MA23957A1 - Trihydrate de methanesulfonate de (1s,2s) -1- (4-hydroxyphenyl) -2- (4-hydroxy-4- phenylpiperidine-1- yl-1- propanol et composition le contenant - Google Patents
Trihydrate de methanesulfonate de (1s,2s) -1- (4-hydroxyphenyl) -2- (4-hydroxy-4- phenylpiperidine-1- yl-1- propanol et composition le contenantInfo
- Publication number
- MA23957A1 MA23957A1 MA24335A MA24335A MA23957A1 MA 23957 A1 MA23957 A1 MA 23957A1 MA 24335 A MA24335 A MA 24335A MA 24335 A MA24335 A MA 24335A MA 23957 A1 MA23957 A1 MA 23957A1
- Authority
- MA
- Morocco
- Prior art keywords
- phenylpiperidine
- hydroxyphenyl
- propanol
- hydroxy
- composition containing
- Prior art date
Links
- QQCRBPTYHQBEJP-UHFFFAOYSA-N 1-(1-hydroxypropyl)-4-phenylpiperidin-4-ol Chemical compound C1CN(C(O)CC)CCC1(O)C1=CC=CC=C1 QQCRBPTYHQBEJP-UHFFFAOYSA-N 0.000 title 1
- -1 4-HYDROXYPHENYL Chemical class 0.000 title 1
- LKGCPYOBWLSCTK-UHFFFAOYSA-N methanesulfonic acid;trihydrate Chemical compound O.O.O.CS(O)(=O)=O LKGCPYOBWLSCTK-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Virology (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US223895P | 1995-08-11 | 1995-08-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA23957A1 true MA23957A1 (fr) | 1997-04-01 |
Family
ID=21699847
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA24335A MA23957A1 (fr) | 1995-08-11 | 1996-08-07 | Trihydrate de methanesulfonate de (1s,2s) -1- (4-hydroxyphenyl) -2- (4-hydroxy-4- phenylpiperidine-1- yl-1- propanol et composition le contenant |
Country Status (41)
| Country | Link |
|---|---|
| US (1) | US6008233A (fr) |
| EP (1) | EP0843661B1 (fr) |
| JP (1) | JP3099072B2 (fr) |
| KR (1) | KR100291882B1 (fr) |
| CN (2) | CN1615861A (fr) |
| AP (1) | AP755A (fr) |
| AR (1) | AR004676A1 (fr) |
| AT (1) | ATE215072T1 (fr) |
| AU (1) | AU710984B2 (fr) |
| BG (1) | BG63678B1 (fr) |
| BR (1) | BR9610766A (fr) |
| CA (1) | CA2228752C (fr) |
| CO (1) | CO4750830A1 (fr) |
| CZ (1) | CZ296236B6 (fr) |
| DE (1) | DE69620191T2 (fr) |
| DK (1) | DK0843661T3 (fr) |
| DZ (1) | DZ2083A1 (fr) |
| ES (1) | ES2170857T3 (fr) |
| GT (1) | GT199600051A (fr) |
| HR (1) | HRP960372B1 (fr) |
| HU (1) | HUP9802862A3 (fr) |
| IL (1) | IL122649A (fr) |
| IS (1) | IS1945B (fr) |
| MA (1) | MA23957A1 (fr) |
| NO (1) | NO310458B1 (fr) |
| NZ (1) | NZ309134A (fr) |
| OA (1) | OA10664A (fr) |
| PE (1) | PE4898A1 (fr) |
| PL (1) | PL185603B1 (fr) |
| PT (1) | PT843661E (fr) |
| RO (1) | RO120134B1 (fr) |
| RS (1) | RS49521B (fr) |
| RU (1) | RU2140910C1 (fr) |
| SA (1) | SA96170171B1 (fr) |
| SK (1) | SK284209B6 (fr) |
| TN (1) | TNSN96104A1 (fr) |
| TR (1) | TR199800208T1 (fr) |
| TW (1) | TW495502B (fr) |
| UA (1) | UA59341C2 (fr) |
| WO (1) | WO1997007098A1 (fr) |
| ZA (1) | ZA966760B (fr) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6046213A (en) * | 1994-08-18 | 2000-04-04 | Pfizer Inc. | Neuroprotective 3-(piperidinyl-1)-chroman-4,7-diol and 1-(4-hydroxyphenyl)-2-(piperidinyl-1)-alkanol derivatives |
| EP0843661B1 (fr) * | 1995-08-11 | 2002-03-27 | Pfizer Inc. | Trihydrate de methanesulfonate de (1s,2s)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propanol |
| GB9820405D0 (en) | 1998-09-18 | 1998-11-11 | Smithkline Beecham Plc | Process |
| AU3676100A (en) * | 1999-04-09 | 2000-11-14 | Mochida Pharmaceutical Co., Ltd. | Remedies for neuropathic pain |
| GB9920917D0 (en) | 1999-09-03 | 1999-11-10 | Sb Pharmco Inc | Novel process |
| GB9920919D0 (en) | 1999-09-03 | 1999-11-10 | Sb Pharmco Inc | Novel compound |
