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IS1945B - (1S,2S)-1-(4-hýdroxýfenýl)-2-(4-hýdroxý-4-fenýlpíperidín-1-ýl)-1-própanól metansúlfónat tríhýdrat - Google Patents

(1S,2S)-1-(4-hýdroxýfenýl)-2-(4-hýdroxý-4-fenýlpíperidín-1-ýl)-1-própanól metansúlfónat tríhýdrat

Info

Publication number
IS1945B
IS1945B IS4643A IS4643A IS1945B IS 1945 B IS1945 B IS 1945B IS 4643 A IS4643 A IS 4643A IS 4643 A IS4643 A IS 4643A IS 1945 B IS1945 B IS 1945B
Authority
IS
Iceland
Prior art keywords
phenylpiperidin
hydroxyphenyl
hydroxy
propanol methanesulfonate
methanesulfonate trihydrate
Prior art date
Application number
IS4643A
Other languages
English (en)
Other versions
IS4643A (is
Inventor
Maria Andino Marta
Gene Sinay Terry
Fred Fiese Eugene
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of IS4643A publication Critical patent/IS4643A/is
Publication of IS1945B publication Critical patent/IS1945B/is

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40Oxygen atoms
    • C07D211/44Oxygen atoms attached in position 4
    • C07D211/52Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Virology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
IS4643A 1995-08-11 1997-12-30 (1S,2S)-1-(4-hýdroxýfenýl)-2-(4-hýdroxý-4-fenýlpíperidín-1-ýl)-1-própanól metansúlfónat tríhýdrat IS1945B (is)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US223895P 1995-08-11 1995-08-11
PCT/IB1996/000592 WO1997007098A1 (en) 1995-08-11 1996-06-20 (1s,2s)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propanolmethanesulfonate trihydrate

Publications (2)

Publication Number Publication Date
IS4643A IS4643A (is) 1997-12-30
IS1945B true IS1945B (is) 2004-08-13

Family

ID=21699847

Family Applications (1)

Application Number Title Priority Date Filing Date
IS4643A IS1945B (is) 1995-08-11 1997-12-30 (1S,2S)-1-(4-hýdroxýfenýl)-2-(4-hýdroxý-4-fenýlpíperidín-1-ýl)-1-própanól metansúlfónat tríhýdrat

Country Status (41)

