[go: up one dir, main page]

AR004676A1 - Un derivado de la sal metanosulfonato de (1s, 2s)-1-(4-hidroxifenil)-2-(4-hidroxi-4-fenilpiperidin-il)-1-propanol, una composicion farmaceutica que lo comprende y metodos para fabricar un medicamento - Google Patents

Un derivado de la sal metanosulfonato de (1s, 2s)-1-(4-hidroxifenil)-2-(4-hidroxi-4-fenilpiperidin-il)-1-propanol, una composicion farmaceutica que lo comprende y metodos para fabricar un medicamento

Info

Publication number
AR004676A1
AR004676A1 ARP960103904A AR10390496A AR004676A1 AR 004676 A1 AR004676 A1 AR 004676A1 AR P960103904 A ARP960103904 A AR P960103904A AR 10390496 A AR10390496 A AR 10390496A AR 004676 A1 AR004676 A1 AR 004676A1
Authority
AR
Argentina
Prior art keywords
phenylpiperidin
propanol
hydroxy
methods
pharmaceutical composition
Prior art date
Application number
ARP960103904A
Other languages
English (en)
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of AR004676A1 publication Critical patent/AR004676A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40Oxygen atoms
    • C07D211/44Oxygen atoms attached in position 4
    • C07D211/52Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Virology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

El trihidrato de la sal metanosulfonato de (1S,2S)-1-(4-hidroxifenil)-2- (4-hidroxi-4-fenilpiperidin-1-il)-1-propanol. La invención se refiere tambien auna composicion farmaceutica para el tratamiento de enfermedades que incluye una cantidadde dicho compuesto que es eficaz en el tratamiento de cadaenfermedad y un vehiculo farmaceuticamente aceptable y a metodos para el tratamiento de enfermedades con dicho compuesto.
ARP960103904A 1995-08-11 1996-08-07 Un derivado de la sal metanosulfonato de (1s, 2s)-1-(4-hidroxifenil)-2-(4-hidroxi-4-fenilpiperidin-il)-1-propanol, una composicion farmaceutica que lo comprende y metodos para fabricar un medicamento AR004676A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US223895P 1995-08-11 1995-08-11

Publications (1)

Publication Number Publication Date
AR004676A1 true AR004676A1 (es) 1999-03-10

Family

ID=21699847

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960103904A AR004676A1 (es) 1995-08-11 1996-08-07 Un derivado de la sal metanosulfonato de (1s, 2s)-1-(4-hidroxifenil)-2-(4-hidroxi-4-fenilpiperidin-il)-1-propanol, una composicion farmaceutica que lo comprende y metodos para fabricar un medicamento

Country Status (41)

