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NO980574L - (1S,2S)-1-(4-Hydroksyfenyl)-2-(4-hydroksy-4-fenylpiperidin-1-yl)-1-propanol-metansulfonattrihydrat - Google Patents

(1S,2S)-1-(4-Hydroksyfenyl)-2-(4-hydroksy-4-fenylpiperidin-1-yl)-1-propanol-metansulfonattrihydrat

Info

Publication number
NO980574L
NO980574L NO980574A NO980574A NO980574L NO 980574 L NO980574 L NO 980574L NO 980574 A NO980574 A NO 980574A NO 980574 A NO980574 A NO 980574A NO 980574 L NO980574 L NO 980574L
Authority
NO
Norway
Prior art keywords
phenylpiperidine
hydroxyphenyl
hydroxy
propanol methanesulfonate
methanesulfonate
Prior art date
Application number
NO980574A
Other languages
English (en)
Other versions
NO310458B1 (no
NO980574D0 (no
Inventor
Marta Maria Andino
Terry Gene Sinay
Eugene Fred Fiese
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of NO980574D0 publication Critical patent/NO980574D0/no
Publication of NO980574L publication Critical patent/NO980574L/no
Publication of NO310458B1 publication Critical patent/NO310458B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40Oxygen atoms
    • C07D211/44Oxygen atoms attached in position 4
    • C07D211/52Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Virology (AREA)
  • Diabetes (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
NO19980574A 1995-08-11 1998-02-10 (1S,2S)-1-(4-hydroksyfenyl)-2-(4-hydroksy-4-fenylpiperidin-1- yl)-1-propanol-metansulfonattrihydrat, anvendelse derav samtfarmasöytisk preparat NO310458B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US223895P 1995-08-11 1995-08-11
PCT/IB1996/000592 WO1997007098A1 (en) 1995-08-11 1996-06-20 (1s,2s)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propanolmethanesulfonate trihydrate

Publications (3)

Publication Number Publication Date
NO980574D0 NO980574D0 (no) 1998-02-10
NO980574L true NO980574L (no) 1998-02-10
NO310458B1 NO310458B1 (no) 2001-07-09

Family

ID=21699847

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19980574A NO310458B1 (no) 1995-08-11 1998-02-10 (1S,2S)-1-(4-hydroksyfenyl)-2-(4-hydroksy-4-fenylpiperidin-1- yl)-1-propanol-metansulfonattrihydrat, anvendelse derav samtfarmasöytisk preparat

Country Status (41)