Country Link
US (1) US6008233A (is)
EP (1) EP0843661B1 (is)
JP (1) JP3099072B2 (is)
KR (1) KR100291882B1 (is)
CN (2) CN1615861A (is)
AP (1) AP755A (is)
AR (1) AR004676A1 (is)
AT (1) ATE215072T1 (is)
AU (1) AU710984B2 (is)
BG (1) BG63678B1 (is)
BR (1) BR9610766A (is)
CA (1) CA2228752C (is)
CO (1) CO4750830A1 (is)
CZ (1) CZ296236B6 (is)
DE (1) DE69620191T2 (is)
DK (1) DK0843661T3 (is)
DZ (1) DZ2083A1 (is)
ES (1) ES2170857T3 (is)
GT (1) GT199600051A (is)
HR (1) HRP960372B1 (is)
HU (1) HUP9802862A3 (is)
IL (1) IL122649A (is)
IS (1) IS1945B (is)
MA (1) MA23957A1 (is)
NO (1) NO310458B1 (is)
NZ (1) NZ309134A (is)
OA (1) OA10664A (is)
PE (1) PE4898A1 (is)
PL (1) PL185603B1 (is)
PT (1) PT843661E (is)
RO (1) RO120134B1 (is)
RS (1) RS49521B (is)
RU (1) RU2140910C1 (is)
SA (1) SA96170171B1 (is)
SK (1) SK284209B6 (is)
TN (1) TNSN96104A1 (is)
TR (1) TR199800208T1 (is)
TW (1) TW495502B (is)
UA (1) UA59341C2 (is)
WO (1) WO1997007098A1 (is)
ZA (1) ZA966760B (is)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6046213A (en) * 1994-08-18 2000-04-04 Pfizer Inc. Neuroprotective 3-(piperidinyl-1)-chroman-4,7-diol and 1-(4-hydroxyphenyl)-2-(piperidinyl-1)-alkanol derivatives
EP0843661B1 (en) * 1995-08-11 2002-03-27 Pfizer Inc. (1s,2s)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propanolmethanesulfonate trihydrate
GB9820405D0 (en) 1998-09-18 1998-11-11 Smithkline Beecham Plc Process
AU3676100A (en) * 1999-04-09 2000-11-14 Mochida Pharmaceutical Co., Ltd. Remedies for neuropathic pain
GB9920917D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel process
GB9920919D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel compound
US6620830B2 (en) * 2000-04-21 2003-09-16 Pfizer, Inc. Thyroid receptor ligands
YU27801A (sh) 2000-04-28 2003-04-30 Pfizer Products Inc. Postupak za dobijanje trihidrata mezilatne soli 1-(4- hidroksifenil)-2-(4-hidroksi-4-fenilpiperidin-1-il)-1-propanola i korisnih intermedijera
YU27701A (sh) * 2000-04-28 2003-04-30 Pfizer Products Inc. Postupak za dobijanje trihidrata mezilatne soli 1-(4- hidroksifenil)-2-(4-hidroksi-4-fenilpiperidin-1-il)1-propanola
IL154378A0 (en) 2000-08-16 2003-09-17 Upjohn Co Compounds for the treatment of addictive disorders
EP1186303A3 (en) * 2000-09-06 2003-12-10 Pfizer Products Inc. Pharmaceutical combinations, for the treatment of stroke and traumatic brain injury, containing a neutrophil inhibiting factor and an selective NMDA-NR2B receptor antagonist
EP1674087A1 (en) 2000-10-02 2006-06-28 Pfizer Products Inc. Prophylactic use of n-methyl-d-aspartate (NMDA) antagonists
IL145584A0 (en) 2000-10-02 2002-06-30 Pfizer Prod Inc Nmda nr2b antagonists for treatment
UA73619C2 (en) * 2000-12-13 2005-08-15 Pfizer Prod Inc Stable pharmaceutical compositions of nmda receptor agonist (variants) and method of treatment
JP4398247B2 (ja) * 2001-10-19 2010-01-13 富山化学工業株式会社 アルキルエーテル誘導体またはその塩
KR100517638B1 (ko) 2002-04-08 2005-09-28 주식회사 엘지생명과학 게미플록사신 산염의 새로운 제조방법
KR101052122B1 (ko) 2005-10-25 2011-07-26 시오노기세야쿠 가부시키가이샤 아미노디히드로티아진 유도체
EP2147914B1 (en) 2007-04-24 2014-06-04 Shionogi&Co., Ltd. Aminodihydrothiazine derivatives substituted with cyclic groups
EP2151435A4 (en) 2007-04-24 2011-09-14 Shionogi & Co PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF ALZHEIMER'S DISEASE
MX2010013256A (es) 2008-06-13 2010-12-21 Shionogi & Co Derivado heterociclico que contiene azufre que tiene actividad inhibitoria de beta-secretasa.
JPWO2010047372A1 (ja) 2008-10-22 2012-03-22 塩野義製薬株式会社 Bace1阻害活性を有する2−アミノピリミジン−4−オンおよび2−アミノピリジン誘導体
JPWO2011071135A1 (ja) 2009-12-11 2013-04-22 塩野義製薬株式会社 オキサジン誘導体
CA2816285A1 (en) 2010-10-29 2012-05-03 Shionogi & Co., Ltd. Naphthyridine derivative
EP2634188A4 (en) 2010-10-29 2014-05-07 Shionogi & Co FUSIONED AMINODIHYDROPYRIMIDINE DERIVATIVE
TW201247635A (en) 2011-04-26 2012-12-01 Shionogi & Co Oxazine derivatives and a pharmaceutical composition for inhibiting BAC1 containing them
JP2016501827A (ja) 2012-10-24 2016-01-21 塩野義製薬株式会社 Bace1阻害作用を有するジヒドロオキサジンまたはオキサゼピン誘導体
EP3194403B1 (en) 2014-09-15 2019-02-06 Rugen Holdings (Cayman) Limited Pyrrolopyrimidine derivatives as nr2b nmda receptor antagonists
WO2016049048A1 (en) * 2014-09-22 2016-03-31 Rugen Holdings (Cayman) Limited Treatment of anxiety disorders and autism spectrum disorders
US10221182B2 (en) 2015-02-04 2019-03-05 Rugen Holdings (Cayman) Limited 3,3-difluoro-piperidine derivatives as NR2B NMDA receptor antagonists
US10584127B2 (en) 2015-06-01 2020-03-10 Rugen Holdings (Cayman) Limited 3,3-difluoropiperidine carbamate heterocyclic compounds as NR2B NMDA receptor antagonists
US11000526B2 (en) 2016-11-22 2021-05-11 Rugen Holdings (Cayman) Limited Treatment of autism spectrum disorders, obsessive-compulsive disorder and anxiety disorders