| US6620830B2 (en) * | 2000-04-21 | 2003-09-16 | Pfizer, Inc. | Thyroid receptor ligands |
| YU27801A (sh) | 2000-04-28 | 2003-04-30 | Pfizer Products Inc. | Postupak za dobijanje trihidrata mezilatne soli 1-(4- hidroksifenil)-2-(4-hidroksi-4-fenilpiperidin-1-il)-1-propanola i korisnih intermedijera |
| YU27701A (sh) * | 2000-04-28 | 2003-04-30 | Pfizer Products Inc. | Postupak za dobijanje trihidrata mezilatne soli 1-(4- hidroksifenil)-2-(4-hidroksi-4-fenilpiperidin-1-il)1-propanola |
| IL154378A0 (en) | 2000-08-16 | 2003-09-17 | Upjohn Co | Compounds for the treatment of addictive disorders |
| EP1186303A3 (fr) * | 2000-09-06 | 2003-12-10 | Pfizer Products Inc. | Combinaisons pharmaceutiques pour le traitement des accidents cerebrovasculaires, contenant un facteur inhibitant la neutrophile et un antagoniste selectif du NMDA-NR2B |
| EP1674087A1 (fr) | 2000-10-02 | 2006-06-28 | Pfizer Products Inc. | Utilisation prophylactique d'antagonistes des récepteurs du N-méthyl-D-aspartate (NMDA) |
| IL145584A0 (en) | 2000-10-02 | 2002-06-30 | Pfizer Prod Inc | Nmda nr2b antagonists for treatment |
| UA73619C2 (en) * | 2000-12-13 | 2005-08-15 | Pfizer Prod Inc | Stable pharmaceutical compositions of nmda receptor agonist (variants) and method of treatment |
| JP4398247B2 (ja) * | 2001-10-19 | 2010-01-13 | 富山化学工業株式会社 | アルキルエーテル誘導体またはその塩 |
| KR100517638B1 (ko) | 2002-04-08 | 2005-09-28 | 주식회사 엘지생명과학 | 게미플록사신 산염의 새로운 제조방법 |
| KR101052122B1 (ko) | 2005-10-25 | 2011-07-26 | 시오노기세야쿠 가부시키가이샤 | 아미노디히드로티아진 유도체 |
| EP2147914B1 (fr) | 2007-04-24 | 2014-06-04 | Shionogi&Co., Ltd. | Dérivés d'aminodihydrothiazine substitués par des groupes cycliques |
| EP2151435A4 (fr) | 2007-04-24 | 2011-09-14 | Shionogi & Co | Composition pharmaceutique pour le traitement de la maladie d'alzheimer |
| MX2010013256A (es) | 2008-06-13 | 2010-12-21 | Shionogi & Co | Derivado heterociclico que contiene azufre que tiene actividad inhibitoria de beta-secretasa. |
| JPWO2010047372A1 (ja) | 2008-10-22 | 2012-03-22 | 塩野義製薬株式会社 | Bace1阻害活性を有する2−アミノピリミジン−4−オンおよび2−アミノピリジン誘導体 |
| JPWO2011071135A1 (ja) | 2009-12-11 | 2013-04-22 | 塩野義製薬株式会社 | オキサジン誘導体 |
| CA2816285A1 (fr) | 2010-10-29 | 2012-05-03 | Shionogi & Co., Ltd. | Derive de naphtyridine |
| EP2634188A4 (fr) | 2010-10-29 | 2014-05-07 | Shionogi & Co | Dérivé d'aminodihydropyrimidine fusionnée |
| TW201247635A (en) | 2011-04-26 | 2012-12-01 | Shionogi & Co | Oxazine derivatives and a pharmaceutical composition for inhibiting BAC1 containing them |
| JP2016501827A (ja) | 2012-10-24 | 2016-01-21 | 塩野義製薬株式会社 | Bace1阻害作用を有するジヒドロオキサジンまたはオキサゼピン誘導体 |
| EP3194403B1 (fr) | 2014-09-15 | 2019-02-06 | Rugen Holdings (Cayman) Limited | Dérivés de pyrrolopyrimidine à titre d'antagonistes des récepteurs nmda nr2b |
| WO2016049048A1 (fr) * | 2014-09-22 | 2016-03-31 | Rugen Holdings (Cayman) Limited | Traitement des troubles de l'anxiété et des troubles du spectre autistique |
| US10221182B2 (en) | 2015-02-04 | 2019-03-05 | Rugen Holdings (Cayman) Limited | 3,3-difluoro-piperidine derivatives as NR2B NMDA receptor antagonists |
| US10584127B2 (en) | 2015-06-01 | 2020-03-10 | Rugen Holdings (Cayman) Limited | 3,3-difluoropiperidine carbamate heterocyclic compounds as NR2B NMDA receptor antagonists |
| US11000526B2 (en) | 2016-11-22 | 2021-05-11 | Rugen Holdings (Cayman) Limited | Treatment of autism spectrum disorders, obsessive-compulsive disorder and anxiety disorders |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990014087A1 (fr) * | 1989-05-17 | 1990-11-29 | Pfizer Inc. | Derives de 2-piperidino-1-alcanol en tant qu'agents antiischemiques |
