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CO5590914A2 - Derivados de 5-(piridin-3-il)-1-azabiciclo [3.2.1] octano - Google Patents

Derivados de 5-(piridin-3-il)-1-azabiciclo [3.2.1] octano

Info

Publication number
CO5590914A2
CO5590914A2 CO04062934A CO04062934A CO5590914A2 CO 5590914 A2 CO5590914 A2 CO 5590914A2 CO 04062934 A CO04062934 A CO 04062934A CO 04062934 A CO04062934 A CO 04062934A CO 5590914 A2 CO5590914 A2 CO 5590914A2
Authority
CO
Colombia
Prior art keywords
groups
group
azepin
trifluoromethoxy
dialkylamino
Prior art date
Application number
CO04062934A
Other languages
English (en)
Inventor
Frederic Galli
Odile Leclerc
Alistair Lochead
Alain Nedelec
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Publication of CO5590914A2 publication Critical patent/CO5590914A2/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08Bridged systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

1.- Compuesto, en forma de enantiómero puro o en forma de rnezcla de enantiómeros, que responde a la fórmula general ( I ): en la cual R representa un átomo de halógeno o un grupo cicloalquilo(C3-C6) o un grupo fenilo substituido por uno o varios grupos elegidos entre un átomo de halógeno, o un grupo alquilo (C1-C6), alcoxi (C1-C6), nitro, amino, dialquilamino (C1-C3), trifluorometilo, trifluorometoxi, ciano, hidroxi, acetilo o metilendioxi, o un grupo piperidinilo, o morfolin-4-ilo, o pirrolidin-1-ilo, o azetidin-1-ilo, o azepin-1-ilo, o azepin-1-ilo, o piridinilo, o quinolinilo, o tienilo, o pirazinilo, o furilo, o benzofurilo, o benzotienilo, o indolilo, o pirimidinilo o isoxazolilo, o fenoxazinilo, o fenoxatiinilo, o dibenzotienilo, o dibenzofurilo, o pirrolilo o naftilo, y cada uno de esos grupos puede eventualmente ser substituido por uno o varios grupos elegidos entre los átomos de halógenos, los grupos alquilo (C1-C6), alcoxi (C1-C6), trifluorometoxi, trifluorometilo, nitro, ciano, hidroxi, amino, dialquilamino (C1-C3) o cicloalquilamino (C1-C8), y se sabe que entre los dos enlaces carbono-carbono representados por - - -, uno es simple y el otro puede ser simple o doble,en estado de base o de sal derivada de adición con un ácido.
CO04062934A 2002-01-07 2004-07-01 Derivados de 5-(piridin-3-il)-1-azabiciclo [3.2.1] octano CO5590914A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0200109A FR2834511B1 (fr) 2002-01-07 2002-01-07 Derives de 5-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
CO5590914A2 true CO5590914A2 (es) 2005-12-30

Family

ID=8871176

Family Applications (1)

Application Number Title Priority Date Filing Date
CO04062934A CO5590914A2 (es) 2002-01-07 2004-07-01 Derivados de 5-(piridin-3-il)-1-azabiciclo [3.2.1] octano

Country Status (35)

Country Link
US (2) US7223750B2 (es)
EP (1) EP1465893B1 (es)
JP (1) JP4402957B2 (es)
KR (1) KR100977332B1 (es)
CN (2) CN1911928A (es)
AR (2) AR038098A1 (es)
AT (1) ATE355290T1 (es)
AU (1) AU2003216777B2 (es)
BR (1) BR0306707A (es)
CA (1) CA2471628C (es)
CO (1) CO5590914A2 (es)
CY (1) CY1106580T1 (es)
DE (1) DE60312123T2 (es)
DK (1) DK1465893T3 (es)
EA (1) EA007793B1 (es)
EC (1) ECSP045176A (es)
ES (1) ES2281631T3 (es)
FR (1) FR2834511B1 (es)
HR (1) HRP20040617B1 (es)
IL (2) IL162524A0 (es)
IS (1) IS2470B (es)
MA (1) MA27165A1 (es)
ME (2) MEP24408A (es)
MX (1) MXPA04006630A (es)
NO (1) NO329309B1 (es)
NZ (1) NZ533793A (es)
PL (1) PL216665B1 (es)
PT (1) PT1465893E (es)
RS (1) RS50921B (es)
SI (1) SI1465893T1 (es)
TN (1) TNSN04120A1 (es)
TW (1) TWI336703B (es)
UA (1) UA77229C2 (es)
WO (1) WO2003057697A1 (es)
ZA (1) ZA200405002B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9902007D0 (en) * 1999-01-30 1999-03-17 Thomas Carpentry Services Limi Improvements relating to door frames
FR2834511B1 (fr) * 2002-01-07 2004-02-13 Sanofi Synthelabo Derives de 5-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, leur preparation et leur application en therapeutique
FR2889701B1 (fr) * 2005-08-12 2007-10-05 Sanofi Aventis Sa Derives de 5-pyridinyl-1-azabicyclo[3.2.1]octane, leur preparation en therapeutique.
FR2889847B1 (fr) * 2005-08-18 2007-10-05 Sanofi Aventis Sa Derives de 5-pyridazinyl-1-azabicyclo[3.2.1]octave, leur preparation en therapeutique.
FR2912404B1 (fr) * 2007-02-09 2009-04-10 Sanofi Aventis Sa Derives d'azabicycloalkane,leur preparation et leur application en therapeutique.
KR101925971B1 (ko) 2011-01-28 2018-12-06 에스케이바이오팜 주식회사 피리돈 유도체 및 이를 포함하는 약학적 조성물
KR101928505B1 (ko) 2011-01-28 2018-12-12 에스케이바이오팜 주식회사 피리돈 유도체 및 이를 포함하는 약학적 조성물
KR20200083976A (ko) 2017-11-03 2020-07-09 알콘 인코포레이티드 눈 장애의 치료를 위한 아자바이시클로 및 디아제핀 유도체

