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EA200600330A1 - Замещённые имидазопиримидины для предупреждения и лечения рака - Google Patents

Замещённые имидазопиримидины для предупреждения и лечения рака

Info

Publication number
EA200600330A1
EA200600330A1 EA200600330A EA200600330A EA200600330A1 EA 200600330 A1 EA200600330 A1 EA 200600330A1 EA 200600330 A EA200600330 A EA 200600330A EA 200600330 A EA200600330 A EA 200600330A EA 200600330 A1 EA200600330 A1 EA 200600330A1
Authority
EA
Eurasian Patent Office
Prior art keywords
sub
cancer
treatment
imidazopirimidines
prevention
Prior art date
Application number
EA200600330A
Other languages
English (en)
Other versions
EA009038B1 (ru
Inventor
Хуан Лоренсо Катена Руис
Карлес Фарреронс Гальеми
Анна Фернандес Серрат
Кармен Серра Комас
Долорс Бальса Лопес
Кармен Лагунас Арналь
Каролина Сальседо Рока
Андрес Фернандес Гарсия
Original Assignee
Лабораториос С.А.Л.В.А.Т., С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Лабораториос С.А.Л.В.А.Т., С.А. filed Critical Лабораториос С.А.Л.В.А.Т., С.А.
Publication of EA200600330A1 publication Critical patent/EA200600330A1/ru
Publication of EA009038B1 publication Critical patent/EA009038B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Соединения общей формулы (I), где А1-А5 и В1-В5 означают, среди прочих, Н, алкил, алкоксил, галоген, карбоксильные производные или производные серы; и Р1-Р3 означают, среди прочих, Н, галоген, алкил или алкоксил. Вышеупомянутые соединения можно применять для химиопрофилактики и лечения как предраковых поражений, так и рака.
EA200600330A 2003-07-30 2004-07-29 Замещенные имидазопиримидины для предупреждения и лечения рака EA009038B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200301906 2003-07-30
PCT/EP2004/008476 WO2005014598A1 (en) 2003-07-30 2004-07-29 Substituted imidazopyrimidines for the prevention and treatment of cancer

Publications (2)

Publication Number Publication Date
EA200600330A1 true EA200600330A1 (ru) 2006-08-25
EA009038B1 EA009038B1 (ru) 2007-10-26

Family

ID=34130555

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200600330A EA009038B1 (ru) 2003-07-30 2004-07-29 Замещенные имидазопиримидины для предупреждения и лечения рака

Country Status (14)

Country Link
US (1) US20060189631A1 (ru)
EP (1) EP1660500B1 (ru)
JP (1) JP2007500160A (ru)
KR (1) KR20060034303A (ru)
CN (1) CN1860121A (ru)
AT (1) ATE380816T1 (ru)
AU (1) AU2004263297A1 (ru)
BR (1) BRPI0412636A (ru)
CA (1) CA2534292A1 (ru)
DE (1) DE602004010680T2 (ru)
EA (1) EA009038B1 (ru)
ES (1) ES2298798T3 (ru)
WO (1) WO2005014598A1 (ru)
ZA (1) ZA200601706B (ru)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007096764A2 (en) * 2006-02-27 2007-08-30 Glenmark Pharmaceuticals S.A. Bicyclic heteroaryl derivatives as cannabinoid receptor modulators
JP2010500365A (ja) 2006-08-07 2010-01-07 インサイト・コーポレイション キナーゼ阻害剤としてのトリアゾロトリアジン
BRPI0719333A2 (pt) 2006-11-22 2014-02-04 Incyte Corp Midazotriazinas e imidazopirimidinas como inbidores de cinase
EP2062893A1 (en) * 2007-10-18 2009-05-27 Bayer Schering Pharma AG Fused imidazoles for cancer treatment
TW200924761A (en) * 2007-08-14 2009-06-16 Bayer Schering Pharma Ag Fused bicyclic imidazoles
BRPI0912882A2 (pt) 2008-05-21 2017-05-16 Incyte Corp sais de 2-flúor-n-metil-4-[7-(quinolin-6-il-metil)-imidazo[1,2-b][1,2,4]triazin-2-il]benzamida e processos relacionados à preparação dos mesmos
CA2777739A1 (en) 2009-10-16 2011-04-21 Rib-X Pharmaceuticals, Inc. Antimicrobial compounds and methods of making and using the same
MX2012008898A (es) 2010-02-03 2012-11-06 Incyte Corp Imidazo - [1, 2 - b] [1, 2, 4] triazinas como inhibidores de c - met.
US8410117B2 (en) * 2010-03-26 2013-04-02 Hoffmann-La Roche Inc. Imidazopyrimidine derivatives
EP2694510B1 (en) 2011-04-07 2015-10-14 Bayer Intellectual Property GmbH Imidazopyridazines as akt kinase inhibitors
CN102796103A (zh) * 2011-05-23 2012-11-28 南京英派药业有限公司 6-（芳基甲酰）咪唑并[1,2-a]嘧啶和6-（芳基甲酰）[1,2,4]三唑并[4,3-a]嘧啶作为Hedgehog抑制剂及其应用
US9233961B2 (en) 2013-03-15 2016-01-12 Novartis Ag Compounds and compositions for the treatment of parasitic diseases
UY35400A (es) * 2013-03-15 2014-10-31 Novartis Ag Compuestos y composiciones para el tratamiento de enfermedades parasitarias
US9296754B2 (en) 2013-03-15 2016-03-29 Novartis Ag Compounds and compositions for the treatment of parasitic diseases
WO2014151729A1 (en) 2013-03-15 2014-09-25 Irm Llc Compounds and compositions for the treatment of parasitic diseases
TWI674263B (zh) 2013-12-19 2019-10-11 瑞士商諾華公司 用於治療寄生蟲疾病之化合物及組合物
SG11201707346RA (en) 2015-03-11 2017-10-30 Melinta Therapeutics Inc Antimicrobial compounds and methods of making and using the same
EP3452479A1 (en) 2016-05-06 2019-03-13 Melinta Therapeutics, Inc. Antimicrobials and methods of making and using same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3455924A (en) * 1967-02-08 1969-07-15 Upjohn Co Dianisylimidazoles
US5700826A (en) * 1995-06-07 1997-12-23 Ontogen Corporation 1,2,4,5-tetra substituted imidazoles as modulators of multi-drug resistance
ES2140354B1 (es) * 1998-08-03 2000-11-01 S A L V A T Lab Sa Imidazo (1,2a) azinas sustituidas como inhibidores selectivos de la cox-2.

Also Published As

Publication number Publication date
ZA200601706B (en) 2007-09-26
ES2298798T3 (es) 2008-05-16
CN1860121A (zh) 2006-11-08
AU2004263297A1 (en) 2005-02-17
US20060189631A1 (en) 2006-08-24
KR20060034303A (ko) 2006-04-21
EP1660500A1 (en) 2006-05-31
DE602004010680T2 (de) 2009-01-02
ATE380816T1 (de) 2007-12-15
EP1660500B1 (en) 2007-12-12
CA2534292A1 (en) 2005-02-17
BRPI0412636A (pt) 2006-09-26
EA009038B1 (ru) 2007-10-26
WO2005014598A1 (en) 2005-02-17
DE602004010680D1 (de) 2008-01-24
JP2007500160A (ja) 2007-01-11

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU