[go: up one dir, main page]

ZA966760B - (1S,2S)-1-(4-Hydroxyphenyl)-2-(4-Hydroxy-4-phenylpiperidin-1-yl)-1-propanol methanesulfonate trihydrate. - Google Patents

(1S,2S)-1-(4-Hydroxyphenyl)-2-(4-Hydroxy-4-phenylpiperidin-1-yl)-1-propanol methanesulfonate trihydrate.

Info

Publication number
ZA966760B
ZA966760B ZA9606760A ZA966760A ZA966760B ZA 966760 B ZA966760 B ZA 966760B ZA 9606760 A ZA9606760 A ZA 9606760A ZA 966760 A ZA966760 A ZA 966760A ZA 966760 B ZA966760 B ZA 966760B
Authority
ZA
South Africa
Prior art keywords
phenylpiperidin
hydroxyphenyl
hydroxy
propanol methanesulfonate
methanesulfonate trihydrate
Prior art date
Application number
ZA9606760A
Other languages
English (en)
Inventor
Marta Maria Andino
Terry Gene Sinay
Eugene Fred Fiese
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of ZA966760B publication Critical patent/ZA966760B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40Oxygen atoms
    • C07D211/44Oxygen atoms attached in position 4
    • C07D211/52Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Endocrinology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
ZA9606760A 1995-08-11 1996-08-08 (1S,2S)-1-(4-Hydroxyphenyl)-2-(4-Hydroxy-4-phenylpiperidin-1-yl)-1-propanol methanesulfonate trihydrate. ZA966760B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US223895P 1995-08-11 1995-08-11

Publications (1)

Publication Number Publication Date
ZA966760B true ZA966760B (en) 1998-02-09

Family

ID=21699847

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9606760A ZA966760B (en) 1995-08-11 1996-08-08 (1S,2S)-1-(4-Hydroxyphenyl)-2-(4-Hydroxy-4-phenylpiperidin-1-yl)-1-propanol methanesulfonate trihydrate.

Country Status (41)

Country Link
US (1) US6008233A (xx)
EP (1) EP0843661B1 (xx)
JP (1) JP3099072B2 (xx)
KR (1) KR100291882B1 (xx)
CN (2) CN1615861A (xx)
AP (1) AP755A (xx)
AR (1) AR004676A1 (xx)
AT (1) ATE215072T1 (xx)
AU (1) AU710984B2 (xx)
BG (1) BG63678B1 (xx)
BR (1) BR9610766A (xx)
CA (1) CA2228752C (xx)
CO (1) CO4750830A1 (xx)
CZ (1) CZ296236B6 (xx)
DE (1) DE69620191T2 (xx)
DK (1) DK0843661T3 (xx)
DZ (1) DZ2083A1 (xx)
ES (1) ES2170857T3 (xx)
GT (1) GT199600051A (xx)
HR (1) HRP960372B1 (xx)
HU (1) HUP9802862A3 (xx)
IL (1) IL122649A (xx)
IS (1) IS1945B (xx)
MA (1) MA23957A1 (xx)
NO (1) NO310458B1 (xx)
NZ (1) NZ309134A (xx)
OA (1) OA10664A (xx)
PE (1) PE4898A1 (xx)
PL (1) PL185603B1 (xx)
PT (1) PT843661E (xx)
RO (1) RO120134B1 (xx)
RS (1) RS49521B (xx)
RU (1) RU2140910C1 (xx)
SA (1) SA96170171B1 (xx)
SK (1) SK284209B6 (xx)
TN (1) TNSN96104A1 (xx)
TR (1) TR199800208T1 (xx)
TW (1) TW495502B (xx)
UA (1) UA59341C2 (xx)
WO (1) WO1997007098A1 (xx)
ZA (1) ZA966760B (xx)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2139857C1 (ru) * 1994-08-18 1999-10-20 Пфайзер Инк. Производные 3-(пиперидинил-1)-хроман-4,7-диола и 1-(4-гидроксифенил)-2-(пиперидинил-1)-алканола, фармацевтическая композиция и способ связывания nmda рецептора
RU2140910C1 (ru) * 1995-08-11 1999-11-10 Пфайзер Инк. Тригидрат метансульфоната (1s,2s)-1-(4-гидроксифенил)-2-(4-гидрокси-4- фенилпиперидин-1-ил)-1-пропанола
GB9820405D0 (en) * 1998-09-18 1998-11-11 Smithkline Beecham Plc Process
WO2000061558A1 (en) * 1999-04-09 2000-10-19 Mochida Pharmaceutical Co., Ltd. Remedies for neuropathic pain
GB9920919D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel compound
GB9920917D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel process
US6620830B2 (en) * 2000-04-21 2003-09-16 Pfizer, Inc. Thyroid receptor ligands
YU27701A (sh) * 2000-04-28 2003-04-30 Pfizer Products Inc. Postupak za dobijanje trihidrata mezilatne soli 1-(4- hidroksifenil)-2-(4-hidroksi-4-fenilpiperidin-1-il)1-propanola
YU27801A (sh) 2000-04-28 2003-04-30 Pfizer Products Inc. Postupak za dobijanje trihidrata mezilatne soli 1-(4- hidroksifenil)-2-(4-hidroksi-4-fenilpiperidin-1-il)-1-propanola i korisnih intermedijera
NZ524741A (en) 2000-08-16 2005-01-28 Upjohn Co Heterocyclic amines, phenylazacycloalkanes, cabergoline and aromatic bicyclic amines for the treatment of alcohol, nicotine and drug addiction
EP1186303A3 (en) * 2000-09-06 2003-12-10 Pfizer Products Inc. Pharmaceutical combinations, for the treatment of stroke and traumatic brain injury, containing a neutrophil inhibiting factor and an selective NMDA-NR2B receptor antagonist
IL145584A0 (en) 2000-10-02 2002-06-30 Pfizer Prod Inc Nmda nr2b antagonists for treatment
EP1674087A1 (en) 2000-10-02 2006-06-28 Pfizer Products Inc. Prophylactic use of n-methyl-d-aspartate (NMDA) antagonists
UA73619C2 (en) * 2000-12-13 2005-08-15 Pfizer Prod Inc Stable pharmaceutical compositions of nmda receptor agonist (variants) and method of treatment
DE60220694T2 (de) * 2001-10-19 2008-02-07 Toyama Chemical Co. Ltd. Alkyletherderivate oder deren salze
KR100517638B1 (ko) 2002-04-08 2005-09-28 주식회사 엘지생명과학 게미플록사신 산염의 새로운 제조방법
US8173642B2 (en) 2005-10-25 2012-05-08 Shionogi & Co., Ltd. Aminodihydrothiazine derivatives
MX2009011498A (es) 2007-04-24 2009-11-10 Shionogi & Co Derivados de aminodihidrotiazina sustituida con un grupo ciclico.
EP2151435A4 (en) 2007-04-24 2011-09-14 Shionogi & Co PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF ALZHEIMER'S DISEASE
KR101324426B1 (ko) 2008-06-13 2013-10-31 시오노기세야쿠 가부시키가이샤 β 세크레타제 저해 작용을 갖는 황 함유 복소환 유도체
EP2360155A4 (en) 2008-10-22 2012-06-20 Shionogi & Co 2-AMINOPYRIDIN-4-ON AND 2-AMINOPYRIDINE DERIVATIVE WITH BACE1-HEMDERING EFFECT
RU2012129168A (ru) 2009-12-11 2014-01-20 Сионоги Энд Ко. Лтд. Производные оксазина
CN103261199A (zh) 2010-10-29 2013-08-21 盐野义制药株式会社 萘啶衍生物
JP5766198B2 (ja) 2010-10-29 2015-08-19 塩野義製薬株式会社 縮合アミノジヒドロピリミジン誘導体
JPWO2012147763A1 (ja) 2011-04-26 2014-07-28 塩野義製薬株式会社 オキサジン誘導体およびそれを含有するbace1阻害剤
JP2016501827A (ja) 2012-10-24 2016-01-21 塩野義製薬株式会社 Bace1阻害作用を有するジヒドロオキサジンまたはオキサゼピン誘導体
SG11201701853YA (en) 2014-09-15 2017-04-27 Rugen Holdings Cayman Ltd Pyrrolopyrimidine derivatives as nr2b nmda receptor antagonists
WO2016049048A1 (en) * 2014-09-22 2016-03-31 Rugen Holdings (Cayman) Limited Treatment of anxiety disorders and autism spectrum disorders
EP3253761A4 (en) 2015-02-04 2018-06-20 Rugen Holdings (Cayman) Limited 3,3-difluoro-piperidine derivatives as nr2b nmda receptor antagonists
KR102613179B1 (ko) 2015-06-01 2023-12-14 뤼겐 홀딩스 (케이맨) 리미티드 Nr2b nmda 수용체 길항제로서의 3,3-디플루오로피페리딘 카바메이트 헤테로사이클릭 화합물
EP3544610A1 (en) 2016-11-22 2019-10-02 Rugen Holdings (Cayman) Limited Treatment of autism spectrum disorders, obsessive-compulsive disorder and anxiety disorders

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK232890A3 (en) * 1989-05-17 1998-11-04 Pfizer 2-piperidino and 2-pyrrolidino-1-alkanols derivatives and preparation method thereof
US5272160A (en) * 1989-05-17 1993-12-21 Pfizer Inc 2-piperidino-1-alkanol derivatives as antiischemic agents
RU2139857C1 (ru) * 1994-08-18 1999-10-20 Пфайзер Инк. Производные 3-(пиперидинил-1)-хроман-4,7-диола и 1-(4-гидроксифенил)-2-(пиперидинил-1)-алканола, фармацевтическая композиция и способ связывания nmda рецептора
RU2140910C1 (ru) * 1995-08-11 1999-11-10 Пфайзер Инк. Тригидрат метансульфоната (1s,2s)-1-(4-гидроксифенил)-2-(4-гидрокси-4- фенилпиперидин-1-ил)-1-пропанола

