ZA966760B - (1S,2S)-1-(4-Hydroxyphenyl)-2-(4-Hydroxy-4-phenylpiperidin-1-yl)-1-propanol methanesulfonate trihydrate. - Google Patents
(1S,2S)-1-(4-Hydroxyphenyl)-2-(4-Hydroxy-4-phenylpiperidin-1-yl)-1-propanol methanesulfonate trihydrate.Info
- Publication number
- ZA966760B ZA966760B ZA9606760A ZA966760A ZA966760B ZA 966760 B ZA966760 B ZA 966760B ZA 9606760 A ZA9606760 A ZA 9606760A ZA 966760 A ZA966760 A ZA 966760A ZA 966760 B ZA966760 B ZA 966760B
- Authority
- ZA
- South Africa
- Prior art keywords
- phenylpiperidin
- hydroxyphenyl
- hydroxy
- propanol methanesulfonate
- methanesulfonate trihydrate
- Prior art date
Links
- LUILKELNVBKKTG-ZOZJKLBQSA-N 1-[(1s,2s)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]-4-phenylpiperidin-4-ol;methanesulfonic acid;trihydrate Chemical compound O.O.O.CS(O)(=O)=O.C1([C@H](O)[C@H](C)N2CCC(O)(CC2)C=2C=CC=CC=2)=CC=C(O)C=C1 LUILKELNVBKKTG-ZOZJKLBQSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- Endocrinology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US223895P | 1995-08-11 | 1995-08-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA966760B true ZA966760B (en) | 1998-02-09 |
Family
ID=21699847
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA9606760A ZA966760B (en) | 1995-08-11 | 1996-08-08 | (1S,2S)-1-(4-Hydroxyphenyl)-2-(4-Hydroxy-4-phenylpiperidin-1-yl)-1-propanol methanesulfonate trihydrate. |
Country Status (41)
| Country | Link |
|---|---|
| US (1) | US6008233A (xx) |
| EP (1) | EP0843661B1 (xx) |
| JP (1) | JP3099072B2 (xx) |
| KR (1) | KR100291882B1 (xx) |
| CN (2) | CN1615861A (xx) |
| AP (1) | AP755A (xx) |
| AR (1) | AR004676A1 (xx) |
| AT (1) | ATE215072T1 (xx) |
| AU (1) | AU710984B2 (xx) |
| BG (1) | BG63678B1 (xx) |
| BR (1) | BR9610766A (xx) |
| CA (1) | CA2228752C (xx) |
| CO (1) | CO4750830A1 (xx) |
| CZ (1) | CZ296236B6 (xx) |
| DE (1) | DE69620191T2 (xx) |
| DK (1) | DK0843661T3 (xx) |
| DZ (1) | DZ2083A1 (xx) |
| ES (1) | ES2170857T3 (xx) |
| GT (1) | GT199600051A (xx) |
| HR (1) | HRP960372B1 (xx) |
| HU (1) | HUP9802862A3 (xx) |
| IL (1) | IL122649A (xx) |
| IS (1) | IS1945B (xx) |
| MA (1) | MA23957A1 (xx) |
| NO (1) | NO310458B1 (xx) |
| NZ (1) | NZ309134A (xx) |
| OA (1) | OA10664A (xx) |
| PE (1) | PE4898A1 (xx) |
| PL (1) | PL185603B1 (xx) |
| PT (1) | PT843661E (xx) |
| RO (1) | RO120134B1 (xx) |
| RS (1) | RS49521B (xx) |
| RU (1) | RU2140910C1 (xx) |
| SA (1) | SA96170171B1 (xx) |
| SK (1) | SK284209B6 (xx) |
| TN (1) | TNSN96104A1 (xx) |
| TR (1) | TR199800208T1 (xx) |
| TW (1) | TW495502B (xx) |
| UA (1) | UA59341C2 (xx) |
| WO (1) | WO1997007098A1 (xx) |
| ZA (1) | ZA966760B (xx) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2139857C1 (ru) * | 1994-08-18 | 1999-10-20 | Пфайзер Инк. | Производные 3-(пиперидинил-1)-хроман-4,7-диола и 1-(4-гидроксифенил)-2-(пиперидинил-1)-алканола, фармацевтическая композиция и способ связывания nmda рецептора |
| RU2140910C1 (ru) * | 1995-08-11 | 1999-11-10 | Пфайзер Инк. | Тригидрат метансульфоната (1s,2s)-1-(4-гидроксифенил)-2-(4-гидрокси-4- фенилпиперидин-1-ил)-1-пропанола |
| GB9820405D0 (en) * | 1998-09-18 | 1998-11-11 | Smithkline Beecham Plc | Process |
| WO2000061558A1 (en) * | 1999-04-09 | 2000-10-19 | Mochida Pharmaceutical Co., Ltd. | Remedies for neuropathic pain |
| GB9920919D0 (en) | 1999-09-03 | 1999-11-10 | Sb Pharmco Inc | Novel compound |
| GB9920917D0 (en) | 1999-09-03 | 1999-11-10 | Sb Pharmco Inc | Novel process |