Country Link
US (1) US6008233A (es)
EP (1) EP0843661B1 (es)
JP (1) JP3099072B2 (es)
KR (1) KR100291882B1 (es)
CN (2) CN1615861A (es)
AP (1) AP755A (es)
AR (1) AR004676A1 (es)
AT (1) ATE215072T1 (es)
AU (1) AU710984B2 (es)
BG (1) BG63678B1 (es)
BR (1) BR9610766A (es)
CA (1) CA2228752C (es)
CO (1) CO4750830A1 (es)
CZ (1) CZ296236B6 (es)
DE (1) DE69620191T2 (es)
DK (1) DK0843661T3 (es)
DZ (1) DZ2083A1 (es)
ES (1) ES2170857T3 (es)
GT (1) GT199600051A (es)
HR (1) HRP960372B1 (es)
HU (1) HUP9802862A3 (es)
IL (1) IL122649A (es)
IS (1) IS1945B (es)
MA (1) MA23957A1 (es)
NO (1) NO310458B1 (es)
NZ (1) NZ309134A (es)
OA (1) OA10664A (es)
PE (1) PE4898A1 (es)
PL (1) PL185603B1 (es)
PT (1) PT843661E (es)
RO (1) RO120134B1 (es)
RS (1) RS49521B (es)
RU (1) RU2140910C1 (es)
SA (1) SA96170171B1 (es)
SK (1) SK284209B6 (es)
TN (1) TNSN96104A1 (es)
TR (1) TR199800208T1 (es)
TW (1) TW495502B (es)
UA (1) UA59341C2 (es)
WO (1) WO1997007098A1 (es)
ZA (1) ZA966760B (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2139857C1 (ru) * 1994-08-18 1999-10-20 Пфайзер Инк. Производные 3-(пиперидинил-1)-хроман-4,7-диола и 1-(4-гидроксифенил)-2-(пиперидинил-1)-алканола, фармацевтическая композиция и способ связывания nmda рецептора
RU2140910C1 (ru) * 1995-08-11 1999-11-10 Пфайзер Инк. Тригидрат метансульфоната (1s,2s)-1-(4-гидроксифенил)-2-(4-гидрокси-4- фенилпиперидин-1-ил)-1-пропанола
GB9820405D0 (en) * 1998-09-18 1998-11-11 Smithkline Beecham Plc Process
WO2000061558A1 (en) * 1999-04-09 2000-10-19 Mochida Pharmaceutical Co., Ltd. Remedies for neuropathic pain
GB9920919D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel compound
GB9920917D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel process
US6620830B2 (en) * 2000-04-21 2003-09-16 Pfizer, Inc. Thyroid receptor ligands
YU27701A (sh) * 2000-04-28 2003-04-30 Pfizer Products Inc. Postupak za dobijanje trihidrata mezilatne soli 1-(4- hidroksifenil)-2-(4-hidroksi-4-fenilpiperidin-1-il)1-propanola
YU27801A (sh) 2000-04-28 2003-04-30 Pfizer Products Inc. Postupak za dobijanje trihidrata mezilatne soli 1-(4- hidroksifenil)-2-(4-hidroksi-4-fenilpiperidin-1-il)-1-propanola i korisnih intermedijera
NZ524741A (en) 2000-08-16 2005-01-28 Upjohn Co Heterocyclic amines, phenylazacycloalkanes, cabergoline and aromatic bicyclic amines for the treatment of alcohol, nicotine and drug addiction
EP1186303A3 (en) * 2000-09-06 2003-12-10 Pfizer Products Inc. Pharmaceutical combinations, for the treatment of stroke and traumatic brain injury, containing a neutrophil inhibiting factor and an selective NMDA-NR2B receptor antagonist
IL145584A0 (en) 2000-10-02 2002-06-30 Pfizer Prod Inc Nmda nr2b antagonists for treatment
EP1674087A1 (en) 2000-10-02 2006-06-28 Pfizer Products Inc. Prophylactic use of n-methyl-d-aspartate (NMDA) antagonists
UA73619C2 (en) * 2000-12-13 2005-08-15 Pfizer Prod Inc Stable pharmaceutical compositions of nmda receptor agonist (variants) and method of treatment
DE60220694T2 (de) * 2001-10-19 2008-02-07 Toyama Chemical Co. Ltd. Alkyletherderivate oder deren salze
KR100517638B1 (ko) 2002-04-08 2005-09-28 주식회사 엘지생명과학 게미플록사신 산염의 새로운 제조방법
US8173642B2 (en) 2005-10-25 2012-05-08 Shionogi & Co., Ltd. Aminodihydrothiazine derivatives
MX2009011498A (es) 2007-04-24 2009-11-10 Shionogi & Co Derivados de aminodihidrotiazina sustituida con un grupo ciclico.
EP2151435A4 (en) 2007-04-24 2011-09-14 Shionogi & Co PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF ALZHEIMER'S DISEASE
KR101324426B1 (ko) 2008-06-13 2013-10-31 시오노기세야쿠 가부시키가이샤 β 세크레타제 저해 작용을 갖는 황 함유 복소환 유도체
EP2360155A4 (en) 2008-10-22 2012-06-20 Shionogi & Co 2-AMINOPYRIDIN-4-ON AND 2-AMINOPYRIDINE DERIVATIVE WITH BACE1-HEMDERING EFFECT
RU2012129168A (ru) 2009-12-11 2014-01-20 Сионоги Энд Ко. Лтд. Производные оксазина
CN103261199A (zh) 2010-10-29 2013-08-21 盐野义制药株式会社 萘啶衍生物
JP5766198B2 (ja) 2010-10-29 2015-08-19 塩野義製薬株式会社 縮合アミノジヒドロピリミジン誘導体
JPWO2012147763A1 (ja) 2011-04-26 2014-07-28 塩野義製薬株式会社 オキサジン誘導体およびそれを含有するbace1阻害剤
JP2016501827A (ja) 2012-10-24 2016-01-21 塩野義製薬株式会社 Bace1阻害作用を有するジヒドロオキサジンまたはオキサゼピン誘導体
SG11201701853YA (en) 2014-09-15 2017-04-27 Rugen Holdings Cayman Ltd Pyrrolopyrimidine derivatives as nr2b nmda receptor antagonists
WO2016049048A1 (en) * 2014-09-22 2016-03-31 Rugen Holdings (Cayman) Limited Treatment of anxiety disorders and autism spectrum disorders
EP3253761A4 (en) 2015-02-04 2018-06-20 Rugen Holdings (Cayman) Limited 3,3-difluoro-piperidine derivatives as nr2b nmda receptor antagonists
KR102613179B1 (ko) 2015-06-01 2023-12-14 뤼겐 홀딩스 (케이맨) 리미티드 Nr2b nmda 수용체 길항제로서의 3,3-디플루오로피페리딘 카바메이트 헤테로사이클릭 화합물
EP3544610A1 (en) 2016-11-22 2019-10-02 Rugen Holdings (Cayman) Limited Treatment of autism spectrum disorders, obsessive-compulsive disorder and anxiety disorders

