OA10664A - (1S,2s)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenyl-piperidin-1-yl)-1-propanol methanesulfonate trihydrate - Google Patents
(1S,2s)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenyl-piperidin-1-yl)-1-propanol methanesulfonate trihydrate Download PDFInfo
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- OA10664A OA10664A OA9800021A OA9800021A OA10664A OA 10664 A OA10664 A OA 10664A OA 9800021 A OA9800021 A OA 9800021A OA 9800021 A OA9800021 A OA 9800021A OA 10664 A OA10664 A OA 10664A
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- LUILKELNVBKKTG-ZOZJKLBQSA-N 1-[(1s,2s)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]-4-phenylpiperidin-4-ol;methanesulfonic acid;trihydrate Chemical compound O.O.O.CS(O)(=O)=O.C1([C@H](O)[C@H](C)N2CCC(O)(CC2)C=2C=CC=CC=2)=CC=C(O)C=C1 LUILKELNVBKKTG-ZOZJKLBQSA-N 0.000 title description 4
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- ODKNJVUHOIMIIZ-RRKCRQDMSA-N floxuridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(F)=C1 ODKNJVUHOIMIIZ-RRKCRQDMSA-N 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
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- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
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- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- AUONNNVJUCSETH-UHFFFAOYSA-N icosanoyl icosanoate Chemical compound CCCCCCCCCCCCCCCCCCCC(=O)OC(=O)CCCCCCCCCCCCCCCCCCC AUONNNVJUCSETH-UHFFFAOYSA-N 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 229960004502 levodopa Drugs 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 102000006239 metabotropic receptors Human genes 0.000 description 1
- 108020004083 metabotropic receptors Proteins 0.000 description 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 239000002899 monoamine oxidase inhibitor Substances 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- DUWWHGPELOTTOE-UHFFFAOYSA-N n-(5-chloro-2,4-dimethoxyphenyl)-3-oxobutanamide Chemical compound COC1=CC(OC)=C(NC(=O)CC(C)=O)C=C1Cl DUWWHGPELOTTOE-UHFFFAOYSA-N 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 101150006061 neur gene Proteins 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 230000007135 neurotoxicity Effects 0.000 description 1
- 231100000228 neurotoxicity Toxicity 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 1
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 1
- 239000003402 opiate agonist Substances 0.000 description 1
- 239000012044 organic layer Substances 0.000 description 1
- 229950010883 phencyclidine Drugs 0.000 description 1
- 230000010287 polarization Effects 0.000 description 1
- 229920000768 polyamine Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 238000000159 protein binding assay Methods 0.000 description 1
- 238000000425 proton nuclear magnetic resonance spectrum Methods 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 230000013275 serotonin uptake Effects 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- 239000012064 sodium phosphate buffer Substances 0.000 description 1
- 229940054269 sodium pyruvate Drugs 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- QEMSVZNTSXPFJA-UHFFFAOYSA-N traxoprodil Chemical compound C1CC(O)(C=2C=CC=CC=2)CCN1C(C)C(O)C1=CC=C(O)C=C1 QEMSVZNTSXPFJA-UHFFFAOYSA-N 0.000 description 1
- NRTLTGGGUQIRRT-UHFFFAOYSA-N triethylazanium;bromide Chemical compound [Br-].CC[NH+](CC)CC NRTLTGGGUQIRRT-UHFFFAOYSA-N 0.000 description 1
- DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 description 1
- 229940045145 uridine Drugs 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
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- 239000003643 water by type Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- Endocrinology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Claims (3)
- 22 r- /| rn> p. I CLAIMS 1. (1 S,2S)-1 -(4-hydroxyphenyl)-2-(4-hydroxy-4-phe n y I p i pe r i d i n -1 -y I )-1 -propanol methanesulfonate trihydrate.
- 2. A pharmaceutical composition for the treatment of a disorder selectedfrom degenerative CNS disorders such as stroke, Alzheimer's disease, 5 Parkinson's disease and Huntington's disease; epilepsy, anxiety, cérébral ischemia,muscular spasms, multiinfarct dementia, traumatic brain injury, pain, AIDS relateddementia, hypoglycemia, migraine, amyotrophie latéral sclerosis, drug and alcoholaddiction, drug and alcohol withdrawal symptoms, psychotic conditions and urinaryincontinence in a mammal, comprising and NMDA antagonizing effective amount of 10 the trihydrate mesylate sait according to claim 1 and a pharmaceutically acceptablecarrier.