| US6620830B2 (en) * | 2000-04-21 | 2003-09-16 | Pfizer, Inc. | Thyroid receptor ligands |
| YU27701A (sh) * | 2000-04-28 | 2003-04-30 | Pfizer Products Inc. | Postupak za dobijanje trihidrata mezilatne soli 1-(4- hidroksifenil)-2-(4-hidroksi-4-fenilpiperidin-1-il)1-propanola |
| YU27801A (sh) | 2000-04-28 | 2003-04-30 | Pfizer Products Inc. | Postupak za dobijanje trihidrata mezilatne soli 1-(4- hidroksifenil)-2-(4-hidroksi-4-fenilpiperidin-1-il)-1-propanola i korisnih intermedijera |
| NZ524741A (en) | 2000-08-16 | 2005-01-28 | Upjohn Co | Heterocyclic amines, phenylazacycloalkanes, cabergoline and aromatic bicyclic amines for the treatment of alcohol, nicotine and drug addiction |
| EP1186303A3 (en) * | 2000-09-06 | 2003-12-10 | Pfizer Products Inc. | Pharmaceutical combinations, for the treatment of stroke and traumatic brain injury, containing a neutrophil inhibiting factor and an selective NMDA-NR2B receptor antagonist |
| IL145584A0 (en) | 2000-10-02 | 2002-06-30 | Pfizer Prod Inc | Nmda nr2b antagonists for treatment |
| EP1674087A1 (en) | 2000-10-02 | 2006-06-28 | Pfizer Products Inc. | Prophylactic use of n-methyl-d-aspartate (NMDA) antagonists |
| UA73619C2 (en) * | 2000-12-13 | 2005-08-15 | Pfizer Prod Inc | Stable pharmaceutical compositions of nmda receptor agonist (variants) and method of treatment |
| DE60220694T2 (de) * | 2001-10-19 | 2008-02-07 | Toyama Chemical Co. Ltd. | Alkyletherderivate oder deren salze |
| KR100517638B1 (ko) | 2002-04-08 | 2005-09-28 | 주식회사 엘지생명과학 | 게미플록사신 산염의 새로운 제조방법 |
| US8173642B2 (en) | 2005-10-25 | 2012-05-08 | Shionogi & Co., Ltd. | Aminodihydrothiazine derivatives |
| MX2009011498A (es) | 2007-04-24 | 2009-11-10 | Shionogi & Co | Derivados de aminodihidrotiazina sustituida con un grupo ciclico. |
| EP2151435A4 (en) | 2007-04-24 | 2011-09-14 | Shionogi & Co | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF ALZHEIMER'S DISEASE |
| KR101324426B1 (ko) | 2008-06-13 | 2013-10-31 | 시오노기세야쿠 가부시키가이샤 | β 세크레타제 저해 작용을 갖는 황 함유 복소환 유도체 |
| EP2360155A4 (en) | 2008-10-22 | 2012-06-20 | Shionogi & Co | 2-AMINOPYRIDIN-4-ON AND 2-AMINOPYRIDINE DERIVATIVE WITH BACE1-HEMDERING EFFECT |
| RU2012129168A (ru) | 2009-12-11 | 2014-01-20 | Сионоги Энд Ко. Лтд. | Производные оксазина |
| CN103261199A (zh) | 2010-10-29 | 2013-08-21 | 盐野义制药株式会社 | 萘啶衍生物 |
| JP5766198B2 (ja) | 2010-10-29 | 2015-08-19 | 塩野義製薬株式会社 | 縮合アミノジヒドロピリミジン誘導体 |
| JPWO2012147763A1 (ja) | 2011-04-26 | 2014-07-28 | 塩野義製薬株式会社 | オキサジン誘導体およびそれを含有するbace1阻害剤 |
| JP2016501827A (ja) | 2012-10-24 | 2016-01-21 | 塩野義製薬株式会社 | Bace1阻害作用を有するジヒドロオキサジンまたはオキサゼピン誘導体 |
| SG11201701853YA (en) | 2014-09-15 | 2017-04-27 | Rugen Holdings Cayman Ltd | Pyrrolopyrimidine derivatives as nr2b nmda receptor antagonists |
| WO2016049048A1 (en) * | 2014-09-22 | 2016-03-31 | Rugen Holdings (Cayman) Limited | Treatment of anxiety disorders and autism spectrum disorders |
| EP3253761A4 (en) | 2015-02-04 | 2018-06-20 | Rugen Holdings (Cayman) Limited | 3,3-difluoro-piperidine derivatives as nr2b nmda receptor antagonists |
| KR102613179B1 (ko) | 2015-06-01 | 2023-12-14 | 뤼겐 홀딩스 (케이맨) 리미티드 | Nr2b nmda 수용체 길항제로서의 3,3-디플루오로피페리딘 카바메이트 헤테로사이클릭 화합물 |
| EP3544610A1 (en) | 2016-11-22 | 2019-10-02 | Rugen Holdings (Cayman) Limited | Treatment of autism spectrum disorders, obsessive-compulsive disorder and anxiety disorders |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK232890A3 (en) * | 1989-05-17 | 1998-11-04 | Pfizer | 2-piperidino and 2-pyrrolidino-1-alkanols derivatives and preparation method thereof |
