EA200400770A1 - Производные 5-(пиридин-3-ил)-1-азабицикло[3.2.1]октана, их получение и применение в терапии - Google Patents
Производные 5-(пиридин-3-ил)-1-азабицикло[3.2.1]октана, их получение и применение в терапииInfo
- Publication number
- EA200400770A1 EA200400770A1 EA200400770A EA200400770A EA200400770A1 EA 200400770 A1 EA200400770 A1 EA 200400770A1 EA 200400770 A EA200400770 A EA 200400770A EA 200400770 A EA200400770 A EA 200400770A EA 200400770 A1 EA200400770 A1 EA 200400770A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- group
- oktana
- piridin
- azabicyclo
- therapy
- Prior art date
Links
- 238000002560 therapeutic procedure Methods 0.000 title 1
- -1 nitro, amino groups Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 102000019315 Nicotinic acetylcholine receptors Human genes 0.000 abstract 1
- 108050006807 Nicotinic acetylcholine receptors Proteins 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 abstract 1
- 125000001041 indolyl group Chemical group 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Данное изобретение относится к соединениям, имеющим общую формулу (I), где R обозначает атом галогена, фенильную группу, которая замещена одной или более чем одной группой, выбранной из атомов галогенов и групп (C-C)алкил, (C-C)алкокси, нитро, амино, трифторметил, циано, гидрокси, ацетил или метилендиокси, пиридинильную группу, тиенильную группу, индолильную группу или пиримидинильную группу, которая возможно замещена одной или более чем одной (C-C)алкоксигруппой. Кроме того, из двух углерод-углеродных связей, обозначенных как, одна является простой, а другая может быть простой или двойной. Соединения по изобретению являются лигандами никотиновых рецепторов.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0200109A FR2834511B1 (fr) | 2002-01-07 | 2002-01-07 | Derives de 5-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, leur preparation et leur application en therapeutique |
| PCT/FR2003/000004 WO2003057697A1 (fr) | 2002-01-07 | 2003-01-03 | Derives de 5-(pyridin-3-yl)-1-azabicyclo [3.2.1] octane, leur preparation et leur application en therapeutique |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200400770A1 true EA200400770A1 (ru) | 2004-12-30 |
| EA007793B1 EA007793B1 (ru) | 2007-02-27 |
Family
ID=8871176
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200400770A EA007793B1 (ru) | 2002-01-07 | 2003-01-03 | Производные 5-(пиридин-3-ил)-1-азабицикло[3.2.1]октана, их получение и применение в терапии |
Country Status (35)
| Country | Link |
|---|---|
| US (2) | US7223750B2 (ru) |
| EP (1) | EP1465893B1 (ru) |
| JP (1) | JP4402957B2 (ru) |
| KR (1) | KR100977332B1 (ru) |
| CN (2) | CN1276921C (ru) |
| AR (2) | AR038098A1 (ru) |
| AT (1) | ATE355290T1 (ru) |
| AU (1) | AU2003216777B2 (ru) |
| BR (1) | BR0306707A (ru) |
| CA (1) | CA2471628C (ru) |
| CO (1) | CO5590914A2 (ru) |
| CY (1) | CY1106580T1 (ru) |
| DE (1) | DE60312123T2 (ru) |
| DK (1) | DK1465893T3 (ru) |
| EA (1) | EA007793B1 (ru) |
| EC (1) | ECSP045176A (ru) |
| ES (1) | ES2281631T3 (ru) |
| FR (1) | FR2834511B1 (ru) |
| HR (1) | HRP20040617B1 (ru) |
| IL (2) | IL162524A0 (ru) |
| IS (1) | IS2470B (ru) |
| MA (1) | MA27165A1 (ru) |
| ME (2) | ME00213B (ru) |
| MX (1) | MXPA04006630A (ru) |
| NO (1) | NO329309B1 (ru) |
| NZ (1) | NZ533793A (ru) |
| PL (1) | PL216665B1 (ru) |
| PT (1) | PT1465893E (ru) |
| RS (1) | RS50921B (ru) |
| SI (1) | SI1465893T1 (ru) |
| TN (1) | TNSN04120A1 (ru) |
| TW (1) | TWI336703B (ru) |
| UA (1) | UA77229C2 (ru) |
| WO (1) | WO2003057697A1 (ru) |
| ZA (1) | ZA200405002B (ru) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9902007D0 (en) * | 1999-01-30 | 1999-03-17 | Thomas Carpentry Services Limi | Improvements relating to door frames |
| FR2834511B1 (fr) * | 2002-01-07 | 2004-02-13 | Sanofi Synthelabo | Derives de 5-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, leur preparation et leur application en therapeutique |
| FR2889701B1 (fr) * | 2005-08-12 | 2007-10-05 | Sanofi Aventis Sa | Derives de 5-pyridinyl-1-azabicyclo[3.2.1]octane, leur preparation en therapeutique. |
| FR2889847B1 (fr) * | 2005-08-18 | 2007-10-05 | Sanofi Aventis Sa | Derives de 5-pyridazinyl-1-azabicyclo[3.2.1]octave, leur preparation en therapeutique. |
| FR2912404B1 (fr) * | 2007-02-09 | 2009-04-10 | Sanofi Aventis Sa | Derives d'azabicycloalkane,leur preparation et leur application en therapeutique. |
| KR101928505B1 (ko) * | 2011-01-28 | 2018-12-12 | 에스케이바이오팜 주식회사 | 피리돈 유도체 및 이를 포함하는 약학적 조성물 |
| KR101925971B1 (ko) * | 2011-01-28 | 2018-12-06 | 에스케이바이오팜 주식회사 | 피리돈 유도체 및 이를 포함하는 약학적 조성물 |
| MX2020004580A (es) | 2017-11-03 | 2020-12-03 | Alcon Inc | Azabiciclo y derivados de diazepina para tratar trastornos oculares. |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5817679A (en) * | 1993-04-01 | 1998-10-06 | University Of Virginia | 7-Azabicyclo 2.2.1!-heptane and -heptene derivatives as cholinergic receptor ligands |
| WO1995003306A1 (en) | 1993-07-22 | 1995-02-02 | E.I. Du Pont De Nemours And Company | Arthropodicidal azacyclic heterocycles |
| FR2786769B1 (fr) * | 1998-12-04 | 2002-10-25 | Synthelabo | Derives de 2,5-diazabicyclo[2.2.1]heptane, leur preparation et leur application en therapeutique |
| FR2786770B1 (fr) * | 1998-12-04 | 2001-01-19 | Synthelabo | Derives de 1,4-diazabicyclo[3.2.2.]nonane, leur preparation et leur application en therapeutique |
| FR2834511B1 (fr) * | 2002-01-07 | 2004-02-13 | Sanofi Synthelabo | Derives de 5-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, leur preparation et leur application en therapeutique |
-
2002
- 2002-01-07 FR FR0200109A patent/FR2834511B1/fr not_active Expired - Fee Related
- 2002-12-31 TW TW091138055A patent/TWI336703B/zh not_active IP Right Cessation
-
2003
- 2003-01-03 PT PT03712202T patent/PT1465893E/pt unknown
- 2003-01-03 PL PL370065A patent/PL216665B1/pl unknown
- 2003-01-03 CA CA2471628A patent/CA2471628C/en not_active Expired - Fee Related
- 2003-01-03 CN CNB038019876A patent/CN1276921C/zh not_active Expired - Fee Related
- 2003-01-03 AU AU2003216777A patent/AU2003216777B2/en not_active Ceased
- 2003-01-03 EP EP03712202A patent/EP1465893B1/fr not_active Expired - Lifetime
- 2003-01-03 DE DE60312123T patent/DE60312123T2/de not_active Expired - Lifetime
- 2003-01-03 ME MEP-2008-244A patent/ME00213B/me unknown
- 2003-01-03 NZ NZ533793A patent/NZ533793A/en not_active IP Right Cessation
- 2003-01-03 WO PCT/FR2003/000004 patent/WO2003057697A1/fr not_active Ceased
- 2003-01-03 AT AT03712202T patent/ATE355290T1/de active
- 2003-01-03 ES ES03712202T patent/ES2281631T3/es not_active Expired - Lifetime
- 2003-01-03 BR BR0306707-6A patent/BR0306707A/pt not_active Application Discontinuation
- 2003-01-03 JP JP2003558012A patent/JP4402957B2/ja not_active Expired - Fee Related
- 2003-01-03 EA EA200400770A patent/EA007793B1/ru not_active IP Right Cessation
- 2003-01-03 DK DK03712202T patent/DK1465893T3/da active
- 2003-01-03 CN CNA2006101091747A patent/CN1911928A/zh active Pending
- 2003-01-03 RS YUP-599/04A patent/RS50921B/sr unknown
- 2003-01-03 IL IL16252403A patent/IL162524A0/xx unknown
- 2003-01-03 AR ARP030100009A patent/AR038098A1/es not_active Application Discontinuation
- 2003-01-03 US US10/500,015 patent/US7223750B2/en not_active Expired - Lifetime
- 2003-01-03 HR HRP20040617AA patent/HRP20040617B1/hr not_active IP Right Cessation
- 2003-01-03 MX MXPA04006630A patent/MXPA04006630A/es active IP Right Grant
- 2003-01-03 SI SI200330774T patent/SI1465893T1/sl unknown
- 2003-01-03 ME MEP-244/08A patent/MEP24408A/xx unknown
- 2003-01-03 KR KR1020047010566A patent/KR100977332B1/ko not_active Expired - Fee Related
- 2003-03-01 UA UA20040605056A patent/UA77229C2/ru unknown
-
2004
- 2004-06-14 IL IL162524A patent/IL162524A/en not_active IP Right Cessation
- 2004-06-16 IS IS7322A patent/IS2470B/is unknown
- 2004-06-24 ZA ZA200405002A patent/ZA200405002B/en unknown
- 2004-06-29 EC EC2004005176A patent/ECSP045176A/es unknown
- 2004-06-30 TN TNP2004000120A patent/TNSN04120A1/fr unknown
- 2004-07-01 CO CO04062934A patent/CO5590914A2/es active IP Right Grant
- 2004-07-01 MA MA27759A patent/MA27165A1/fr unknown
- 2004-07-05 NO NO20042846A patent/NO329309B1/no not_active IP Right Cessation
-
2007
- 2007-04-05 US US11/696,993 patent/US7585974B2/en not_active Expired - Fee Related
- 2007-05-10 CY CY20071100641T patent/CY1106580T1/el unknown
-
2012
- 2012-05-28 AR ARP120101864A patent/AR086573A2/es not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HC1A | Change in name of an applicant in a eurasian application | ||
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ KZ KG MD TJ TM |
|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): BY RU |