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK232890A3 (en) * 1989-05-17 1998-11-04 Pfizer 2-piperidino and 2-pyrrolidino-1-alkanols derivatives and preparation method thereof
US5272160A (en) * 1989-05-17 1993-12-21 Pfizer Inc 2-piperidino-1-alkanol derivatives as antiischemic agents
RU2139857C1 (ru) * 1994-08-18 1999-10-20 Пфайзер Инк. Производные 3-(пиперидинил-1)-хроман-4,7-диола и 1-(4-гидроксифенил)-2-(пиперидинил-1)-алканола, фармацевтическая композиция и способ связывания nmda рецептора
RU2140910C1 (ru) * 1995-08-11 1999-11-10 Пфайзер Инк. Тригидрат метансульфоната (1s,2s)-1-(4-гидроксифенил)-2-(4-гидрокси-4- фенилпиперидин-1-ил)-1-пропанола

Also Published As

Publication number Publication date
EP0843661A1 (en) 1998-05-27
MA23957A1 (fr) 1997-04-01
DE69620191T2 (de) 2002-07-18
PT843661E (pt) 2002-07-31
AU5908496A (en) 1997-03-12
KR100291882B1 (ko) 2001-10-26
UA59341C2 (uk) 2003-09-15
CO4750830A1 (es) 1999-03-31
NO310458B1 (no) 2001-07-09
BG63678B1 (bg) 2002-09-30
AP9600856A0 (en) 1996-10-31
SA96170171B1 (ar) 2006-05-20
HUP9802862A3 (en) 1999-05-28
DE69620191D1 (de) 2002-05-02
ATE215072T1 (de) 2002-04-15
RS49521B (sr) 2006-10-27
SK284209B6 (en) 2004-11-03
TW495502B (en) 2002-07-21
JP3099072B2 (ja) 2000-10-16
KR19990036321A (ko) 1999-05-25
AP755A (en) 1999-08-02
MX9801149A (es) 1998-05-31
HUP9802862A2 (hu) 1999-04-28
DZ2083A1 (fr) 2002-10-23
CZ296236B6 (cs) 2006-02-15
NO980574D0 (no) 1998-02-10
CA2228752C (en) 2002-12-10
BR9610766A (pt) 1999-07-13
IS4643A (is) 1997-12-30
CN1615861A (zh) 2005-05-18
WO1997007098A1 (en) 1997-02-27
TNSN96104A1 (fr) 2005-03-15
ZA966760B (en) 1998-02-09
IL122649A0 (en) 1998-08-16
PL325050A1 (en) 1998-07-06
GT199600051A (es) 1997-12-26
AU710984B2 (en) 1999-10-07
ES2170857T3 (es) 2002-08-16
IL122649A (en) 2001-08-26
JPH10510552A (ja) 1998-10-13
CZ39098A3 (cs) 1999-02-17
CN1198739A (zh) 1998-11-11
HRP960372B1 (en) 2003-04-30
RO120134B1 (ro) 2005-09-30
IS1945B (is) 2004-08-13
SK16698A3 (en) 1999-06-11
RU2140910C1 (ru) 1999-11-10
US6008233A (en) 1999-12-28
OA10664A (en) 2000-11-06
DK0843661T3 (da) 2002-07-22
NO980574L (no) 1998-02-10
PL185603B1 (pl) 2003-06-30
HRP960372A2 (en) 1998-04-30
PE4898A1 (es) 1998-03-16
TR199800208T1 (es) 1998-05-21
CA2228752A1 (en) 1997-02-27
YU46196A (sh) 1999-07-28
BG102289A (en) 1998-09-30
EP0843661B1 (en) 2002-03-27
NZ309134A (en) 1999-09-29