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990014087A1 (en) * 1989-05-17 1990-11-29 Pfizer Inc. 2-piperidino-1-alkanol derivatives as antiischemic agents
US5272160A (en) * 1989-05-17 1993-12-21 Pfizer Inc 2-piperidino-1-alkanol derivatives as antiischemic agents
US6046213A (en) * 1994-08-18 2000-04-04 Pfizer Inc. Neuroprotective 3-(piperidinyl-1)-chroman-4,7-diol and 1-(4-hydroxyphenyl)-2-(piperidinyl-1)-alkanol derivatives
EP0843661B1 (en) * 1995-08-11 2002-03-27 Pfizer Inc. (1s,2s)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propanolmethanesulfonate trihydrate

Also Published As

Publication number Publication date
AU5908496A (en) 1997-03-12
CZ296236B6 (cs) 2006-02-15
KR100291882B1 (ko) 2001-10-26
TNSN96104A1 (fr) 2005-03-15
IL122649A0 (en) 1998-08-16
NO980574D0 (no) 1998-02-10
DK0843661T3 (da) 2002-07-22
CN1615861A (zh) 2005-05-18
BG102289A (en) 1998-09-30
NZ309134A (en) 1999-09-29
NO980574L (no) 1998-02-10
PL325050A1 (en) 1998-07-06
SK16698A3 (en) 1999-06-11
HRP960372A2 (en) 1998-04-30
WO1997007098A1 (en) 1997-02-27
IS4643A (is) 1997-12-30
PL185603B1 (pl) 2003-06-30
ATE215072T1 (de) 2002-04-15
CN1198739A (zh) 1998-11-11
TW495502B (en) 2002-07-21
IL122649A (en) 2001-08-26
YU46196A (sh) 1999-07-28
RS49521B (sr) 2006-10-27
KR19990036321A (ko) 1999-05-25
RO120134B1 (ro) 2005-09-30
EP0843661B1 (en) 2002-03-27
DE69620191D1 (de) 2002-05-02
EP0843661A1 (en) 1998-05-27
HUP9802862A2 (hu) 1999-04-28
DE69620191T2 (de) 2002-07-18
CA2228752A1 (en) 1997-02-27
SA96170171B1 (ar) 2006-05-20
JPH10510552A (ja) 1998-10-13
CO4750830A1 (es) 1999-03-31
CZ39098A3 (cs) 1999-02-17
PE4898A1 (es) 1998-03-16
DZ2083A1 (fr) 2002-10-23
AP755A (en) 1999-08-02
RU2140910C1 (ru) 1999-11-10
CA2228752C (en) 2002-12-10
BR9610766A (pt) 1999-07-13
HUP9802862A3 (en) 1999-05-28
AR004676A1 (es) 1999-03-10
TR199800208T1 (is) 1998-05-21
NO310458B1 (no) 2001-07-09
ES2170857T3 (es) 2002-08-16
AU710984B2 (en) 1999-10-07
HRP960372B1 (en) 2003-04-30
UA59341C2 (uk) 2003-09-15
MX9801149A (es) 1998-05-31
US6008233A (en) 1999-12-28
BG63678B1 (bg) 2002-09-30
OA10664A (en) 2000-11-06
ZA966760B (en) 1998-02-09
GT199600051A (es) 1997-12-26
PT843661E (pt) 2002-07-31
SK284209B6 (en) 2004-11-03
MA23957A1 (fr) 1997-04-01
JP3099072B2 (ja) 2000-10-16
AP9600856A0 (en) 1996-10-31

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