Country Link
US (1) US6008233A (no)
EP (1) EP0843661B1 (no)
JP (1) JP3099072B2 (no)
KR (1) KR100291882B1 (no)
CN (2) CN1198739A (no)
AP (1) AP755A (no)
AR (1) AR004676A1 (no)
AT (1) ATE215072T1 (no)
AU (1) AU710984B2 (no)
BG (1) BG63678B1 (no)
BR (1) BR9610766A (no)
CA (1) CA2228752C (no)
CO (1) CO4750830A1 (no)
CZ (1) CZ296236B6 (no)
DE (1) DE69620191T2 (no)
DK (1) DK0843661T3 (no)
DZ (1) DZ2083A1 (no)
ES (1) ES2170857T3 (no)
GT (1) GT199600051A (no)
HR (1) HRP960372B1 (no)
HU (1) HUP9802862A3 (no)
IL (1) IL122649A (no)
IS (1) IS1945B (no)
MA (1) MA23957A1 (no)
NO (1) NO310458B1 (no)
NZ (1) NZ309134A (no)
OA (1) OA10664A (no)
PE (1) PE4898A1 (no)
PL (1) PL185603B1 (no)
PT (1) PT843661E (no)
RO (1) RO120134B1 (no)
RS (1) RS49521B (no)
RU (1) RU2140910C1 (no)
SA (1) SA96170171B1 (no)
SK (1) SK284209B6 (no)
TN (1) TNSN96104A1 (no)
TR (1) TR199800208T1 (no)
TW (1) TW495502B (no)
UA (1) UA59341C2 (no)
WO (1) WO1997007098A1 (no)
ZA (1) ZA966760B (no)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ284852A (en) * 1994-08-18 1998-06-26 Pfizer 3-(piperidin-1-yl)-chroman-4,7-diol and 1-(4-hydrophenyl)-2-(piperidin-1-yl) alkanol derivatives; medicaments; used as a neuroprotective agent
UA59341C2 (uk) * 1995-08-11 2003-09-15 Пфайзер, Інк. (1s,2s)-1-(4-гідроксифеніл)-2-(4-гідрокси-4-фенілпіперидин-1-іл)-1-пропанолметансульфонат тригідрат
GB9820405D0 (en) 1998-09-18 1998-11-11 Smithkline Beecham Plc Process
EP1182193A4 (en) * 1999-04-09 2002-09-11 Mochida Pharm Co Ltd REMEDIES FOR NEUROGENIC PAIN
GB9920919D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel compound
GB9920917D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel process
US6620830B2 (en) * 2000-04-21 2003-09-16 Pfizer, Inc. Thyroid receptor ligands
YU27801A (sh) * 2000-04-28 2003-04-30 Pfizer Products Inc. Postupak za dobijanje trihidrata mezilatne soli 1-(4- hidroksifenil)-2-(4-hidroksi-4-fenilpiperidin-1-il)-1-propanola i korisnih intermedijera
YU27701A (sh) * 2000-04-28 2003-04-30 Pfizer Products Inc. Postupak za dobijanje trihidrata mezilatne soli 1-(4- hidroksifenil)-2-(4-hidroksi-4-fenilpiperidin-1-il)1-propanola
WO2002013807A2 (en) 2000-08-16 2002-02-21 Pharmacia & Upjohn Company Compounds for the treatment of addictive disorders
EP1186303A3 (en) * 2000-09-06 2003-12-10 Pfizer Products Inc. Pharmaceutical combinations, for the treatment of stroke and traumatic brain injury, containing a neutrophil inhibiting factor and an selective NMDA-NR2B receptor antagonist
IL145584A0 (en) * 2000-10-02 2002-06-30 Pfizer Prod Inc Nmda nr2b antagonists for treatment
EP1674087A1 (en) 2000-10-02 2006-06-28 Pfizer Products Inc. Prophylactic use of n-methyl-d-aspartate (NMDA) antagonists
UA73619C2 (en) * 2000-12-13 2005-08-15 Pfizer Prod Inc Stable pharmaceutical compositions of nmda receptor agonist (variants) and method of treatment
ES2287324T3 (es) * 2001-10-19 2007-12-16 Toyama Chemical Co., Ltd. Derivados de alquil eter o sus sales.
KR100517638B1 (ko) 2002-04-08 2005-09-28 주식회사 엘지생명과학 게미플록사신 산염의 새로운 제조방법
CN103936690B (zh) 2005-10-25 2016-06-08 盐野义制药株式会社 氨基二氢噻嗪衍生物
RU2476430C2 (ru) 2007-04-24 2013-02-27 Сионоги Энд Ко., Лтд. Производные аминодигидротиазина, замещенные циклической группой
WO2008133273A1 (ja) 2007-04-24 2008-11-06 Shionogi & Co., Ltd. アルツハイマー症治療用医薬組成物
ES2738123T3 (es) 2008-06-13 2020-01-20 Shionogi & Co Derivado heterocíclico que contiene azufre que tiene actividad inhibitoria de ß-secretasa
WO2010047372A1 (ja) 2008-10-22 2010-04-29 塩野義製薬株式会社 Bace1阻害活性を有する2-アミノピリミジン-4-オンおよび2-アミノピリジン誘導体
WO2011071135A1 (ja) 2009-12-11 2011-06-16 塩野義製薬株式会社 オキサジン誘導体
US8927721B2 (en) 2010-10-29 2015-01-06 Shionogi & Co., Ltd. Naphthyridine derivative
WO2012057247A1 (ja) 2010-10-29 2012-05-03 塩野義製薬株式会社 縮合アミノジヒドロピリミジン誘導体
JPWO2012147763A1 (ja) 2011-04-26 2014-07-28 塩野義製薬株式会社 オキサジン誘導体およびそれを含有するbace1阻害剤
EP2912035A4 (en) 2012-10-24 2016-06-15 Shionogi & Co DERIVATIVES OF DIHYDROOXAZINE OR OXAZEPINE HAVING BACE1 INHIBITING ACTIVITY
MX2017002775A (es) 2014-09-15 2017-08-10 Rugen Holdings (Cayman) Ltd Derivados de pirrolopirimidina como antagonistas del receptor de n-metil-d-aspartato (nmda), subunidad nr2b.
US20180271869A1 (en) * 2014-09-22 2018-09-27 Jie Liu Treatment of anxiety disorders and autism spectrum disorders
US10221182B2 (en) 2015-02-04 2019-03-05 Rugen Holdings (Cayman) Limited 3,3-difluoro-piperidine derivatives as NR2B NMDA receptor antagonists
CN107849010B (zh) 2015-06-01 2021-11-09 卢郡控股(开曼)有限公司 作为nr2b nmda受体拮抗剂的3,3‐二氟哌啶氨基甲酸酯杂环化合物
US11000526B2 (en) 2016-11-22 2021-05-11 Rugen Holdings (Cayman) Limited Treatment of autism spectrum disorders, obsessive-compulsive disorder and anxiety disorders