Similar Documents

Publication Publication Date Title
AR004676A1 (es) Un derivado de la sal metanosulfonato de (1s, 2s)-1-(4-hidroxifenil)-2-(4-hidroxi-4-fenilpiperidin-il)-1-propanol, una composicion farmaceutica que lo comprende y metodos para fabricar un medicamento
ES2119034T3 (es) Preparaciones farmaceuticas de sales de tramadol de liberacion retardada.
MX9706449A (es) Composicion farmaceutica para compuestos de piperidinalcanol.
ES2162615T3 (es) Metodo para tratar o prevenir diabetes de tipo 1 mediante la administracion oral de insulina.
RU2220723C2 (ru) Средство и способ лечения или профилактики артериосклероза
BR9909277A (pt) Compostos com atividade em receptores muscarìnicos
ES2137888A1 (es) Agente antifungico, compuesto para el mismo procedimiento para su produccion y metodo para su utilizacion.
AR013742A1 (es) Metodo para el tratamiento de la hipercolesterolemia con polidialilamina no substituida
UY26372A1 (es) "imidazo-3-il-aminas bicíclicas procedimiento para su preparación y medicamentos que las contienen "
BR0013065A (pt) Método e composto para tratar de uma doença associada com recrutamento e/ ou ativação aberrante de leucócitos
AR028504A2 (es) Combinacion, metodo para mejorar la apariencia corporal de un mamifero, composicion farmaceutica, uso de dicha combinacion para la preparacion de un medicamento para la prevencion, demora de progreso, o tratamiento de desordenes metabolicos, y paquete comercial
BR9607965A (pt) Composto composição farmacêutica e processo para tratar uma doença parasítica em um mamífero
BR9916114A (pt) Uso de apomorfina na fabricação de um medicamento para tratamento de disfunção erétil orgânica masculina
PA8467401A1 (es) Procedimiento para tratar la insuficiencia cardiaca
PA8542901A1 (es) Uso de (z)-2-ciano-3-hidroxi-but-2-acido enoico-(4-trifluorometilfenil)-amida para tratar la esclerosis multiple
EA199800717A1 (ru) Способ лечения заболеваний млекопитающих и цвиттерионная композиция
ES2092646T3 (es) Metanoantracenos como antagonistas de dopamina.
ES2135342B1 (es) Uso del raloxifeno o una sal o salvato del mismo en la preparacion de un medicamento para prevenir el cancer de mama.
ES2189252T3 (es) Composiciones analgesicas que comprenden un antagonista de la colecistoquinina y un opioide.
CO5060499A1 (es) Metodos y composiciones para el tratamiento de enfermedad de reflujo gastroesofagico
RU97120700A (ru) Новое фармакологическое применение антагонистов a-ii рецептора
AR039162A1 (es) Formulaciones de venlafaxina de liberacion extendida
AR002191A1 (es) Composicion farmaceutica oral de compuestos de piperidinoalcanol en forma de solucion, procedimiento para su preparacion
PT768083E (pt) Sertralina para o tratamento de doentes pos-enfarte miocardico
ES2092645T3 (es) Metanoantracenos como antagonistas de dopamina.

Legal Events

Date Code Title Description
FB Suspension of granting procedure