- 3. A pharmaceutical composition for the treatment of a disorder selectedfrom degenerative CNS disorders such as stroke, Alzheimer's disease, Parkinson'sdisease and Huntington's disease; epilepsy, anxiety, cérébral ischemia, muscular 15 spasms, multiinfarct dementia, traumatic brain injury, pain, AIDS related dementia,hypoglycemia, migraine, amyotrophie latéral sclerosis, drug and alcohol addiction,drug and alcohol withdrawal symptoms, psychotic conditions and urinaryincontinence in a mammal, comprising an amount of the trihydrate mesylate saitaccording to claim 1 that is effective in treating each disorder and a pharmaceutically 20 acceptable carrier.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US223895P | 1995-08-11 | 1995-08-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| OA10664A true OA10664A (en) | 2000-11-06 |
Family
ID=21699847
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| OA9800021A OA10664A (en) | 1995-08-11 | 1998-02-10 | (1S,2s)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenyl-piperidin-1-yl)-1-propanol methanesulfonate trihydrate |
Country Status (41)
| Country | Link |
|---|---|
| US (1) | US6008233A (fr) |
| EP (1) | EP0843661B1 (fr) |
| JP (1) | JP3099072B2 (fr) |
| KR (1) | KR100291882B1 (fr) |
| CN (2) | CN1615861A (fr) |
| AP (1) | AP755A (fr) |
| AR (1) | AR004676A1 (fr) |
| AT (1) | ATE215072T1 (fr) |
| AU (1) | AU710984B2 (fr) |
| BG (1) | BG63678B1 (fr) |
| BR (1) | BR9610766A (fr) |
| CA (1) | CA2228752C (fr) |
| CO (1) | CO4750830A1 (fr) |
| CZ (1) | CZ296236B6 (fr) |
| DE (1) | DE69620191T2 (fr) |
| DK (1) | DK0843661T3 (fr) |
| DZ (1) | DZ2083A1 (fr) |
| ES (1) | ES2170857T3 (fr) |
| GT (1) | GT199600051A (fr) |
| HR (1) | HRP960372B1 (fr) |
| HU (1) | HUP9802862A3 (fr) |
| IL (1) | IL122649A (fr) |
| IS (1) | IS1945B (fr) |
| MA (1) | MA23957A1 (fr) |
| NO (1) | NO310458B1 (fr) |
| NZ (1) | NZ309134A (fr) |
| OA (1) | OA10664A (fr) |
| PE (1) | PE4898A1 (fr) |
| PL (1) | PL185603B1 (fr) |
| PT (1) | PT843661E (fr) |
| RO (1) | RO120134B1 (fr) |
| RS (1) | RS49521B (fr) |
| RU (1) | RU2140910C1 (fr) |
| SA (1) | SA96170171B1 (fr) |
| SK (1) | SK284209B6 (fr) |
| TN (1) | TNSN96104A1 (fr) |
| TR (1) | TR199800208T1 (fr) |
| TW (1) | TW495502B (fr) |
| UA (1) | UA59341C2 (fr) |
| WO (1) | WO1997007098A1 (fr) |
| ZA (1) | ZA966760B (fr) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2139857C1 (ru) * | 1994-08-18 | 1999-10-20 | Пфайзер Инк. | Производные 3-(пиперидинил-1)-хроман-4,7-диола и 1-(4-гидроксифенил)-2-(пиперидинил-1)-алканола, фармацевтическая композиция и способ связывания nmda рецептора |
| RU2140910C1 (ru) * | 1995-08-11 | 1999-11-10 | Пфайзер Инк. | Тригидрат метансульфоната (1s,2s)-1-(4-гидроксифенил)-2-(4-гидрокси-4- фенилпиперидин-1-ил)-1-пропанола |
| GB9820405D0 (en) * | 1998-09-18 | 1998-11-11 | Smithkline Beecham Plc | Process |
| WO2000061558A1 (fr) * | 1999-04-09 | 2000-10-19 | Mochida Pharmaceutical Co., Ltd. | Remedes pour douleurs neurogenes |
| GB9920919D0 (en) | 1999-09-03 | 1999-11-10 | Sb Pharmco Inc | Novel compound |
| GB9920917D0 (en) | 1999-09-03 | 1999-11-10 | Sb Pharmco Inc | Novel process |
| US6620830B2 (en) * | 2000-04-21 | 2003-09-16 | Pfizer, Inc. | Thyroid receptor ligands |
| YU27701A (sh) * | 2000-04-28 | 2003-04-30 | Pfizer Products Inc. | Postupak za dobijanje trihidrata mezilatne soli 1-(4- hidroksifenil)-2-(4-hidroksi-4-fenilpiperidin-1-il)1-propanola |
