date
PL3380471T3 true PL3380471T3 (pl) 2021-12-20

Family

ID=58763706

Family Applications (1)

Application Number Title Priority Date Filing Date
PL16869342T PL3380471T3 (pl) 2015-11-25 2016-11-25 Tetrahydro-8h-pirydo[1,2-a]pirazyn-8-ony jako inhibitory comt do leczenia chorób i zaburzeń neurodegeneracyjnych

Country Status (8)

Country Link
US (2) US10934283B2 (pl)
EP (1) EP3380471B8 (pl)
CA (1) CA3006189C (pl)
DK (1) DK3380471T3 (pl)
ES (1) ES2893613T3 (pl)
HU (1) HUE056356T2 (pl)
PL (1) PL3380471T3 (pl)
WO (1) WO2017091818A1 (pl)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA40532A (fr) 2014-08-28 2021-04-28 Asceneuron Sa Inhibiteurs de glycosidases
US11261183B2 (en) 2016-02-25 2022-03-01 Asceneuron Sa Sulfoximine glycosidase inhibitors
US11612599B2 (en) 2016-02-25 2023-03-28 Asceneuron Sa Glycosidase inhibitors
MX381953B (es) 2016-02-25 2025-03-13 Asceneuron S A Sales de derivados de piperazina obtenidas por adicion de acidos.
US10556902B2 (en) 2016-02-25 2020-02-11 Asceneuron Sa Glycosidase inhibitors
EP3672959A1 (en) 2017-08-24 2020-07-01 Asceneuron SA Linear glycosidase inhibitors
WO2019037861A1 (en) * 2017-08-24 2019-02-28 Asceneuron S.A. ANNOTATED GLYCOSIDASE INHIBITORS
WO2020039028A1 (en) 2018-08-22 2020-02-27 Asceneuron S. A. Tetrahydro-benzoazepine glycosidase inhibitors
CN113166083A (zh) 2018-08-22 2021-07-23 阿森纽荣股份公司 用作糖苷酶抑制剂的哌嗪衍生物的琥珀酸盐和富马酸盐酸加成盐
US11731972B2 (en) 2018-08-22 2023-08-22 Asceneuron Sa Spiro compounds as glycosidase inhibitors
US12016852B2 (en) 2018-08-22 2024-06-25 Asceneuron Sa Pyrrolidine glycosidase inhibitors

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9709105A (pt) 1996-05-20 1999-08-03 Darwin Discovery Ltd Sulfonamidas de quinolina como inibidoras de tnf e como inobidoras de pde-iv
GB0130696D0 (en) 2001-12-21 2002-02-06 Smithkline Beecham Plc Chemical Compounds
AU2002950217A0 (en) 2002-07-16 2002-09-12 Prana Biotechnology Limited 8- Hydroxy Quinoline Derivatives
KR20060037442A (ko) * 2003-08-14 2006-05-03 화이자 인코포레이티드 Hiv 감염 치료용 피페라진 유도체
SI2481410T1 (sl) 2007-01-31 2017-01-31 Bial - Portela & Ca., S.A. Derivati nitrokatehola kot COMT inhibitorji, ki se dajejo s specifičnim dozirnim režimom
CA2721493C (en) 2008-04-18 2017-11-28 Intec Pharma Ltd. Carbidopa/levodopa gastroretentive drug delivery
CA2789471C (en) 2010-03-04 2018-01-02 Merck Sharp & Dohme Corp. Inhibitors of catechol o-methyl transferase and their use in the treatment of psychotic disorders
GB201004372D0 (en) 2010-03-16 2010-04-28 Almac Sciences Scotland Ltd Compounds for purification
US20140186280A1 (en) 2010-08-13 2014-07-03 Varinel Inc Neuroprotective and neuro-restorative iron chelators and monoamine oxidase inhibitors and uses thereof
US8987441B2 (en) * 2010-09-24 2015-03-24 Shionogi & Co., Ltd. Substituted polycyclic carbamoyl pyridone derivative prodrug
US9951057B2 (en) 2015-01-30 2018-04-24 Lieber Institute For Brain Development COMT inhibiting methods and compositions

Also Published As

Publication number Publication date
EP3380471B1 (en) 2021-09-08
CA3006189C (en) 2023-12-19
CA3006189A1 (en) 2017-06-01
ES2893613T3 (es) 2022-02-09
DK3380471T3 (da) 2021-10-11
EP3380471B8 (en) 2022-01-19
EP3380471A1 (en) 2018-10-03
EP3380471A4 (en) 2019-05-15
WO2017091818A1 (en) 2017-06-01
HUE056356T2 (hu) 2022-02-28
US10934283B2 (en) 2021-03-02
US20210139479A1 (en) 2021-05-13
US20180305354A1 (en) 2018-10-25

Similar Documents

Publication Publication Date Title
IL288712B1 (en) Methods for treating abnormal movement disorders
PL3380471T3 (pl) Tetrahydro-8h-pirydo[1,2-a]pirazyn-8-ony jako inhibitory comt do leczenia chorób i zaburzeń neurodegeneracyjnych
SG10201912632YA (en) Pyrimidin-2-ylamino-1h-pyrazols as lrrk2 inhibitors for use in the treatment of neurodegenerative disorders
IL258471A (en) 11,13-modified saxitoxins for the treatment of pain
IL262348A (en) Preparations for the treatment of excessive radiation disorders
EP3329018A4 (en) Methods for treating hepcidin-mediated disorders
EP3283655A4 (en) Methods for treating myeloproliferative disorders
SI3524255T1 (sl) Sestavek za zdravljenje aken
IL258032A (en) Compounds and preparations for the treatment of ocular disorders
SG11201708181RA (en) Methods for the treatment of inflammatory disorders
SG11201708198SA (en) Methods for the treatment of cardiovascular disorders
EP3200795A4 (en) Use of agents for treating fat-related disorders
EP3507277B8 (en) Hydroxynorketamine derivatives for the treatment of disorders
HK40007576A (en) Pyrimidin-2-ylamino-1h-pyrazols as lrrk2 inhibitors for use in the treatment of neurodegenerative disorders
GB201521543D0 (en) Methods for the treatment of inflammatory disorders
GB201513993D0 (en) Methods for the treatment of inflammatory disorders
GB201513345D0 (en) Methods for the treatment of Inflammatory disorders
GB201507113D0 (en) Methods for the treatment of inflammatory disorders
GB201506419D0 (en) Methods for the treatment of inflammatory disorders
GB201506229D0 (en) Methods For the Treatment Of Inflammatory Disorders
GB201521542D0 (en) Methods for the treatment of cardiovascular disorders
PT3524255T (pt) Composição para o tratamento do acne
PL3273997T3 (pl) Kompozycja do leczenia nieżytu nosa
GB201513991D0 (en) Methods for the treatment of cardiovascular disorders
GB201513344D0 (en) Methods for the treatment of Cardiovascular disorders