Also Published As

Publication number Publication date
EP0843661A1 (en) 1998-05-27
MA23957A1 (fr) 1997-04-01
DE69620191T2 (de) 2002-07-18
PT843661E (pt) 2002-07-31
AU5908496A (en) 1997-03-12
KR100291882B1 (ko) 2001-10-26
UA59341C2 (uk) 2003-09-15
CO4750830A1 (es) 1999-03-31
NO310458B1 (no) 2001-07-09
BG63678B1 (bg) 2002-09-30
AP9600856A0 (en) 1996-10-31
SA96170171B1 (ar) 2006-05-20
HUP9802862A3 (en) 1999-05-28
DE69620191D1 (de) 2002-05-02
ATE215072T1 (de) 2002-04-15
RS49521B (sr) 2006-10-27
SK284209B6 (en) 2004-11-03
TW495502B (en) 2002-07-21
JP3099072B2 (ja) 2000-10-16
KR19990036321A (ko) 1999-05-25
AP755A (en) 1999-08-02
MX9801149A (es) 1998-05-31
HUP9802862A2 (hu) 1999-04-28
DZ2083A1 (fr) 2002-10-23
CZ296236B6 (cs) 2006-02-15
NO980574D0 (no) 1998-02-10
CA2228752C (en) 2002-12-10
BR9610766A (pt) 1999-07-13
IS4643A (is) 1997-12-30
CN1615861A (zh) 2005-05-18
WO1997007098A1 (en) 1997-02-27
TNSN96104A1 (fr) 2005-03-15
IL122649A0 (en) 1998-08-16
PL325050A1 (en) 1998-07-06
GT199600051A (es) 1997-12-26
AU710984B2 (en) 1999-10-07
ES2170857T3 (es) 2002-08-16
IL122649A (en) 2001-08-26
JPH10510552A (ja) 1998-10-13
CZ39098A3 (cs) 1999-02-17
CN1198739A (zh) 1998-11-11
HRP960372B1 (en) 2003-04-30
RO120134B1 (ro) 2005-09-30
IS1945B (is) 2004-08-13
SK16698A3 (en) 1999-06-11
RU2140910C1 (ru) 1999-11-10
US6008233A (en) 1999-12-28
OA10664A (en) 2000-11-06
DK0843661T3 (da) 2002-07-22
NO980574L (no) 1998-02-10
PL185603B1 (pl) 2003-06-30
HRP960372A2 (en) 1998-04-30
PE4898A1 (es) 1998-03-16
TR199800208T1 (xx) 1998-05-21
CA2228752A1 (en) 1997-02-27
YU46196A (xx) 1999-07-28
BG102289A (en) 1998-09-30
AR004676A1 (es) 1999-03-10
EP0843661B1 (en) 2002-03-27
NZ309134A (en) 1999-09-29

Similar Documents

Publication Publication Date Title
ZA966760B (en) (1S,2S)-1-(4-Hydroxyphenyl)-2-(4-Hydroxy-4-phenylpiperidin-1-yl)-1-propanol methanesulfonate trihydrate.
MX194138B (es) Tintes azoicos de imidazol cationicos.
ZA985875B (en) Azetidines.
AU2349795A (en) Connector for wires, etc.
ZA971285B (en) Cationic detergent compounds.
CY2333B1 (en) 10-Aminoaliphatyl-dibenz (b,f) oxepins with antineur odegenarative activity.
ZA966773B (en) Sulfonyl-or sulfinyl-benzoylguanidin derivate.
GB9824177D0 (en) Take out mechanism for an i.s machine
ZA962753B (en) 1,3-Dihydro-2H-imidazol-2-one derivatives.
ZA9710212B (en) Thermal barrier for a primary pump.
ZA974950B (en) N-acetonylbenzamide fungicides.
ZA969796B (en) Fungicidal compounds.
GB2289775B (en) I.S Machine
GB9824172D0 (en) I.S. machine
GB9513892D0 (en) Brush assembly for d.c. machine
ZA964565B (en) Pyridiniminyl-1,2-benzisoxazoles and -benzisothiazoles
GB9824196D0 (en) I.S.machine
ZA966778B (en) Filler for sliding gates.
GB9824195D0 (en) I.s. machine
SI0843661T1 (en) (1s,2s)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propanolmethanesulfonate trihydrate
ZA969127B (en) Fungicidal compounds.
ZA976694B (en) Fungicides.
EP0669375A3 (en) Polymer blends.
ZA981988B (en) Packaging machine.
IT1269022B (it) Tappo per operazioni di sfecciatura.