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5817679A (en) * 1993-04-01 1998-10-06 University Of Virginia 7-Azabicyclo 2.2.1!-heptane and -heptene derivatives as cholinergic receptor ligands
AU7474794A (en) 1993-07-22 1995-02-20 E.I. Du Pont De Nemours And Company Arthropodicidal azacyclic heterocycles
FR2786769B1 (fr) * 1998-12-04 2002-10-25 Synthelabo Derives de 2,5-diazabicyclo[2.2.1]heptane, leur preparation et leur application en therapeutique
FR2786770B1 (fr) * 1998-12-04 2001-01-19 Synthelabo Derives de 1,4-diazabicyclo[3.2.2.]nonane, leur preparation et leur application en therapeutique
FR2834511B1 (fr) * 2002-01-07 2004-02-13 Sanofi Synthelabo Derives de 5-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
EP1465893B1 (fr) 2007-02-28
CN1911928A (zh) 2007-02-14
UA77229C2 (uk) 2006-11-15
US7223750B2 (en) 2007-05-29
CN1276921C (zh) 2006-09-27
EP1465893A1 (fr) 2004-10-13
RS59904A (sr) 2006-10-27
AR038098A1 (es) 2004-12-29
US20070185137A1 (en) 2007-08-09
US7585974B2 (en) 2009-09-08
KR100977332B1 (ko) 2010-08-20
HK1066547A1 (en) 2005-03-24
ZA200405002B (en) 2006-05-31
MXPA04006630A (es) 2004-11-10
CA2471628C (en) 2011-03-22
JP2005514422A (ja) 2005-05-19
IS2470B (is) 2008-12-15
CN1612876A (zh) 2005-05-04
EA007793B1 (ru) 2007-02-27
DE60312123D1 (de) 2007-04-12
JP4402957B2 (ja) 2010-01-20
US20050020568A1 (en) 2005-01-27
TWI336703B (en) 2011-02-01
FR2834511B1 (fr) 2004-02-13
RS50921B (sr) 2010-08-31
DE60312123T2 (de) 2007-09-13
WO2003057697A1 (fr) 2003-07-17
ES2281631T3 (es) 2007-10-01
MEP24408A (en) 2010-10-10
TW200305413A (en) 2003-11-01
IL162524A0 (en) 2005-11-20
NZ533793A (en) 2007-01-26
IS7322A (is) 2004-06-16
DK1465893T3 (da) 2007-06-04
HRP20040617A2 (en) 2004-10-31
NO329309B1 (no) 2010-09-27
AU2003216777A1 (en) 2003-07-24
CY1106580T1 (el) 2012-01-25
ECSP045176A (es) 2004-08-27
ME00213B (me) 2011-02-10
PL370065A1 (en) 2005-05-16
NO20042846L (no) 2004-09-21
AR086573A2 (es) 2014-01-08
FR2834511A1 (fr) 2003-07-11
EA200400770A1 (ru) 2004-12-30
IL162524A (en) 2010-05-17
HRP20040617B1 (hr) 2012-10-31
PT1465893E (pt) 2007-05-31
BR0306707A (pt) 2005-02-09
TNSN04120A1 (fr) 2006-06-01
KR20040077705A (ko) 2004-09-06
SI1465893T1 (sl) 2007-08-31
AU2003216777B2 (en) 2008-10-02
MA27165A1 (fr) 2005-01-03
CA2471628A1 (en) 2003-07-17
PL216665B1 (pl) 2014-04-30
ATE355290T1 (de) 2006-03-15

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