| US5272160A (en) * | 1989-05-17 | 1993-12-21 | Pfizer Inc | 2-piperidino-1-alkanol derivatives as antiischemic agents |
| RU2139857C1 (ru) * | 1994-08-18 | 1999-10-20 | Пфайзер Инк. | Производные 3-(пиперидинил-1)-хроман-4,7-диола и 1-(4-гидроксифенил)-2-(пиперидинил-1)-алканола, фармацевтическая композиция и способ связывания nmda рецептора |
| RU2140910C1 (ru) * | 1995-08-11 | 1999-11-10 | Пфайзер Инк. | Тригидрат метансульфоната (1s,2s)-1-(4-гидроксифенил)-2-(4-гидрокси-4- фенилпиперидин-1-ил)-1-пропанола |
-
1996
- 1996-06-20 RU RU98102116A patent/RU2140910C1/ru not_active IP Right Cessation
- 1996-06-20 DK DK96916266T patent/DK0843661T3/da active
- 1996-06-20 UA UA98020673A patent/UA59341C2/uk unknown
- 1996-06-20 TR TR1998/00208T patent/TR199800208T1/xx unknown
- 1996-06-20 AT AT96916266T patent/ATE215072T1/de not_active IP Right Cessation
- 1996-06-20 HU HU9802862A patent/HUP9802862A3/hu unknown
- 1996-06-20 RO RO98-00231A patent/RO120134B1/ro unknown
- 1996-06-20 BR BR9610766A patent/BR9610766A/pt not_active Application Discontinuation
- 1996-06-20 KR KR1019980700989A patent/KR100291882B1/ko not_active Expired - Fee Related
- 1996-06-20 AU AU59084/96A patent/AU710984B2/en not_active Ceased
- 1996-06-20 DE DE69620191T patent/DE69620191T2/de not_active Expired - Fee Related
- 1996-06-20 CN CNA031584969A patent/CN1615861A/zh active Pending
- 1996-06-20 NZ NZ309134A patent/NZ309134A/en unknown
- 1996-06-20 EP EP96916266A patent/EP0843661B1/en not_active Expired - Lifetime
- 1996-06-20 PL PL96325050A patent/PL185603B1/pl not_active IP Right Cessation
- 1996-06-20 ES ES96916266T patent/ES2170857T3/es not_active Expired - Lifetime
- 1996-06-20 CN CN96195649A patent/CN1198739A/zh active Pending
- 1996-06-20 SK SK166-98A patent/SK284209B6/sk unknown
- 1996-06-20 JP JP09509083A patent/JP3099072B2/ja not_active Expired - Fee Related
- 1996-06-20 CA CA002228752A patent/CA2228752C/en not_active Expired - Fee Related
- 1996-06-20 CZ CZ0039098A patent/CZ296236B6/cs not_active IP Right Cessation
- 1996-06-20 PT PT96916266T patent/PT843661E/pt unknown
- 1996-06-20 WO PCT/IB1996/000592 patent/WO1997007098A1/en not_active Ceased
- 1996-06-20 IL IL12264996A patent/IL122649A/xx not_active IP Right Cessation
- 1996-06-20 US US09/011,426 patent/US6008233A/en not_active Expired - Fee Related
- 1996-06-24 TW TW085107571A patent/TW495502B/zh not_active IP Right Cessation
- 1996-07-04 GT GT199600051A patent/GT199600051A/es unknown
- 1996-07-23 SA SA96170171A patent/SA96170171B1/ar unknown
- 1996-08-06 PE PE1996000587A patent/PE4898A1/es not_active Application Discontinuation
- 1996-08-07 DZ DZ960127A patent/DZ2083A1/fr active
- 1996-08-07 AR ARP960103904A patent/AR004676A1/es unknown
- 1996-08-07 MA MA24335A patent/MA23957A1/fr unknown
- 1996-08-07 TN TNTNSN96104A patent/TNSN96104A1/fr unknown
- 1996-08-08 AP APAP/P/1996/000856A patent/AP755A/en active
- 1996-08-08 ZA ZA9606760A patent/ZA966760B/xx unknown
- 1996-08-09 CO CO96042164A patent/CO4750830A1/es unknown
- 1996-08-09 HR HR960372A patent/HRP960372B1/xx not_active IP Right Cessation
- 1996-08-09 RS YU46196A patent/RS49521B/sr unknown
-
1997
- 1997-12-30 IS IS4643A patent/IS1945B/is unknown
-
1998
- 1998-02-10 OA OA9800021A patent/OA10664A/en unknown
- 1998-02-10 NO NO19980574A patent/NO310458B1/no unknown
- 1998-02-27 BG BG102289A patent/BG63678B1/bg unknown
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