| YU27801A (sh) | 2000-04-28 | 2003-04-30 | Pfizer Products Inc. | Postupak za dobijanje trihidrata mezilatne soli 1-(4- hidroksifenil)-2-(4-hidroksi-4-fenilpiperidin-1-il)-1-propanola i korisnih intermedijera |
| NZ524741A (en) | 2000-08-16 | 2005-01-28 | Upjohn Co | Heterocyclic amines, phenylazacycloalkanes, cabergoline and aromatic bicyclic amines for the treatment of alcohol, nicotine and drug addiction |
| EP1186303A3 (fr) * | 2000-09-06 | 2003-12-10 | Pfizer Products Inc. | Combinaisons pharmaceutiques pour le traitement des accidents cerebrovasculaires, contenant un facteur inhibitant la neutrophile et un antagoniste selectif du NMDA-NR2B |
| IL145584A0 (en) | 2000-10-02 | 2002-06-30 | Pfizer Prod Inc | Nmda nr2b antagonists for treatment |
| EP1674087A1 (fr) | 2000-10-02 | 2006-06-28 | Pfizer Products Inc. | Utilisation prophylactique d'antagonistes des récepteurs du N-méthyl-D-aspartate (NMDA) |
| UA73619C2 (en) * | 2000-12-13 | 2005-08-15 | Pfizer Prod Inc | Stable pharmaceutical compositions of nmda receptor agonist (variants) and method of treatment |
| DE60220694T2 (de) * | 2001-10-19 | 2008-02-07 | Toyama Chemical Co. Ltd. | Alkyletherderivate oder deren salze |
| KR100517638B1 (ko) | 2002-04-08 | 2005-09-28 | 주식회사 엘지생명과학 | 게미플록사신 산염의 새로운 제조방법 |
| US8173642B2 (en) | 2005-10-25 | 2012-05-08 | Shionogi & Co., Ltd. | Aminodihydrothiazine derivatives |
| MX2009011498A (es) | 2007-04-24 | 2009-11-10 | Shionogi & Co | Derivados de aminodihidrotiazina sustituida con un grupo ciclico. |
| EP2151435A4 (fr) | 2007-04-24 | 2011-09-14 | Shionogi & Co | Composition pharmaceutique pour le traitement de la maladie d'alzheimer |
| KR101324426B1 (ko) | 2008-06-13 | 2013-10-31 | 시오노기세야쿠 가부시키가이샤 | β 세크레타제 저해 작용을 갖는 황 함유 복소환 유도체 |
| EP2360155A4 (fr) | 2008-10-22 | 2012-06-20 | Shionogi & Co | 2-aminopyridin-4-one et dérivé de 2-aminopyridine dont l'activité inhibe la bace1 |
| RU2012129168A (ru) | 2009-12-11 | 2014-01-20 | Сионоги Энд Ко. Лтд. | Производные оксазина |
| CN103261199A (zh) | 2010-10-29 | 2013-08-21 | 盐野义制药株式会社 | 萘啶衍生物 |
| JP5766198B2 (ja) | 2010-10-29 | 2015-08-19 | 塩野義製薬株式会社 | 縮合アミノジヒドロピリミジン誘導体 |
| JPWO2012147763A1 (ja) | 2011-04-26 | 2014-07-28 | 塩野義製薬株式会社 | オキサジン誘導体およびそれを含有するｂａｃｅ１阻害剤 |
| JP2016501827A (ja) | 2012-10-24 | 2016-01-21 | 塩野義製薬株式会社 | Ｂａｃｅ１阻害作用を有するジヒドロオキサジンまたはオキサゼピン誘導体 |
| SG11201701853YA (en) | 2014-09-15 | 2017-04-27 | Rugen Holdings Cayman Ltd | Pyrrolopyrimidine derivatives as nr2b nmda receptor antagonists |
| WO2016049048A1 (fr) * | 2014-09-22 | 2016-03-31 | Rugen Holdings (Cayman) Limited | Traitement des troubles de l'anxiété et des troubles du spectre autistique |
| EP3253761A4 (fr) | 2015-02-04 | 2018-06-20 | Rugen Holdings (Cayman) Limited | Dérivés 3,3-difluoro-pipéridine en tant qu'antagonistes des récepteurs nmda nr2b |
| KR102613179B1 (ko) | 2015-06-01 | 2023-12-14 | 뤼겐 홀딩스 (케이맨) 리미티드 | Nr2b nmda 수용체 길항제로서의 3,3-디플루오로피페리딘 카바메이트 헤테로사이클릭 화합물 |
| EP3544610A1 (fr) | 2016-11-22 | 2019-10-02 | Rugen Holdings (Cayman) Limited | Traitement de troubles du spectre autistique, de troubles obsessivo-compulsifs et de troubles de l'anxiété |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK232890A3 (en) * | 1989-05-17 | 1998-11-04 | Pfizer | 2-piperidino and 2-pyrrolidino-1-alkanols derivatives and preparation method thereof |