| US5272160A (en) * | 1989-05-17 | 1993-12-21 | Pfizer Inc | 2-piperidino-1-alkanol derivatives as antiischemic agents |
| US6046213A (en) * | 1994-08-18 | 2000-04-04 | Pfizer Inc. | Neuroprotective 3-(piperidinyl-1)-chroman-4,7-diol and 1-(4-hydroxyphenyl)-2-(piperidinyl-1)-alkanol derivatives |
| EP0843661B1 (fr) * | 1995-08-11 | 2002-03-27 | Pfizer Inc. | Trihydrate de methanesulfonate de (1s,2s)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propanol |
-
1996
- 1996-06-20 EP EP96916266A patent/EP0843661B1/fr not_active Expired - Lifetime
- 1996-06-20 UA UA98020673A patent/UA59341C2/uk unknown
- 1996-06-20 BR BR9610766A patent/BR9610766A/pt not_active Application Discontinuation
- 1996-06-20 CZ CZ0039098A patent/CZ296236B6/cs not_active IP Right Cessation
- 1996-06-20 AU AU59084/96A patent/AU710984B2/en not_active Ceased
- 1996-06-20 KR KR1019980700989A patent/KR100291882B1/ko not_active Expired - Fee Related
- 1996-06-20 SK SK166-98A patent/SK284209B6/sk unknown
- 1996-06-20 CN CNA031584969A patent/CN1615861A/zh active Pending
- 1996-06-20 US US09/011,426 patent/US6008233A/en not_active Expired - Fee Related
- 1996-06-20 WO PCT/IB1996/000592 patent/WO1997007098A1/fr not_active Ceased
- 1996-06-20 TR TR1998/00208T patent/TR199800208T1/xx unknown
- 1996-06-20 JP JP09509083A patent/JP3099072B2/ja not_active Expired - Fee Related
- 1996-06-20 HU HU9802862A patent/HUP9802862A3/hu unknown
- 1996-06-20 ES ES96916266T patent/ES2170857T3/es not_active Expired - Lifetime
- 1996-06-20 RO RO98-00231A patent/RO120134B1/ro unknown
- 1996-06-20 PL PL96325050A patent/PL185603B1/pl not_active IP Right Cessation
- 1996-06-20 DK DK96916266T patent/DK0843661T3/da active
- 1996-06-20 PT PT96916266T patent/PT843661E/pt unknown
- 1996-06-20 DE DE69620191T patent/DE69620191T2/de not_active Expired - Fee Related
- 1996-06-20 IL IL12264996A patent/IL122649A/xx not_active IP Right Cessation
- 1996-06-20 AT AT96916266T patent/ATE215072T1/de not_active IP Right Cessation
- 1996-06-20 CN CN96195649A patent/CN1198739A/zh active Pending
- 1996-06-20 NZ NZ309134A patent/NZ309134A/en unknown
- 1996-06-20 RU RU98102116A patent/RU2140910C1/ru not_active IP Right Cessation
- 1996-06-20 CA CA002228752A patent/CA2228752C/fr not_active Expired - Fee Related
- 1996-06-24 TW TW085107571A patent/TW495502B/zh not_active IP Right Cessation
- 1996-07-04 GT GT199600051A patent/GT199600051A/es unknown
- 1996-07-23 SA SA96170171A patent/SA96170171B1/ar unknown
- 1996-08-06 PE PE1996000587A patent/PE4898A1/es not_active Application Discontinuation
- 1996-08-07 DZ DZ960127A patent/DZ2083A1/fr active
- 1996-08-07 MA MA24335A patent/MA23957A1/fr unknown
- 1996-08-07 TN TNTNSN96104A patent/TNSN96104A1/fr unknown
- 1996-08-07 AR ARP960103904A patent/AR004676A1/es unknown
- 1996-08-08 AP APAP/P/1996/000856A patent/AP755A/en active
- 1996-08-08 ZA ZA9606760A patent/ZA966760B/xx unknown
- 1996-08-09 HR HR960372A patent/HRP960372B1/xx not_active IP Right Cessation
- 1996-08-09 RS YU46196A patent/RS49521B/sr unknown
- 1996-08-09 CO CO96042164A patent/CO4750830A1/es unknown
-
1997
- 1997-12-30 IS IS4643A patent/IS1945B/is unknown
-
1998
- 1998-02-10 OA OA9800021A patent/OA10664A/en unknown
- 1998-02-10 NO NO19980574A patent/NO310458B1/no unknown
- 1998-02-27 BG BG102289A patent/BG63678B1/bg unknown
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