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Publication number Priority date Publication date Assignee Title
US5272160A (en) * 1989-05-17 1993-12-21 Pfizer Inc 2-piperidino-1-alkanol derivatives as antiischemic agents
WO1990014087A1 (en) * 1989-05-17 1990-11-29 Pfizer Inc. 2-piperidino-1-alkanol derivatives as antiischemic agents
NZ284852A (en) * 1994-08-18 1998-06-26 Pfizer 3-(piperidin-1-yl)-chroman-4,7-diol and 1-(4-hydrophenyl)-2-(piperidin-1-yl) alkanol derivatives; medicaments; used as a neuroprotective agent
UA59341C2 (uk) * 1995-08-11 2003-09-15 Пфайзер, Інк. (1s,2s)-1-(4-гідроксифеніл)-2-(4-гідрокси-4-фенілпіперидин-1-іл)-1-пропанолметансульфонат тригідрат

Also Published As

Publication number Publication date
YU46196A (sh) 1999-07-28
HUP9802862A3 (en) 1999-05-28
JP3099072B2 (ja) 2000-10-16
AP755A (en) 1999-08-02
ATE215072T1 (de) 2002-04-15
DE69620191T2 (de) 2002-07-18
IS4643A (is) 1997-12-30
CO4750830A1 (es) 1999-03-31
NO310458B1 (no) 2001-07-09
HRP960372B1 (en) 2003-04-30
DK0843661T3 (da) 2002-07-22
CZ39098A3 (cs) 1999-02-17
PE4898A1 (es) 1998-03-16
RS49521B (sr) 2006-10-27
PT843661E (pt) 2002-07-31
AU5908496A (en) 1997-03-12
RO120134B1 (ro) 2005-09-30
BG63678B1 (bg) 2002-09-30
UA59341C2 (uk) 2003-09-15
US6008233A (en) 1999-12-28
NO980574D0 (no) 1998-02-10
SK284209B6 (en) 2004-11-03
WO1997007098A1 (en) 1997-02-27
CA2228752A1 (en) 1997-02-27
IS1945B (is) 2004-08-13
KR19990036321A (ko) 1999-05-25
HRP960372A2 (en) 1998-04-30
AU710984B2 (en) 1999-10-07
BR9610766A (pt) 1999-07-13
AP9600856A0 (en) 1996-10-31
JPH10510552A (ja) 1998-10-13
TR199800208T1 (no) 1998-05-21
GT199600051A (es) 1997-12-26
MX9801149A (es) 1998-05-31
CN1198739A (zh) 1998-11-11
PL325050A1 (en) 1998-07-06
CN1615861A (zh) 2005-05-18
AR004676A1 (es) 1999-03-10
BG102289A (en) 1998-09-30
KR100291882B1 (ko) 2001-10-26
NZ309134A (en) 1999-09-29
OA10664A (en) 2000-11-06
ZA966760B (en) 1998-02-09
DZ2083A1 (fr) 2002-10-23
SA96170171B1 (ar) 2006-05-20
MA23957A1 (fr) 1997-04-01
CZ296236B6 (cs) 2006-02-15
PL185603B1 (pl) 2003-06-30
HUP9802862A2 (hu) 1999-04-28
SK16698A3 (en) 1999-06-11
TNSN96104A1 (fr) 2005-03-15
IL122649A (en) 2001-08-26
EP0843661A1 (en) 1998-05-27
CA2228752C (en) 2002-12-10
IL122649A0 (en) 1998-08-16
ES2170857T3 (es) 2002-08-16
EP0843661B1 (en) 2002-03-27
RU2140910C1 (ru) 1999-11-10
DE69620191D1 (de) 2002-05-02
TW495502B (en) 2002-07-21

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