| US5272160A (en) * | 1989-05-17 | 1993-12-21 | Pfizer Inc | 2-piperidino-1-alkanol derivatives as antiischemic agents |
| RU2139857C1 (ru) * | 1994-08-18 | 1999-10-20 | Пфайзер Инк. | Производные 3-(пиперидинил-1)-хроман-4,7-диола и 1-(4-гидроксифенил)-2-(пиперидинил-1)-алканола, фармацевтическая композиция и способ связывания nmda рецептора |
| RU2140910C1 (ru) * | 1995-08-11 | 1999-11-10 | Пфайзер Инк. | Тригидрат метансульфоната (1s,2s)-1-(4-гидроксифенил)-2-(4-гидрокси-4- фенилпиперидин-1-ил)-1-пропанола |
-
1996
- 1996-06-20 RU RU98102116A patent/RU2140910C1/ru not_active IP Right Cessation
- 1996-06-20 DK DK96916266T patent/DK0843661T3/da active
- 1996-06-20 UA UA98020673A patent/UA59341C2/uk unknown
- 1996-06-20 TR TR1998/00208T patent/TR199800208T1/xx unknown
- 1996-06-20 AT AT96916266T patent/ATE215072T1/de not_active IP Right Cessation
- 1996-06-20 HU HU9802862A patent/HUP9802862A3/hu unknown
- 1996-06-20 RO RO98-00231A patent/RO120134B1/ro unknown
- 1996-06-20 BR BR9610766A patent/BR9610766A/pt not_active Application Discontinuation
- 1996-06-20 KR KR1019980700989A patent/KR100291882B1/ko not_active Expired - Fee Related
- 1996-06-20 AU AU59084/96A patent/AU710984B2/en not_active Ceased
- 1996-06-20 DE DE69620191T patent/DE69620191T2/de not_active Expired - Fee Related
- 1996-06-20 CN CNA031584969A patent/CN1615861A/zh active Pending
- 1996-06-20 NZ NZ309134A patent/NZ309134A/en unknown
- 1996-06-20 EP EP96916266A patent/EP0843661B1/fr not_active Expired - Lifetime
- 1996-06-20 PL PL96325050A patent/PL185603B1/pl not_active IP Right Cessation
- 1996-06-20 ES ES96916266T patent/ES2170857T3/es not_active Expired - Lifetime
- 1996-06-20 CN CN96195649A patent/CN1198739A/zh active Pending
- 1996-06-20 SK SK166-98A patent/SK284209B6/sk unknown
- 1996-06-20 JP JP09509083A patent/JP3099072B2/ja not_active Expired - Fee Related
- 1996-06-20 CA CA002228752A patent/CA2228752C/fr not_active Expired - Fee Related
- 1996-06-20 CZ CZ0039098A patent/CZ296236B6/cs not_active IP Right Cessation
- 1996-06-20 PT PT96916266T patent/PT843661E/pt unknown
- 1996-06-20 WO PCT/IB1996/000592 patent/WO1997007098A1/fr not_active Ceased
- 1996-06-20 IL IL12264996A patent/IL122649A/xx not_active IP Right Cessation
- 1996-06-20 US US09/011,426 patent/US6008233A/en not_active Expired - Fee Related
- 1996-06-24 TW TW085107571A patent/TW495502B/zh not_active IP Right Cessation
- 1996-07-04 GT GT199600051A patent/GT199600051A/es unknown
- 1996-07-23 SA SA96170171A patent/SA96170171B1/ar unknown
- 1996-08-06 PE PE1996000587A patent/PE4898A1/es not_active Application Discontinuation
- 1996-08-07 DZ DZ960127A patent/DZ2083A1/fr active
- 1996-08-07 AR ARP960103904A patent/AR004676A1/es unknown
- 1996-08-07 MA MA24335A patent/MA23957A1/fr unknown
- 1996-08-07 TN TNTNSN96104A patent/TNSN96104A1/fr unknown
- 1996-08-08 AP APAP/P/1996/000856A patent/AP755A/en active
- 1996-08-08 ZA ZA9606760A patent/ZA966760B/xx unknown
- 1996-08-09 CO CO96042164A patent/CO4750830A1/es unknown
- 1996-08-09 HR HR960372A patent/HRP960372B1/xx not_active IP Right Cessation
- 1996-08-09 RS YU46196A patent/RS49521B/sr unknown
-
1997
- 1997-12-30 IS IS4643A patent/IS1945B/is unknown
-
1998
- 1998-02-10 OA OA9800021A patent/OA10664A/en unknown
- 1998-02-10 NO NO19980574A patent/NO310458B1/no unknown
- 1998-02-27 BG BG102289A patent/BG63678B1/bg unknown
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