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WO2011016674A3 - 신규 유기 게르마늄 화합물 - Google Patents

신규 유기 게르마늄 화합물 Download PDF

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Publication number
WO2011016674A3
WO2011016674A3 PCT/KR2010/005114 KR2010005114W WO2011016674A3 WO 2011016674 A3 WO2011016674 A3 WO 2011016674A3 KR 2010005114 W KR2010005114 W KR 2010005114W WO 2011016674 A3 WO2011016674 A3 WO 2011016674A3
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WIPO (PCT)
Prior art keywords
linear
ascorbic acid
group
aryl group
branched
Prior art date
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Ceased
Application number
PCT/KR2010/005114
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English (en)
French (fr)
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WO2011016674A2 (ko
Inventor
함승욱
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Industry Academic Cooperation Foundation of Chung Ang University
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Industry Academic Cooperation Foundation of Chung Ang University
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Application filed by Industry Academic Cooperation Foundation of Chung Ang University filed Critical Industry Academic Cooperation Foundation of Chung Ang University
Publication of WO2011016674A2 publication Critical patent/WO2011016674A2/ko
Publication of WO2011016674A3 publication Critical patent/WO2011016674A3/ko
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/30—Germanium compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers
    • A61K2800/522—Antioxidants; Radical scavengers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

본 발명은 하기 화학식 1로 표시되는 유기 게르마늄 화합물 또는 이들의 염에 관한 것이다. [화학식 1] 상기 화학식 1에서, R1, R2 및 R3는 서로 동일하거나 상이하고, 각각 독립적으로 C1-C6의 직쇄 또는 가지쇄의 알킬기, C2-C6의 직쇄 또는 가지쇄의 알케닐기, C2-C6의 직쇄 또는 가지쇄의 알키닐기, 아릴기, C1-C6의 직쇄 또는 가지쇄의 알킬기로 치환된 아릴기, C2-C6의 직쇄 또는 가지쇄의 알케닐기로 치환된 아릴기, C2-C6의 직쇄 또는 가지쇄의 알키닐기로 치환된 아릴기이고; R4는 단당류(monosaccharide), 알코올(alcohol), L-아스코르브산(L-ascorbic acid), L-아스코르브산의 푸란 고리 2번 탄소 위치의 히드록실기가 보호된 L-아스코르브산 유도체, 또는 이들의 아민 유도체이고; m은 0 내지 10의 정수이고; X는 CO 또는 CH2이고; Ge는 게르마늄이다. 본 발명의 신규 유기 게르마늄 화합물은 수용성이 현저히 향상되어 생체내로의 흡수가 용이하고 조직에서 축적되지 않아 체내에서 독성이 없고 게르마늄의 본래 효능을 충분히 발휘할 수 있다. 또한, L-아스코르브산이 결합된 화합물의 경우 강력한 항산화 활성을 나타낸다.
PCT/KR2010/005114 2009-08-05 2010-08-04 신규 유기 게르마늄 화합물 Ceased WO2011016674A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2009-0072132 2009-08-05
KR1020090072132A KR101200996B1 (ko) 2009-08-05 2009-08-05 신규 유기 게르마늄 화합물

Publications (2)

Publication Number Publication Date
WO2011016674A2 WO2011016674A2 (ko) 2011-02-10
WO2011016674A3 true WO2011016674A3 (ko) 2011-06-30

Family

ID=43544786

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2010/005114 Ceased WO2011016674A2 (ko) 2009-08-05 2010-08-04 신규 유기 게르마늄 화합물

Country Status (2)

Country Link
KR (1) KR101200996B1 (ko)
WO (1) WO2011016674A2 (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101492811B1 (ko) * 2013-04-23 2015-02-13 김영민 게르마늄 부식산의 분리방법
KR20230062092A (ko) * 2021-10-29 2023-05-09 한국전자통신연구원 기지국 부하 제어 방법 및 장치

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009096737A2 (ko) * 2008-01-31 2009-08-06 Chung-Ang University Industry-Academy Cooperation Foundation 신규 유기 게르마늄 화합물 및 이를 유효성분으로 포함하는 조성물

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009096737A2 (ko) * 2008-01-31 2009-08-06 Chung-Ang University Industry-Academy Cooperation Foundation 신규 유기 게르마늄 화합물 및 이를 유효성분으로 포함하는 조성물

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ANDREA VASELLA.: "AN APPROACH TO THE SYNTHESIS OF POLYSACCHARIDE ANALOGUES", PURE & APPL. CHEM., vol. 70, no. 2, 1998, pages 425 - 430 *
CHISATO HIRAYAMA ET AL.: "Propagermanium: a nonspecific immune modulator for chronic hepatitis B", JOURNAL OF GASTROENTEROLOGY, vol. 38, no. 6, 2003, pages 525 - 532 *
YOKO IMAFUKU ET AL.: "Synthesis and characterization of some penicillins modified with germanium-containing moieties", APPLIED ORGANOMETALLIC CHEMISTRY, vol. 18, no. ISSUE, August 2004 (2004-08-01), pages 384 - 393 *
YOSHITO TAKEUCHI ET AL.: "Synthesis and characterization of several cephalothin derivatives modified with germanium-containing moieties", APPLIED ORGANOMETALLIC CHEMISTRY, SPECIAL ISSUE: DEDICATED TO THE MEMORY OF PROFESSOR COIN EABORN, vol. 19, no. ISSUE, April 2005 (2005-04-01), pages 473 - 478 *

Also Published As

Publication number Publication date
KR20110014458A (ko) 2011-02-11
KR101200996B1 (ko) 2012-11-13
WO2011016674A2 (ko) 2011-02-10

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